LOCUS       NM_016283               1626 bp    mRNA    linear   PRI 28-JUN-2024
DEFINITION  Homo sapiens adenylate kinase 6 (AK6), transcript variant 2, mRNA.
ACCESSION   NM_016283
VERSION     NM_016283.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Xu,R., Yang,Y. and Zheng,X.
  TITLE     Unique structural features of the adenylate kinase hCINAP/AK6 and
            its multifaceted functions in carcinogenesis and tumor progression
  JOURNAL   FEBS Lett 595 (16), 2071-2084 (2021)
   PUBMED   34245011
  REMARK    GeneRIF: Unique structural features of the adenylate kinase
            hCINAP/AK6 and its multifaceted functions in carcinogenesis and
            tumor progression.
            Review article
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Ke,S., Zhang,R., He,Y., Mu,H., Sun,F., Liu,W., Li,J. and Song,X.
  TITLE     Human adenylate kinase 6 regulates WNK1 (with no lysine kinase-1)
            phosphorylation states and affects ion homeostasis in NT2 cells
  JOURNAL   Exp Cell Res 402 (1), 112565 (2021)
   PUBMED   33744230
  REMARK    GeneRIF: Human adenylate kinase 6 regulates WNK1 (with no lysine
            kinase-1) phosphorylation states and affects ion homeostasis in NT2
            cells.
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Zhang,Y., Jiang,L., Qin,N., Cao,M., Liang,X. and Wang,R.
  TITLE     hCINAP is potentially a direct target gene of HIF-1 and is required
            for hypoxia-induced EMT and apoptosis in cervical cancer cells
  JOURNAL   Biochem Cell Biol 99 (2), 203-213 (2021)
   PUBMED   32830518
  REMARK    GeneRIF: hCINAP is potentially a direct target gene of HIF-1 and is
            required for hypoxia-induced EMT and apoptosis in cervical cancer
            cells.
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Wang,H.S., Zhu,Y. and Sun,F.
  TITLE     [Expressions of the adenylate kinase family in asthenospermia]
  JOURNAL   Zhonghua Nan Ke Xue 25 (12), 1077-1082 (2019)
   PUBMED   32251557
  REMARK    GeneRIF: The mRNA and protein expressions of AK1, AK6 and AK7 are
            significantly down-regulated in the sperm of asthenospermia
            patients, which may be closely related with reduced sperm motility.
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Xu,R., Yu,S., Zhu,D., Huang,X., Xu,Y., Lao,Y., Tian,Y., Zhang,J.,
            Tang,Z., Zhang,Z., Yi,J., Zhu,H.H. and Zheng,X.
  TITLE     hCINAP regulates the DNA-damage response and mediates the
            resistance of acute myelocytic leukemia cells to therapy
  JOURNAL   Nat Commun 10 (1), 3812 (2019)
   PUBMED   31444354
  REMARK    GeneRIF: These results provide mechanistic insight into the
            function of hCINAP during the DNA-damage response and its role in
            acute myelocytic leukemia resistance to therapy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Ren,H., Liang,Y., Li,R., Ding,H., Qiu,S., Lu,S., An,J., Li,L.,
            Luo,M., Zheng,X. and Su,X.D.
  TITLE     Protein preparation, crystallization and preliminary X-ray analysis
            of human adrenal gland protein AD-004
  JOURNAL   Acta Crystallogr D Biol Crystallogr 60 (Pt 7), 1292-1294 (2004)
   PUBMED   15213396
  REMARK    GeneRIF: purification and X ray crystal structure
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J Biol Chem 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J Biol Chem 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF151895.1, BC007426.2 and AC145132.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016283.4.
            
            Summary: This gene encodes a protein that belongs to the adenylate
            kinase family of enzymes. The protein has a nuclear localization
            and contains Walker A (P-loop) and Walker B motifs and a
            metal-coordinating residue. The protein may be involved in
            regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID:
            6880) are two distinct genes that share 5' exons. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.49026.1,
                                           SRR1660807.103430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380822.9/ ENSP00000370201.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-875               AF151895.1         3-877
            876-884             BC007426.2         863-871
            885-1626            AC145132.2         26298-27039
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1626
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /note="adenylate kinase 6"
                     /db_xref="GeneID:102157402"
                     /db_xref="HGNC:HGNC:49151"
                     /db_xref="MIM:619357"
     exon            1..58
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..549
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /EC_number="2.7.4.3"
                     /note="isoform b is encoded by transcript variant 2;
                     adrenal gland protein AD-004; coilin interacting protein;
                     ATP-AMP transphosphorylase 6; coilin interacting nuclear
                     ATPase protein; sperm protein HTL-T-97p"
                     /codon_start=1
                     /product="adenylate kinase isoenzyme 6 isoform b"
                     /protein_id="NP_057367.1"
                     /db_xref="CCDS:CCDS4001.1"
                     /db_xref="GeneID:102157402"
                     /db_xref="HGNC:HGNC:49151"
                     /db_xref="MIM:619357"
                     /translation="MLLPNILLTGTPGVGKTTLGKELASKSGLKYINVGDLAREEQLY
                     DGYDEEYDCPILDEDRVVDELDNQMREGGVIVDYHGCDFFPERWFHIVFVLRTDTNVL
                     YERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNKPEELENNVDQIL
                     KWIEQWIKDHNS"
     exon            59..151
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /inference="alignment:Splign:2.1.0"
     exon            152..210
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /inference="alignment:Splign:2.1.0"
     exon            211..356
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /inference="alignment:Splign:2.1.0"
     exon            357..1626
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      863..868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /note="hexamer: AATAAA"
     polyA_site      884
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /note="major polyA site"
     regulatory      1122..1127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /note="hexamer: AATATA"
     polyA_site      1147
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
                     /note="hexamer: TATAAA"
     polyA_site      1626
                     /gene="AK6"
                     /gene_synonym="AD-004; CGI-137; CINAP; CIP; hCINAP"
ORIGIN      
        1 gaggcgcccg aagccgtcgc ggcggggacc atgttgcttc cgaacatcct gctcaccggt
       61 acaccagggg ttggaaaaac cacactaggc aaagaacttg cgtcaaaatc aggactgaaa
      121 tacattaatg tgggtgattt agctcgagaa gagcaattgt atgatggcta tgatgaagag
      181 tatgactgtc ccattttaga tgaagacaga gtagttgatg agttagataa ccaaatgaga
      241 gaaggtggag ttattgttga ttaccatggt tgtgatttct tccctgaacg ctggtttcat
      301 atagtttttg tgctgagaac agataccaat gtattgtacg aaagacttga aacaaggggt
      361 tataatgaga agaaactaac agacaatatt cagtgtgaga tttttcaagt tctttatgaa
      421 gaagccacag catcctacaa ggaagaaatc gtgcatcagc tgcccagtaa taaaccagaa
      481 gagctagaaa ataatgtaga tcagatcttg aaatggattg agcagtggat caaagatcat
      541 aactcttgac ttataaggct agctacttaa taatcactct tgttgatatc tctgccgaca
      601 tcatagaaat tgttcaagtg tcagtaacac tttattaaaa tcatgttgca gaaccagcag
      661 gtggatagta tataggttta tgcctgtgtt tctttttctc catgagaaag ctaaacatga
      721 aatataatga atatagtatt attaaggatt gagacaaaaa ctgtgatttt aatacttaaa
      781 ttgctaaaga ataaataaat ctgacaaaat gggtggatat cttttaagtt tattacagaa
      841 aaaaatgcag atgatctctt aaaataaaac taaagataaa gcaacagagt attccttttt
      901 tctttcttta aattagaaaa aaagttaagt gttgtactcg atacaaagtt caaaaggtac
      961 aaaagagcat gttgaaaagt taggtctccc ttccagacca ccctatcccc aggcacccca
     1021 ggttccttcc ctttaggaaa taatgttact ggtttcctat atgtcttttt agaggtttta
     1081 tgcctgcaca gtgtatatgt acatgtgtac attttttaaa gaatataaca gtatattatg
     1141 cacactattc tgtacctttc ttttttcact tactatattt gaagattata tcatctcagt
     1201 acagacctcc ctgttctttt ttttagttga gatagatata catatcatac aataaaattt
     1261 accattttga agtgtataat cagaaccggg tatggtggct tatgcctgta atcccagcaa
     1321 atggggaggc tgaggtggag aatcgcttga ggcaggagtt caagaccagc ctgggcaaca
     1381 tagtgagacc ttagactcta aaaataaaca taaataaaat ttataatccg ttggttttta
     1441 gcttattaac aaggttatgt aactgtcacc actgtggagg aagcagtgat gataaaggga
     1501 actcctatac cctttagcag tcactctcta ttctttcctc ctcatcccct tgcagtcact
     1561 agtctacttt ctgtctctat ggatttgcat attctggata tttcatataa atgggattat
     1621 acagta
//
