LOCUS       NM_001622               1574 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens alpha 2-HS glycoprotein (AHSG), transcript variant 2,
            mRNA.
ACCESSION   NM_001622
VERSION     NM_001622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1574)
  AUTHORS   Pamies,A., Llop,D., Ibarretxe,D., Rosales,R., Girona,J., Masana,L.,
            Vallve,J.C. and Paredes,S.
  TITLE     Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A
            and Catestatin with Serological and Inflammatory Markers in
            Rheumatoid Arthritis Patients
  JOURNAL   Int J Mol Sci 25 (18), 9910 (2024)
   PUBMED   39337398
  REMARK    GeneRIF: Enhanced Association of Novel Cardiovascular Biomarkers
            Fetuin-A and Catestatin with Serological and Inflammatory Markers
            in Rheumatoid Arthritis Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1574)
  AUTHORS   Kulakli,S., Yildirmak,S., Oguz,I.D., Usta,M., Tosun,A. and Aksan,B.
  TITLE     Evaluation of atherosclerotic risk in rosacea patients through
            serum fetuin-A and carotid intima media thickness
  JOURNAL   J Cosmet Dermatol 23 (3), 1075-1084 (2024)
   PUBMED   37994275
  REMARK    GeneRIF: Evaluation of atherosclerotic risk in rosacea patients
            through serum fetuin-A and carotid intima media thickness.
REFERENCE   3  (bases 1 to 1574)
  AUTHORS   Al Ali,L., van de Vegte,Y.J., Said,M.A., Groot,H.E., Hendriks,T.,
            Yeung,M.W., Lipsic,E. and van der Harst,P.
  TITLE     Fetuin-A and its genetic association with cardiometabolic disease
  JOURNAL   Sci Rep 13 (1), 21469 (2023)
   PUBMED   38052855
  REMARK    GeneRIF: Fetuin-A and its genetic association with cardiometabolic
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1574)
  AUTHORS   Mahmmoed,B., Hilal,N. and Sarhat,E.
  TITLE     EVALUATION OF FETUIN-A LEVEL IN POLYCYSTIC OVARY SYNDROME AND ITS
            ASSOCIATION WITH ASPROSIN AND SOME BIOCHEMICAL PARAMETERS
  JOURNAL   Georgian Med News (343), 63-66 (2023)
   PUBMED   38096518
  REMARK    GeneRIF: EVALUATION OF FETUIN-A LEVEL IN POLYCYSTIC OVARY SYNDROME
            AND ITS ASSOCIATION WITH ASPROSIN AND SOME BIOCHEMICAL PARAMETERS.
REFERENCE   5  (bases 1 to 1574)
  AUTHORS   Xing,X., Cao,F., Gao,L. and Song,M.
  TITLE     AHSG, a Gene Promoting Tumour Proliferation, Migration and
            Invasion, is an Independent Prognostic Factor for Poor Overall
            Survival in Lung Adenocarcinoma
  JOURNAL   Mol Biol Rep 50 (9), 7659-7666 (2023)
   PUBMED   37535244
  REMARK    GeneRIF: AHSG, a Gene Promoting Tumour Proliferation, Migration and
            Invasion, is an Independent Prognostic Factor for Poor Overall
            Survival in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 1574)
  AUTHORS   Yang,F., Schwartz,Z., Swain,L.D., Lee,C.C., Bowman,B.H. and
            Boyan,B.D.
  TITLE     Alpha 2-HS-glycoprotein: expression in chondrocytes and
            augmentation of alkaline phosphatase and phospholipase A2 activity
  JOURNAL   Bone 12 (1), 7-15 (1991)
   PUBMED   2054237
REFERENCE   7  (bases 1 to 1574)
  AUTHORS   Kellermann,J., Haupt,H., Auerswald,E.A. and Muller-Ester,W.
  TITLE     The arrangement of disulfide loops in human alpha 2-HS
            glycoprotein. Similarity to the disulfide bridge structures of
            cystatins and kininogens
  JOURNAL   J Biol Chem 264 (24), 14121-14128 (1989)
   PUBMED   2760061
REFERENCE   8  (bases 1 to 1574)
  AUTHORS   Araki,T., Yoshioka,Y. and Schmid,K.
  TITLE     The position of the disulfide bonds in human plasma alpha 2
            HS-glycoprotein and the repeating double disulfide bonds in the
            domain structure
  JOURNAL   Biochim Biophys Acta 994 (3), 195-199 (1989)
   PUBMED   2645941
REFERENCE   9  (bases 1 to 1574)
  AUTHORS   Magnuson,V.L., McCombs,J.L., Lee,C.C., Yang,F., Bowman,B.H. and
            McGill,J.R.
  TITLE     Human alpha 2-HS-glycoprotein localized to 3q27----q29 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 47 (1-2), 72-74 (1988)
   PUBMED   3356172
REFERENCE   10 (bases 1 to 1574)
  AUTHORS   Lee,C.C., Bowman,B.H. and Yang,F.M.
  TITLE     Human alpha 2-HS-glycoprotein: the A and B chains with a connecting
            sequence are encoded by a single mRNA transcript
  JOURNAL   Proc Natl Acad Sci U S A 84 (13), 4403-4407 (1987)
   PUBMED   3474608
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK303754.1, AC068631.16 and
            BC052590.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001622.3.
            
            Summary: The protein encoded by this gene is a negatively-charged
            serum glycoprotein that is synthesized by hepatocytes. The encoded
            protein consists of two polypeptide chains, which are both cleaved
            from a proprotein encoded from a single mRNA. It is involved in
            several processes, including endocytosis, brain development, and
            the formation of bone tissue. Defects in this gene are a cause of
            susceptibility to leanness. [provided by RefSeq, Aug 2017].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is 1 aa shorter compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.47881.1,
                                           SRR5189664.168104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411641.7/ ENSP00000393887.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1009              AK303754.1         137-1145
            1010-1337           AC068631.16        40491-40818         c
            1338-1574           BC052590.1         1317-1553
FEATURES             Location/Qualifiers
     source          1..1574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..1574
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /note="alpha 2-HS glycoprotein"
                     /db_xref="GeneID:197"
                     /db_xref="HGNC:HGNC:349"
                     /db_xref="MIM:138680"
     exon            1..295
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1186
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; fetuin-A; alpha-2-Z-globulin;
                     ba-alpha-2-glycoprotein"
                     /codon_start=1
                     /product="alpha-2-HS-glycoprotein isoform 2 preproprotein"
                     /protein_id="NP_001613.2"
                     /db_xref="CCDS:CCDS3278.1"
                     /db_xref="GeneID:197"
                     /db_xref="HGNC:HGNC:349"
                     /db_xref="MIM:138680"
                     /translation="MKSLVLLLCLAQLWGCHSAPHGPGLIYRQPNCDDPETEEAALVA
                     IDYINQNLPWGYKHTLNQIDEVKVWPQQPSGELFEIEIDTLETTCHVLDPTPVARCSV
                     RQLKEHAVEGDCDFQLLKLDGKFSVVYAKCDSSPDSAEDVRKVCQDCPLLAPLNDTRV
                     VHAAKAALAAFNAQNNGSNFQLEEISRAQLVPLPPSTYVEFTVSGTDCVAKEATEAAK
                     CNLLAEKQYGFCKATLSEKLGGAEVAVTCMVFQTQPVSSQPQPEGANEAVPTPVVDPD
                     APPSPPLGAPGLPPAGSPPDSHVLLAAPPGHQLHRAHYDLRHTFMGVVSLGSPSGEVS
                     HPRKTRTVVQPSVGAAAGPVVPPCPGRIRHFKV"
     exon            296..406
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            407..491
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            492..655
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            656..757
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            758..841
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1574
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1552..1557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /note="hexamer: AATAAA"
     polyA_site      1574
                     /gene="AHSG"
                     /gene_synonym="A2HS; AHS; APMR1; FETUA; HSGA"
                     /note="major polyA site"
ORIGIN      
        1 ctacctttcc cagcagagca cctgggttgg tcccgaagcc tccaaccacc tgcacgcctg
       61 ccagggcctc tctggggcag ccatgaagtc cctcgtcctg ctcctttgtc ttgctcagct
      121 ctggggctgc cactcagccc cacatggccc agggctgatt tatagacaac cgaactgcga
      181 tgatccagaa actgaggaag cagctctggt ggctatagac tacatcaatc aaaaccttcc
      241 ttggggatac aaacacacct tgaaccagat tgatgaagta aaggtgtggc ctcagcagcc
      301 ctccggagag ctgtttgaga ttgaaataga caccctggaa accacctgcc atgtgctgga
      361 ccccacccct gtggcaagat gcagcgtgag gcagctgaag gagcatgctg tcgaaggaga
      421 ctgtgatttc cagctgttga aactagatgg caagttttcc gtggtatacg caaaatgtga
      481 ttccagtcca gactcagccg aggacgtgcg caaggtgtgc caagactgcc ccctgctggc
      541 cccgctgaac gacaccaggg tggtgcacgc cgcgaaagct gccctggccg ccttcaacgc
      601 tcagaacaac ggctccaatt ttcagctgga ggaaatttcc cgggctcagc ttgtgcccct
      661 cccaccttct acctatgtgg agtttacagt gtctggcact gactgtgttg ctaaagaggc
      721 cacagaggca gccaagtgta acctgctggc agaaaagcaa tatggctttt gtaaggcaac
      781 actcagtgag aagcttggtg gggcagaggt tgcagtgacc tgcatggtgt tccaaacaca
      841 gcccgtgagc tcacagcccc aaccagaagg tgccaatgaa gcagtcccca cacccgtggt
      901 ggacccagat gcacctccgt cccctccact tggcgcacct ggactccctc cagctggctc
      961 acccccagac tcccatgtgt tactggcagc tcctccagga caccagttgc accgggcgca
     1021 ctacgacctg cgccacacct tcatgggtgt ggtctcattg gggtcaccct caggagaagt
     1081 gtcgcacccc cggaaaacac gcacagtggt gcagcctagt gttggtgctg ctgctgggcc
     1141 agtggttcct ccatgtccgg ggaggatcag acacttcaag gtctaggcta gacatggcag
     1201 agatgaggag gtttggcaca gaaaacatag ccaccatttt gtccaagcct gggcatgggt
     1261 ggggggcctt gtctgctggc cacgcaagtg tcacatgcga tctacattaa tatcaagtct
     1321 tgactcccta cttcccgtca ttcctcacag gacagaagca gagtgggtgg tggttatgtt
     1381 tgacagaagg cattaggttg acaacttgtc atgattttga cggtaagcca ccatgattgt
     1441 gttctctgcc tctggttgac cttacaaaaa ccattggaac tgtgactttg aaaggtgctc
     1501 ttgctaagct tatatgtgcc tgttaatgaa agtgcctgaa agaccttcct taataaagaa
     1561 ggttctaagc tgaa
//
