LOCUS       NM_016108               2136 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens androgen induced 1 (AIG1), transcript variant 1, mRNA.
ACCESSION   NM_016108
VERSION     NM_016108.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Nakada-Tsukui,K., Sekizuka,T., Sato-Ebine,E., Escueta-de Cadiz,A.,
            Ji,D.D., Tomii,K., Kuroda,M. and Nozaki,T.
  TITLE     AIG1 affects in vitro and in vivo virulence in clinical isolates of
            Entamoeba histolytica
  JOURNAL   PLoS Pathog 14 (3), e1006882 (2018)
   PUBMED   29554130
  REMARK    GeneRIF: High AIG1 expression is associated with virulence in
            clinical isolates of Entamoeba histolytica.
            Erratum:[PLoS Pathog. 2018 May 31;14(5):e1007091. doi:
            10.1371/journal.ppat.1007091.. PMID: 29851996]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Parsons,W.H., Kolar,M.J., Kamat,S.S., Cognetta,A.B. 3rd,
            Hulce,J.J., Saez,E., Kahn,B.B., Saghatelian,A. and Cravatt,B.F.
  TITLE     AIG1 and ADTRP are atypical integral membrane hydrolases that
            degrade bioactive FAHFAs
  JOURNAL   Nat Chem Biol 12 (5), 367-372 (2016)
   PUBMED   27018888
  REMARK    GeneRIF: These results indicate that AIG1 and ADTRP are founding
            members of an evolutionarily conserved class of transmembrane
            threonine hydrolases involved in bioactive lipid metabolism.
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Ellinghaus,E., Stanulla,M., Richter,G., Ellinghaus,D., te
            Kronnie,G., Cario,G., Cazzaniga,G., Horstmann,M., Panzer
            Grumayer,R., Cave,H., Trka,J., Cinek,O., Teigler-Schlegel,A.,
            ElSharawy,A., Hasler,R., Nebel,A., Meissner,B., Bartram,T.,
            Lescai,F., Franceschi,C., Giordan,M., Nurnberg,P., Heinzow,B.,
            Zimmermann,M., Schreiber,S., Schrappe,M. and Franke,A.
  TITLE     Identification of germline susceptibility loci in
            ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
  JOURNAL   Leukemia 26 (5), 902-909 (2012)
   PUBMED   22076464
REFERENCE   5  (bases 1 to 2136)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2136)
  AUTHORS   Wu,G., Sun,M., Zhang,W. and Huo,K.
  TITLE     AIG1 is a novel Pirh2-interacting protein that activates the NFAT
            signaling pathway
  JOURNAL   Front Biosci (Elite Ed) 3 (3), 834-842 (2011)
   PUBMED   21622095
  REMARK    GeneRIF: identified a novel Pirh2-interacting protein, AIG1, by
            yeast two-hybrid screening and confirmed its interaction with p53
            both in vitro and in vivo
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2136)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   8  (bases 1 to 2136)
  AUTHORS   Seo,J., Kim,J. and Kim,M.
  TITLE     Cloning of androgen-inducible gene 1 (AIG1) from human dermal
            papilla cells
  JOURNAL   Mol Cells 11 (1), 35-40 (2001)
   PUBMED   11266118
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298533.1, BC025278.1, AL136116.11 and BG196820.1.
            
            On May 17, 2019 this sequence version replaced NM_016108.3.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.588002.1,
                                           SRR1803611.222987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357847.9/ ENSP00000350509.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK298533.1         48-69
            23-1382             BC025278.1         1-1360
            1383-1399           AL136116.11        73414-73430
            1400-1421           BG196820.1         689-710
            1422-2136           AL136116.11        73453-74167
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..2136
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /note="androgen induced 1"
                     /db_xref="GeneID:51390"
                     /db_xref="HGNC:HGNC:21607"
                     /db_xref="MIM:608514"
     exon            1..178
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..754
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /note="isoform a is encoded by transcript variant 1;
                     androgen-induced gene 1 protein; FAHFA hydrolase AIG1;
                     fatty acid esters of hydroxy fatty acids hydrolase AIG1"
                     /codon_start=1
                     /product="androgen-induced gene 1 protein isoform a"
                     /protein_id="NP_057192.2"
                     /db_xref="CCDS:CCDS5198.1"
                     /db_xref="GeneID:51390"
                     /db_xref="HGNC:HGNC:21607"
                     /db_xref="MIM:608514"
                     /translation="MALVPCQVLRMAILLSYCSILCNYKAIEMPSHQTYGGSWKFLTF
                     IDLVIQAVFFGICVLTDLSSLLTRGSGNQEQERQLKKLISLRDWMLAVLAFPVGVFVV
                     AVFWIIYAYDREMIYPKLLDNFIPGWLNHGMHTTVLPFILIEMRTSHHQYPSRSSGLT
                     AICTFSVGYILWVCWVHHVTGMWVYPFLEHIGPGARIIFFGSTTILMNFLYLLGEVLN
                     NYIWDTQKSMEEEKEKPKLE"
     exon            179..334
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..436
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..552
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..716
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..2136
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1360..1365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /note="hexamer: AATAAA"
     polyA_site      1382
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /note="major polyA site"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
                     /note="hexamer: ATTAAA"
     polyA_site      2136
                     /gene="AIG1"
                     /gene_synonym="AIG-1; dJ95L4.1"
ORIGIN      
        1 ctccttgccg cccagccggt ccaggcctct ggcgaacatg gcgcttgtcc cctgccaggt
       61 gctgcggatg gcaatcctgc tgtcttactg ctctatcctg tgtaactaca aggccatcga
      121 aatgccctca caccagacct acggagggag ctggaaattc ctgacgttca ttgatctggt
      181 tatccaggct gtcttttttg gcatctgtgt gctgactgat ctttccagtc ttctgactcg
      241 aggaagtggg aaccaggagc aagagaggca gctcaagaag ctcatctctc tccgggactg
      301 gatgttagct gtgttggcct ttcctgttgg ggtttttgtt gtagcagtgt tctggatcat
      361 ttatgcctat gacagagaga tgatataccc gaagctgctg gataatttta tcccagggtg
      421 gctgaatcac ggaatgcaca cgacggttct gccctttata ttaatcgaga tgaggacatc
      481 gcaccatcag tatcccagca ggagcagcgg acttaccgcc atatgtacct tctctgttgg
      541 ctatatatta tgggtgtgct gggtgcatca tgtaactggc atgtgggtgt accctttcct
      601 ggaacacatt ggcccaggag ccagaatcat cttctttggg tctacaacca tcttaatgaa
      661 cttcctgtac ctgctgggag aagttctgaa caactatatc tgggatacac agaaaagtat
      721 ggaagaagag aaagaaaagc ctaaattgga atgagatcca agtctaaacg caagagctag
      781 attgagccgc cattgaagac tccttcccct cgggcattgg cagtggggga gaaaaggctt
      841 caaaggaact tggtggcatc agcacccccc tcccccaatg aggacacctt ttatatataa
      901 atatgtataa acatagaata cagttgtttc caaaagaact caccctcact gtgtgttaaa
      961 gaattcttcc caaagtcatt actgataata acattttttc cttttctagt tttaaaacca
     1021 gaattggacc ttggattttt attttggcaa ttgtaactcc atctaatcaa gaaagaataa
     1081 aagtttattg cacttctttt tgagaaatat gttaaagtca aaggggcata tatagagtaa
     1141 ggcttttgtg tatttaatcc taaaggtggc tgtaatcatg aacctaggcc accatgggga
     1201 cctgagaggg aaggggacag atgtttctca ttgcataatg tcacagttgc ctcaaatgag
     1261 caccatttgt aataatgatg tcaatttcat gaaaagcctg agtgtattgc atctcttgat
     1321 ttaatcatgt gaaacttttc ctagatgcaa atgctgacta ataaagacaa agccaccctg
     1381 aacctgacgt ctgcattgtg catctcaaaa tcctaacagc attagtatct ccttttcatt
     1441 tttattacct gttgaaaatg ggtttactga acctggttct ttcctataat ttttggattt
     1501 taaaaaatgt gaatcttttt gataactcca aaacaaattt tttttttctt tttttccaga
     1561 tggagtctca ctctgtcgcc caggctggag tacagtggcg tgatctcagc tcacggcaag
     1621 ctccgcttcc cgggttcatg ccattctcct gccttctcag cctcccgagt agctgggact
     1681 acaggcgcct gccacacgcc cggcttattt tttgtatttt tagtagagac ggggtttcac
     1741 cttgttagcc aggatggtct cgatctcctg accttgtgat ccacacgcct cggcctccca
     1801 aagtgctggg attacagaca tgaaccaccg cgcccagcca caaaattgtt tttaaaaaaa
     1861 ctattttaca aaatctttga ccgtaattat ttttaagatg aaaaatatgt tatataaatt
     1921 ataaaatgtt acttaacaca aatataagta ttgattgccc aatgttgaga gagatcaaca
     1981 aatgatataa aaccattcac tccaaaatta taattacatt ttaaaattaa aaaatgaaaa
     2041 gcattaaact ttttaatttg aaaaaaattt aaactcaaaa agttaattta aaattagtta
     2101 catttaaatg taattaaatg ctaaaaatct ctcttc
//
