LOCUS       NM_001377236            5661 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens aryl hydrocarbon receptor repressor (AHRR), transcript
            variant 1, mRNA.
ACCESSION   NM_001377236
VERSION     NM_001377236.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5661)
  AUTHORS   Pospiech,E., Rudnicka,J., Noroozi,R., Pisarek-Pacek,A., Wysocka,B.,
            Masny,A., Boron,M., Migacz-Gruszka,K., Pruszkowska-Przybylska,P.,
            Kobus,M., Lisman,D., Zielinska,G., Cytacka,S., Iljin,A.,
            Wiktorska,J.A., Michalczyk,M., Kaczka,P., Krzysztofik,M., Sitek,A.,
            Spolnicka,M., Ossowski,A. and Branicki,W.
  TITLE     DNA methylation at AHRR as a master predictor of smoke exposure and
            a biomarker for sleep and exercise
  JOURNAL   Clin Epigenetics 16 (1), 147 (2024)
   PUBMED   39425209
  REMARK    GeneRIF: DNA methylation at AHRR as a master predictor of smoke
            exposure and a biomarker for sleep and exercise.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5661)
  AUTHORS   Pelland-St-Pierre,L., Pham,M.C., Nguyen,A.Q.H., Pasquet,R.,
            Taylor,S.A., Bosson-Rieutort,D., Koushik,A. and Ho,V.
  TITLE     The Influence of Smoking and Occupational Risk Factors on DNA
            Methylation in the AHRR and F2RL3 Genes
  JOURNAL   Cancer Epidemiol Biomarkers Prev 33 (2), 224-233 (2024)
   PUBMED   38051301
  REMARK    GeneRIF: The Influence of Smoking and Occupational Risk Factors on
            DNA Methylation in the AHRR and F2RL3 Genes.
REFERENCE   3  (bases 1 to 5661)
  AUTHORS   Dahl,C., Hvidtfeldt,U.A., Tjonneland,A., Guldberg,P. and
            Raaschou-Nielsen,O.
  TITLE     Blood Leukocyte AHRR Methylation and Risk of Non-smoking-associated
            Cancer: A Case-cohort Study of Non-Hodgkin Lymphoma
  JOURNAL   Cancer Res Commun 3 (9), 1781-1787 (2023)
   PUBMED   37691855
  REMARK    GeneRIF: Blood Leukocyte AHRR Methylation and Risk of
            Non-smoking-associated Cancer: A Case-cohort Study of Non-Hodgkin
            Lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5661)
  AUTHORS   Ardizzoia,A., Jemma,A., Redaelli,S., Silva,M., Bentivegna,A.,
            Lavitrano,M. and Conconi,D.
  TITLE     AhRR and PPP1R3C: Potential Prognostic Biomarkers for Serous
            Ovarian Cancer
  JOURNAL   Int J Mol Sci 24 (14), 11455 (2023)
   PUBMED   37511212
  REMARK    GeneRIF: AhRR and PPP1R3C: Potential Prognostic Biomarkers for
            Serous Ovarian Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5661)
  AUTHORS   Jacobsen,K.K., Kobylecki,C.J., Skov-Jeppesen,S.M. and Bojesen,S.E.
  TITLE     Development and validation of a simple general population lung
            cancer risk model including AHRR-methylation
  JOURNAL   Lung Cancer 181, 107229 (2023)
   PUBMED   37150141
  REMARK    GeneRIF: Development and validation of a simple general population
            lung cancer risk model including AHRR-methylation.
REFERENCE   6  (bases 1 to 5661)
  AUTHORS   Karchner,S.I., Jenny,M.J., Tarrant,A.M., Evans,B.R., Kang,H.J.,
            Bae,I., Sherr,D.H. and Hahn,M.E.
  TITLE     The active form of human aryl hydrocarbon receptor (AHR) repressor
            lacks exon 8, and its Pro 185 and Ala 185 variants repress both AHR
            and hypoxia-inducible factor
  JOURNAL   Mol Cell Biol 29 (13), 3465-3477 (2009)
   PUBMED   19380484
  REMARK    GeneRIF: Results identify aryl hydrocarbon receptor (AHR) repressor
            (AHRR) Delta8 as the active form of human AHRR and reveal novel
            aspects of its function and specificity as a repressor of AHR.
REFERENCE   7  (bases 1 to 5661)
  AUTHORS   Baba,T., Mimura,J., Gradin,K., Kuroiwa,A., Watanabe,T., Matsuda,Y.,
            Inazawa,J., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Structure and expression of the Ah receptor repressor gene
  JOURNAL   J Biol Chem 276 (35), 33101-33110 (2001)
   PUBMED   11423533
REFERENCE   8  (bases 1 to 5661)
  AUTHORS   Watanabe,T., Imoto,I., Kosugi,Y., Fukuda,Y., Mimura,J., Fujii,Y.,
            Isaka,K., Takayama,M., Sato,A. and Inazawa,J.
  TITLE     Human arylhydrocarbon receptor repressor (AHRR) gene: genomic
            structure and analysis of polymorphism in endometriosis
  JOURNAL   J Hum Genet 46 (6), 342-346 (2001)
   PUBMED   11393538
REFERENCE   9  (bases 1 to 5661)
  AUTHORS   Mimura,J., Ema,M., Sogawa,K. and Fujii-Kuriyama,Y.
  TITLE     Identification of a novel mechanism of regulation of Ah (dioxin)
            receptor function
  JOURNAL   Genes Dev 13 (1), 20-25 (1999)
   PUBMED   9887096
REFERENCE   10 (bases 1 to 5661)
  AUTHORS   Brown,S., Wiebel,F.J., Gelboin,H.V. and Minna,J.D.
  TITLE     Assignment of a locus required for flavoprotein-linked
            monooxygenase expression to human chromosome 2
  JOURNAL   Proc Natl Acad Sci U S A 73 (12), 4628-4632 (1976)
   PUBMED   1070014
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118458.2 and AC010442.7.
            
            Summary: The protein encoded by this gene participates in the aryl
            hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin
            toxicity, and is involved in regulation of cell growth and
            differentiation. It functions as a feedback modulator by repressing
            AhR-dependent gene expression. Alternatively spliced transcript
            variants encoding different isoforms have been described for this
            gene. [provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.22631.1,
                                           SRR14038194.1615326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684583.1/ ENSP00000507476.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC118458.2         30369-30474         c
            107-178             AC118458.2         8224-8295           c
            179-360             AC010442.7         148524-148705       c
            361-467             AC010442.7         125719-125825       c
            468-557             AC010442.7         89002-89091         c
            558-687             AC010442.7         79577-79706         c
            688-824             AC010442.7         78458-78594         c
            825-1024            AC010442.7         74429-74628         c
            1025-1086           AC010442.7         69911-69972         c
            1087-1228           AC010442.7         69488-69629         c
            1229-5661           AC010442.7         64150-68582         c
FEATURES             Location/Qualifiers
     source          1..5661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.33"
     gene            1..5661
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /note="aryl hydrocarbon receptor repressor"
                     /db_xref="GeneID:57491"
                     /db_xref="HGNC:HGNC:346"
                     /db_xref="MIM:606517"
     exon            1..106
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            107..178
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2210
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /note="dioxin receptor repressor; aryl hydrocarbon
                     hydroxylase regulator; ahR repressor; class E basic
                     helix-loop-helix protein 77"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor repressor"
                     /protein_id="NP_001364165.1"
                     /db_xref="CCDS:CCDS93682.1"
                     /db_xref="GeneID:57491"
                     /db_xref="HGNC:HGNC:346"
                     /db_xref="MIM:606517"
                     /translation="MIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAEL
                     DHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSC
                     PLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIH
                     VDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLT
                     RCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLP
                     SAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLV
                     LREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRE
                     TPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPIS
                     HPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPME
                     DMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATF
                     PTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDG
                     LPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSAL
                     ATLVPPQASGCTFLP"
     exon            179..360
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            361..467
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            468..557
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            558..687
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            688..824
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1024
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1086
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1228
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..5661
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5604..5609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /note="hexamer: ATTAAA"
     regulatory      5628..5633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /note="hexamer: AATACA"
     polyA_site      5629
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
     polyA_site      5661
                     /gene="AHRR"
                     /gene_synonym="AHH; AHHR; bHLHe77"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgggtt cccgggatgc gagcgccggc acccgccgcc acagctcctg gccagggcgc
       61 gctgccccgc gggtgtgcct gagcctccgc gccccgcagg ccctgggccg aggacgatga
      121 tcccgccggg ggagtgcacg tacgcgggcc ggaagcggag gaggcccctg cagaaacaga
      181 ggcccgccgt gggggcagag aagtccaacc cctccaagcg acaccgggac cgcctcaacg
      241 ccgagttgga ccacctggcc agcctgctgc cgttcccgcc tgacatcatc tccaagctgg
      301 acaagctttc tgtcctgcgc ctcagtgtca gttacctccg ggtgaagagc ttcttccaag
      361 tcgtgcagga gcagagctca cggcagcctg cggccggcgc cccctcgccc ggagacagct
      421 gtcctcttgc agggtctgcc gtgctggagg gaaggctgct gttggagtct cttaatggct
      481 ttgctctggt cgtgagtgca gaagggacga tattttatgc atcagcaacg atcgtggact
      541 atctgggctt ccatcagacg gatgtaatgc accagaacat ttatgactac atccacgtgg
      601 acgaccgcca ggacttctgc cggcagctcc actgggccat ggaccctccc caggtggtgt
      661 ttgggcagcc cccgcccttg gagacaggag atgatgctat cctggggagg ctgctcaggg
      721 cccaggagtg gggcacaggc acgcccaccg agtactcggc cttcctgacc cgctgcttca
      781 tctgccgtgt gcgctgcctg ctggacagca cctcgggctt cctgacgatg cagtttcaag
      841 gaaaactaaa attcctgttt ggacagaaga agaaggcgcc gtcaggagcc atgctcccgc
      901 cgcggctgtc gctgttctgc attgcggcac ccgttctcct cccctccgca gcggagatga
      961 aaatgaggag cgcgctcctg agggcaaaac ccagagcaga caccgcagcc accgcggatg
     1021 caaaagtaaa agccaccacc agtctgtgcg aatcggaact gcatggaaaa cccaattact
     1081 cagcaggaag gagcagcaga gagagcggcg ttttggtgct cagggaacag actgacgctg
     1141 gccgatgggc acaggttccc gccagggccc catgcctgtg cctccggggt ggccctgacc
     1201 ttgtccttga ccccaagggg ggctcagggg acagggagga ggagcagcac aggatgctga
     1261 gcagggcctc tggagtgaca gggcggaggg agactccagg acccacaaag cccctgccct
     1321 ggacagcggg aaagcacagt gaggatggtg ccaggccgag gctgcagccc agcaagaatg
     1381 acccgccctc cctgcgcccc atgccccgcg gctcctgcct gccctgcccg tgtgtccagg
     1441 gcactttcag gaactcgccc atctctcacc cgccgagccc gtcccccagt gcctactcca
     1501 gccggaccag cagacccatg cgggatgtcg gtgaggacca ggtgcaccct cccctctgcc
     1561 actttcccca gaggagcctg cagcaccagc tccctcagcc tggagctcag cgttttgcca
     1621 cgaggggcta tcccatggag gacatgaagc tgcaaggtgt accgatgcct ccgggggacc
     1681 tgtgtggtcc gacgctgctg ctagatgtgt ccatcaagat ggagaaggac tctgggtgtg
     1741 agggtgctgc agacggctgt gtgcccagcc aggtgtggct gggggccagt gacaggagcc
     1801 acccagccac cttccctacc aggatgcacc tgaaaacaga gccagactct cggcaacagg
     1861 tgtacatctc gcacctgggg cacggcgtgc ggggggctca gccccatggg agggccactg
     1921 ctgggcgcag cagggagctg acccctttcc accctgcaca ctgtgcctgc ctggagccca
     1981 cagacggcct tccccagtcg gagcctcccc accagctctg tgcacggggc cgaggtgaac
     2041 agtcctgcac ctgcagagct gctgaggccg cccctgtggt caagcgggag cccttggact
     2101 caccccagtg ggctactcac agccagggaa tggtgcccgg gatgttgccc aaaagtgcct
     2161 tggccacgct ggtcccgccc caagcttcgg ggtgcacatt cctgccatag cgcagtgacc
     2221 accatccaag ctcagatctg tgtgtctacg ctcagatgcg tcggtggctg ggctgccctg
     2281 ctcctggtca ggccggagcc cgtcctaaga cacacgcttt gcagagctgt gcatgcgcag
     2341 tctgctagtg tgtgtgtgca gcatacgcag gagcctatcc tgaattttgt aaaatatccc
     2401 aacagttctt aaatgaaaac tggccttaag tctattcaag catgacagca tttctctttg
     2461 aggaattaaa atctttagga aagtgatcat ggctggacag cttcatgccc cagaggcagc
     2521 gagcacccgt cccatggctg ccaagtccac agtcggggat gaagcagtcg ggtgatgctc
     2581 ccaagtccgc agtcggggat gaagcggtcg ggtgatgctc ccaagtccgc agtcggggat
     2641 gaagcggtcg ggtgacacac ctagctcagc cctcccaggc cacctgcagc tcccagcctg
     2701 tgctgtgcag gcagggtcag cccatcgcca cagtgcactg tagaggccag cacacggcaa
     2761 attagaaata caacacgcgg agaaaggggt ccgtgagccc actcatagag gaatctagaa
     2821 cgttccaggc agcagaggct ggcagcgtgg gtcccacact gccccacacc gtgcggcagg
     2881 tgctccatgg cgccatgaca gagtctgagg ccagacctgg actggaattg acagcataac
     2941 ccctgttcct tctggacatc tcccgagttc tcagtgggtc tctgcggacg gttcttccta
     3001 atctgcctct tggtacatca cgtaatacag agttcacaga ctccgggttt ggaagtacag
     3061 agaaacacac aacgtagaga gaagacacag gaaactgcgc tgcctgtggg ggtttctctc
     3121 tggctggctg tacagttcac tcaaatgagg gttcccattg ccatcctagg agaataatta
     3181 gggacaagac agacaagtat taatagcatt aaaacagttg taaaggcgat attttctgag
     3241 agtaggaaat ttggatacaa aagcataagt cagaaagtga aggtcaccaa tccaccaacc
     3301 cgagaaccta cagctgatgg tgcatttcag gcttcttcca cggtctggcc tggaacccca
     3361 cccggctggt gcaggcatca gatcagggtg tagaagtcac cccaagcaag aggaagccag
     3421 gcagtgaggc cctggggtgt ggctgcagct gggcccacct gtgcgggggt gggaaggccc
     3481 catcctcagg gagagggcat cggcgccctg acgtcagctc cactgggagt ggcaggagct
     3541 gtgggagccc atgggtgagg gacccaccac cccgctgcac tgtgcattgt gcctcccgtg
     3601 tggacgccct ctctgttgtt ggcccgcggg tgagggaccc accaccccta gggacccacc
     3661 accccgccgc actgtgcatt ctgcctcctg tgtggacgcc ctctctgttg tcagtggctt
     3721 tgaggtgtca gtgcttactt agatgctggt ttaatgctgg acccatttgt taaacgcacc
     3781 ttcactttgt caaaacccag gtttggttgg caggactggg tcttctgccc aatgccaggt
     3841 gcctgcgcct ctcagtggcc tggttcttgg acagtttgcc cccatgtggc agggataggg
     3901 ataaggatct cctctcagta ctggaagaga acagccaacc atctgagccc agagtcacag
     3961 atccatcgtg gccccctatg acccccaagc cctaccgagg gggcactcac tctctgctta
     4021 gccagggggc gtctttcaaa aggtgacctc catgctgtgc tgtcgtgggt gtgagacgtg
     4081 ctcatggcct tccactgcca tctctccctt atctgatgcc taaagtcacg atggggacag
     4141 agctacccag gggccagcca tggggtgacc agccacctga gggtcagtca cctgtggaga
     4201 gcaggcacct gtgaagacca ggcacctgag gactggcgcc tacttcccac tttggcccta
     4261 cactggcaca gagcccctct ttattcattt ctcatgctga gcatggcaca cttctggcct
     4321 ctgggcattt atggatttaa gaccaggatg gtatttcaga agcttcccac ttccttccta
     4381 ttctaaccga gtgcccagct cctttgctga tcatggaaag acccttaata attaggcctg
     4441 caggccaggc gcagtggctc atgcctataa tcccagcact ttaggaggtc aaggtaggag
     4501 gatcgcttaa gcccaggagt tcaagaccag cctgggcaac acaggaagaa tgtgtctcta
     4561 caaaaaataa ttaaaaatca gatctgctgt atccctgaaa aagtctcaat caacatgcat
     4621 gttccactct tggagttccc tgttctgagg gccagccacg tcctgtgtcc tggagcttag
     4681 ccctcagcag ctcccttcag cctgggcgcc gcctgggtcc caaacgtggc agctgctctt
     4741 ccagtctcgg ggccgaggag ggcagggagc tcagtgactg agagtcttgt gtatcacatg
     4801 tcttgagtgt cctggagcca acggctgtca ctgggaaaaa caccaggccc caaagatcga
     4861 atcagagacg tggctgcgtg tttgcgattg tagccaggcc cttcagtgtc atcaaaggag
     4921 cactggggcc tccttaagca cagacggcag cccctgccca ggaggcttct tcaccacgtc
     4981 ctgccctgca gcctcccaga cctttagatg cgcccctgcc caaggccctc ctggtgacag
     5041 gtgccagatt gagtggtggg ttgctgccag gcaggccacg ctgtgttgac gctgcactca
     5101 gcacgtgggt gttggctctg ccggttttgt ggtgtgggga ccctacagga ggctgcggcc
     5161 ctgagagcct gggatcagcg aggtgtccga catcccttcc tcaacggcaa caaaaactcc
     5221 ccaagtcagc actttggtta ttttatagcc acaaccctct tggaaaacag tggggaagac
     5281 tatggaacat agaaagtgtg gatgtatcac ttctctctaa aatgtcattg ttagcactaa
     5341 ttacaggttc atgtttttct gtgtatgtag cttttcccta tatagctgaa aaagtattaa
     5401 agtcaaatat aaggtgggaa tgggatggaa gggaggagat caatacaact tatatttttg
     5461 cagtttctac tggaagaaaa aagttttcaa tacctagacc aacttgttga atttttaaaa
     5521 cttatgcact ataaatgcaa ctttctctac tgctttctca gtgcctttag gaagctttca
     5581 aatttttttg tactgtggtt tgtattaaat ttgcaatatt gatgtaaaat acatgacatg
     5641 ctagtacatg tttaacaaaa a
//
