LOCUS       NM_012111               1337 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens activator of HSP90 ATPase activity 1 (AHSA1),
            transcript variant 1, mRNA.
ACCESSION   NM_012111
VERSION     NM_012111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Hussein,S.K., Bhat,R., Overduin,M. and LaPointe,P.
  TITLE     Recruitment of Ahsa1 to Hsp90 is regulated by a conserved peptide
            that inhibits ATPase stimulation
  JOURNAL   EMBO Rep 25 (8), 3532-3546 (2024)
   PUBMED   38937628
  REMARK    GeneRIF: Recruitment of Ahsa1 to Hsp90 is regulated by a conserved
            peptide that inhibits ATPase stimulation.
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Tang,J., Hu,H., Zhou,C. and Zhang,N.
  TITLE     Human Aha1's N-terminal extension confers it holdase activity in
            vitro
  JOURNAL   Protein Sci 32 (9), e4735 (2023)
   PUBMED   37486705
  REMARK    GeneRIF: Human Aha1's N-terminal extension confers it holdase
            activity in vitro.
REFERENCE   3  (bases 1 to 1337)
  AUTHORS   Biebl,M.M. and Buchner,J.
  TITLE     p23 and Aha1: Distinct Functions Promote Client Maturation
  JOURNAL   Subcell Biochem 101, 159-187 (2023)
   PUBMED   36520307
  REMARK    GeneRIF: p23 and Aha1: Distinct Functions Promote Client
            Maturation.
            Review article
REFERENCE   4  (bases 1 to 1337)
  AUTHORS   Li,W. and Liu,J.
  TITLE     The Prognostic and Immunotherapeutic Significance of AHSA1 in
            Pan-Cancer, and Its Relationship With the Proliferation and
            Metastasis of Hepatocellular Carcinoma
  JOURNAL   Front Immunol 13, 845585 (2022)
   PUBMED   35757728
  REMARK    GeneRIF: The Prognostic and Immunotherapeutic Significance of AHSA1
            in Pan-Cancer, and Its Relationship With the Proliferation and
            Metastasis of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1337)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1337)
  AUTHORS   Wang,X., Venable,J., LaPointe,P., Hutt,D.M., Koulov,A.V.,
            Coppinger,J., Gurkan,C., Kellner,W., Matteson,J., Plutner,H.,
            Riordan,J.R., Kelly,J.W., Yates,J.R. 3rd and Balch,W.E.
  TITLE     Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in
            cystic fibrosis
  JOURNAL   Cell 127 (4), 803-815 (2006)
   PUBMED   17110338
  REMARK    GeneRIF: Hsp90 cochaperones modulate Hsp90-dependent stability of
            CFTR protein folding in the endoplasmic reticulum
REFERENCE   7  (bases 1 to 1337)
  AUTHORS   Swick,L. and Kapatos,G.
  TITLE     A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein
            interactions
  JOURNAL   J Neurochem 97 (5), 1447-1455 (2006)
   PUBMED   16696853
REFERENCE   8  (bases 1 to 1337)
  AUTHORS   Lotz,G.P., Lin,H., Harst,A. and Obermann,W.M.
  TITLE     Aha1 binds to the middle domain of Hsp90, contributes to client
            protein activation, and stimulates the ATPase activity of the
            molecular chaperone
  JOURNAL   J Biol Chem 278 (19), 17228-17235 (2003)
   PUBMED   12604615
REFERENCE   9  (bases 1 to 1337)
  AUTHORS   Panaretou,B., Siligardi,G., Meyer,P., Maloney,A., Sullivan,J.K.,
            Singh,S., Millson,S.H., Clarke,P.A., Naaby-Hansen,S., Stein,R.,
            Cramer,R., Mollapour,M., Workman,P., Piper,P.W., Pearl,L.H. and
            Prodromou,C.
  TITLE     Activation of the ATPase activity of hsp90 by the stress-regulated
            cochaperone aha1
  JOURNAL   Mol Cell 10 (6), 1307-1318 (2002)
   PUBMED   12504007
  REMARK    GeneRIF: stimulates the inherent ATPase activity of Hsp90
REFERENCE   10 (bases 1 to 1337)
  AUTHORS   Sevier,C.S. and Machamer,C.E.
  TITLE     p38: A novel protein that associates with the vesicular stomatitis
            virus glycoprotein
  JOURNAL   Biochem Biophys Res Commun 287 (2), 574-582 (2001)
   PUBMED   11554768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000321.2 and AF161440.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012111.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ243310.1, SRR1163657.47594.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216479.8/ ENSP00000216479.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1180              BC000321.2         12-1191
            1181-1337           AF161440.1         888-1044
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1337
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /note="activator of HSP90 ATPase activity 1"
                     /db_xref="GeneID:10598"
                     /db_xref="HGNC:HGNC:1189"
                     /db_xref="MIM:608466"
     exon            1..177
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1114
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activator of 90 kDa heat shock protein ATPase homolog 1;
                     AHA1, activator of heat shock 90kDa protein ATPase homolog
                     1"
                     /codon_start=1
                     /product="activator of 90 kDa heat shock protein ATPase
                     homolog 1 isoform 1"
                     /protein_id="NP_036243.1"
                     /db_xref="CCDS:CCDS9863.1"
                     /db_xref="GeneID:10598"
                     /db_xref="HGNC:HGNC:1189"
                     /db_xref="MIM:608466"
                     /translation="MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLF
                     LAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGH
                     VEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFT
                     QGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTS
                     PEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRF
                     KSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYG
                     ARLF"
     exon            178..368
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            369..451
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            452..569
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            570..658
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            659..787
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            788..889
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            890..941
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1337
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1316..1321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="AHSA1"
                     /gene_synonym="AHA1; C14orf3; hAha1; p38"
                     /note="major polyA site"
ORIGIN      
        1 agtagtttcc aggcgctgcc gggcggctgg cactaagcgg tcctgaggct gtggctacgg
       61 ctgctccgga gctggtggcg ccgcgatagg agagccgatg gccaagtggg gtgagggaga
      121 cccacgctgg atcgtggagg agcgggcgga cgccaccaac gtcaacaact ggcactggac
      181 ggagagagat gcttcaaatt ggtccacgga taagctgaaa acactgttcc tggcagtgca
      241 ggttcaaaat gaagaaggca agtgtgaggt gacggaagtg agtaagcttg atggagaggc
      301 atccattaac aatcgcaaag ggaaacttat cttcttttat gaatggagcg tcaaactaaa
      361 ctggacaggt acttctaagt caggagtaca atacaaagga catgtggaga tccccaattt
      421 gtctgatgaa aacagcgtgg atgaagtgga gattagtgtg agccttgcca aagatgagcc
      481 tgacacaaat ctcgtggcct taatgaagga agaaggggtg aaacttctaa gagaagcaat
      541 gggaatttac atcagcaccc tcaaaacaga gttcacccag ggcatgatct tacctacaat
      601 gaatggagag tcagtagacc cagtggggca gccagcactg aaaactgagg agcgcaaggc
      661 taagcctgct ccttcaaaaa cccaggccag acctgttgga gtcaaaatcc ccacttgtaa
      721 gatcactctt aaggaaacct tcctgacgtc accagaggag ctctatagag tgtttaccac
      781 ccaagagctg gtgcaggcct ttacccatgc tcctgcaaca ttagaagcag acagaggtgg
      841 aaagttccac atggtagatg gcaacgtctc tggggaattt actgatctgg tccctgagaa
      901 acatattgtg atgaagtgga ggtttaaatc ttggccagag ggacactttg ccaccatcac
      961 cttgaccttc atcgacaaga acggagagac tgagctgtgc atggaaggtc gaggcatccc
     1021 tgctcctgag gaagagcgga cgcgacaggg ctggcagcgg tactactttg agggcattaa
     1081 acagaccttt ggctatggcg cacgcttatt ttagggccag cggcagggga ctccagcctg
     1141 ctggacactt cagtccagct ctctcctgac tggggcttgc gactcacagg attgcatcgt
     1201 cccagctgct aacttggggc cggggcccct cccttccaca tataccttgg gtttgtgcat
     1261 gttttctgct gggtgggttc agagggcaat ttctctttta tgtgtacata tgctaaataa
     1321 acataattta aaaaaca
//
