LOCUS       NM_022831               2975 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens axin interactor, dorsalization associated (AIDA),
            mRNA.
ACCESSION   NM_022831 XM_942659
VERSION     NM_022831.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2975)
  AUTHORS   Zhang,P., Luo,J., Wu,T., Wang,X., Yang,F., Yu,Y., Lu,L. and Yu,H.
  TITLE     MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and
            Inflammation
  JOURNAL   Int Heart J 63 (5), 928-938 (2022)
   PUBMED   36184552
  REMARK    GeneRIF: MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury
            and Inflammation.
REFERENCE   2  (bases 1 to 2975)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2975)
  AUTHORS   Lalonde,S., Codina-Fauteux,V.A., de Bellefon,S.M., Leblanc,F.,
            Beaudoin,M., Simon,M.M., Dali,R., Kwan,T., Lo,K.S., Pastinen,T. and
            Lettre,G.
  TITLE     Integrative analysis of vascular endothelial cell genomic features
            identifies AIDA as a coronary artery disease candidate gene
  JOURNAL   Genome Biol 20 (1), 133 (2019)
   PUBMED   31287004
  REMARK    GeneRIF: genetic variant acts in the vascular endothelium to
            modulate inter-individual risk in coronary artery disease
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2975)
  AUTHORS   Vinayagam,A., Stelzl,U., Foulle,R., Plassmann,S., Zenkner,M.,
            Timm,J., Assmus,H.E., Andrade-Navarro,M.A. and Wanker,E.E.
  TITLE     A directed protein interaction network for investigating
            intracellular signal transduction
  JOURNAL   Sci Signal 4 (189), rs8 (2011)
   PUBMED   21900206
REFERENCE   5  (bases 1 to 2975)
  AUTHORS   Rui,Y., Xu,Z., Xiong,B., Cao,Y., Lin,S., Zhang,M., Chan,S.C.,
            Luo,W., Han,Y., Lu,Z., Ye,Z., Zhou,H.M., Han,J., Meng,A. and
            Lin,S.C.
  TITLE     A beta-catenin-independent dorsalization pathway activated by
            Axin/JNK signaling and antagonized by aida
  JOURNAL   Dev Cell 13 (2), 268-282 (2007)
   PUBMED   17681137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL392172.9 and AL592148.7.
            
            On Aug 31, 2019 this sequence version replaced NM_022831.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833718.1, AK022868.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340020.11/ ENSP00000339161.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AL392172.9         24525-24808         c
            285-354             AL392172.9         15465-15534         c
            355-408             AL392172.9         6527-6580           c
            409-463             AL392172.9         6106-6160           c
            464-527             AL592148.7         191946-192009       c
            528-634             AL592148.7         191281-191387       c
            635-757             AL592148.7         180447-180569       c
            758-880             AL592148.7         177664-177786       c
            881-998             AL592148.7         174484-174601       c
            999-2975            AL592148.7         172364-174340       c
FEATURES             Location/Qualifiers
     source          1..2975
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2975
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /note="axin interactor, dorsalization associated"
                     /db_xref="GeneID:64853"
                     /db_xref="HGNC:HGNC:25761"
                     /db_xref="MIM:612375"
     exon            1..284
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1095
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /note="axin interaction partner and dorsalization
                     antagonist"
                     /codon_start=1
                     /product="axin interactor, dorsalization-associated
                     protein"
                     /protein_id="NP_073742.2"
                     /db_xref="CCDS:CCDS1533.1"
                     /db_xref="GeneID:64853"
                     /db_xref="HGNC:HGNC:25761"
                     /db_xref="MIM:612375"
                     /translation="MSEVTRSLLQRWGASFRRGADFDSWGQLVEAIDEYQILARHLQK
                     EAQAQHNNSEFTEEQKKTIGKIATCLELRSAALQSTQSQEEFKLEDLKKLEPILKNIL
                     TYNKEFPFDVQPVPLRRILAPGEEENLEFEEDEEEGGAGAGSPDSFPARVPGTLLPRL
                     PSEPGMTLLTIRIEKIGLKDAGQCIDPYITVSVKDLNGIDLTPVQDTPVASRKEDTYV
                     HFNVDIELQKHVEKLTKGAAIFFEFKHYKPKKRFTSTKCFAFMEMDEIKPGPIVIELY
                     KKPTDFKRKKLQLLTKKPLYLHLHQTLHKE"
     exon            285..354
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            355..408
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            409..463
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            464..527
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            528..634
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            635..757
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            758..880
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            881..998
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     exon            999..2975
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /note="hexamer: ATTAAA"
     polyA_site      2975
                     /gene="AIDA"
                     /gene_synonym="C1orf80"
                     /note="major polyA site"
ORIGIN      
        1 caaagtttgg ctgtggcggc aaatgggctt gggcggctcc tcggcgggtg gcggtggtgg
       61 ccgtagcggt tcctcctggc cctgttaatg tcggggccag gccgggggag gatggcgccc
      121 tagaacccgg ccttgctggg gtaggggcgg gaggggacgg ggtggggacc ggccatgtcg
      181 gaggtgaccc ggagtctgct gcagcgctgg ggcgccagtt ttaggagagg cgccgacttc
      241 gactcttggg gccagctggt ggaggcgata gacgagtatc agatattagc aagacatcta
      301 caaaaggagg cccaagctca acacaataat tctgaattca cagaagaaca aaagaaaacc
      361 ataggcaaaa ttgcaacatg cttggaattg cgaagtgcag ctttacagtc cacacagtct
      421 caagaagaat ttaaactgga ggacctgaag aagctagaac caatcctaaa gaatattctt
      481 acatataata aagaattccc atttgatgtt cagcctgtcc cattaagaag aattttggca
      541 cctggtgaag aagagaattt ggaatttgaa gaagatgaag aagagggtgg tgctggagca
      601 gggtctcctg attcttttcc tgctagagtt cccggtactt tattaccaag gttgccatcg
      661 gaaccaggaa tgacattact cactatcaga attgagaaaa ttggtttgaa agatgctggg
      721 cagtgcatcg atccctatat tacagttagt gtaaaggatc tgaatggcat agacttaact
      781 cctgtgcaag atactcctgt ggcttcaaga aaagaagata catatgttca ttttaatgtg
      841 gacattgagc tccagaagca tgttgaaaaa ttaaccaaag gtgcagctat cttctttgaa
      901 ttcaaacact acaagcctaa aaaaaggttt accagcacca agtgttttgc tttcatggag
      961 atggatgaaa ttaaacctgg gccaattgta atagaactat acaagaaacc cactgacttt
     1021 aaaagaaaga aattgcaatt attgaccaag aaaccacttt atcttcatct acatcaaact
     1081 ttgcacaagg aatgatcctg acatgatgaa cctggaactt ctgtgaattt taccactcag
     1141 tagaaaccat catagctctg tgtagcatat tcacccttca acaggcagga agcaagccgt
     1201 acccagacca gtaggccgga cggagtccaa tgcaaagctg taccacagaa ttcagagtcc
     1261 agcacatcac actgacgtat aggactcctt gggatacagg tttattgtag attttgaaac
     1321 atgtttttac ttttctatta attgtgcaat taatagtcta ttttctaatt taccactact
     1381 cctaccctgc ttcctggaac aatactgttg tgggtaggat gtgctcatct tcagacttaa
     1441 tacagcaata agaatgtgct agagtttaca catctgttca cttttgctcc aatatgctct
     1501 tttgacttaa cgtcaagctt tgggttgatg tgggtagggt agtgtcaaac tgctttgaga
     1561 ggaatgggac cagttctgct gcctaagaag gtctgtctgg atgtttatag gcagcacctc
     1621 tgaagtggcc taaattcacc ctgatctgat agttttcctg cttagaaagt gtgccttggc
     1681 cagatcagta tcccacatgg gagtgttccc taggttgtag ctgtgattgt ttccagatga
     1741 ccagattgtt tttctgaaaa tgagcatatt tttagtcatg tcgattagct gttcttctac
     1801 atcacattgt tactctttct gatgatgatt ctagggttaa cattggaacc atctcaaaat
     1861 aattacaaag ttttagatgg gtttacaatg tcttctaaac aatgtaatct aaaaataatt
     1921 gagtcagatg ctaacgagat actgcaggca taactgctgt ttttctgaca actgattgtg
     1981 aaaccttaaa acctgcatac ctcttcttac agtgaggagt atgcaaaatc tggaaagata
     2041 ttctattttt tttatatagg tagataggat cgccatttat ttcctattta gatatactga
     2101 cattcatcca tatgaaaata tgcaggtcat tagcttacta taatttactt ttgacttaat
     2161 ggggcataaa taaaactttc atagtacaca tgaggtggat atttgataca cagaacattt
     2221 gcggtgggct ttctgtgggt tagatgtaaa gcccacatat tttaatattc actattttaa
     2281 atgagcaatg catgagggga atgcagtgtc agtacctggc ctatttttaa actagtgtaa
     2341 tcaccctagt cataccattc agtatgtttg ctttttaaaa taagtaacca caactaagtt
     2401 gttgtagccc ttgcacttca agagatctag tctttacttt cagttgtctg ttaggtccat
     2461 tctgtttact agacggatgt taataaaaac tatgcgagcc tgaatgaatt ctcagccaaa
     2521 tttagtcttg tctctcatct tgattggatt aattccaaat tctaaaatga ttcagtccac
     2581 aatagctcta ggggatgaag aatttgcctt actttgccca gttcctaaga ctgtgagttg
     2641 tcaaatccct agactgtaag ctcttcaagg agcaagaggc gcattttctc cgtgtcatgt
     2701 aatttttcta aggtgcttgg cagcactctg taccctgtgg agtactcagt accttttgtt
     2761 tgatgttgct gacaagacct gaaaaaaaat cccttaaaaa aaaaacccat taaagtgtag
     2821 caaaaccgat gtattatttt ttctcttttc tcataaacca taagatatgt atatcaaaat
     2881 gataatttat atgaagcatc tgctatcctt cacataagta tagtttatat gaactacaaa
     2941 tacctttcat caacattaaa gaagcttaaa ttgaa
//
