LOCUS       NM_003977               1236 bp    mRNA    linear   PRI 17-JAN-2025
DEFINITION  Homo sapiens AHR interacting HSP90 co-chaperone (AIP), transcript
            variant 1, mRNA.
ACCESSION   NM_003977
VERSION     NM_003977.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1236)
  AUTHORS   Xiang,B., Zhang,X., Liu,W., Mao,B., Zhao,Y., Wang,Y., Gong,W.,
            Ye,H., Li,Y., Zhang,Z., Yu,Y. and He,M.
  TITLE     Germline AIP variants in sporadic young acromegaly and pituitary
            gigantism: clinical and genetic insights from a Han Chinese cohort
  JOURNAL   Endocrine 85 (3), 1346-1356 (2024)
   PUBMED   38851643
  REMARK    GeneRIF: Germline AIP variants in sporadic young acromegaly and
            pituitary gigantism: clinical and genetic insights from a Han
            Chinese cohort.
REFERENCE   2  (bases 1 to 1236)
  AUTHORS   Vroonen,L., Beckers,A., Camby,S., Cuny,T., Beckers,P.,
            Jaffrain-Rea,M.L., Cogne,M., Naves,L., Ferriere,A., Romanet,P.,
            Elenkova,A., Karhu,A., Brue,T., Barlier,A., Petrossians,P. and
            Daly,A.F.
  TITLE     The clinical and therapeutic profiles of prolactinomas associated
            with germline pathogenic variants in the aryl hydrocarbon receptor
            interacting protein (AIP) gene
  JOURNAL   Front Endocrinol (Lausanne) 14, 1242588 (2023)
   PUBMED   37711900
  REMARK    GeneRIF: The clinical and therapeutic profiles of prolactinomas
            associated with germline pathogenic variants in the aryl
            hydrocarbon receptor interacting protein (AIP) gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1236)
  AUTHORS   Detomas,M., Altieri,B., Flitsch,J., Saeger,W., Korbonits,M. and
            Deutschbein,T.
  TITLE     Novel AIP mutation in exon 6 causing acromegaly in a German family
  JOURNAL   J Endocrinol Invest 46 (8), 1705-1709 (2023)
   PUBMED   36757586
  REMARK    GeneRIF: Novel AIP mutation in exon 6 causing acromegaly in a
            German family.
REFERENCE   4  (bases 1 to 1236)
  AUTHORS   Trofimiuk-Muldner,M., Domagala,B., Sokolowski,G., Skalniak,A. and
            Hubalewska-Dydejczyk,A.
  TITLE     AIP gene germline variants in adult Polish patients with apparently
            sporadic pituitary macroadenomas
  JOURNAL   Front Endocrinol (Lausanne) 14, 1098367 (2023)
   PUBMED   36843582
  REMARK    GeneRIF: AIP gene germline variants in adult Polish patients with
            apparently sporadic pituitary macroadenomas.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1236)
  AUTHORS   Ortiz,N.R., Guy,N., Garcia,Y.A., Sivils,J.C., Galigniana,M.D. and
            Cox,M.B.
  TITLE     Functions of the Hsp90-Binding FKBP Immunophilins
  JOURNAL   Subcell Biochem 101, 41-80 (2023)
   PUBMED   36520303
  REMARK    GeneRIF: Functions of the Hsp90-Binding FKBP Immunophilins.
REFERENCE   6  (bases 1 to 1236)
  AUTHORS   Carver,L.A. and Bradfield,C.A.
  TITLE     Ligand-dependent interaction of the aryl hydrocarbon receptor with
            a novel immunophilin homolog in vivo
  JOURNAL   J Biol Chem 272 (17), 11452-11456 (1997)
   PUBMED   9111057
REFERENCE   7  (bases 1 to 1236)
  AUTHORS   Ma,Q. and Whitlock,J.P. Jr.
  TITLE     A novel cytoplasmic protein that interacts with the Ah receptor,
            contains tetratricopeptide repeat motifs, and augments the
            transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 272 (14), 8878-8884 (1997)
   PUBMED   9083006
REFERENCE   8  (bases 1 to 1236)
  AUTHORS   Kuzhandaivelu,N., Cong,Y.S., Inouye,C., Yang,W.M. and Seto,E.
  TITLE     XAP2, a novel hepatitis B virus X-associated protein that inhibits
            X transactivation
  JOURNAL   Nucleic Acids Res 24 (23), 4741-4750 (1996)
   PUBMED   8972861
REFERENCE   9  (bases 1 to 1236)
  AUTHORS   Chen,H.S. and Perdew,G.H.
  TITLE     Subunit composition of the heteromeric cytosolic aryl hydrocarbon
            receptor complex
  JOURNAL   J Biol Chem 269 (44), 27554-27558 (1994)
   PUBMED   7961671
REFERENCE   10 (bases 1 to 1236)
  AUTHORS   Korbonits,M. and Hernandez-Ramirez,L.C.
  TITLE     AIP Familial Isolated Pituitary Adenomas
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22720333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003419.3, HY065637.1,
            U31913.1 and U78521.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003977.3.
            
            Summary: The protein encoded by this gene is a receptor for aryl
            hydrocarbons and a ligand-activated transcription factor. The
            encoded protein is found in the cytoplasm as part of a multiprotein
            complex, but upon binding of ligand is transported to the nucleus.
            This protein can regulate the expression of many xenobiotic
            metabolizing enzymes. Also, the encoded protein can bind
            specifically to and inhibit the activity of hepatitis B virus.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.47397.1,
                                           SRR5189658.52040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279146.8/ ENSP00000279146.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AP003419.3         163491-163493
            4-124               HY065637.1         1-121
            125-894             U31913.1           1-770
            895-1236            U78521.1           879-1220
FEATURES             Location/Qualifiers
     source          1..1236
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1236
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /note="AHR interacting HSP90 co-chaperone"
                     /db_xref="GeneID:9049"
                     /db_xref="HGNC:HGNC:358"
                     /db_xref="MIM:605555"
     exon            1..232
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1126
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /EC_number="5.2.1.8"
                     /note="isoform 1 is encoded by transcript variant 1; AH
                     receptor-interacting protein; FKBP prolyl isomerase 16;
                     X-associated protein-2; immunophilin homolog ARA9; HBV
                     X-associated protein 2; hepatitis B virus X-associated
                     cellular protein 2; aryl hydrocarbon receptor-associated
                     protein 9; FK506-binding protein 37; Ah receptor activated
                     9; aryl hydrocarbon receptor interacting protein"
                     /codon_start=1
                     /product="AH receptor-interacting protein isoform 1"
                     /protein_id="NP_003968.3"
                     /db_xref="CCDS:CCDS8168.1"
                     /db_xref="GeneID:9049"
                     /db_xref="HGNC:HGNC:358"
                     /db_xref="MIM:605555"
                     /translation="MADIIARLREDGIQKRVIQEGRGELPDFQDGTKATFHYRTLHSD
                     DEGTVLDDSRARGKPMELIIGKKFKLPVWETIVCTMREGEIAQFLCDIKHVVLYPLVA
                     KSLRNIAVGKDPLEGQRHCCGVAQMREHSSLGHADLDALQQNPQPLIFHMEMLKVESP
                     GTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGHVKEAAAKYYDAIACLKNLQMKEQP
                     GSPEWIQLDQQITPLLLNYCQCKLVVEEYYEVLDHCSSILNKYDDNVKAYFKRGKAHA
                     AVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH"
     exon            233..412
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..601
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..778
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..920
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1236
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1213..1218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /note="hexamer: TATAAA"
     polyA_site      1236
                     /gene="AIP"
                     /gene_synonym="ARA9; FKBP16; FKBP37; PITA1; SMTPHN; XAP-2;
                     XAP2"
                     /note="major polyA site"
ORIGIN      
        1 cccttttggc ttctgccctc aaccaaaatg gcgctagctc ggaagctgcc gaggtgctag
       61 gagttgccga agcaagtccg gaagctaccg agcgagtccg gaagttgccg aaagggagca
      121 gcggggaagg aggatggcgg atatcatcgc aagactccgg gaggacggga tccaaaaacg
      181 tgtgatacag gaaggccgag gagagctccc ggactttcaa gatgggacca aggccacgtt
      241 ccactaccgg acgctgcaca gtgacgacga gggcaccgtg ctggacgaca gccgggctcg
      301 tggcaagccc atggagctca tcattggcaa gaagttcaag ctgcctgtgt gggagaccat
      361 cgtgtgcacc atgcgagaag gggagattgc ccagttcctc tgtgacatca agcatgtggt
      421 cctgtacccg ctggtggcca agagtctccg caacatcgcg gtgggcaagg accccctgga
      481 gggccagcgg cactgctgcg gtgttgcaca gatgcgtgaa cacagctccc tgggccatgc
      541 tgacctggac gccctgcagc agaaccccca gcccctcatc ttccacatgg agatgctgaa
      601 ggtggagagc cctggcacgt accagcagga cccatgggcc atgacagacg aagagaaggc
      661 aaaggcagtg ccacttatcc accaggaggg caaccggttg taccgcgagg ggcatgtgaa
      721 ggaggctgct gccaagtact acgatgccat tgcctgcctc aagaacctgc agatgaagga
      781 acagcctggg tcccctgaat ggatccagct ggaccagcag atcacgccgc tgctgctcaa
      841 ctactgccag tgcaagctgg tggtcgagga gtactacgag gtgctggacc actgctcttc
      901 catcctcaac aagtacgacg acaacgtcaa ggcctacttc aagcggggca aggcccacgc
      961 ggccgtgtgg aatgcccagg aggcccaggc tgactttgcc aaagtgctgg agctggaccc
     1021 agccctggcg cctgtggtga gccgagagct gcgggccctg gaggcacgga tccggcagaa
     1081 ggacgaagag gacaaagccc ggttccgggg gatcttctcc cattgacagg agcacttggc
     1141 cctgccttac ctgccaagcc cactgctgca gctgccagcc cccctgcccg tgctgcgtca
     1201 tgcttctgtg tatataaagg cctttattta tctctc
//
