LOCUS       NM_001623                655 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens allograft inflammatory factor 1 (AIF1), transcript
            variant 3, mRNA.
ACCESSION   NM_001623
VERSION     NM_001623.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 655)
  AUTHORS   Chen,L., Zhao,Y., Li,M. and Lv,G.
  TITLE     Proteome-wide Mendelian randomization highlights AIF1 and HLA-DQA2
            as targets for primary sclerosing cholangitis
  JOURNAL   Hepatol Int 18 (2), 517-528 (2024)
   PUBMED   37950809
  REMARK    GeneRIF: Proteome-wide Mendelian randomization highlights AIF1 and
            HLA-DQA2 as targets for primary sclerosing cholangitis.
REFERENCE   2  (bases 1 to 655)
  AUTHORS   Liu,W., Shi,T., Zheng,D., Ke,G. and Chen,J.
  TITLE     Identification of allograft inflammatory factor-1 suppressing the
            progression and indicating good prognosis of osteosarcoma
  JOURNAL   BMC Musculoskelet Disord 25 (1), 233 (2024)
   PUBMED   38521928
  REMARK    GeneRIF: Identification of allograft inflammatory factor-1
            suppressing the progression and indicating good prognosis of
            osteosarcoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 655)
  AUTHORS   Liu,X., Zhang,D., Hu,J., Xu,S., Xu,C. and Shen,Y.
  TITLE     Allograft inflammatory factor 1 is a potential diagnostic,
            immunological, and prognostic biomarker in pan-cancer
  JOURNAL   Aging (Albany NY) 15 (7), 2582-2609 (2023)
   PUBMED   37014322
  REMARK    GeneRIF: Allograft inflammatory factor 1 is a potential diagnostic,
            immunological, and prognostic biomarker in pan-cancer.
REFERENCE   4  (bases 1 to 655)
  AUTHORS   Deininger,M.H., Meyermann,R. and Schluesener,H.J.
  TITLE     The allograft inflammatory factor-1 family of proteins
  JOURNAL   FEBS Lett 514 (2-3), 115-121 (2002)
   PUBMED   11943136
  REMARK    Review article
REFERENCE   5  (bases 1 to 655)
  AUTHORS   Neville,M.J. and Campbell,R.D.
  TITLE     A new member of the Ig superfamily and a V-ATPase G subunit are
            among the predicted products of novel genes close to the TNF locus
            in the human MHC
  JOURNAL   J Immunol 162 (8), 4745-4754 (1999)
   PUBMED   10202016
REFERENCE   6  (bases 1 to 655)
  AUTHORS   Autieri,M.V. and Agrawal,N.
  TITLE     IRT-1, a novel interferon-gamma-responsive transcript encoding a
            growth-suppressing basic leucine zipper protein
  JOURNAL   J Biol Chem 273 (24), 14731-14737 (1998)
   PUBMED   9614071
REFERENCE   7  (bases 1 to 655)
  AUTHORS   Autieri,M.V.
  TITLE     cDNA cloning of human allograft inflammatory factor-1: tissue
            distribution, cytokine induction, and mRNA expression in injured
            rat carotid arteries
  JOURNAL   Biochem Biophys Res Commun 228 (1), 29-37 (1996)
   PUBMED   8912632
REFERENCE   8  (bases 1 to 655)
  AUTHORS   Utans,U., Quist,W.C., McManus,B.M., Wilson,J.E., Arceci,R.J.,
            Wallace,A.F. and Russell,M.E.
  TITLE     Allograft inflammatory factory-1. A cytokine-responsive macrophage
            molecule expressed in transplanted human hearts
  JOURNAL   Transplantation 61 (9), 1387-1392 (1996)
   PUBMED   8629302
REFERENCE   9  (bases 1 to 655)
  AUTHORS   Utans,U., Arceci,R.J., Yamashita,Y. and Russell,M.E.
  TITLE     Cloning and characterization of allograft inflammatory factor-1: a
            novel macrophage factor identified in rat cardiac allografts with
            chronic rejection
  JOURNAL   J Clin Invest 95 (6), 2954-2962 (1995)
   PUBMED   7769138
REFERENCE   10 (bases 1 to 655)
  AUTHORS   Iris,F.J., Bougueleret,L., Prieur,S., Caterina,D., Primas,G.,
            Perrot,V., Jurka,J., Rodriguez-Tome,P., Claverie,J.M., Dausset,J.
            et al.
  TITLE     Dense Alu clustering and a potential new member of the NF kappa B
            family within a 90 kilobase HLA class III segment
  JOURNAL   Nat Genet 3 (2), 137-145 (1993)
   PUBMED   8499947
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV735626.1, JQ782414.1 and
            AV716806.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001623.4.
            
            Summary: This gene encodes a protein that binds actin and calcium.
            This gene is induced by cytokines and interferon and may promote
            macrophage activation and growth of vascular smooth muscle cells
            and T-lymphocytes. Polymorphisms in this gene may be associated
            with systemic sclerosis. Alternative splicing results in multiple
            transcript variants, but the full-length and coding nature of some
            of these variants is not certain. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009474.1, AV716933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376059.8/ ENSP00000365227.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AV735626.1         72-72
            2-597               JQ782414.1         1-596
            598-655             AV716806.1         543-600
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..655
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /note="allograft inflammatory factor 1"
                     /db_xref="GeneID:199"
                     /db_xref="HGNC:HGNC:352"
                     /db_xref="MIM:601833"
     exon            1..121
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..540
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     interferon gamma responsive transcript; protein G1;
                     ionized calcium-binding adapter molecule 1"
                     /codon_start=1
                     /product="allograft inflammatory factor 1 isoform 3"
                     /protein_id="NP_001614.3"
                     /db_xref="CCDS:CCDS4706.1"
                     /db_xref="GeneID:199"
                     /db_xref="HGNC:HGNC:352"
                     /db_xref="MIM:601833"
                     /translation="MSQTRDLQGGKAFGLLKAQQEERLDEINKQFLDDPKYSSDEDLP
                     SKLEGFKEKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIGEVSSGSGETFS
                     YPDFLRMMLGKRSAILKMILMYEEKAREKEKPTGPPAKKAISELP"
     exon            122..183
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            184..250
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..292
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..455
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..655
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      635..640
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /note="hexamer: AATAAA"
     polyA_site      655
                     /gene="AIF1"
                     /gene_synonym="AIF-1; IBA1; IRT-1; IRT1"
                     /note="major polyA site"
ORIGIN      
        1 aggcttctga gaagactggt gggagagaag gagagcctgc agacagaggc ctccagcttg
       61 gtctgtctcc ccacctctac cagcatctgc tgagctatga gccaaaccag ggatttacag
      121 ggaggaaaag ctttcggact gctgaaggcc cagcaggaag agaggctgga tgagatcaac
      181 aagcaattcc tagacgatcc caaatatagc agtgatgagg atctgccctc caaactggaa
      241 ggcttcaaag agaaatacat ggagtttgac cttaatggaa atggcgatat tgatatcatg
      301 tccctgaaac gaatgctgga gaaacttgga gtccccaaga ctcacctaga gctaaagaaa
      361 ttaattggag aggtgtccag tggctccggg gagacgttca gctaccctga ctttctcagg
      421 atgatgctgg gcaagagatc tgccatccta aaaatgatcc tgatgtatga ggaaaaagcg
      481 agagaaaagg aaaagccaac aggcccccca gccaagaaag ctatctctga gttgccctga
      541 tttgaaggga aaagggatga tgggattgaa ggggcttcta atgacccaga tatggaaaca
      601 gaagacaaaa ttgtaagcca gagtcaacaa attaaataaa ttaccccctc ctcca
//
