LOCUS       NM_174858               3280 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens adenylate kinase 5 (AK5), transcript variant 1, mRNA.
ACCESSION   NM_174858
VERSION     NM_174858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Ahn,B., Chae,Y.S., Lee,S.K., Kim,M., Kim,H.S., Moon,J.W. and
            Park,S.H.
  TITLE     Identification of novel DNA hypermethylation of the adenylate
            kinase 5 promoter in colorectal adenocarcinoma
  JOURNAL   Sci Rep 11 (1), 12626 (2021)
   PUBMED   34135408
  REMARK    GeneRIF: Identification of novel DNA hypermethylation of the
            adenylate kinase 5 promoter in colorectal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Zhang,L.H., Wang,Z., Fan,Q.Q., Yin,Z.J., Jin,L.F., Mao,Y. and
            Hua,D.
  TITLE     AK5, a novel prognosis marker, inhibits apoptosis and promotes
            autophagy as well as proliferation in human gastric cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (22), 9900-9906 (2019)
   PUBMED   31799658
  REMARK    GeneRIF: AK5, a novel prognosis marker, inhibits apoptosis and
            promotes autophagy as well as proliferation in human gastric
            cancer.
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Lai,Y., Hu,X., Chen,G., Wang,X. and Zhu,B.
  TITLE     Down-regulation of adenylate kinase 5 in temporal lobe epilepsy
            patients and rat model
  JOURNAL   J Neurol Sci 366, 20-26 (2016)
   PUBMED   27288770
  REMARK    GeneRIF: Results indicate that AK5 expression significantly
            decreased in temporal lobe epilepsy: the expression of AK5 in
            epileptic brain tissue may play important roles in epilepsy,
            especially refractory epilepsy
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Amiri,M., Conserva,F., Panayiotou,C., Karlsson,A. and Solaroli,N.
  TITLE     The human adenylate kinase 9 is a nucleoside mono- and diphosphate
            kinase
  JOURNAL   Int J Biochem Cell Biol 45 (5), 925-931 (2013)
   PUBMED   23416111
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Solaroli,N., Panayiotou,C., Johansson,M. and Karlsson,A.
  TITLE     Identification of two active functional domains of human adenylate
            kinase 5
  JOURNAL   FEBS Lett 583 (17), 2872-2876 (2009)
   PUBMED   19647735
  REMARK    GeneRIF: Data demonstrate that human adenylate kinase 5 has two
            separate functional domains and that both have enzymatic activity.
REFERENCE   6  (bases 1 to 3280)
  AUTHORS   Van Rompay,A.R., Johansson,M. and Karlsson,A.
  TITLE     Identification of a novel human adenylate kinase. cDNA cloning,
            expression analysis, chromosome localization and characterization
            of the recombinant protein
  JOURNAL   Eur J Biochem 261 (2), 509-517 (1999)
   PUBMED   10215863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF445193.1, BC036666.1 and
            AW665223.1.
            
            On Nov 23, 2018 this sequence version replaced NM_174858.2.
            
            Summary: This gene encodes a member of the adenylate kinase family,
            which is involved in regulating the adenine nucleotide composition
            within a cell by catalyzing the reversible transfer of phosphate
            groups among adenine nucleotides. This member is related to the
            UMP/CMP kinase of several species. It is located in the cytosol and
            expressed exclusively in brain. Alternatively spliced transcript
            variants encoding distinct isoforms have been identified for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript yet it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036666.1, SRR1660807.28804.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354567.7/ ENSP00000346577.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1978              AF445193.1         43-2020
            1979-3169           BC036666.1         1947-3137
            3170-3280           AW665223.1         5-115               c
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..3280
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /note="adenylate kinase 5"
                     /db_xref="GeneID:26289"
                     /db_xref="HGNC:HGNC:365"
                     /db_xref="MIM:608009"
     exon            1..355
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1984
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenylate kinase 6; adenylate kinase isoenzyme 5; AK 5;
                     ATP-AMP transphosphorylase 5"
                     /codon_start=1
                     /product="adenylate kinase isoenzyme 5 isoform 1"
                     /protein_id="NP_777283.1"
                     /db_xref="CCDS:CCDS675.1"
                     /db_xref="GeneID:26289"
                     /db_xref="HGNC:HGNC:365"
                     /db_xref="MIM:608009"
                     /translation="MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQK
                     VKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIH
                     QFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQY
                     ISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVID
                     GFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLM
                     NFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDP
                     SMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQ
                     CEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA
                     SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVD
                     DTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF"
     exon            356..542
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            543..710
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            711..880
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            881..994
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1186
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1277
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1354
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1397
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1442
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1606
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1723
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1915
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..3280
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2025..2030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /note="hexamer: ATTAAA"
     polyA_site      2045
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /note="major polyA site"
     regulatory      3258..3263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /note="hexamer: AATAAA"
     polyA_site      3280
                     /gene="AK5"
                     /gene_synonym="AK6"
                     /note="major polyA site"
ORIGIN      
        1 ggcggccgcg ctgcctggca gcccgggaag ccgcggcaca gctgctcggc gcctgcagct
       61 ccggctcggg ggctggaacc gaagcggggg cggcgggagc gcggagacca cagcccccgg
      121 ggagaggcgg agggggtccc tggcctgggc ggagaggctg agctgagtgc gcgtgagaaa
      181 gagggctgca ccgctgctcg gcgcggactc tgccagcccc agcttcagcc ccggctcagg
      241 tcgccgcagc ccgggagcct ccccgcttgc gccccaaggc acgcgcggca cagccatgaa
      301 caccaacgat gccaaggagt atctggcccg gagggaaatc cctcagcttt ttgagagcct
      361 tttgaatgga ctgatgtgtt ctaagcccga agatccagta gaatacttgg aaagttgttt
      421 acaaaaagta aaggaactgg gtggctgtga caaggtgaaa tgggatacat ttgtaagcca
      481 ggaaaagaag accttacctc cactaaatgg aggacagtca cggagatcct ttctaagaaa
      541 tgtaatgcct gaaaactcaa actttccata tcggcggtat gaccggctcc ctccaatcca
      601 tcaattctcc atagaaagtg acacggatct ctctgagact gcagagttga ttgaggagta
      661 tgaggttttt gatcctacca gacctcgacc aaaaatcatt cttgttatag gtggtccagg
      721 aagtggaaag ggtactcaga gtttgaaaat tgcagaacga tatggattcc aatacatttc
      781 tgtgggagaa ttattaagaa agaagatcca cagtaccagc agcaatagga aatggagtct
      841 tattgccaag ataattacaa ctggagaatt ggccccacag gaaacaacaa ttacagagat
      901 aaaacaaaaa ttgatgcaaa tacctgatga agagggcatt gttattgatg gatttccaag
      961 agatgttgcc caggctctat cttttgagga ccaaatctgt acccccgatt tggtggtatt
     1021 cctggcttgt gctaatcaga gactcaaaga aagattactg aagcgtgcag aacagcaggg
     1081 ccgaccagac gacaatgtaa aagctaccca aaggagacta atgaacttca agcagaatgc
     1141 tgctccattg gttaaatact tccaggaaaa ggggctcatc atgacatttg atgccgaccg
     1201 cgatgaggat gaggtgttct atgacatcag catggcagtt gacaacaagt tatttccaaa
     1261 caaagaggct gcagcaggtt caagtgacct tgatccttcg atgatattgg acactggaga
     1321 gatcattgat acaggatctg attatgaaga tcagggtgat gaccagttaa atgtatttgg
     1381 agaggacact atgggaggtt tcatggaaga tttgagaaag tgtaaaatta ttttcataat
     1441 tggtggtcct ggctctggca aaggcacaca gtgtgaaaag ctggtggaaa aatatggatt
     1501 tacacatctc tcaactggcg agctcctgcg tgaggaactg gcatcagaat ctgaaagaag
     1561 caaattgatc agagacatta tggaacgtgg agacctggtg ccctcaggca tcgttttgga
     1621 gctcctgaag gaggccatgg tggccagcct cggggacacc aggggcttcc tgattgacgg
     1681 ctatcctcgg gaggtgaagc aaggggaaga gttcggacgc aggattggag acccacagtt
     1741 ggtgatctgt atggactgct cggcagacac catgaccaac cgccttctcc aaaggagccg
     1801 gagcagcctg cctgtggacg acaccaccaa gaccatcgcc aagcgcctag aagcctacta
     1861 ccgagcgtcc atccccgtga tcgcctacta cgagacaaaa acacagctac acaagataaa
     1921 tgcagaggga acaccagagg acgtttttct tcaactctgc acagctattg actctatttt
     1981 ctgaaggcaa aaatgcatgt ttgttagaat ggaaacagaa aaacattaaa aagttcattc
     2041 cttaacacaa tgtttcaagt taaacctttt gtgtcaccgc ccccaccaac caccacctcc
     2101 taaatcctga cagcactgtt tgcttcccag ctagacctgt gtgagaggtg tctggaaatc
     2161 atgcatggtg tatttgggac tatatcaacc tattctccac acttcagaca actgtctgca
     2221 ctcacggcac acacactttg tatcatgcag gccacactca gagctagtca gtacatgaac
     2281 agtggtgcgg tgccagtctg tgtccgttgt gatcacaggc cttgctagac cctgatcatc
     2341 tggttctcct ctcattaagc atccctaacc cccagtcaca ccttcctctt acatactgtt
     2401 ccccaatgga ggcccctggc ataggggaca gccctgggca tcttcctttg gtgtctggct
     2461 gttttgtcaa ctctcatcca ctggtggctc agagccataa ggtgggttga ttacacaatg
     2521 ccttgtacat gatatagagg catcaagcaa gtaaaatttg acagaaattt taaaatatga
     2581 agatgtatag ctttcccaag atgatggtaa aacccaggtt agtcatcagt aaccttctct
     2641 attattatta ttttttagaa acttggaata ctgtcgtcat ggctaagaga acaaatctga
     2701 taaattgtgt aacctagtct cttctctaca tggtgatgca tttcagcaat tataaattaa
     2761 tataaatgac caaaagtaac ttaaaagcat gagatatttg ctatttcatt cattgggcac
     2821 atatcaaatt ataattttga ttttaaatgg tcacccatgt atttatttgt tgccaagcaa
     2881 gtaaaaaaat accctaacaa acctgatgtg ggtgggaggg gcatgtcagt aagtggtgtg
     2941 ttcaatgtgt ttgtttcata tgggcccttt ccaggagttt gcaaaccttg tcatacccat
     3001 atgcaaaact gtgtttcctt gcattaaacc agtgaagttt gggttctctt ttgtgctatc
     3061 aatcagttgt aaaatcagag ctgcttatat attctactgg aataactgca tcttccactc
     3121 agtcactaca aaaaagcata gtttcagttt gcatgaattt tttttttttt cttcaatggc
     3181 tgtgcagata aggatccatt tctgggatag aattgtattt tttaagtcat ttttttttct
     3241 tgaaatggat atgtacaaat aaaataaatg gaagacagga
//
