LOCUS       NM_001621               6243 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens aryl hydrocarbon receptor (AHR), mRNA.
ACCESSION   NM_001621
VERSION     NM_001621.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6243)
  AUTHORS   de Juan,A., Tabtim-On,D., Coillard,A., Becher,B., Goudot,C. and
            Segura,E.
  TITLE     The aryl hydrocarbon receptor shapes monocyte transcriptional
            responses to interleukin-4 by prolonging STAT6 binding to promoters
  JOURNAL   Sci Signal 17 (858), eadn6324 (2024)
   PUBMED   39405377
  REMARK    GeneRIF: The aryl hydrocarbon receptor shapes monocyte
            transcriptional responses to interleukin-4 by prolonging STAT6
            binding to promoters.
REFERENCE   2  (bases 1 to 6243)
  AUTHORS   Wu,N., Li,J., Li,L., Yang,L., Dong,L., Shen,C., Sha,S., Fu,Y.,
            Dong,E., Zheng,F., Tan,Z. and Tao,J.
  TITLE     MerTK+ macrophages promote melanoma progression and immunotherapy
            resistance through AhR-ALKAL1 activation
  JOURNAL   Sci Adv 10 (40), eado8366 (2024)
   PUBMED   39365866
  REMARK    GeneRIF: MerTK[+] macrophages promote melanoma progression and
            immunotherapy resistance through AhR-ALKAL1 activation.
REFERENCE   3  (bases 1 to 6243)
  AUTHORS   Serna,E., Verdu,D., Valls,A., Belenguer-Varea,A.,
            Tarazona-Santabalbina,F.J., Borras,C. and Vina,J.
  TITLE     Involvement of Aryl Hydrocarbon Receptor in Longevity and
            Healthspan: Insights from Humans, Mice, and C. elegans
  JOURNAL   Int J Mol Sci 25 (18), 9943 (2024)
   PUBMED   39337431
  REMARK    GeneRIF: Involvement of Aryl Hydrocarbon Receptor in Longevity and
            Healthspan: Insights from Humans, Mice, and C. elegans.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6243)
  AUTHORS   Aboelroos,S.A., Segaey,D.G.E., Elgawad,A.K.A., Orabi,M.,
            Mohamed,M.H. and Hassan,N.R.
  TITLE     Association of Estrogen Receptor-alpha and Aryl Hydrocarbon
            Receptor Gene Polymorphisms with Ischemic Stroke in an Egyptian
            Population: A Pilot Study
  JOURNAL   J Mol Neurosci 74 (3), 85 (2024)
   PUBMED   39264466
  REMARK    GeneRIF: Association of Estrogen Receptor-alpha and Aryl
            Hydrocarbon Receptor Gene Polymorphisms with Ischemic Stroke in an
            Egyptian Population: A Pilot Study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6243)
  AUTHORS   Yang,Y.B., Peng,Z., Peng,S.L., Mei,G.Q. and Cheng,Y.M.
  TITLE     [The involvement and underlying mechanism of the aryl hydrocarbon
            receptor (AhR) in the impairment of male mammalian fertility
            induced by environmental pollutants]
  JOURNAL   Sheng Li Xue Bao 76 (4), 631-642 (2024)
   PUBMED   39192795
  REMARK    GeneRIF: [The involvement and underlying mechanism of the aryl
            hydrocarbon receptor (AhR) in the impairment of male mammalian
            fertility induced by environmental pollutants].
            Review article
REFERENCE   6  (bases 1 to 6243)
  AUTHORS   Yamaguchi,Y. and Kuo,M.T.
  TITLE     Functional analysis of aryl hydrocarbon receptor nuclear
            translocator interactions with aryl hydrocarbon receptor in the
            yeast two-hybrid system
  JOURNAL   Biochem Pharmacol 50 (8), 1295-1302 (1995)
   PUBMED   7488247
REFERENCE   7  (bases 1 to 6243)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   8  (bases 1 to 6243)
  AUTHORS   Lindebro,M.C., Poellinger,L. and Whitelaw,M.L.
  TITLE     Protein-protein interaction via PAS domains: role of the PAS domain
            in positive and negative regulation of the bHLH/PAS dioxin
            receptor-Arnt transcription factor complex
  JOURNAL   EMBO J 14 (14), 3528-3539 (1995)
   PUBMED   7628454
REFERENCE   9  (bases 1 to 6243)
  AUTHORS   Kawajiri,K., Watanabe,J., Eguchi,H., Nakachi,K., Kiyohara,C. and
            Hayashi,S.
  TITLE     Polymorphisms of human Ah receptor gene are not involved in lung
            cancer
  JOURNAL   Pharmacogenetics 5 (3), 151-158 (1995)
   PUBMED   7550366
REFERENCE   10 (bases 1 to 6243)
  AUTHORS   Hayashi,S., Watanabe,J., Nakachi,K., Eguchi,H., Gotoh,O. and
            Kawajiri,K.
  TITLE     Interindividual difference in expression of human Ah receptor and
            related P450 genes
  JOURNAL   Carcinogenesis 15 (5), 801-806 (1994)
   PUBMED   7515333
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK307495.1, D16354.1, L19872.1,
            BX505160.1, AA329775.1 and AC003075.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001621.4.
            
            Summary: The protein encoded by this gene is a ligand-activated
            helix-loop-helix transcription factor involved in the regulation of
            biological responses to planar aromatic hydrocarbons. This receptor
            has been shown to regulate xenobiotic-metabolizing enzymes such as
            cytochrome P450. Before ligand binding, the encoded protein is
            sequestered in the cytoplasm; upon ligand binding, this protein
            moves to the nucleus and stimulates transcription of target genes.
            [provided by RefSeq, Sep 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.231889.1,
                                           SRR1660809.233497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242057.9/ ENSP00000242057.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AK307495.1         1-31
            32-3030             D16354.1           1-2999
            3031-3825           L19872.1           2793-3587
            3826-3888           BX505160.1         116-178
            3889-4691           L19872.1           3653-4455
            4692-4746           AA329775.1         119-173
            4747-6243           AC003075.2         113160-114656
FEATURES             Location/Qualifiers
     source          1..6243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..6243
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="aryl hydrocarbon receptor"
                     /db_xref="GeneID:196"
                     /db_xref="HGNC:HGNC:348"
                     /db_xref="MIM:600253"
     exon            1..678
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     CDS             614..3160
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="AH-receptor; aromatic hydrocarbon receptor; class E
                     basic helix-loop-helix protein 76; ah receptor"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor"
                     /protein_id="NP_001612.1"
                     /db_xref="CCDS:CCDS5366.1"
                     /db_xref="GeneID:196"
                     /db_xref="HGNC:HGNC:348"
                     /db_xref="MIM:600253"
                     /translation="MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLN
                     TELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCR
                     AANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYE
                     LIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMER
                     CFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPS
                     ILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCA
                     ESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGT
                     EHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDS
                     LNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTI
                     LKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDF
                     SGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQ
                     HHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGIS
                     QEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVT
                     CLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTHVGQMQYNPVLPGQQAF
                     LNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGFL"
     exon            679..866
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            867..973
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1063
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1187
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1318
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1521
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1631
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1773
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..3016
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..6243
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5846..5851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="hexamer: AATAAA"
     polyA_site      5867
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="major polyA site"
     regulatory      6224..6229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="hexamer: AATAAA"
     polyA_site      6243
                     /gene="AHR"
                     /gene_synonym="bHLHe76; FVH3; RP85"
                     /note="major polyA site"
ORIGIN      
        1 agtggctggg gagtcccgtc gacgctctgt tccgagagcg tgccccggac cgccagctca
       61 gaacaggggc agccgtgtag ccgaacggaa gctgggagca gccgggactg gtggcccgcg
      121 cccgagctcc gcaggcggga agcaccctgg atttaggaag tcccgggagc agcgcggcgg
      181 cacctccctc acccaagggg ccgcggcgac ggtcacgggg cgcggcgcca ccgtgagcga
      241 cccaggccag gattctaaat agacggccca ggctcctcct ccgcccgggc cgcctcacct
      301 gcgggcattg ccgcgccgcc tccgccggtg tagacggcac ctgcgccgcc ttgctcgcgg
      361 gtctccgccc ctcgcccacc ctcactgcgc caggcccagg cagctcacct gtactggcgc
      421 gggctgcgga agcctgcgtg agccgaggcg ttgaggcgcg gcgcccacgc cactgtcccg
      481 agaggacgca ggtggagcgg gcgcggcttc gcggaacccg gcgccggccg ccgcagtggt
      541 cccagcctac accgggttcc ggggacccgg ccgccagtgc ccggggagta gccgccgccg
      601 tcggctgggc accatgaaca gcagcagcgc caacatcacc tacgccagtc gcaagcggcg
      661 gaagccggtg cagaaaacag taaagccaat cccagctgaa ggaatcaagt caaatccttc
      721 caagcggcat agagaccgac ttaatacaga gttggaccgt ttggctagcc tgctgccttt
      781 cccacaagat gttattaata agttggacaa actttcagtt cttaggctca gcgtcagtta
      841 cctgagagcc aagagcttct ttgatgttgc attaaaatcc tcccctactg aaagaaacgg
      901 aggccaggat aactgtagag cagcaaattt cagagaaggc ctgaacttac aagaaggaga
      961 attcttatta caggctctga atggctttgt attagttgtc actacagatg ctttggtctt
     1021 ttatgcttct tctactatac aagattatct agggtttcag cagtctgatg tcatacatca
     1081 gagtgtatat gaacttatcc ataccgaaga ccgagctgaa tttcagcgtc agctacactg
     1141 ggcattaaat ccttctcagt gtacagagtc tggacaagga attgaagaag ccactggtct
     1201 cccccagaca gtagtctgtt ataacccaga ccagattcct ccagaaaact ctcctttaat
     1261 ggagaggtgc ttcatatgtc gtctaaggtg tctgctggat aattcatctg gttttctggc
     1321 aatgaatttc caagggaagt taaagtatct tcatggacag aaaaagaaag ggaaagatgg
     1381 atcaatactt ccacctcagt tggctttgtt tgcgatagct actccacttc agccaccatc
     1441 catacttgaa atccggacca aaaattttat ctttagaacc aaacacaaac tagacttcac
     1501 acctattggt tgtgatgcca aaggaagaat tgttttagga tatactgaag cagagctgtg
     1561 cacgagaggc tcaggttatc agtttattca tgcagctgat atgctttatt gtgccgagtc
     1621 ccatatccga atgattaaga ctggagaaag tggcatgata gttttccggc ttcttacaaa
     1681 aaacaaccga tggacttggg tccagtctaa tgcacgcctg ctttataaaa atggaagacc
     1741 agattatatc attgtaactc agagaccact aacagatgag gaaggaacag agcatttacg
     1801 aaaacgaaat acgaagttgc cttttatgtt taccactgga gaagctgtgt tgtatgaggc
     1861 aaccaaccct tttcctgcca taatggatcc cttaccacta aggactaaaa atggcactag
     1921 tggaaaagac tctgctacca catccactct aagcaaggac tctctcaatc ctagttccct
     1981 cctggctgcc atgatgcaac aagatgagtc tatttatctc tatcctgctt caagtacttc
     2041 aagtactgca ccttttgaaa acaacttttt caacgaatct atgaatgaat gcagaaattg
     2101 gcaagataat actgcaccga tgggaaatga tactatcctg aaacatgagc aaattgacca
     2161 gcctcaggat gtgaactcat ttgctggagg tcacccaggg ctctttcaag atagtaaaaa
     2221 cagtgacttg tacagcataa tgaaaaacct aggcattgat tttgaagaca tcagacacat
     2281 gcagaatgaa aaatttttca gaaatgattt ttctggtgag gttgacttca gagacattga
     2341 cttaacggat gaaatcctga cgtatgtcca agattcttta agtaagtctc ccttcatacc
     2401 ttcagattat caacagcaac agtccttggc tctgaactca agctgtatgg tacaggaaca
     2461 cctacatcta gaacagcaac agcaacatca ccaaaagcaa gtagtagtgg agccacagca
     2521 acagctgtgt cagaagatga agcacatgca agttaatggc atgtttgaaa attggaactc
     2581 taaccaattc gtgcctttca attgtccaca gcaagaccca caacaatata atgtctttac
     2641 agacttacat gggatcagtc aagagttccc ctacaaatct gaaatggatt ctatgcctta
     2701 tacacagaac tttatttcct gtaatcagcc tgtattacca caacattcca aatgtacaga
     2761 gctggactac cctatgggga gttttgaacc atccccatac cccactactt ctagtttaga
     2821 agattttgtc acttgtttac aacttcctga aaaccaaaag catggattaa atccacagtc
     2881 agccataata actcctcaga catgttatgc tggggccgtg tcgatgtatc agtgccagcc
     2941 agaacctcag cacacccacg tgggtcagat gcagtacaat ccagtactgc caggccaaca
     3001 ggcattttta aacaagtttc agaatggagt tttaaatgaa acatatccag ctgaattaaa
     3061 taacataaat aacactcaga ctaccacaca tcttcagcca cttcatcatc cgtcagaagc
     3121 cagacctttt cctgatttga catccagtgg attcctgtaa ttccaagccc aattttgacc
     3181 ctggtttttg gattaaatta gtttgtgaag gattatggaa aaataaaact gtcactgttg
     3241 gacgtcagca agttcacatg gaggcattga tgcatgctat tcacaattat tccaaaccaa
     3301 attttaattt ttgcttttag aaaagggagt ttaaaaatgg tatcaaaatt acatatacta
     3361 cagtcaagat agaaagggtg ctgccacgga gtggtgaggt accgtctaca tttcacatta
     3421 ttctgggcac cacaaaatat acaaaacttt atcagggaaa ctaagattct tttaaattag
     3481 aaaatattct ctatttgaat tatttctgtc acagtaaaaa taaaatactt tgagttttga
     3541 gctactggat tcttattagt tccccaaata caaagttaga gaactaaact agtttttcct
     3601 atcatgttaa cctctgcttt tatctcagat gttaaaataa atggtttggt gctttttata
     3661 aaaagataat ctcagtgctt tcctccttca ctgtttcatc taagtgcctc acattttttt
     3721 ctacctataa cactctagga tgtatatttt atataaagta ttctttttct tttttaaatt
     3781 aatatctttc tgcacacaaa tattatttgt gtttcctaaa tccaaccatt ttcattaatt
     3841 caggcatatt ttaactccac tgcttaccta ctttcttcag gtaaagggca aataatgatc
     3901 gaaaaaataa ttatttatta cataatttag ttgtttctag actataaatg ttgctatgtg
     3961 ccttatgttg aaaaaattta aaagtaaaat gtctttccaa attatttctt aattattata
     4021 aaaatattaa gacaatagca cttaaattcc tcaacagtgt tttcagaaga aataaatata
     4081 ccactcttta cctttattga tatctccatg atgatagttg aatgttgcaa tgtgaaaaat
     4141 ctgctgttaa ctgcaacctt gtttattaaa ttgcaagaag ctttatttct agctttttaa
     4201 ttaagcaaag cacccatttc aatgtgtata aattgtcttt aaaaactgtt ttagacctat
     4261 aatccttgat aatatattgt gttgacttta taaatttcgc ttcttagaac agtggaaact
     4321 atgtgttttt ctcatatttg aggagtgtta agattgcaga tagcaaggtt tggtgcaaag
     4381 tattgtaatg agtgaattga atggtgcatt gtatagatat aatgaacaaa attatttgta
     4441 agatatttgc agtttttcat tttaaaaagt ccatacctta tatatgcact taatttgttg
     4501 gggctttaca tactttatca atgtgtcttt ctaagaaatc aagtaatgaa tccaactgct
     4561 taaagttggt attaataaaa agacaaccac atagttcgtt taccttcaaa ctttaggttt
     4621 ttttaatgat atactgatct tcattaccaa taggcaaatt aatcacccta ccaactttac
     4681 tgtcctaaca tggtttaaaa gaaaaaatga caccatcttt tattcttttt tttttttttt
     4741 tttgagagag agtcttactc tgccgcccaa actggagtgc agtggcacaa tcttggctca
     4801 ctgcaacctc tacctcctgg gttcaagtga ttctcttgcc tcagcctccc gagttgctgg
     4861 gattacaggc atgtgccacc atgcccagct aatttttgta tttttagtag aaacgggttt
     4921 caccatgttg gccagactgg tctcaaactc ctgacctcag gtgagcctcc caccttggcc
     4981 tcccaaagtg ctgggattac aggcgtgagc cactgcattc agctcttctt ttctttagat
     5041 atgagagctg aagagcttag acacattttg catgtattat ttgaaaatct gatggaatcc
     5101 caaactgaga tgtattaaaa tacaattttt ggccgggtgc agtggctcac gcctgtaatc
     5161 ccagcacttg gggagggcga ggagggtgga tcacgaggtc aagagatgga gaccatcctg
     5221 accaacatgg tgaaaccctg tctctactaa aaatacagaa attagctggg catggtggcg
     5281 tgagcctgta gtcctagcta ctcaggaggc tgaggcagga gaatagcctg aacctgggaa
     5341 tcggaggttg cagagccaag atcgccccac tgcactccag cctggcaata gaccgagact
     5401 ccgtctccaa aaaaaaaaaa aatacaattt ttatttcttt tacttttttt agtaagttaa
     5461 tgtatataaa aatggcttcg gacaaaatat ctctgagttc tgtgtatttt cagtcaaaac
     5521 tttaaacctg tagaatcaat ttaagtgttg gaaaaaattt gtctgaaaca tttcataatt
     5581 tgtttccagc atgaggtatc taaggattta gaccagaggt ctagattaat actctatttt
     5641 tacatttaaa ccttttatta taagtcttac ataaaccatt tttgttactc tcttccacat
     5701 gttactggat aaattgttta gtggaaaata ggctttttaa tcatgaatat gatgacaatc
     5761 agttatacag ttataaaatt aaaagtttga aaagcaatat tgtatatttt tatctatata
     5821 aaataactaa aatgtatcta agaataataa aatcacgtta aaccaaatac acgtttgtct
     5881 gtattgttaa gtgccaaaca aaggatactt agtgcactgc tacattgtgg gatttatttc
     5941 tagatgatgt gcacatctaa ggatatggat gtgtctaatt tagtcttttc ctgtaccagg
     6001 tttttcttac aatacctgaa gacttaccag tattctagtg tattatgaag ctttcaacat
     6061 tactatgcac aaactagtgt ttttcgatgt tactaaattt taggtaaatg ctttcatggc
     6121 ttttttcttc aaaatgttac tgcttacata tatcatgcat agatttttgc ttaaagtatg
     6181 atttataata tcctcattat caaagttgta tacaataata tataataaaa taacaaatat
     6241 gaa
//
