LOCUS       NM_020661               2803 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens activation induced cytidine deaminase (AICDA),
            transcript variant 1, mRNA.
ACCESSION   NM_020661
VERSION     NM_020661.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2803)
  AUTHORS   Jaiswal,A., Roy,R., Tamrakar,A., Singh,A.K., Kar,P. and Kodgire,P.
  TITLE     Activation-induced cytidine deaminase an antibody diversification
            enzyme interacts with chromatin modifier UBN1 in B-cells
  JOURNAL   Sci Rep 13 (1), 19615 (2023)
   PUBMED   37949972
  REMARK    GeneRIF: Activation-induced cytidine deaminase an antibody
            diversification enzyme interacts with chromatin modifier UBN1 in
            B-cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2803)
  AUTHORS   Jiao,J., Lv,Z., Wang,Y., Fan,L. and Yang,A.
  TITLE     The off-target effects of AID in carcinogenesis
  JOURNAL   Front Immunol 14, 1221528 (2023)
   PUBMED   37600817
  REMARK    GeneRIF: The off-target effects of AID in carcinogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2803)
  AUTHORS   Xiao,J., Li,J. and Yao,X.
  TITLE     [Activation-induced cytidine deaminase (AID) involved in the
            regulation of B cell immune senescence]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 39 (5), 474-478 (2023)
   PUBMED   37248842
  REMARK    GeneRIF: [Activation-induced cytidine deaminase (AID) involved in
            the regulation of B cell immune senescence].
REFERENCE   4  (bases 1 to 2803)
  AUTHORS   Wang,Y., Miao,Y., Zhou,W., Bi,Y., Ji,Y. and Ma,Y.
  TITLE     Activation-induced cytidine deaminase displays an alternative
            co-factor for modulating PIM1 expression in diffuse large B cell
            lymphoma cell lines
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (3), 1-7 (2023)
   PUBMED   37300695
  REMARK    GeneRIF: Activation-induced cytidine deaminase displays an
            alternative co-factor for modulating PIM1 expression in diffuse
            large B cell lymphoma cell lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2803)
  AUTHORS   Sakhtemani,R., Perera,M.L.W., Hubschmann,D., Siebert,R.,
            Lawrence,M.S. and Bhagwat,A.S.
  TITLE     Human activation-induced deaminase lacks strong replicative strand
            bias or preference for cytosines in hairpin loops
  JOURNAL   Nucleic Acids Res 50 (9), 5145-5157 (2022)
   PUBMED   35524550
  REMARK    GeneRIF: Human activation-induced deaminase lacks strong
            replicative strand bias or preference for cytosines in hairpin
            loops.
REFERENCE   6  (bases 1 to 2803)
  AUTHORS   Noguchi,E., Shibasaki,M., Inudou,M., Kamioka,M., Yokouchi,Y.,
            Yamakawa-Kobayashi,K., Hamaguchi,H., Matsui,A. and Arinami,T.
  TITLE     Association between a new polymorphism in the activation-induced
            cytidine deaminase gene and atopic asthma and the regulation of
            total serum IgE levels
  JOURNAL   J Allergy Clin Immunol 108 (3), 382-386 (2001)
   PUBMED   11544457
REFERENCE   7  (bases 1 to 2803)
  AUTHORS   Minegishi,Y., Lavoie,A., Cunningham-Rundles,C., Bedard,P.M.,
            Hebert,J., Cote,L., Dan,K., Sedlak,D., Buckley,R.H., Fischer,A.,
            Durandy,A. and Conley,M.E.
  TITLE     Mutations in activation-induced cytidine deaminase in patients with
            hyper IgM syndrome
  JOURNAL   Clin Immunol 97 (3), 203-210 (2000)
   PUBMED   11112359
REFERENCE   8  (bases 1 to 2803)
  AUTHORS   Revy,P., Muto,T., Levy,Y., Geissmann,F., Plebani,A., Sanal,O.,
            Catalan,N., Forveille,M., Dufourcq-Labelouse,R., Gennery,A.,
            Tezcan,I., Ersoy,F., Kayserili,H., Ugazio,A.G., Brousse,N.,
            Muramatsu,M., Notarangelo,L.D., Kinoshita,K., Honjo,T., Fischer,A.
            and Durandy,A.
  TITLE     Activation-induced cytidine deaminase (AID) deficiency causes the
            autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
  JOURNAL   Cell 102 (5), 565-575 (2000)
   PUBMED   11007475
REFERENCE   9  (bases 1 to 2803)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 2803)
  AUTHORS   Muto,T., Muramatsu,M., Taniwaki,M., Kinoshita,K. and Honjo,T.
  TITLE     Isolation, tissue distribution, and chromosomal localization of the
            human activation-induced cytidine deaminase (AID) gene
  JOURNAL   Genomics 68 (1), 85-88 (2000)
   PUBMED   10950930
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP225441.1, AC092184.7,
            AB040431.1 and AJ577811.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020661.3.
            
            Summary: This gene encodes a RNA-editing deaminase that is a member
            of the cytidine deaminase family. AICDA is specifically expressed
            and active in germinal center-like B cells. In the germinal center,
            AICDA is involved in somatic hypermutation, gene conversion, and
            class-switch recombination of immunoglobulin genes. An epigenetic
            role in neoplastic transformation and lymphoma progression has been
            experimentally ascribed to AICDA using mouse models. Defects in
            this gene are the cause of autosomal recessive hyper-IgM
            immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul
            2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040431.1, EU794587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149876, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229335.11/ ENSP00000229335.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP225441.1         9-16
            9-14                AC092184.7         34985-34990
            15-16               BP225441.1         23-24
            17-556              AB040431.1         1-540
            557-635             AJ577811.1         257-335
            636-2803            AB040431.1         620-2787
FEATURES             Location/Qualifiers
     source          1..2803
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..2803
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /note="activation induced cytidine deaminase"
                     /db_xref="GeneID:57379"
                     /db_xref="HGNC:HGNC:13203"
                     /db_xref="MIM:605257"
     exon            1..100
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..689
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /EC_number="3.5.4.38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     integrated into Burkitt's lymphoma cell line Ramos;
                     cytidine aminohydrolase; single-stranded DNA cytosine
                     deaminase; epididymis secretory protein Li 284"
                     /codon_start=1
                     /product="single-stranded DNA cytosine deaminase isoform
                     1"
                     /protein_id="NP_065712.1"
                     /db_xref="CCDS:CCDS41747.1"
                     /db_xref="GeneID:57379"
                     /db_xref="HGNC:HGNC:13203"
                     /db_xref="MIM:605257"
                     /translation="MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSL
                     DFGYLRNKNGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNP
                     NLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHERTFK
                     AWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL"
     exon            101..248
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..519
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..635
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            636..2803
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /note="hexamer: AGTAAA"
     polyA_site      2667
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /note="major polyA site"
     regulatory      2777..2782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
                     /note="hexamer: AATAAA"
     polyA_site      2803
                     /gene="AICDA"
                     /gene_synonym="AID; ARP2; CDA2; HEL-S-284; HIGM2"
ORIGIN      
        1 gtcagactaa gacagagaac catcattaat tgaagtgaga tttttctggc ctgagacttg
       61 cagggaggca agaagacact ctggacacca ctatggacag cctcttgatg aaccggagga
      121 agtttcttta ccaattcaaa aatgtccgct gggctaaggg tcggcgtgag acctacctgt
      181 gctacgtagt gaagaggcgt gacagtgcta catccttttc actggacttt ggttatcttc
      241 gcaataagaa cggctgccac gtggaattgc tcttcctccg ctacatctcg gactgggacc
      301 tagaccctgg ccgctgctac cgcgtcacct ggttcacctc ctggagcccc tgctacgact
      361 gtgcccgaca tgtggccgac tttctgcgag ggaaccccaa cctcagtctg aggatcttca
      421 ccgcgcgcct ctacttctgt gaggaccgca aggctgagcc cgaggggctg cggcggctgc
      481 accgcgccgg ggtgcaaata gccatcatga ccttcaaaga ttatttttac tgctggaata
      541 cttttgtaga aaaccacgaa agaactttca aagcctggga agggctgcat gaaaattcag
      601 ttcgtctctc cagacagctt cggcgcatcc ttttgcccct gtatgaggtt gatgacttac
      661 gagacgcatt tcgtactttg ggactttgat agcaacttcc aggaatgtca cacacgatga
      721 aatatctctg ctgaagacag tggataaaaa acagtccttc aagtcttctc tgtttttatt
      781 cttcaactct cactttctta gagtttacag aaaaaatatt tatatacgac tctttaaaaa
      841 gatctatgtc ttgaaaatag agaaggaaca caggtctggc cagggacgtg ctgcaattgg
      901 tgcagttttg aatgcaacat tgtcccctac tgggaataac agaactgcag gacctgggag
      961 catcctaaag tgtcaacgtt tttctatgac ttttaggtag gatgagagca gaaggtagat
     1021 cctaaaaagc atggtgagag gatcaaatgt ttttatatca acatccttta ttatttgatt
     1081 catttgagtt aacagtggtg ttagtgatag atttttctat tcttttccct tgacgtttac
     1141 tttcaagtaa cacaaactct tccatcaggc catgatctat aggacctcct aatgagagta
     1201 tctgggtgat tgtgacccca aaccatctct ccaaagcatt aatatccaat catgcgctgt
     1261 atgttttaat cagcagaagc atgtttttat gtttgtacaa aagaagattg ttatgggtgg
     1321 ggatggaggt atagaccatg catggtcacc ttcaagctac tttaataaag gatcttaaaa
     1381 tgggcaggag gactgtgaac aagacaccct aataatgggt tgatgtctga agtagcaaat
     1441 cttctggaaa cgcaaactct tttaaggaag tccctaattt agaaacaccc acaaacttca
     1501 catatcataa ttagcaaaca attggaagga agttgcttga atgttgggga gaggaaaatc
     1561 tattggctct cgtgggtctc ttcatctcag aaatgccaat caggtcaagg tttgctacat
     1621 tttgtatgtg tgtgatgctt ctcccaaagg tatattaact atataagaga gttgtgacaa
     1681 aacagaatga taaagctgcg aaccgtggca cacgctcata gttctagctg cttgggaggt
     1741 tgaggaggga ggatggcttg aacacaggtg ttcaaggcca gcctgggcaa cataacaaga
     1801 tcctgtctct caaaaaaaaa aaaaaaaaaa agaaagagag agggccgggc gtggtggctc
     1861 acgcctgtaa tcccagcact ttgggaggcc gagccgggcg gatcacctgt ggtcaggagt
     1921 ttgagaccag cctggccaac atggcaaaac cccgtctgta ctcaaaatgc aaaaattagc
     1981 caggcgtggt agcaggcacc tgtaatccca gctacttggg aggctgaggc aggagaatcg
     2041 cttgaaccca ggaggtggag gttgcagtaa gctgagatcg tgccgttgca ctccagcctg
     2101 ggcgacaaga gcaagactct gtctcagaaa aaaaaaaaaa aaagagagag agagagaaag
     2161 agaacaatat ttgggagaga aggatgggga agcattgcaa ggaaattgtg ctttatccaa
     2221 caaaatgtaa ggagccaata agggatccct atttgtctct tttggtgtct atttgtccct
     2281 aacaactgtc tttgacagtg agaaaaatat tcagaataac catatccctg tgccgttatt
     2341 acctagcaac ccttgcaatg aagatgagca gatccacagg aaaacttgaa tgcacaactg
     2401 tcttatttta atcttattgt acataagttt gtaaaagagt taaaaattgt tacttcatgt
     2461 attcatttat attttatatt attttgcgtc taatgatttt ttattaacat gatttccttt
     2521 tctgatatat tgaaatggag tctcaaagct tcataaattt ataactttag aaatgattct
     2581 aataacaacg tatgtaattg taacattgca gtaatggtgc tacgaagcca tttctcttga
     2641 tttttagtaa acttttatga cagcaaattt gcttctggct cactttcaat cagttaaata
     2701 aatgataaat aattttggaa gctgtgaaga taaaatacca aataaaataa tataaaagtg
     2761 atttatatga agttaaaata aaaaatcagt atgatggaat aaa
//
