LOCUS       NM_006621               3943 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens adenosylhomocysteinase like 1 (AHCYL1), transcript
            variant 1, mRNA.
ACCESSION   NM_006621 NM_014121
VERSION     NM_006621.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3943)
  AUTHORS   Budnik,N., Leroux,A.E., Cooke,M., Kazanietz,M.G., Vigliano,C.,
            Kobayashi,K. and Perez-Castro,C.
  TITLE     The role of S-adenosylhomocysteine hydrolase-like 1 in cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (7), 119819 (2024)
   PUBMED   39154900
  REMARK    GeneRIF: The role of S-adenosylhomocysteine hydrolase-like 1 in
            cancer.
            Review article
REFERENCE   2  (bases 1 to 3943)
  AUTHORS   Cai,C., Tu,J., Najarro,J., Zhang,R., Fan,H., Zhang,F.Q., Li,J.,
            Xie,Z., Su,R., Dong,L., Arellano,N., Ciboddo,M., Elf,S.E., Gao,X.,
            Chen,J. and Wu,R.
  TITLE     NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for
            Melanoma Tumor Growth
  JOURNAL   Mol Cancer Res 22 (4), 386-401 (2024)
   PUBMED   38294692
  REMARK    GeneRIF: NRAS Mutant Dictates AHCYL1-Governed ER Calcium
            Homeostasis for Melanoma Tumor Growth.
REFERENCE   3  (bases 1 to 3943)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3943)
  AUTHORS   Wischhof,L., Adhikari,A., Mondal,M., Marsal-Cots,A., Biernat,J.,
            Mandelkow,E.M., Mandelkow,E., Ehninger,D., Nicotera,P. and Bano,D.
  TITLE     Unbiased proteomic profiling reveals the IP3R modulator
            AHCYL1/IRBIT as a novel interactor of microtubule-associated
            protein tau
  JOURNAL   J Biol Chem 298 (4), 101774 (2022)
   PUBMED   35218773
  REMARK    GeneRIF: Unbiased proteomic profiling reveals the IP3R modulator
            AHCYL1/IRBIT as a novel interactor of microtubule-associated
            protein tau.
REFERENCE   5  (bases 1 to 3943)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   6  (bases 1 to 3943)
  AUTHORS   Imabayashi,H., Mori,T., Gojo,S., Kiyono,T., Sugiyama,T., Irie,R.,
            Isogai,T., Hata,J., Toyama,Y. and Umezawa,A.
  TITLE     Redifferentiation of dedifferentiated chondrocytes and
            chondrogenesis of human bone marrow stromal cells via chondrosphere
            formation with expression profiling by large-scale cDNA analysis
  JOURNAL   Exp Cell Res 288 (1), 35-50 (2003)
   PUBMED   12878157
REFERENCE   7  (bases 1 to 3943)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
REFERENCE   8  (bases 1 to 3943)
  AUTHORS   Dekker,J.W., Budhia,S., Angel,N.Z., Cooper,B.J., Clark,G.J.,
            Hart,D.N. and Kato,M.
  TITLE     Identification of an S-adenosylhomocysteine hydrolase-like
            transcript induced during dendritic cell differentiation
  JOURNAL   Immunogenetics 53 (12), 993-1001 (2002)
   PUBMED   11904675
REFERENCE   9  (bases 1 to 3943)
  AUTHORS   Cleaver,J.E., Afzal,V., Feeney,L., McDowell,M., Sadinski,W.,
            Volpe,J.P., Busch,D.B., Coleman,D.M., Ziffer,D.W., Yu,Y.,
            Nagasawa,H. and Little,J.B.
  TITLE     Increased ultraviolet sensitivity and chromosomal instability
            related to P53 function in the xeroderma pigmentosum variant
  JOURNAL   Cancer Res 59 (5), 1102-1108 (1999)
   PUBMED   10070969
REFERENCE   10 (bases 1 to 3943)
  AUTHORS   Pawlak,A., Toussaint,C., Levy,I., Bulle,F., Poyard,M., Barouki,R.
            and Guellaen,G.
  TITLE     Characterization of a large population of mRNAs from human testis
  JOURNAL   Genomics 26 (1), 151-158 (1995)
   PUBMED   7782076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772411.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_006621.6.
            
            Summary: The protein encoded by this gene interacts with inositol
            1,4,5-trisphosphate receptor, type 1 and may be involved in the
            conversion of S-adenosyl-L-homocysteine to L-homocysteine and
            adenosine. Several transcript variants encoding two different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110896.1, GQ900917.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369799.10/ ENSP00000358814.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AL772411.1         12380-12787
            409-520             AL772411.1         36649-36760
            521-664             AL772411.1         38829-38972
            665-765             AL772411.1         39977-40077
            766-868             AL772411.1         40512-40614
            869-963             AL772411.1         42378-42472
            964-1070            AL772411.1         43040-43146
            1071-1187           AL772411.1         43959-44075
            1188-1251           AL772411.1         44282-44345
            1252-1340           AL772411.1         45110-45198
            1341-1411           AL772411.1         45561-45631
            1412-1506           AL772411.1         45988-46082
            1507-1605           AL772411.1         46167-46265
            1606-1674           AL772411.1         46666-46734
            1675-1753           AL772411.1         47163-47241
            1754-1874           AL772411.1         48346-48466
            1875-3943           AL772411.1         49289-51357
FEATURES             Location/Qualifiers
     source          1..3943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3943
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /note="adenosylhomocysteinase like 1"
                     /db_xref="GeneID:10768"
                     /db_xref="HGNC:HGNC:344"
                     /db_xref="MIM:607826"
     exon            1..408
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1881
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /EC_number="3.13.2.1"
                     /note="isoform a is encoded by transcript variant 1;
                     S-adenosyl homocysteine hydrolase homolog; epididymis
                     secretory sperm binding protein; dendritic cell expressed
                     AHCY-like protein; inositol 1,4,5-trisphosphate
                     receptor-binding protein; putative adenosylhomocysteinase
                     2; adoHcyase 2; DC-expressed AHCY-like molecule;
                     S-adenosyl-L-homocysteine hydrolase 2;
                     S-adenosylhomocysteine hydrolase-like protein 1; protein
                     phosphatase 1, regulatory subunit 78; IP(3)Rs binding
                     protein released with IP(3)"
                     /codon_start=1
                     /product="S-adenosylhomocysteine hydrolase-like protein 1
                     isoform a"
                     /protein_id="NP_006612.2"
                     /db_xref="CCDS:CCDS818.1"
                     /db_xref="GeneID:10768"
                     /db_xref="HGNC:HGNC:344"
                     /db_xref="MIM:607826"
                     /translation="MSMPDAMPLPGVGEELKQAKEIEDAEKYSFMATVTKAPKKQIQF
                     ADDMQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSPREKQQTNSKGS
                     SNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQTAV
                     LIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNM
                     DGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAM
                     NVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALG
                     AIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSC
                     IVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCSTV
                     PTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPSFDAHLTELT
                     DDQAKYLGLNKNGPFKPNYYRY"
     exon            409..520
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            521..664
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            665..765
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            766..868
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            869..963
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1070
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1187
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1251
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1340
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1411
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1506
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1605
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1674
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1753
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1874
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..3943
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3924..3929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /note="hexamer: ATTAAA"
     polyA_site      3943
                     /gene="AHCYL1"
                     /gene_synonym="DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA"
                     /note="major polyA site"
ORIGIN      
        1 gctttgcgtg cgtgtttgcg tacagcggag gtggcggcgc gggcaggtcg gagctcggag
       61 ctgctgttct ggttctcttg tggccgccgt cgctgtccgg ctgccttggg ctgccgaaca
      121 gacaaggcgt gggccacagc acctcagaag ccgacgcagc tcgacgcagg ggccggcagg
      181 agggtgggcg atcgcgtgtc ggagggcgcc gcgcgggcag gcgggcgggc gccagagggg
      241 gaaagaggcg ggggcggcgg gtcagccgct ggccgggccg gccggggaat gtcgatgcct
      301 gacgcgatgc cgctgcccgg ggtcggggag gagctgaagc aggccaagga gatcgaggac
      361 gccgagaagt actccttcat ggccaccgtc accaaggcgc ccaagaagca aatccagttt
      421 gctgatgaca tgcaggagtt caccaaattc cccaccaaaa ctggccgaag atctttgtct
      481 cgctcgatct cacagtcctc cactgacagc tacagttcag ctgcatccta cacagatagc
      541 tctgatgatg aggtttctcc ccgagagaag cagcaaacca actccaaggg cagcagcaat
      601 ttctgtgtga agaacatcaa gcaggcagaa tttggacgcc gggagattga gattgcagag
      661 caagacatgt ctgctctgat ttcactcagg aaacgtgctc agggggagaa gcccttggct
      721 ggtgctaaaa tagtgggctg tacacacatc acagcccaga cagcggtgtt gattgagaca
      781 ctctgtgccc tgggggctca gtgccgctgg tctgcttgta acatctactc aactcagaat
      841 gaagtagctg cagcactggc tgaggctgga gttgcagtgt tcgcttggaa gggcgagtca
      901 gaagatgact tctggtggtg tattgaccgc tgtgtgaaca tggatgggtg gcaggccaac
      961 atgatcctgg atgatggggg agacttaacc cactgggttt ataagaagta tccaaacgtg
     1021 tttaagaaga tccgaggcat tgtggaagag agcgtgactg gtgttcacag gctgtatcag
     1081 ctctccaaag ctgggaagct ctgtgttccg gccatgaacg tcaatgattc tgttaccaaa
     1141 cagaagtttg ataacttgta ctgctgccga gaatccattt tggatggcct gaagaggacc
     1201 acagatgtga tgtttggtgg gaaacaagtg gtggtgtgtg gctatggtga ggtaggcaag
     1261 ggctgctgtg ctgctctcaa agctcttgga gcaattgtct acattaccga aatcgacccc
     1321 atctgtgctc tgcaggcctg catggatggg ttcagggtgg taaagctaaa tgaagtcatc
     1381 cggcaagtcg atgtcgtaat aacttgcaca ggaaataaga atgtagtgac acgggagcac
     1441 ttggatcgca tgaaaaacag ttgtatcgta tgcaatatgg gccactccaa cacagaaatc
     1501 gatgtgacca gcctccgcac tccggagctg acgtgggagc gagtacgttc tcaggtggac
     1561 catgtcatct ggccagatgg caaacgagtt gtcctcctgg cagagggtcg tctactcaat
     1621 ttgagctgct ccacagttcc cacctttgtt ctgtccatca cagccacaac acaggctttg
     1681 gcactgatag aactctataa tgcacccgag gggcgataca agcaggatgt gtacttgctt
     1741 cctaagaaaa tggatgaata cgttgccagc ttgcatctgc catcatttga tgcccacctt
     1801 acagagctga cagatgacca agcaaaatat ctgggactca acaaaaatgg gccattcaaa
     1861 cctaattatt acagatacta atggaccata ctaccaagga ccagtccacc tgaaccacac
     1921 actctaaaga aatatttttt aagataactt ttattttctt cttactcctt tcctcttgat
     1981 ttttttccta taatttcatt cttgtttttt catctcatta tccaagttct gcagaccaca
     2041 caggaacttg cttcatggct ctttagatga aatagaagtt cagggttcct cactctagtc
     2101 actaaagaag gattttactc tcccagccca gaaaggtgat tctttcttta ccatttctgg
     2161 ggactttagt cttaattagg taccttatta acaggaaatg ctaaggtacc ttctctgtgg
     2221 aacaatctgc aatgtctaaa tcgccttaaa agagcccatt tcttagctgc tgaaatcagt
     2281 gctctttcac ttcttcagag aagcagggat ggtacctacc cggcaggtag gttagatgtg
     2341 ggtggtgcat gttaatttcc cttagaagtt ccaagccctg tttcctgcgt aaaggtggta
     2401 tgtccagttc agagatgtgt ataatgagca tggcttgtta agatcaggag gcccacttgg
     2461 atttatagta tagcccttcc tccactccca ccagacttgc tcatttttcg agtttttaac
     2521 tagactacac tctattgagt ttaattttgt cctctaggat ttatttctgt tgtccaaaaa
     2581 aaaaaaaaaa gaaaagaaaa attaaggaga atttttggtg ttaatgctga ggaattgctt
     2641 gagtggttag ttgttaccaa tttctctttt gaacctttgg agctaaggat gctgagtcta
     2701 gagaaatgct agtctcaagc cctgttaagt ccctctgttt ctagcccgta gttcatagca
     2761 tcagtgaact ggagccacaa cagcaaattc tatcagctgt gtaccataca gcttgtgctg
     2821 aaggcgaatt tcttgagcca ttactcagta taaagcactg agttctatct ttaggattta
     2881 tctttaagag caaatttctg gtcagctgtg cttctgcaac ctaaaatatt taaagggagg
     2941 taggtgtggg caggaggagg aatgataaat tgggccaggg caagaaaaat ctagcttcat
     3001 ataatttgtc tgggactata caccctatat aatgttagtt ttacagaagt aatatgactt
     3061 ttgattgcta cataccacaa agagtttatg aactgagatc ataaagggca actgatgtgt
     3121 gaagaaagta gtcagtacat cctggctcat gctctgaaag aatatccaga gaggctctct
     3181 caaagatcag ggagatgtat tcccatgcca tgcaccctgc ttcccagcat ttctgcatgg
     3241 tcaagtgagc tttatgctca tgagctttaa gtatataatt atccaggatt ttaaatcctc
     3301 aacttgttct agcttgtgat ccctcaaagt tgggtcatac gttagtgcta gatactagaa
     3361 attttcactt ttccactgat cagagagaca gacattaaaa acaaaaatag aagaaaggaa
     3421 agctttcacc ctgcagcttc ttagcaggga acaattgtct tgccaaaact tttttccctt
     3481 ttctctccca ttttctttta cccaatccct tcttactcct tgccagtgtg accatgcttt
     3541 cttctctgta gatgttaaca gttaaggcct attttcctcg ggcacttaac caaccaatca
     3601 gaacaccaca tctgttaggg gaggtaacct ggccaacagt gtatccatca cgttagccct
     3661 gctggaggga agggacccac attcacctgc cctctgacct gccccttgat cccatatcta
     3721 ttaccgtgtc cataggaata ataggtaagg gctctgtctc tgtcaagcca tgtaacaaag
     3781 gacactgtta aaaaaaaaaa aaagtctggc atcagaggga gcatgtggag agcaacttgg
     3841 gaagaacaag ttcattttgt attgaatgat ttttaatgaa tgcaatatta atccttgcag
     3901 atgagcaata atcattaaaa tcgattaaaa tgataagacc tta
//
