LOCUS       NM_006303               1198 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens aminoacyl tRNA synthetase complex interacting
            multifunctional protein 2 (AIMP2), transcript variant 1, mRNA.
ACCESSION   NM_006303
VERSION     NM_006303.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1198)
  AUTHORS   Kim,H., Shin,J.Y., Ham,S., Kim,J.H., Lee,G.H., Lee,N.E., Kim,H.T.,
            Cho,S.H., Kim,S. and Lee,Y.
  TITLE     AIMP2 accumulation in brain leads to cognitive deficits and blood
            secretion in Parkinson's disease
  JOURNAL   J Transl Med 22 (1), 919 (2024)
   PUBMED   39390613
  REMARK    GeneRIF: AIMP2 accumulation in brain leads to cognitive deficits
            and blood secretion in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1198)
  AUTHORS   Ren,J., Yu,L., Zhang,Q., Ren,P., Cai,Y., Wang,X., Lan,K. and Wu,S.
  TITLE     AIMP2 restricts EV71 replication by recruiting SMURF2 to promote
            the degradation of 3D polymerase
  JOURNAL   Virol Sin 39 (4), 632-644 (2024)
   PUBMED   38945214
  REMARK    GeneRIF: AIMP2 restricts EV71 replication by recruiting SMURF2 to
            promote the degradation of 3D polymerase.
REFERENCE   3  (bases 1 to 1198)
  AUTHORS   Jaramillo Ponce,J.R., Kapps,D., Paulus,C., Chicher,J. and
            Frugier,M.
  TITLE     Discovery of two distinct aminoacyl-tRNA synthetase complexes
            anchored to the Plasmodium surface tRNA import protein
  JOURNAL   J Biol Chem 298 (6), 101987 (2022)
   PUBMED   35487244
  REMARK    GeneRIF: Discovery of two distinct aminoacyl-tRNA synthetase
            complexes anchored to the Plasmodium surface tRNA import protein.
REFERENCE   4  (bases 1 to 1198)
  AUTHORS   Kim,D.G., Choi,Y., Lee,Y., Lim,S., Kong,J., Song,J., Roh,Y.,
            Harmalkar,D.S., Lee,K., Goo,J.I., Cho,H.Y., Mushtaq,A.U., Lee,J.,
            Park,S.H., Kim,D., Min,B.S., Lee,K.Y., Jeon,Y.H., Lee,S., Lee,K.
            and Kim,S.
  TITLE     AIMP2-DX2 provides therapeutic interface to control KRAS-driven
            tumorigenesis
  JOURNAL   Nat Commun 13 (1), 2572 (2022)
   PUBMED   35546148
  REMARK    GeneRIF: AIMP2-DX2 provides therapeutic interface to control
            KRAS-driven tumorigenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1198)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1198)
  AUTHORS   Lamour,V., Quevillon,S., Diriong,S., N'Guyen,V.C., Lipinski,M. and
            Mirande,M.
  TITLE     Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme
            as a case of horizontal gene transfer
  JOURNAL   Proc Natl Acad Sci U S A 91 (18), 8670-8674 (1994)
   PUBMED   8078941
REFERENCE   7  (bases 1 to 1198)
  AUTHORS   Shiba,K., Suzuki,N., Shigesada,K., Namba,Y., Schimmel,P. and
            Noda,T.
  TITLE     Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence
            of the anticodon-binding domain and acquisition of a new structural
            unit
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7435-7439 (1994)
   PUBMED   8052601
REFERENCE   8  (bases 1 to 1198)
  AUTHORS   Kaiser,E., Hu,B., Becher,S., Eberhard,D., Schray,B., Baack,M.,
            Hameister,H. and Knippers,R.
  TITLE     The human EPRS locus (formerly the QARS locus): a gene encoding a
            class I and a class II aminoacyl-tRNA synthetase
  JOURNAL   Genomics 19 (2), 280-290 (1994)
   PUBMED   8188258
REFERENCE   9  (bases 1 to 1198)
  AUTHORS   Escalante,C. and Yang,D.C.
  TITLE     Expression of human aspartyl-tRNA synthetase in Escherichia coli.
            Functional analysis of the N-terminal putative amphiphilic helix
  JOURNAL   J Biol Chem 268 (8), 6014-6023 (1993)
   PUBMED   8449960
REFERENCE   10 (bases 1 to 1198)
  AUTHORS   Norcum,M.T.
  TITLE     Structural analysis of the high molecular mass aminoacyl-tRNA
            synthetase complex. Effects of neutral salts and detergents
  JOURNAL   J Biol Chem 266 (23), 15398-15405 (1991)
   PUBMED   1651330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005995.3 and BC002853.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006303.3.
            
            Summary: The protein encoded by this gene is part of the
            aminoacyl-tRNA synthetase complex, which contains nine different
            aminoacyl-tRNA synthetases and three non-enzymatic factors. The
            encoded protein is one of the non-enzymatic factors and is required
            for assembly and stability of the complex. [provided by RefSeq, May
            2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U24169.1, SRR1163655.540417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223029.8/ ENSP00000223029.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC005995.3         34055-34281         c
            228-434             AC005995.3         28201-28407         c
            435-666             AC005995.3         25508-25739         c
            667-1159            AC005995.3         19758-20250         c
            1160-1198           BC002853.1         1141-1179
FEATURES             Location/Qualifiers
     source          1..1198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.1"
     gene            1..1198
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /note="aminoacyl tRNA synthetase complex interacting
                     multifunctional protein 2"
                     /db_xref="GeneID:7965"
                     /db_xref="HGNC:HGNC:20609"
                     /db_xref="MIM:600859"
     exon            1..227
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1055
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /note="isoform a is encoded by transcript variant 1;
                     ARS-interacting multi-functional protein 2; aminoacyl tRNA
                     synthase complex-interacting multifunctional protein 2;
                     multisynthetase complex auxiliary component p38;
                     multisynthase complex auxiliary component p38; protein
                     JTV-1"
                     /codon_start=1
                     /product="aminoacyl tRNA synthase complex-interacting
                     multifunctional protein 2 isoform a"
                     /protein_id="NP_006294.2"
                     /db_xref="CCDS:CCDS5344.1"
                     /db_xref="GeneID:7965"
                     /db_xref="HGNC:HGNC:20609"
                     /db_xref="MIM:600859"
                     /translation="MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPGAGHV
                     QEESNLSLQALESRQDDILKRLYELKAAVDGLSKMIQTPDADLDVTNIIQADEPTTLT
                     TNALDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCEHFRVLSTVHTHSSVKS
                     VPENLLKCFGEQNKKQPRQDYQLGFTLIWKNVPKTQMKFSIQTMCPIEGEGNIARFLF
                     SLFGQKHNAVNATLIDSWVDIAIFQLKEGSSKEKAAVFRSMNSALGKSPWLAGNELTV
                     ADVVLWSVLQQIGGCSVTVPANVQRWMRSCENLAPFNTALKLLK"
     exon            228..434
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /inference="alignment:Splign:2.1.0"
     exon            435..666
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1198
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1177..1182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /note="hexamer: AATAAA"
     polyA_site      1198
                     /gene="AIMP2"
                     /gene_synonym="HLD17; JTV-1; JTV1; P38"
                     /note="major polyA site"
ORIGIN      
        1 agaagggagg tggccggtct ccgtcgtgac ctctgacggt ttctgagcgt tggcctttgg
       61 cacgcgctac ccccttttgc tttggttctg ccatgccgat gtaccaggta aagccctatc
      121 acgggggcgg cgcgcctctc cgtgtggagc ttcccacctg catgtaccgg ctccccaacg
      181 tgcacggcag gagctacggc ccagcgccgg gcgctggcca cgtgcaggaa gagtctaacc
      241 tgtctctgca agctcttgag tcccgccaag atgatatttt aaaacgtctg tatgagttga
      301 aagctgcagt tgatggcctc tccaagatga ttcaaacacc agatgcagac ttggatgtaa
      361 ccaacataat ccaagcggat gagcccacga ctttaaccac caatgcgctg gacttgaatt
      421 cagtgcttgg gaaggattac ggggcgctga aagacatcgt gatcaacgca aacccggcct
      481 cccctcccct ctccctgctt gtgctgcaca ggctgctctg tgagcacttc agggtcctgt
      541 ccacggtgca cacgcactcc tcggtcaaga gcgtgcctga aaaccttctc aagtgctttg
      601 gagaacagaa taaaaaacag ccccgccaag actatcagct gggattcact ttaatttgga
      661 agaatgtgcc gaagacgcag atgaaattca gcatccagac gatgtgcccc atcgaaggcg
      721 aagggaacat tgcacgtttc ttgttctctc tgtttggcca gaagcataat gctgtcaacg
      781 caacccttat agatagctgg gtagatattg cgatttttca gttaaaagag ggaagcagta
      841 aagaaaaagc cgctgttttc cgctccatga actctgctct tgggaagagc ccttggctcg
      901 ctgggaatga actcaccgta gcagacgtgg tgctgtggtc tgtactccag cagatcggag
      961 gctgcagtgt gacagtgcca gccaatgtgc agaggtggat gaggtcttgt gaaaacctgg
     1021 ctccttttaa cacggccctc aagctcctta agtgaattgc cgtaactgat tttaaagggt
     1081 ttagatttta agaatggtgc tctttcatgc ctattatcag taaggggact tgtattagag
     1141 tcagagtctt tttatttagg ccagttgtca agtgtcaata aaagcatcat gtaattta
//
