LOCUS       NM_001145194            3065 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens A-kinase anchor inhibitor 1 (AKAIN1), transcript
            variant 1, mRNA.
ACCESSION   NM_001145194 XM_001719925 XM_001719927 XM_931384 XM_931389
            XM_945724 XM_945726
VERSION     NM_001145194.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Fukuda,M. and Aizawa,Y.
  TITLE     Hypothetical gene C18orf42 encodes a novel protein kinase A-binding
            protein
  JOURNAL   Genes Cells 20 (4), 267-280 (2015)
   PUBMED   25653177
  REMARK    GeneRIF: These findings suggest that C18orf42 may be a novel PKA
            signaling gene that serves as an endogenous disruptor peptide for
            PKA-AKAP interactions.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001496.4 and AP005380.2.
            
            On May 17, 2019 this sequence version replaced NM_001145194.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.114515.1,
                                           SRR1660805.98491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434239.4/ ENSP00000399075.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AP001496.4         59808-60027         c
            221-3065            AP005380.2         103671-106515       c
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..3065
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="A-kinase anchor inhibitor 1"
                     /db_xref="GeneID:642597"
                     /db_xref="HGNC:HGNC:28285"
                     /db_xref="MIM:616427"
     exon            1..220
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..414
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A-kinase anchor protein C18orf42; A-kinase anchor protein
                     inhibitor 1; A kinase (PRKA) anchor inhibitor 1"
                     /codon_start=1
                     /product="A-kinase anchor protein inhibitor 1 isoform 1"
                     /protein_id="NP_001138666.1"
                     /db_xref="CCDS:CCDS54179.1"
                     /db_xref="GeneID:642597"
                     /db_xref="HGNC:HGNC:28285"
                     /db_xref="MIM:616427"
                     /translation="MVFAPGEKPGNEPEEVKLQNASKQIVQNAILQAVQQVSQESQRR
                     EERISDNRDHIQLGVGELTKKHEKK"
     exon            221..3065
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1126..1131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="hexamer: AATAAG"
     polyA_site      1144
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="major polyA site"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="hexamer: AATAAA"
     polyA_site      2306
                     /gene="AKAIN1"
                     /gene_synonym="C18orf42"
                     /note="major polyA site"
ORIGIN      
        1 attgtggagg cagagcgcgc ggcggcggct ggagctgcgg ccccaggatc tagcggcggg
       61 agctgtccgg ggtgctgacc gccccgcccg ccgcccgccc agcgcgccct cctgcaccgg
      121 accccgccaa gtccggcctt cttcccatcc tccgtctgcc tgtctttctc tcttaatctg
      181 ggggcgtagc ggctggaaga aatcatggtg ttcgctccag gtgagaaacc tggaaatgag
      241 cctgaagagg tgaagctgca gaatgccagc aaacagattg tgcagaatgc aatcctgcaa
      301 gctgtgcagc aagtctccca ggagagtcag cgcagagaag agagaatcag tgacaaccgg
      361 gaccacatcc aactgggcgt tggggagtta accaagaagc acgaaaagaa gtaacatggt
      421 ggatttggct cttgacatgt gcttggtttc tagccttcct cttagtatag gacgcatctc
      481 caaaatgttg ccagtaaagc aaaccgaagt gtcaccggca cctagctgta gaatgaattc
      541 acactagccc ctggctgaga agcactgttt tgaaaaagtg cattagacga ttctgttcat
      601 atttatgcag tgcctctgag acatagtggg gccaaatatg acactgtaat tgcaaaagta
      661 gttttgcagg ccaatttatt tttaaagttc ttttatttga aaaaaagaat tctatgtctc
      721 gtttatttac ttctgccttt tatgcgttcc ttctgtgaat ttaacaagca gcctttttgc
      781 tgaaatactg aatacagtac tgagttcttt atggtatatt aaaaagacat gctagaaagg
      841 tgagggaatg cagttttagt taccttcaaa tgtgaaattg aaggctttaa gtgggttcag
      901 gtctaagatc aaattaagaa aagggaaatt ctaaggctga gtccctcggg accataccaa
      961 ggcatttact aatatttatg ttattttaag aaagggagga gtttaagttt ctcaagaact
     1021 cagtctttta gtctcaattc tctgaatgat ttcataattg gtgtttatgc tctgtgtaga
     1081 aatcttttgg gaatattatg gatttctttt ctcaagatta aataaaataa gacaagtgag
     1141 tctacacatg tgagttgcca atgactcatt tccttagcag cctcatggag aatggctaga
     1201 agtgtagatt tcttcaacag ctgcctatca ttaagagact tacacttggg gctgattatg
     1261 gggtgcaaca tccttggaag ggattctggg gtccttaacg aatgctgttt tgccactagg
     1321 ctatgcattt gcattaggac cttactaact tttcccattc acacattaaa tttttttttt
     1381 gagattatga aaatcataca ggtcaggaat acatgagaac acaatgggga cagtaaagtg
     1441 acagtgtttt gaatgcagtg acagagatat gtgtgtgtac acgtgtaata aagttatctg
     1501 tgcagcaaca ggatcaatcc ctgctccact tctgtgagga taatgcacat atttctggag
     1561 tatctacagt cccatttcct gggcttcaca aaagttattg aattggtgct attggggaca
     1621 gaggaagaat ttgaccttgg ttaaaaacct tctagtttca gagtatcaat atctacattt
     1681 gatttttttt taaagcaaag tattcgggta taaattgtga ctgatattaa gatatacttc
     1741 taaaattcca atatgctaca gtttctagaa taaatagttg gataatagat aatgaatgaa
     1801 aaatatctta ccagctttgt tatgctatct cccacagtgc acaggtggaa taaattcaca
     1861 ggaaacatgg aaggagaagg aagcagaagg gcttaaaatt taaagattgt ttactcacaa
     1921 gtatttcttt tagcagaatt catgccaagt gaagagtgag tttaagtcga ccaaaagtca
     1981 tataactgat gtgatataat tgcatagcat acatagtgag aatgaaggta ttcagggaaa
     2041 ttattcagga gtgccacaaa taaaataaat aaataaatct aatgcttgta gtttgtaagt
     2101 gatctggtac tatgtctact cagatatctg gatatgacca gcctttgttt ttgctgtcaa
     2161 gtgacagaaa catataaaca tactattttt cctctctgat gtgtctgtac taaaaaattg
     2221 ggaatttttg gaacatctta ttgacctctg tgtctaaatg ttatttataa ataaaacaca
     2281 tacagctttg aaatatctta agcaaagttt tctagactct gccgtttggc tcattttgta
     2341 cgtggatctt accattattt ggaaccatga gacttccaag gctattttca aacccctaga
     2401 tatcatgacc aggggaagtg cttccttaat gggcccttca ctgtgactgt gtgaggacag
     2461 ccatgggatg gtgggtcctg aggcttgaag agaaaaggat gtatgctaag aagtggtctt
     2521 ttgatctaaa aaattcaagg taagtgggtc tggaaggtag agtgtctgcc ataatttttg
     2581 agatggaaaa tcgacagcaa ggaacagaga tatgactaag ttgttgggag gacaaaagga
     2641 ggttcagcaa tgcctgtcct caataggtag gtgccatatt ggcaaaattc taagaaagct
     2701 cagtcataaa aacaaacgag ttaaagacct ataaactttt acagatcttt cagtatgaag
     2761 aaaaagttac tagattttac aaggggccta cagaacttca tttgacatag gattaaggtg
     2821 gatttccact tgattatcat cataaaccag atcacagctt ttagtttcag aaatgagtgg
     2881 gaacatttac ttagtgtcct ttatctttct gatttactgc atacacaggc ttcccatctc
     2941 tgtgtgttca gctgttcgtc ttctctgttg cctgccccta gggtggatct aaagaaagaa
     3001 atcctttcat gttacttttc tctgctgtaa tcatctgttc agtgcaaaca gtattgtaaa
     3061 ttgat
//
