LOCUS       NM_001371928            6428 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens AT-hook DNA binding motif containing 1 (AHDC1),
            transcript variant 2, mRNA.
ACCESSION   NM_001371928
VERSION     NM_001371928.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6428)
  AUTHORS   Kitagawa,T., Kobayashi,D., Baron,B., Okita,H., Miyamoto,T.,
            Takai,R., Paudel,D., Ohta,T., Asaoka,Y., Tokunaga,M., Nakagawa,K.,
            Furutani-Seiki,M., Araki,N., Kuramitsu,Y. and Kobayashi,M.
  TITLE     AT-hook DNA-binding motif-containing protein one knockdown
            downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma
            cells
  JOURNAL   PLoS One 17 (10), e0269077 (2022)
   PUBMED   36194562
  REMARK    GeneRIF: AT-hook DNA-binding motif-containing protein one knockdown
            downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma
            cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6428)
  AUTHORS   Collier,A., Liu,A., Torkelson,J., Pattison,J., Gaddam,S., Zhen,H.,
            Patel,T., McCarthy,K., Ghanim,H. and Oro,A.E.
  TITLE     Gibbin mesodermal regulation patterns epithelial development
  JOURNAL   Nature 606 (7912), 188-196 (2022)
   PUBMED   35585237
  REMARK    GeneRIF: Gibbin mesodermal regulation patterns epithelial
            development.
REFERENCE   3  (bases 1 to 6428)
  AUTHORS   Faergeman,S.L., Bojesen,A.B., Rasmussen,M., Becher,N.,
            Andreasen,L., Andersen,B.N., Erbs,E., Lildballe,D.L.,
            Nielsen,J.E.K., Zilmer,M., Hammer,T.B., Andersen,M.O.,
            Brasch-Andersen,C., Fagerberg,C.R., Illum,N.O., Thorup,M.B. and
            Gregersen,P.A.
  TITLE     Phenotypic heterogeneity and mosaicism in Xia-Gibbs syndrome: Five
            Danish patients with novel variants in AHDC1
  JOURNAL   Eur J Med Genet 64 (9), 104280 (2021)
   PUBMED   34229113
  REMARK    GeneRIF: Phenotypic heterogeneity and mosaicism in Xia-Gibbs
            syndrome: Five Danish patients with novel variants in AHDC1.
REFERENCE   4  (bases 1 to 6428)
  AUTHORS   Khayat,M.M., Li,H., Chander,V., Hu,J., Hansen,A.W., Li,S.,
            Traynelis,J., Shen,H., Weissenberger,G., Stossi,F., Johnson,H.L.,
            Lupski,J.R., Posey,J.E., Sabo,A., Meng,Q., Murdock,D.R., Wangler,M.
            and Gibbs,R.A.
  TITLE     Phenotypic and protein localization heterogeneity associated with
            AHDC1 pathogenic protein-truncating alleles in Xia-Gibbs syndrome
  JOURNAL   Hum Mutat 42 (5), 577-591 (2021)
   PUBMED   33644933
  REMARK    GeneRIF: Phenotypic and protein localization heterogeneity
            associated with AHDC1 pathogenic protein-truncating alleles in
            Xia-Gibbs syndrome.
REFERENCE   5  (bases 1 to 6428)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6428)
  AUTHORS   Wang,Q., Huang,X., Liu,Y., Peng,Q., Zhang,Y., Liu,J. and Yuan,H.
  TITLE     Microdeletion and microduplication of 1p36.11p35.3 involving AHDC1
            contribute to neurodevelopmental disorder
  JOURNAL   Eur J Med Genet 63 (1), 103611 (2020)
   PUBMED   30615951
  REMARK    GeneRIF: Microdeletion and microduplication of 1p36.11p35.3
            involving AHDC1 contribute to neurodevelopmental disorder.
REFERENCE   7  (bases 1 to 6428)
  AUTHORS   Cheng,X., Tang,F., Hu,X., Li,H., Li,M., Fu,Y., Yan,L., Li,Z.,
            Gou,P., Su,N., Gong,C., He,W., Xiang,R., Bu,D. and Shen,Y.
  TITLE     Two Chinese Xia-Gibbs syndrome patients with partial growth hormone
            deficiency
  JOURNAL   Mol Genet Genomic Med 7 (4), e00596 (2019)
   PUBMED   30729726
  REMARK    GeneRIF: De novo heterozygous variants in AHDC1 gene were
            identified in two patients with partial growth hormone deficiency.
REFERENCE   8  (bases 1 to 6428)
  AUTHORS   Feng,Y., Qu,L., Wang,X. and Liu,C.
  TITLE     LINC01133 promotes the progression of cervical cancer by sponging
            miR-4784 to up-regulate AHDC1
  JOURNAL   Cancer Biol Ther 20 (12), 1453-1461 (2019)
   PUBMED   31390932
  REMARK    GeneRIF: we unveiled that LINC01133 may function as a ceRNA for
            miR-4784 to advance AHDC1 expression, intensifying CC cell
            malignant phenotypes and EMT process, which may demonstrate the
            implied value of LINC01133 as a therapeutic target for CC patients.
REFERENCE   9  (bases 1 to 6428)
  AUTHORS   Xia,F., Bainbridge,M.N., Tan,T.Y., Wangler,M.F., Scheuerle,A.E.,
            Zackai,E.H., Harr,M.H., Sutton,V.R., Nalam,R.L., Zhu,W., Nash,M.,
            Ryan,M.M., Yaplito-Lee,J., Hunter,J.V., Deardorff,M.A.,
            Penney,S.J., Beaudet,A.L., Plon,S.E., Boerwinkle,E.A., Lupski,J.R.,
            Eng,C.M., Muzny,D.M., Yang,Y. and Gibbs,R.A.
  TITLE     De novo truncating mutations in AHDC1 in individuals with syndromic
            expressive language delay, hypotonia, and sleep apnea
  JOURNAL   Am J Hum Genet 94 (5), 784-789 (2014)
   PUBMED   24791903
  REMARK    GeneRIF: this study hasidentified AHDC1 de novo truncating
            mutations that most likely cause syndromic expressive language
            delay, hypotonia, and sleep apnea.
REFERENCE   10 (bases 1 to 6428)
  AUTHORS   Chander,V., Wangler,M., Gibbs,R. and Murdock,D.
  TITLE     Xia-Gibbs Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34902026
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031729.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein containing two AT-hooks, which
            likely function in DNA binding. Mutations in this gene were found
            in individuals with Xia-Gibbs syndrome. [provided by RefSeq, Jun
            2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2519105.1,
                                           SRR14038193.2577349.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673934.1/ ENSP00000501218.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL031729.16        50357-50395
            40-175              AL031729.16        50638-50773
            176-273             AL031729.16        51007-51104
            274-451             AL031729.16        95618-95795
            452-677             AL031729.16        95971-96196
            678-789             AL031729.16        101316-101427
            790-827             AL031729.16        101572-101609
            828-5756            AL031729.16        102312-107240
            5757-6428           AL031729.16        119585-120256
FEATURES             Location/Qualifiers
     source          1..6428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11-p35.3"
     gene            1..6428
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="AT-hook DNA binding motif containing 1"
                     /db_xref="GeneID:27245"
                     /db_xref="HGNC:HGNC:25230"
                     /db_xref="MIM:615790"
     exon            1..39
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            40..175
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            176..273
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            274..451
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            452..677
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            678..789
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            790..827
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     exon            828..5756
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     CDS             902..5713
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="AT-hook DNA-binding motif-containing protein 1"
                     /codon_start=1
                     /product="transcription factor Gibbin"
                     /protein_id="NP_001358857.1"
                     /db_xref="CCDS:CCDS30652.1"
                     /db_xref="GeneID:27245"
                     /db_xref="HGNC:HGNC:25230"
                     /db_xref="MIM:615790"
                     /translation="MRVKPQGLVVTSSAVCSSPDYLREPKYYPGGPPTPRPLLPTRPP
                     ASPPDKAFSTHAFSENPRPPPRRDPSTRRPPVLAKGDDPLPPRAARPVSQARCPTPVG
                     DGSSSRRCWDNGRVNLRPVVQLIDIMKDLTRLSQDLQHSGVHLDCGGLRLSRPPAPPP
                     GDLQYSFFSSPSLANSIRSPEERATPHAKSERPSHPLYEPEPEPRDSPQPGQGHSPGA
                     TAAATGLPPEPEPDSTDYSELADADILSELASLTCPEAQLLEAQALEPPSPEPEPQLL
                     DPQPRFLDPQALEPLGEALELPPLQPLADPLGLPGLALQALDTLPDSLESQLLDPQAL
                     DPLPKLLDVPGRRLEPQQPLGHCPLAEPLRLDLCSPHGPPGPEGHPKYALRRTDRPKI
                     LCRRRKAGRGRKADAGPEGRLLPLPMPTGLVAALAEPPPPPPPPPPALPGPGPVSVPE
                     LKPESSQTPVVSTRKGKCRGVRRMVVKMAKIPVSLGRRNKTTYKVSSLSSSLSVEGKE
                     LGLRVSAEPTPLLKMKNNGRNVVVVFPPGEMPIILKRKRGRPPKNLLLGPGKPKEPAV
                     VAAEAATVAAATMAMPEVKKRRRRKQKLASPQPSYAADANDSKAEYSDVLAKLAFLNR
                     QSQCAGRCSPPRCWTPSEPESVHQAPDTQSISHFLHRVQGFRRRGGKAGGFGGRGGGH
                     AAKSARCSFSDFFEGIGKKKKVVAVAAAGVGGPGLTELGHPRKRGRGEVDAVTGKPKR
                     KRRSRKNGTLFPEQVPSGPGFGEAGAEWAGDKGGGWAPHHGHPGGQAGRNCGFQGTEA
                     RAFASTGLESGASGRGSYYSTGAPSGQTELSQERQNLFTGYFRSLLDSDDSSDLLDFA
                     LSASRPESRKASGTYAGPPTSALPAQRGLATFPSRGAKASPVAVGSSGAGADPSFQPV
                     LSARQTFPPGRAASYGLTPAASDCRAAETFPKLVPPPSAMARSPTTHPPANTYLPQYG
                     GYGAGQSVFAPTKPFTGQDCANSKDCSFAYGSGNSLPASPSSAHSAGYAPPPTGGPCL
                     PPSKASFFSSSEGAPFSGSAPTPLRCDSRASTVSPGGYMVPKGTTASATSAASAASSS
                     SSSFQPSPENCRQFAGASQWPFRQGYGGLDWASEAFSQLYNPSFDCHVSEPNVILDIS
                     NYTPQKVKQQTAVSETFSESSSDSTQFNQPVGGGGFRRANSEASSSEGQSSLSSLEKL
                     MMDWNEASSAPGYNWNQSVLFQSSSKPGRGRRKKVDLFEASHLGFPTSASAAASGYPS
                     KRSTGPRQPRGGRGGGACSAKKERGGAAAKAKFIPKPQPVNPLFQDSPDLGLDYYSGD
                     SSMSPLPSQSRAFGVGERDPCDFIGPYSMNPSTPSDGTFGQGFHCDSPSLGAPELDGK
                     HFPPLAHPPTVFDAGLQKAYSPTCSPTLGFKEELRPPPTKLAACEPLKHGLQGASLGH
                     AAAAQAHLSCRDLPLGQPHYDSPSCKGTAYWYPPGSAARSPPYEGKVGTGLLADFLGR
                     TEAACLSAPHLASPPATPKADKEPLEMARPPGPPRGPAAAAAGYGCPLLSDLTLSPVP
                     RDSLLPLQDTAYRYPGFMPQAHPGLGGGPKSGFLGPMAEPHPEDTFTVTSL"
     exon            5757..6428
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6166..6171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="hexamer: TATAAA"
     polyA_site      6199
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="major polyA site"
     polyA_site      6375
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="major polyA site"
     regulatory      6410..6415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="hexamer: AACAAA"
     polyA_site      6428
                     /gene="AHDC1"
                     /gene_synonym="MRD25; XIGIS"
                     /note="major polyA site"
ORIGIN      
        1 agaggcagcg gcggcggcgg cggagacgga gagaggcagc ttggagagca gagaaaggca
       61 gagagagcga gaaatagaga cagtctgaga gacagacaga cagccagaga gagcgggagg
      121 gaggagggcg gaggaggagg agcaggagga ctacgcgggg cgcgttccct cccagcagcc
      181 gggcgcccgc gtcgctgcca ccgccggaag acagacgtcc cccaaaaccc ctcgcctggc
      241 tcggacccac ggagccggca gcccagcact ccgatgggag cttgcctgat tgtcaaccca
      301 tcggcctgga ccccagagcc cacccagttg agcgtgtgca gagggccccg agtgcggggc
      361 gacgctcagg ccgttgcaga gaccaccctg gagatgctga tgaagacagg cctttcctgc
      421 tgagcccagc ctatcttcgc agcctgctca gaaaggggaa ctgaggctca tggatataca
      481 gtgagtccta cctcctagcc tgaggactct tccctgcgcc ttgatgacct gagagaactg
      541 ggaggagaaa ggggttgtga caatgaccag gactcagggc agaggtggaa accagagtgc
      601 ctgatgtgtg cagctgctga cccccccagg acacctctct accggagtct gtggaagcag
      661 agaactggga ggccaaggcg ctgtccacgc cccgaggcct gggctcaggc cgaagttgct
      721 ccacagcacc cccagctgac agccagcgac tggcagagcc cccaggcacg ggggccctct
      781 ctcttccaga gatctccagt gtgacagccc aggcggcaga gccgagggtc ctggtcccgg
      841 cttctcgcac cctcatgtca gccccggccc cgcccggcgg cctgcggagg acaaggtcag
      901 gatgcgtgtg aagccccagg gcctggtggt gacttccagt gccgtgtgca gctctcctga
      961 ctacctccgg gaacccaagt actaccccgg cggccccccc accccccggc ccctgcttcc
     1021 cacccggccc cctgccagcc cacctgacaa ggccttctcc acccacgcct tctccgagaa
     1081 cccacgccca cccccacgcc gggaccccag cacccggcgc ccaccagtcc ttgccaaggg
     1141 ggacgacccg ctgcccccac gggcagcccg tcctgtctca caggcccgct gccccacacc
     1201 ggtcggagac ggcagcagct cccgacgctg ctgggacaac gggcgggtga acctgcgacc
     1261 agtggtgcag ctgattgaca tcatgaagga cctgacacgc ctctcccagg acctgcagca
     1321 cagtggtgta cacctggact gtggtgggct ccgactgagc cgcccgcctg caccgccacc
     1381 cggcgaccta cagtacagct tcttctcctc acccagtttg gccaacagca tccgtagccc
     1441 tgaggagcgg gccaccccac acgccaagtc ggagcggccc agccatcccc tctacgagcc
     1501 tgagcctgag cctagggaca gtccccagcc tggccaaggc catagtcccg gagccacggc
     1561 tgcggccacg ggtctgcccc cagagcctga gccagacagc actgattact cagaacttgc
     1621 tgacgccgac atccttagtg agctggcctc cctcacttgc ccagaggccc agctgctaga
     1681 ggcccaggcc ctcgagccac catcgcccga gccggagcct cagctcctgg acccccagcc
     1741 ccgcttcctg gacccgcagg cactagagcc gctcggggaa gctctggagc tgccacccct
     1801 gcaacctctt gctgatcctc tggggctgcc gggcctggct ctccaggccc tggacaccct
     1861 gcctgactcc ttggagtcgc agctgcttga cccccaggca ctcgaccccc tgcccaagct
     1921 gcttgacgtc ccaggtcgcc gtctggagcc ccagcagccc ctggggcact gcccactggc
     1981 cgagcccttg cgcctggact tgtgctcacc gcacggcccc cccgggcctg agggtcaccc
     2041 caagtacgcc ttgcggcgca ctgataggcc aaagatcctg tgtcgccggc ggaaagccgg
     2101 acggggacgc aaggcagacg ccggacccga gggccgccta ctgcccctgc ctatgcccac
     2161 ggggctggtg gctgccctgg ccgaaccccc accaccaccg cctcctccac cccctgccct
     2221 gccaggccca ggcccggtct cagtcccaga gttgaagccg gaatcttccc agaccccagt
     2281 ggtctctacc cgcaaaggca agtgccgggg cgtgcggcgc atggtggtga agatggccaa
     2341 gatccccgta tcgctggggc ggcggaacaa gaccacatac aaagtgtctt ccttgagcag
     2401 cagcctgagc gtggagggca aggagctggg cctgcgcgtg tcggctgagc ccaccccgct
     2461 gctgaagatg aagaacaatg ggcggaacgt ggtagtggtc ttcccacccg gtgagatgcc
     2521 cattattctc aaacgtaagc gcggccgccc tcctaagaac ctgctgctgg gtcccggcaa
     2581 gcccaaggag ccagctgtgg tggcggccga ggcagccact gtggcagcgg ccaccatggc
     2641 catgccagag gtaaaaaaac gacggcggcg gaagcagaag ctggcatctc cccagccatc
     2701 ctatgcagca gacgccaacg acagcaaggc cgagtactca gacgtcctgg ccaagctggc
     2761 cttcctgaac cgccagagcc agtgcgctgg acggtgctca ccgccccgct gctggacacc
     2821 cagtgagccg gagtcggtgc accaggcccc cgacacccag agcatctccc acttcctgca
     2881 tcgtgtgcag ggcttccggc ggcgtggggg caaagcaggc ggttttggtg gccggggtgg
     2941 gggccatgcg gccaagtcag cccgatgctc cttcagtgac ttctttgagg gcatcggcaa
     3001 gaaaaagaag gtggtggccg tggcagccgc tggggtcggg ggcccgggcc ttactgagtt
     3061 ggggcaccca cgcaaacggg gccgggggga ggtagacgct gtgactggga agccaaagcg
     3121 caagagacgg tcccggaaga atgggactct gttcccagag caggtgccca gtggcccagg
     3181 ctttggggag gcaggtgctg agtgggccgg ggataagggt ggtggctggg cccctcacca
     3241 tgggcaccca ggcggacaag ctggccgaaa ctgtgggttt caggggaccg aggcccgggc
     3301 ctttgcctcc actgggctgg agagtggagc ctcaggccgt ggcagctact acagcacggg
     3361 tgcaccctca ggccagaccg agctcagcca ggagcgccaa aacctcttca ccggctactt
     3421 tcgctcgctg ctcgattcgg atgactcctc cgatctcttg gactttgccc tctcagcctc
     3481 tcgcccagag tcccggaagg catcgggcac ctatgcaggg ccacccacca gtgccctgcc
     3541 tgcccagcgg ggcctggcca ccttccctag ccggggagcc aaggccagcc cagtggcagt
     3601 gggtagcagc ggggctgggg cggacccctc ctttcagcct gtcctgtccg cgcgccagac
     3661 cttcccacca ggacgagcag caagctatgg gctaactcca gccgcttcag actgccgggc
     3721 agccgagacc ttccccaagc tggtgccccc gccctcagcc atggcccgct cacctaccac
     3781 ccacccgcct gccaacacct acctgcccca gtacggcggc tatggggccg gacaaagcgt
     3841 attcgcccca actaagccct ttacaggcca ggactgcgct aacagcaagg actgcagctt
     3901 cgcctatggc agtggcaaca gcctccctgc ctcacccagc agcgcccaca gcgccggcta
     3961 tgccccaccg cctaccgggg gcccctgcct gccaccaagc aaggcctcct tcttcagcag
     4021 ctctgagggg gcccccttct ctggttcagc ccccacgccc ctgcgctgtg acagccgggc
     4081 cagcacagtc tcgcccggtg gctacatggt acccaagggc accacagcct ctgccacctc
     4141 tgcagcctct gccgcctcct cctcctcctc ctccttccag ccctcgcccg agaactgtcg
     4201 gcagtttgcg ggggcttctc agtggccttt ccggcagggc tatggaggcc tggactgggc
     4261 ctcagaggcc tttagtcagc tctacaatcc cagttttgac tgccacgtca gcgagcccaa
     4321 cgtgatcctg gacatctcca actacacacc gcagaaggtg aagcagcaga cggctgtgtc
     4381 ggagaccttc tctgagtcat cctccgacag cacccagttc aatcagccgg ttggtggcgg
     4441 ggggtttcgg cgtgccaaca gcgaggcctc aagtagtgag ggccagtcga gcctgtccag
     4501 cctggagaaa ctgatgatgg actggaacga ggcatcatct gcccccggct acaactggaa
     4561 ccagagtgtc ctctttcaga gtagctccaa gccgggccgt ggacggcgga agaaggtgga
     4621 cctgttcgag gcctcacatc tgggcttccc gacatccgcc tctgccgctg cctcaggcta
     4681 cccatccaaa cggagcactg ggccccggca gccgcgaggt ggacggggcg gtggggcctg
     4741 ctcagccaag aaggagcggg gtggcgcagc ggccaaagcc aagttcatcc ccaagccaca
     4801 gccagtcaac ccactgttcc aggacagtcc tgacctcggc ctggactact atagcgggga
     4861 cagcagcatg tcaccactgc cctcacagtc gagggccttc ggcgtgggag agcgagaccc
     4921 ctgtgacttc ataggaccct actccatgaa cccgtccacg ccttccgatg gcacctttgg
     4981 ccaaggcttc cactgcgact cgcccagcct gggtgctccc gagcttgatg gcaagcattt
     5041 cccaccgctg gcccacccac ccacggtgtt tgacgccggc ctgcagaagg catactcgcc
     5101 cacctgctcg cctacactgg gcttcaagga agagctgcgg ccaccgccca caaagctggc
     5161 tgcctgcgag cccctcaagc atggactcca gggggccagc ctgggccacg cagctgcagc
     5221 ccaggcccac ctgagctgcc gggacctgcc gctgggccag ccccactacg attcccccag
     5281 ctgcaagggc acagcctatt ggtaccctcc aggctcagct gcccgcagcc cgccctatga
     5341 aggcaaggtg ggtacagggc tgctggctga cttcctgggc aggacggagg ccgcgtgcct
     5401 cagtgcccct cacctggcta gcccaccagc cacgcccaag gccgacaagg agccactgga
     5461 aatggcccgg ccccctggcc caccccgtgg ccctgctgca gccgctgctg gctatggctg
     5521 cccactcctt agtgacttga ccctgtcccc cgtgccgagg gactcgctgc tgcccctgca
     5581 ggacaccgcc tacaggtacc caggctttat gccccaggcg catcctggcc tgggtggggg
     5641 ccccaagagc ggcttcctgg ggcccatggc ggaacctcac cccgaggaca cattcaccgt
     5701 cacatccctg tagtgccaac tgaagtgccg actggaccgc gaggttttgt tcctggcttt
     5761 cagaaaacca acgccaagat ccctcccagc gtccacatcg tcctctggca ggagctcctg
     5821 cccctctgcc tcccaccctg ccccctacac cccctgcaga cccatctccc tccaccccct
     5881 cccacccatc tcctccacgc agaagccgaa ggtgagccct ttctgcacaa aaccagcaat
     5941 tgtaaatact ttttaaaaat gtacaaaact taaaaacaaa acacagtttt agaaaaagac
     6001 aaaaaaaaaa aagagagaga gagagcgaga gagcgagcgt gtgcaagagg ttgcgagcgg
     6061 ggccccgagg tgtccagagc ccctgcaagt atgcactgag aaatttatct acaggtcgtt
     6121 tgacaaaaat gaacaatatc ctatttattg tatatactgt tttattataa atcgtggatt
     6181 gtatattgca ttctgtaaac ctgctgtggt cccgtggtgt gcaaattcgc atggtggggg
     6241 ggagggagaa gaacctcttg cgggagcttt ttttttcttt cttatttttc actcttttgg
     6301 gttttctctt ctgttgttgt tgttgttgtt ttctgttggc aggacacacc caaagatcca
     6361 agtttgtatt aaaaagaaat gaaaaaaagc aaaaaaaaaa caaaaaaaaa acaaaaaaaa
     6421 aaaaccaa
//
