LOCUS       NM_001350770            2696 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens AFG2 interacting ribosome maturation factor (AIRIM),
            transcript variant 19, mRNA.
ACCESSION   NM_001350770 XM_017001546
VERSION     NM_001350770.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Krishnamoorthy,V., Foglizzo,M., Dilley,R.L., Wu,A., Datta,A.,
            Dutta,P., Campbell,L.J., Degtjarik,O., Musgrove,L.J.,
            Calabrese,A.N., Zeqiraj,E. and Greenberg,R.A.
  TITLE     The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis
            to ensure genome integrity
  JOURNAL   Cell 187 (9), 2250-2268 (2024)
   PUBMED   38554706
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Sun,J., Zhang,X. and Sun,Y.
  TITLE     C1orf109 promotes malignant phenotype of liver cancer via wnt
            signaling pathway in a CK2-dependent manner
  JOURNAL   J Mol Histol 54 (2), 135-145 (2023)
   PUBMED   36988773
  REMARK    GeneRIF: C1orf109 promotes malignant phenotype of liver cancer via
            wnt signaling pathway in a CK2-dependent manner.
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Ni,C., Schmitz,D.A., Lee,J., Pawlowski,K., Wu,J. and Buszczak,M.
  TITLE     Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5
            control a late step in human ribosome assembly
  JOURNAL   Cell Rep 38 (13), 110597 (2022)
   PUBMED   35354024
  REMARK    GeneRIF: Labeling of heterochronic ribosomes reveals C1ORF109 and
            SPATA5 control a late step in human ribosome assembly.
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Cheng,C.Y., Schache,M., Ikram,M.K., Young,T.L., Guggenheim,J.A.,
            Vitart,V., MacGregor,S., Verhoeven,V.J., Barathi,V.A., Liao,J.,
            Hysi,P.G., Bailey-Wilson,J.E., St Pourcain,B., Kemp,J.P.,
            McMahon,G., Timpson,N.J., Evans,D.M., Montgomery,G.W., Mishra,A.,
            Wang,Y.X., Wang,J.J., Rochtchina,E., Polasek,O., Wright,A.F.,
            Amin,N., van Leeuwen,E.M., Wilson,J.F., Pennell,C.E., van
            Duijn,C.M., de Jong,P.T., Vingerling,J.R., Zhou,X., Chen,P., Li,R.,
            Tay,W.T., Zheng,Y., Chew,M., Burdon,K.P., Craig,J.E., Iyengar,S.K.,
            Igo,R.P. Jr., Lass,J.H. Jr., Chew,E.Y., Haller,T., Mihailov,E.,
            Metspalu,A., Wedenoja,J., Simpson,C.L., Wojciechowski,R., Hohn,R.,
            Mirshahi,A., Zeller,T., Pfeiffer,N., Lackner,K.J., Bettecken,T.,
            Meitinger,T., Oexle,K., Pirastu,M., Portas,L., Nag,A.,
            Williams,K.M., Yonova-Doing,E., Klein,R., Klein,B.E.,
            Hosseini,S.M., Paterson,A.D., Makela,K.M., Lehtimaki,T.,
            Kahonen,M., Raitakari,O., Yoshimura,N., Matsuda,F., Chen,L.J.,
            Pang,C.P., Yip,S.P., Yap,M.K., Meguro,A., Mizuki,N., Inoko,H.,
            Foster,P.J., Zhao,J.H., Vithana,E., Tai,E.S., Fan,Q., Xu,L.,
            Campbell,H., Fleck,B., Rudan,I., Aung,T., Hofman,A.,
            Uitterlinden,A.G., Bencic,G., Khor,C.C., Forward,H., Parssinen,O.,
            Mitchell,P., Rivadeneira,F., Hewitt,A.W., Williams,C., Oostra,B.A.,
            Teo,Y.Y., Hammond,C.J., Stambolian,D., Mackey,D.A., Klaver,C.C.,
            Wong,T.Y., Saw,S.M. and Baird,P.N.
  CONSRTM   Consortium for Refractive Error and Myopia; Fuchs' Genetics
            Multi-Center Study Group; Wellcome Trust Case Control Consortium 2;
            Diabetes Control and Complications Trial/Epidemiology of Diabetes
            Interventions, and Complications Research Group
  TITLE     Nine loci for ocular axial length identified through genome-wide
            association studies, including shared loci with refractive error
  JOURNAL   Am J Hum Genet 93 (2), 264-277 (2013)
   PUBMED   24144296
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Liu,S.S., Zheng,H.X., Jiang,H.D., He,J., Yu,Y., Qu,Y.P., Yue,L.,
            Zhang,Y. and Li,Y.
  TITLE     Identification and characterization of a novel gene, c1orf109,
            encoding a CK2 substrate that is involved in cancer cell
            proliferation
  JOURNAL   J Biomed Sci 19 (1), 49 (2012)
   PUBMED   22548824
  REMARK    GeneRIF: our findings suggest that C1ORF109 may be the downstream
            target of protein kinase CK2 and involved in the regulation of
            cancer cell proliferation.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA709845.1, DA472787.1, AK000515.1, DA608785.1, AA307727.1 and
            BC018109.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001350770.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.498208.1,
                                           SRR14038192.1303934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2467150
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000486637.2/ ENSP00000476779.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               DA709845.1         1-503
            504-554             DA472787.1         469-519
            555-733             AK000515.1         214-392
            734-760             DA608785.1         1-27
            761-1125            AA307727.1         149-513
            1126-1270           DA608785.1         397-541
            1271-2696           BC018109.1         1145-2570
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2696
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /note="AFG2 interacting ribosome maturation factor"
                     /db_xref="GeneID:54955"
                     /db_xref="HGNC:HGNC:26039"
                     /db_xref="MIM:614799"
     exon            1..528
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /inference="alignment:Splign:2.1.0"
     exon            529..806
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..1143
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /note="isoform 3 is encoded by transcript variant 19;
                     uncharacterized protein C1orf109; ribosome biogenesis
                     protein C1orf109"
                     /codon_start=1
                     /product="AFG2-interacting ribosome maturation factor
                     isoform 3"
                     /protein_id="NP_001337699.1"
                     /db_xref="CCDS:CCDS423.1"
                     /db_xref="GeneID:54955"
                     /db_xref="HGNC:HGNC:26039"
                     /db_xref="MIM:614799"
                     /translation="MTQDRPLLAVQEALKKCFPVVEEQQGLWQSALRDCQPLLSSLSN
                     LAEQLQAAQNLRFEDVPALRAFPDLKERLRRKQLVAGDIVLDKLGERLAILLKVRDMV
                     SSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLL
                     SSIQWGDLANIQALPKAWDRISKDEHQDLVQDILLNVSFFLEE"
     exon            807..986
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1105
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..2696
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /note="hexamer: AATAAA"
     polyA_site      2696
                     /gene="AIRIM"
                     /gene_synonym="C1orf109"
                     /note="major polyA site"
ORIGIN      
        1 atgcgcagag agactgtggg cgcgtggtgc agtccctgga gggttctcac gctttggctg
       61 tctggacttt taagtttttc cgctttttca ggaaggcgac cggcagcctc gggcagggga
      121 gacaggactg tatgtcagag aagagacggc gcttggacgc caggaatcct ctgaagcagg
      181 agactgccct atccaggtta cccttcccga ggggaaacca gggtctcctt cagaaagctg
      241 aggcaggccg ggcgcggtgg ctcacgcctg taatcccagc actttggaag accgaggcgg
      301 gcggatcacc tgaggtcagg aaccccgtct actaaaaata caaaaattag ccaggcgtgt
      361 tggcgggcac ctgtattccc agctactcgg gaggctgagg caggagaatt gcttgaaccc
      421 gggatgcgga ggttgcagtg agccgagata gcgccactgc actccagcct gggcgacagt
      481 gagactccgt ctcgaaaaaa aaacaaaaaa aaaaccctgc ttctggagaa gatgactcaa
      541 gaccggcctc tgcttgccgt gcaggaggcg ctgaagaagt gcttccccgt ggtggaggag
      601 cagcagggcc tgtggcagag tgccctgcgg gactgccagc ccctcctgtc ctccctcagc
      661 aacctggcgg aacagctgca ggccgcacag aacctgcggt ttgaggatgt gccggcgctt
      721 cgggccttcc cagatttaaa agagcggctg aggcgtaagc agctggtggc tggtgacatc
      781 gtcctggaca agctagggga aaggctagcc atcctcctca aggtgcgaga catggtcagc
      841 agccatgtgg agcgagtgtt tcagatctat gagcaacacg cagacacagt tggcattgat
      901 gctgtcctgc agccttcagc agtgagcccc tctgtggctg acatgttgga atggttgcag
      961 gatattgaga gacattatcg aaagtcgtac ctgaagagaa agtatcttct ttcgtctatc
     1021 cagtggggag acttggcaaa catacaagct ttgcccaagg cctgggaccg aatttcaaaa
     1081 gacgaacacc aagatcttgt acaagatatc ctattgaatg tttccttctt cctggaagag
     1141 taaggaagct atgcgtatct ggagaccacg ggtaccacag ttgaagactg acattctgaa
     1201 ccctgatgtt tctaaagaaa cgtcagtatt tcagtctgac atatttgaaa catcagtgcc
     1261 ttgaacctta ggactgggtc ttggggagga ttagcgccta gatgtctgat tttggagctg
     1321 cagcatgcca ggccgtggct gagagtatgt gagccatgcc ttgccctttt ctgaggctca
     1381 gggaagtgga tggagctaga gagacaacag gaaagacggt gctgaagaac atagtgtctt
     1441 tcctctattg tggacctaaa gaggtgggga agcaaggaca agaggcaaag agccacactg
     1501 cccttggcat catccaaagc attgtctggt tgacaccagg tcctggtttt gtgtcttttg
     1561 tcaatacctg aatccttgac aaaagaaaaa gtggttttga tgatttaaag aaataagggt
     1621 gattttgaca gaaaatatat tttaaaaatt ttgaccaatt gcaatagtta tcctcaagcc
     1681 aatttccaga acctgccacc agggggaggt ggtgcagcat gaatcattct gaatgctttg
     1741 tctttgaagt gttcccctat tgctgttacc atctcagagg aagtaactgg gcatggtgag
     1801 actcctaaaa tgacaggagt ttttttggcc aaagctggca tctgacttgc cacattcctc
     1861 tgagtctgga gtagccgcag gggtgggaga atgccagccc agagtcagtc catcggggtt
     1921 acatttccaa ggtctgctgc cttcatctat gtaatggccg tgttactttc agatctttca
     1981 gcttcccaga gtgttgtggg aatcttggtc attgaatgta aagggactta gtaaagggta
     2041 tagatatttt tcaaaaatga aaataacttt ttttcttata agtgataagc ttttataaag
     2101 atcataggaa aactagaaaa aatgtaaaat gtagaaaatt gtaaaacaaa cttcattaga
     2161 gatattttga tagatacctt ttcagtgtct atttacaaat tttttctttt aatatagata
     2221 gggtctcact atattgccca gctcactcct gagctcaagg gatcctccca ccatagcctc
     2281 ccaaaatatt ggaaatacag gcatgagcca ctgctcctga ccaattcaca aattttttta
     2341 aagaacaaac gtgctatcat cgatacatac tgttaggttg tcttttttta aaaaacctaa
     2401 tgtaatttgt tcatcttttt atatctgtaa atatagctca acacagttat attctttttg
     2461 tgaatgtatt atatctacaa tttacctttt ttcttagatt ttacatgcat tttcccaaat
     2521 ctttgtgttt gcctatctgt aaaggtaata cattctgatt acaaaaaatg aaaatgttac
     2581 atagaaatgt accgttatcc atctaccaga taactattat taataatgtg tatttatttt
     2641 tccaggaatt aaaaaacatc tatcatataa gtattgcaaa taaaacttaa aaagca
//
