LOCUS       NM_015328               5049 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adenosylhomocysteinase like 2 (AHCYL2), transcript
            variant 1, mRNA.
ACCESSION   NM_015328
VERSION     NM_015328.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5049)
  AUTHORS   Yamaguchi,S. and Ishikawa,T.
  TITLE     AHCYL2 (long-IRBIT) as a potential regulator of the electrogenic
            Na(+)-HCO3(-) cotransporter NBCe1-B
  JOURNAL   FEBS Lett 588 (5), 672-677 (2014)
   PUBMED   24472682
REFERENCE   2  (bases 1 to 5049)
  AUTHORS   Frazier-Wood,A.C., Aslibekyan,S., Borecki,I.B., Hopkins,P.N.,
            Lai,C.Q., Ordovas,J.M., Straka,R.J., Tiwari,H.K. and Arnett,D.K.
  TITLE     Genome-wide association study indicates variants associated with
            insulin signaling and inflammation mediate lipoprotein responses to
            fenofibrate
  JOURNAL   Pharmacogenet Genomics 22 (10), 750-757 (2012)
   PUBMED   22890011
REFERENCE   3  (bases 1 to 5049)
  AUTHORS   Aslibekyan,S., Kabagambe,E.K., Irvin,M.R., Straka,R.J.,
            Borecki,I.B., Tiwari,H.K., Tsai,M.Y., Hopkins,P.N., Shen,J.,
            Lai,C.Q., Ordovas,J.M. and Arnett,D.K.
  TITLE     A genome-wide association study of inflammatory biomarker changes
            in response to fenofibrate treatment in the Genetics of Lipid
            Lowering Drug and Diet Network
  JOURNAL   Pharmacogenet Genomics 22 (3), 191-197 (2012)
   PUBMED   22228203
REFERENCE   4  (bases 1 to 5049)
  AUTHORS   Thye,T., Vannberg,F.O., Wong,S.H., Owusu-Dabo,E., Osei,I.,
            Gyapong,J., Sirugo,G., Sisay-Joof,F., Enimil,A., Chinbuah,M.A.,
            Floyd,S., Warndorff,D.K., Sichali,L., Malema,S., Crampin,A.C.,
            Ngwira,B., Teo,Y.Y., Small,K., Rockett,K., Kwiatkowski,D.,
            Fine,P.E., Hill,P.C., Newport,M., Lienhardt,C., Adegbola,R.A.,
            Corrah,T., Ziegler,A., Morris,A.P., Meyer,C.G., Horstmann,R.D. and
            Hill,A.V.S.
  CONSRTM   African TB Genetics Consortium; Wellcome Trust Case Control
            Consortium
  TITLE     Genome-wide association analyses identifies a susceptibility locus
            for tuberculosis on chromosome 18q11.2
  JOURNAL   Nat Genet 42 (9), 739-741 (2010)
   PUBMED   20694014
  REMARK    Erratum:[Nat Genet. 2011 Oct;43(10):1040]
REFERENCE   5  (bases 1 to 5049)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   6  (bases 1 to 5049)
  AUTHORS   LLeonart,M.E., Vidal,F., Gallardo,D., Diaz-Fuertes,M., Rojo,F.,
            Cuatrecasas,M., Lopez-Vicente,L., Kondoh,H., Blanco,C., Carnero,A.
            and Ramon y Cajal,S.
  TITLE     New p53 related genes in human tumors: significant downregulation
            in colon and lung carcinomas
  JOURNAL   Oncol Rep 16 (3), 603-608 (2006)
   PUBMED   16865262
  REMARK    GeneRIF: Downregulation of KIAA0828 is associated with colon and
            lung carcinomas
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC024325.1 and AB020635.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_015328.3.
            
            Summary: The protein encoded by this gene acts as a homotetramer
            and may be involved in the conversion of S-adenosyl-L-homocysteine
            to L-homocysteine and adenosine. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024325.1, SRR1803617.143123.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325006.8/ ENSP00000315931.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2504              BC024325.1         8-2511
            2505-2522           AB020635.1         2482-2499
            2523-5049           BC024325.1         2512-5038
FEATURES             Location/Qualifiers
     source          1..5049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..5049
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /note="adenosylhomocysteinase like 2"
                     /db_xref="GeneID:23382"
                     /db_xref="HGNC:HGNC:22204"
                     /db_xref="MIM:616520"
     exon            1..410
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1883
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /EC_number="3.13.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     S-adenosylhomocysteine hydrolase-like 2; putative
                     adenosylhomocysteinase 3; S-adenosyl-L-homocysteine
                     hydrolase 3; IP(3)Rs binding protein released with IP(3)
                     2; long-IRBIT"
                     /codon_start=1
                     /product="adenosylhomocysteinase 3 isoform a"
                     /protein_id="NP_056143.1"
                     /db_xref="CCDS:CCDS5812.1"
                     /db_xref="GeneID:23382"
                     /db_xref="HGNC:HGNC:22204"
                     /db_xref="MIM:616520"
                     /translation="MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPP
                     AGGGDPEAPAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGG
                     EALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAA
                     SYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRA
                     QGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGF
                     PVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVE
                     ESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGG
                     KQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDI
                     VITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVI
                     WPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLP
                     KKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY"
     exon            411..522
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..666
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..767
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..870
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..965
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1072
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1189
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1253
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1342
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1413
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1508
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1607
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1676
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1755
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1876
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..5049
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5028..5033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /note="hexamer: AATAAA"
     polyA_site      5049
                     /gene="AHCYL2"
                     /gene_synonym="ADOHCYASE3; IRBIT2"
                     /note="major polyA site"
ORIGIN      
        1 aagagcagga gctggagtct gagccggtgg ttgcagcgga ggcggtgatg tcggtgcagg
       61 ttgtgtcagc cgcggctgcc gccaaggtgc ctgaggtgga gctgaaggac ctgagcccct
      121 ccgaggcgga gtcgcaacta ggactgagca cggccgccgt gggcgccatg gcccccccgg
      181 cgggcggtgg agaccctgag gctccagctc ccgccgcgga gcggcccccg gtccccggcc
      241 cgggctcggg gcccgccgcc gctctcagcc ccgccgccgg gaaggtgcct caggcgtcgg
      301 ccatgaagcg gagcgaccca catcaccagc accagcggca ccgcgacggc ggcgaggccc
      361 tggtcagccc cgacggcacc gtcaccgagg cgccgcgcac agtcaagaag cagatccagt
      421 ttgctgacca gaagcaagaa ttcaacaaac gtcccaccaa aattggacgt cgctctttgt
      481 ctcgttccat ttctcagtca tctactgaca gctacagctc agcggcttca tatacagata
      541 gctctgatga tgagacatcg cccagggaca agcagcaaaa gaactctaag ggaagcagtg
      601 acttctgtgt taagaacatc aaacaggcag agtttggacg aagagaaatt gaaattgctg
      661 aacaagaaat gcctgcattg atggctttga ggaagagagc tcaaggagaa aagcctttgg
      721 ctggagccaa aatcgtgggt tgcacacaca tcactgctca gactgctgtg cttatggaaa
      781 ctctgggtgc tctgggggcc cagtgccgat gggctgcctg caacatctat tccactctca
      841 atgaagtggc tgctgctcta gcagaaagtg gatttcctgt ttttgcctgg aagggagagt
      901 cagaagatga cttttggtgg tgtatcgata gatgtgtgaa tgtggagggc tggcagccaa
      961 acatgatctt ggatgatgga ggggatctta cccactggat ttataaaaag tatcccaaca
     1021 tgtttaagaa aatcaagggc atagtagagg agagtgttac tggagttcac aggctgtacc
     1081 aactgtccaa agctgggaag ctgtgtgttc cagccatgaa tgtcaatgac tcagtcacca
     1141 aacagaaatt tgacaacctc tactgttgcc gtgaatcaat tcttgatgga cttaaaagga
     1201 caacagacat gatgtttggt ggaaagcaag tggtagtctg tggctatgga gaggtgggga
     1261 aagggtgctg tgctgccctg aaagccatgg gctccattgt gtatgtaact gaaattgacc
     1321 ccatctgtgc cctgcaagcc tgtatggatg gatttcgact ggtgaaatta aatgaggtca
     1381 tccgacaagt ggacattgtt attacctgta caggtaacaa gaatgtggta accagagagc
     1441 acttggaccg tatgaagaat agctgcatcg tttgtaacat gggacattcc aacacagaga
     1501 ttgacgtggc gagtctgcgg acaccagaac tgacctggga gcgagtgaga tctcaagttg
     1561 accatgtgat atggcctgat ggcaagagga tagtactgct ggcagagggc cgcctgctga
     1621 accttagctg ctccacagtg cctacatttg tgctctcaat cactgctact actcaggctc
     1681 ttgccttgat agagctttac aatgctcctg agggtcgcta taagcaggat gtctacctgt
     1741 tgcccaagaa gatggatgag tatgtggcca gcctacacct gcctaccttt gatgcccact
     1801 tgacagagct gacagatgaa caggccaagt atctgggact caacaagaat gggcccttca
     1861 agcctaatta ctacaggtat taagttcctg taactcaaac cagaattttt aaggaataga
     1921 actccaagcc ttttctccac tactatacaa gaaagaattc agcaagctgc ttctccaatc
     1981 aaagctgcct gccgtgctca ccctgtgtgt taggttattt atttattaaa atcaagaatc
     2041 ctgtgcctgt agtgttggcc cagagtgtgg ttactgccct gagggccatg aaagccacag
     2101 aggatgggct gaggaaggaa agaaatgggg ttactgctcc cagtgcatca tttgcatcat
     2161 tccccattga ctgaatcctc agcagtggcc gtttttcctc ttgtccaggc tcacgagtta
     2221 gtccagggat tccatactcc ctattccctg gagttttctg gaataaattt tcagcacctg
     2281 cttttctcag cttggccctt ccccgggtga ggccgtttgg aattaacatg gccagtgttt
     2341 cacacaagat tgggttccca atcttgacca tcactatcac tgccttcttt atataaaggc
     2401 taataaggaa ggagtgttat ttatggcttt gccaagctac atcaagaact cagctgtgct
     2461 gtgcctacca ggggtctcct ttcttaccca ggactccttt cttctccttg aatatttatg
     2521 tccattttaa cacttcctgg ttgcaagagg gatgtgcctc cattatttcc tccacagttt
     2581 tggtatttgt cagacatttg ttctgctgtc tttctaatcc agccaacgtc tgctcaggaa
     2641 gtggggccag ctccactggg acccatagtt ttacttcctt gtcatttgat tggatagttt
     2701 ccaaggaagc ccctccagat tggcactatc tcagaaaagg agagcttgtt gtgaaacact
     2761 gcttcctgaa acttcctgct attgcctaaa gctacgtctg aaactgagta gggaaaggca
     2821 tacttttcca gggacttagg gggataggct ttggaaatgg gacaggtctt tcagactcac
     2881 agcttgatac cctaacaaag cagagtatat ttatttgttt cccaggaagg ccattgcagt
     2941 ttgactggct gagggataca gagatgaaat tgtaaactgt atccagatta tcaaagctaa
     3001 tttgactagt ttgaacctcg tcagacattc attcctttgg ccattgccat ggatgaaacc
     3061 gagatctgca gtctgatctg tggacttctc tgctggcata tcttttatga tttaacctct
     3121 tccatttgat gattctgtat ttcagagtca gtttcttgag taactccagt gctacaaaaa
     3181 gaattagtaa tgtggtgtgg gcagcgtgac attttatgtc ccacccaaaa attggattcc
     3241 ttttggagac tgatctgttg gtctcaggca tttcattagg accagattgg ttctaagagt
     3301 tagtctggac tggccctagg aaacttgaat taaataagcc tcttcccctt accgatcctt
     3361 tttaacactc tcaggtttgt ttgtttccca cttttttcct atgctggtct gcctcaaagt
     3421 ctcaagacca aggtgactca agataacacc agaccacgca tgatcaccaa aaccttccca
     3481 tcctgattct cttcttctac ctctaccctc tccaacttct cctggtcttc acatatactc
     3541 tcaaagctag tctgaaagtg accttacttt cggaagtagg gaagtggaac tttggtaaat
     3601 gactgtttgc ctcatttaat agtatacagg ctcagcccat agactacagt tcttcagagg
     3661 ccatatgtct cagcaagtac tggttatatt ctttttttgt aaggaagatc ataaatgcta
     3721 aaaattccac taagccattc agttcttcct tttgcctacc tagtcctgat ttttgtatta
     3781 attggttccc tttagcaagg gattcagatc tttgtacctt atcttatatc cagagcagat
     3841 tccatttggc agatagatgg tctctagcct attgtattct tagaccaaaa atcataacct
     3901 gctgtttctc agcaaagcct tgctctctgg agcttactat gtgctggtac ttaaagagta
     3961 cattctgcct tgctgtagtg aagagaccca ctccaaataa aaaaggggcc acacggggct
     4021 tctaagttag gttgccagtg ttgctgccca tgatgagtta tttgcctctg agtttcagat
     4081 gacctctctg tagggacact gtgttatcaa ccattaagaa gaaagaacca caagcctccc
     4141 aagtatttgg gttctatctt agggttgaaa tctggtcatt attccctcta cccttggaat
     4201 cagagcaatg tgtcttcttt cctccaacct cttaccttag atgcatcctg gttatctgga
     4261 agcatgggaa agaaggctac ttatctcttt gtatgtggct ccagtctgtg aggatacata
     4321 acattttctc tacaatgaat ctgtgctaat attttgcctt ctttctttct tttcttttca
     4381 cccttagaga cagggtttca ctatgttgcc caggctggtc tcaaactcct gggctcaagc
     4441 aatcctcctg cctcagcttc ctgagtagct ggaaccacag gtgtgtgcta ccgtgcctgg
     4501 cacttttttg ccttcttaat ggagatattc agttttcttt ttttcattta aacaaagaaa
     4561 aaaaatgtat ctactctacc ttccctctgc tctcctccct ccctatccta cttgcccata
     4621 tgagcacggc tccccatggc cacatactcc tgcaaagctt ttatgctgct tcgcttttct
     4681 ctaaacagat ctgatattgc tgctcctgtg gttttctcaa aattaacttt gccgtggttt
     4741 ttaaaaagga atcaaaatgc attgttgcat taagcttttt caataaagga aaattacgga
     4801 aggaaaatag gcaacaccag caaattatat gtggacaggt tctaaactct atatatacat
     4861 atatatatat atatctatat atctatatac gtaatcatct agttctgtca tcttactgaa
     4921 aggaataaca cttctaaaga tcaccatttc tgagaagttc ttggaaatct ttatgtctaa
     4981 gtgattgtat tagatcagca ataatgacta tgtaatctca aaaaacaaat aaaatattct
     5041 taacatgga
//
