LOCUS       NM_032797               3134 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens AIF family member 2 (AIFM2), transcript variant 2,
            mRNA.
ACCESSION   NM_032797
VERSION     NM_032797.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3134)
  AUTHORS   Tan,Y.R., Jiang,B.H., Feng,W.J., He,Z.L., Jiang,Y.L., Xun,Y.,
            Wu,X.P., Li,Y.H. and Zhu,H.B.
  TITLE     Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma
            progression through regulating AIFM2 and GPX4 expression
  JOURNAL   Aging (Albany NY) 16 (2), 1796-1807 (2024)
   PUBMED   38244593
  REMARK    GeneRIF: Circ0060467 sponges miR-6805 to promote hepatocellular
            carcinoma progression through regulating AIFM2 and GPX4 expression.
REFERENCE   2  (bases 1 to 3134)
  AUTHORS   Yuan,S., Xi,S., Weng,H., Guo,M.M., Zhang,J.H., Yu,Z.P., Zhang,H.,
            Yu,Z., Xing,Z., Liu,M.Y., Ming,D.J., Sah,R.K., Zhou,Y., Li,G.,
            Zeng,T., Hong,X., Li,Y., Zeng,X.T. and Hu,H.
  TITLE     YTHDC1 as a tumor progression suppressor through modulating
            FSP1-dependent ferroptosis suppression in lung cancer
  JOURNAL   Cell Death Differ 30 (12), 2477-2490 (2023)
   PUBMED   37903990
  REMARK    GeneRIF: YTHDC1 as a tumor progression suppressor through
            modulating FSP1-dependent ferroptosis suppression in lung cancer.
REFERENCE   3  (bases 1 to 3134)
  AUTHORS   Yang,M., Shen,Z., Zhang,X., Song,Z., Zhang,Y., Lin,Z. and Chen,L.
  TITLE     Ferroptosis of macrophages facilitates bone loss in apical
            periodontitis via NRF2/FSP1/ROS pathway
  JOURNAL   Free Radic Biol Med 208, 334-347 (2023)
   PUBMED   37619958
  REMARK    GeneRIF: Ferroptosis of macrophages facilitates bone loss in apical
            periodontitis via NRF2/FSP1/ROS pathway.
REFERENCE   4  (bases 1 to 3134)
  AUTHORS   Gong,J., Liu,Y., Wang,W., He,R., Xia,Q., Chen,L., Zhao,C., Gao,Y.,
            Shi,Y., Bai,Y., Liao,Y., Zhang,Q., Zhu,F., Wang,M., Li,X. and
            Qin,R.
  TITLE     TRIM21-Promoted FSP1 Plasma Membrane Translocation Confers
            Ferroptosis Resistance in Human Cancers
  JOURNAL   Adv Sci (Weinh) 10 (29), e2302318 (2023)
   PUBMED   37587773
  REMARK    GeneRIF: TRIM21-Promoted FSP1 Plasma Membrane Translocation Confers
            Ferroptosis Resistance in Human Cancers.
REFERENCE   5  (bases 1 to 3134)
  AUTHORS   Liu,M.R., Shi,C., Song,Q.Y., Kang,M.J., Jiang,X., Liu,H. and
            Pei,D.S.
  TITLE     Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1
            ubiquitination and degradation in hepatocellular carcinoma
  JOURNAL   Hepatol Commun 7 (10), e0246 (2023)
   PUBMED   37695069
  REMARK    GeneRIF: Sorafenib induces ferroptosis by promoting TRIM54-mediated
            FSP1 ubiquitination and degradation in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3134)
  AUTHORS   Wu,M., Xu,L.G., Su,T., Tian,Y., Zhai,Z. and Shu,H.B.
  TITLE     AMID is a p53-inducible gene downregulated in tumors
  JOURNAL   Oncogene 23 (40), 6815-6819 (2004)
   PUBMED   15273740
  REMARK    GeneRIF: AMID is a p53-downstream gene involved in tumorigenesis.
REFERENCE   7  (bases 1 to 3134)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   8  (bases 1 to 3134)
  AUTHORS   Ohiro,Y., Garkavtsev,I., Kobayashi,S., Sreekumar,K.R., Nantz,R.,
            Higashikubo,B.T., Duffy,S.L., Higashikubo,R., Usheva,A., Gius,D.,
            Kley,N. and Horikoshi,N.
  TITLE     A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue
            of the apoptosis-inducing factor (AIF)
  JOURNAL   FEBS Lett 524 (1-3), 163-171 (2002)
   PUBMED   12135761
  REMARK    GeneRIF: encodes a homologue of the apoptosis-inducing factor
REFERENCE   9  (bases 1 to 3134)
  AUTHORS   Wu,M., Xu,L.G., Li,X., Zhai,Z. and Shu,H.B.
  TITLE     AMID, an apoptosis-inducing factor-homologous
            mitochondrion-associated protein, induces caspase-independent
            apoptosis
  JOURNAL   J Biol Chem 277 (28), 25617-25623 (2002)
   PUBMED   11980907
  REMARK    GeneRIF: induces caspase-independent apoptosis
REFERENCE   10 (bases 1 to 3134)
  AUTHORS   Horikoshi,N., Cong,J., Kley,N. and Shenk,T.
  TITLE     Isolation of differentially expressed cDNAs from p53-dependent
            apoptotic cells: activation of the human homologue of the
            Drosophila peroxidasin gene
  JOURNAL   Biochem Biophys Res Commun 261 (3), 864-869 (1999)
   PUBMED   10441517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG332787.1, AL731540.4,
            BC023601.2 and AI922797.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032797.5.
            
            Summary: This gene encodes a flavoprotein oxidoreductase that binds
            single stranded DNA and is thought to contribute to apoptosis in
            the presence of bacterial and viral DNA. The expression of this
            gene is also found to be induced by tumor suppressor protein p53 in
            colon cancer cells. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027403.1, SRR14038195.1414066.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307864.3/ ENSP00000312370.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                BG332787.1         110-158
            50-61               AL731540.4         75307-75318         c
            62-92               BG332787.1         159-189
            93-1112             BC023601.2         189-1208
            1113-2614           AL731540.4         55333-56834         c
            2615-3134           AI922797.1         11-530              c
FEATURES             Location/Qualifiers
     source          1..3134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3134
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="AIF family member 2"
                     /db_xref="GeneID:84883"
                     /db_xref="HGNC:HGNC:21411"
                     /db_xref="MIM:605159"
     exon            1..92
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            93..283
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1227
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="apoptosis-inducing factor (AIF)-like
                     mitochondrion-associated inducer of death;
                     apoptosis-inducing factor 2; p53-responsive gene 3
                     protein; apoptosis-inducing factor,
                     mitochondrion-associated, 2; ferroptosis suppressor 1;
                     apoptosis inducing factor mitochondria associated 2"
                     /codon_start=1
                     /product="ferroptosis suppressor protein 1"
                     /protein_id="NP_116186.1"
                     /db_xref="CCDS:CCDS7297.1"
                     /db_xref="GeneID:84883"
                     /db_xref="HGNC:HGNC:21411"
                     /db_xref="MIM:605159"
                     /translation="MGSQVSVESGALHVVIVGGGFGGIAAASQLQALNVPFMLVDMKD
                     SFHHNVAALRASVETGFAKKTFISYSVTFKDNFRQGLVVGIDLKNQMVLLQGGEALPF
                     SHLILATGSTGPFPGKFNEVSSQQAAIQAYEDMVRQVQRSRFIVVVGGGSAGVEMAAE
                     IKTEYPEKEVTLIHSQVALADKELLPSVRQEVKEILLRKGVQLLLSERVSNLEELPLN
                     EYREYIKVQTDKGTEVATNLVILCTGIKINSSAYRKAFESRLASSGALRVNEHLQVEG
                     HSNVYAIGDCADVRTPKMAYLAGLHANIAVANIVNSVKQRPLQAYKPGALTFLLSMGR
                     NDGVGQISGFYVGRLMVRLTKSRDLFVSTSWKTMRQSPP"
     exon            284..399
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..519
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            520..612
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..721
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            722..874
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1075
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..3134
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="hexamer: ATTAAA"
     polyA_site      1426
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="major polyA site"
     regulatory      3111..3116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="hexamer: AATAAA"
     polyA_site      3134
                     /gene="AIFM2"
                     /gene_synonym="AMID; FSP1; PRG3"
                     /note="major polyA site"
ORIGIN      
        1 agcgcctcgg gtcagtaact cgggaagacg accaagcggg agcgggagcg ggagcgggag
       61 ccggagcgag agcgcgcggg cgcggccgac agtgcctgat ttgagatggg gtcccaggtc
      121 tcggtggaat cgggagctct gcacgtggtg attgtgggtg ggggctttgg cgggatcgca
      181 gcagccagcc agctgcaggc cctgaacgtc cccttcatgc tggtggacat gaaggactcc
      241 ttccaccaca atgtggctgc tctccgagcc tccgtggaga cagggttcgc caaaaagaca
      301 ttcatttctt actcggtgac tttcaaggac aacttccggc aggggctagt agtggggata
      361 gacctgaaga accagatggt gctgctgcag ggtggcgagg ccctgccctt ctctcatctt
      421 atcctggcca cgggcagcac tgggcccttc ccgggcaagt ttaatgaggt ttccagccag
      481 caggccgcta tccaggccta tgaggacatg gtgaggcagg tccagcgctc acggttcatc
      541 gtggtggtgg gaggaggctc ggctggagtg gagatggcag cagagattaa aacagaatat
      601 cctgagaaag aggtcactct cattcactcc caagtggccc tggctgacaa ggagctcctg
      661 ccctccgtcc ggcaggaagt gaaggagatc ctcctccgga agggcgtgca gctgctgctg
      721 agtgagcggg tgagcaatct ggaggagctg cctctcaatg agtatcgaga gtacatcaaa
      781 gtgcagacgg acaaaggcac agaggtggcc accaacctgg tgattctctg caccggcatc
      841 aagatcaaca gctccgccta ccgcaaagcg tttgagagca gactagccag cagtggtgct
      901 ctgagagtga acgagcacct ccaggtggag ggccacagca acgtctacgc cattggtgac
      961 tgtgccgacg tgaggacgcc caagatggcc tatcttgccg gcctccacgc caacatcgcc
     1021 gtggccaaca tcgtcaactc tgtgaagcag cggcctctcc aggcctacaa gccgggtgca
     1081 ctgacgttcc tcctgtccat ggggagaaat gacggtgtgg gccaaatcag tggcttctat
     1141 gtgggccggc tcatggttcg gctgaccaag agccgggacc tgttcgtctc tacgagctgg
     1201 aaaaccatga ggcagtctcc accttgatgg agaggccagg cgggagaact accgcagcag
     1261 gtgggcgtac ggactgcttg gcgcatggca cccgcctggc aagtgctaga actaatgcta
     1321 ttcttctgga ataagatgcc aatgatgtgg tggctagaaa tgcaacttgt ataaaacaaa
     1381 aatgggagag agagaggtat taaacaaata ccccccttag aggatacttt ctgggtttgg
     1441 aaggtgtgct tgctgtggta ctgggtgagc ggctcatgtg tgctggctgc atggtgctgg
     1501 ggaggccaca gccagccctt cctctgcacc tgcctcctct gggatgtgca tgtgtgtgta
     1561 cgtgcttgtg gtcatgacgc gtgccattta gagctctcag agcagggcag attgctgggc
     1621 tctggtggcc agtgtctgtc tgtgagggca ggaaggagag ctgcacattg agaacaaagg
     1681 agggacctga ggtggagaga ggcccagcac cccaaatctc tgccatcaca cggtcgggga
     1741 gcccatacat tctgcaacaa ccagggactt cacaggagcc ttgttttcaa tttgctaaca
     1801 ggtgcataat ccctgtgctc cttaagcctc atggccttcc tacatttcca ctttatttgt
     1861 ttgtttgttt atttattttt gagacagtct cgccctgtca cccaggctgg agtgcagtgg
     1921 cacgatctca gctcactgca acctacgcct tctgggttca cgtgattctc ttgccttagc
     1981 ctcccaagta gctgggacta caggcacgtg ccaccatgcc tggctaattt ttgtattttt
     2041 taaatagaga cggggtttca ctgtgttggc caggctggtc tcgaacacct gacctcaggt
     2101 gatccattcg tcttggcctc tcgaagtgct gggattccag gcgtgagcca ctgcggccag
     2161 cacatttcca cttttagatc ctactccata ccacaggttt catttaagaa gaaagagcta
     2221 gataaatgtg ctcttctggt taccccaccc tgacagagtg catttttaca cggctagcag
     2281 gggttgagac tgcagcctgg cctgccagcc attggaggtg tttaaggaag ggcagataat
     2341 gtgactcttt gcggggtgcc atctgcttac ccattagcga gcagaggggg tttctgcggg
     2401 tgacccccag catatttcta ggttacttat gggcagattt gtaagtgaca aaactccagc
     2461 tgatgctggg aatggggaga gggcccttga gggactttgt ggttttgtgc ttctggtttc
     2521 ctggccaacc ccagggtcac ttgtctggag gcccagctgg gcactaatgt ctgccaccga
     2581 ctatgttaca gtgtataaat gattcctcta tttgggagag atcttccaat ccagaggagc
     2641 ccctcttgga ctgcctgggt taaatctgca tagcagaagt ggttgatgag ttcatctgaa
     2701 gaaattcagg ccccacctcc ccaccctgcc cctccctgct cccttttgat ggtggcctct
     2761 gggtactcgg gcagagtcct tgggacacca gcctctctgg ggttctcagg ccatcccgtt
     2821 ggggctgtcg cccaggccta agtgagtcgt gtgcctctat tggaggatgg ctgttcccct
     2881 ggtggttgca tccaagtatc tgtctttctt tatggaccac gaagggaagc ccaccttcct
     2941 ggaggcagga ccttcggcct aagaaacaca ggccctggtg ctatctgacc tggggtccag
     3001 cgaggtggga atcccagtgt gtgagcgaca ggccttcttc tattgactta caatattcta
     3061 gaaggaccta cgtgtgggga cacagttttc caaactgagg aaaatgttgc aataaaagaa
     3121 tatgttgtaa gaaa
//
