LOCUS       NM_001322084            3270 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens adenosylhomocysteinase (AHCY), transcript variant 4,
            mRNA.
ACCESSION   NM_001322084 XM_005260316
VERSION     NM_001322084.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3270)
  AUTHORS   Boczki,P., Colombo,M., Weiner,J., Rapohn,I., Lacher,M., Kiess,W.,
            Hanschkow,M., Korner,A. and Landgraf,K.
  TITLE     Inhibition of AHCY impedes proliferation and differentiation of
            mouse and human adipocyte progenitor cells
  JOURNAL   Adipocyte 13 (1), 2290218 (2024)
   PUBMED   38064408
  REMARK    GeneRIF: Inhibition of AHCY impedes proliferation and
            differentiation of mouse and human adipocyte progenitor cells.
REFERENCE   2  (bases 1 to 3270)
  AUTHORS   Pavicic,I., Rokic,F. and Vugrek,O.
  TITLE     Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt
            Signaling Pathway in SW480 Cells
  JOURNAL   Int J Mol Sci 24 (22), 16102 (2023)
   PUBMED   38003292
  REMARK    GeneRIF: Effects of S-Adenosylhomocysteine Hydrolase Downregulation
            on Wnt Signaling Pathway in SW480 Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3270)
  AUTHORS   Vande Voorde,J., Steven,R.T., Najumudeen,A.K., Ford,C.A.,
            Dexter,A., Gonzalez-Fernandez,A., Nikula,C.J., Xiang,Y., Ford,L.,
            Maneta Stavrakaki,S., Gilroy,K., Zeiger,L.B., Pennel,K.,
            Hatthakarnkul,P., Elia,E.A., Nasif,A., Murta,T., Manoli,E.,
            Mason,S., Gillespie,M., Lannagan,T.R.M., Vlahov,N., Ridgway,R.A.,
            Nixon,C., Raven,A., Mills,M., Athineos,D., Kanellos,G., Nourse,C.,
            Gay,D.M., Hughes,M., Burton,A., Yan,B., Sellers,K., Wu,V., De
            Ridder,K., Shokry,E., Huerta Uribe,A., Clark,W., Clark,G.,
            Kirschner,K., Thienpont,B., Li,V.S.W., Maddocks,O.D.K., Barry,S.T.,
            Goodwin,R.J.A., Kinross,J., Edwards,J., Yuneva,M.O., Sumpton,D.,
            Takats,Z., Campbell,A.D., Bunch,J. and Sansom,O.J.
  TITLE     Metabolic profiling stratifies colorectal cancer and reveals
            adenosylhomocysteinase as a therapeutic target
  JOURNAL   Nat Metab 5 (8), 1303-1318 (2023)
   PUBMED   37580540
  REMARK    GeneRIF: Metabolic profiling stratifies colorectal cancer and
            reveals adenosylhomocysteinase as a therapeutic target.
REFERENCE   4  (bases 1 to 3270)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3270)
  AUTHORS   Liu,Z., Wang,A., Pu,Y., Li,Z., Xue,R., Zhang,C., Xiang,X., E,J.Y.,
            Bu,Z., Bai,F. and Ji,J.
  TITLE     Genomic and transcriptomic profiling of hepatoid adenocarcinoma of
            the stomach
  JOURNAL   Oncogene 40 (38), 5705-5717 (2021)
   PUBMED   34326469
  REMARK    GeneRIF: Genomic and transcriptomic profiling of hepatoid
            adenocarcinoma of the stomach.
REFERENCE   6  (bases 1 to 3270)
  AUTHORS   Coulter-Karis,D.E. and Hershfield,M.S.
  TITLE     Sequence of full length cDNA for human S-adenosylhomocysteine
            hydrolase
  JOURNAL   Ann Hum Genet 53 (2), 169-175 (1989)
   PUBMED   2596825
REFERENCE   7  (bases 1 to 3270)
  AUTHORS   Arredondo-Vega,F.X., Charlton,J.A., Edwards,Y.H., Hopkinson,D.A.
            and Whitehouse,D.B.
  TITLE     Isozyme and DNA analysis of human S-adenosyl-L-homocysteine
            hydrolase (AHCY)
  JOURNAL   Ann Hum Genet 53 (2), 157-167 (1989)
   PUBMED   2574561
REFERENCE   8  (bases 1 to 3270)
  AUTHORS   Bissbort,S., Bender,K., Wienker,T.F. and Grzeschik,K.H.
  TITLE     Genetics of human S-adenosylhomocysteine hydrolase. A new
            polymorphism in man
  JOURNAL   Hum Genet 65 (1), 68-71 (1983)
   PUBMED   6580258
REFERENCE   9  (bases 1 to 3270)
  AUTHORS   Hershfield,M.S.
  TITLE     Apparent suicide inactivation of human lymphoblast
            S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine
            arabinoside. A basis for direct toxic effects of analogs of
            adenosine
  JOURNAL   J Biol Chem 254 (1), 22-25 (1979)
   PUBMED   309884
REFERENCE   10 (bases 1 to 3270)
  AUTHORS   Hershfield,M.S. and Krodich,N.M.
  TITLE     S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a
            target for adenosine toxicity
  JOURNAL   Science 202 (4369), 757-760 (1978)
   PUBMED   715439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB452063.1, AL356299.16 and
            AI057366.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001322084.1.
            
            Summary: S-adenosylhomocysteine hydrolase belongs to the
            adenosylhomocysteinase family. It catalyzes the reversible
            hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado)
            and L-homocysteine (Hcy). Thus, it regulates the intracellular
            S-adenosylhomocysteine (SAH) concentration thought to be important
            for transmethylation reactions. Deficiency in this protein is one
            of the different causes of hypermethioninemia. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jun 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.675411.1,
                                           SRR18074967.3012849.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               DB452063.1         17-391
            376-1233            AL356299.16        31135-31992         c
            1234-1424           AL356299.16        24772-24962         c
            1425-1500           AL356299.16        23458-23533         c
            1501-1650           AL356299.16        21735-21884         c
            1651-1763           AL356299.16        20796-20908         c
            1764-1971           AL356299.16        20108-20315         c
            1972-2059           AL356299.16        19928-20015         c
            2060-2177           AL356299.16        19709-19826         c
            2178-2372           AL356299.16        14817-15011         c
            2373-3047           AL356299.16        9868-10542          c
            3048-3270           AI057366.1         13-235              c
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..3270
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="adenosylhomocysteinase"
                     /db_xref="GeneID:191"
                     /db_xref="HGNC:HGNC:343"
                     /db_xref="MIM:180960"
     exon            1..1233
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1424
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     CDS             1290..2504
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /EC_number="3.13.2.1"
                     /note="isoform 2 is encoded by transcript variant 4;
                     S-adenosylhomocysteine hydrolase;
                     S-adenosyl-L-homocysteine hydrolase; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="adenosylhomocysteinase isoform 2"
                     /protein_id="NP_001309013.1"
                     /db_xref="CCDS:CCDS54457.1"
                     /db_xref="GeneID:191"
                     /db_xref="HGNC:HGNC:343"
                     /db_xref="MIM:180960"
                     /translation="MPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGA
                     EVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILD
                     DGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSK
                     FDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDP
                     INALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDV
                     EIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSF
                     TNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
                     CDGPFKPDHYRY"
     exon            1425..1500
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1650
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1763
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1971
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2059
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2177
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2372
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..3270
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3248..3253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="hexamer: AATAAA"
     polyA_site      3270
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="major polyA site"
ORIGIN      
        1 gcaaactggc ggcgtgctcc gcgggagagc acacctggcc acggcctggg acggctggca
       61 cctgccggac cctgctcggg gggcctgcgc ccggcctcct aggcctggac cggaccctgt
      121 ccagctgggc ggccccgacg agcgtccacc cctctctggg cctcctacag ggacggcgag
      181 ggcaccccgg agggtgtatg aggagaggcc tggaaagcga gccccaggcc ggctccgatc
      241 ctcctctccc ctgggacttt gggccagtta cccaacctgt ggggtccccc acccctccag
      301 caggggcagc cttgcagaaa tctcgaagaa aatttggagt ggtttgaaaa atcctgctgt
      361 cccaccgatt gaagtgtaat acagggatag ttaacgttta cttagtgttt cctgtgggat
      421 cggcactgcc ttctagcttt attctagtct catggctcta tagggaaact gttctcattt
      481 tatgatgaga atcctgaggc agaggtaact tgccctcagt cttacagctg gtggtgatgg
      541 agcaagattg gaacgcaggc catctagatc tctgagcgca ccctttcacc actgtgtgca
      601 agcgaataca cgcggaacaa tcctagtgaa ttttcagcaa aaaccagttc agtttggctg
      661 gtagcttttc aagtaacttt gacactattg gaccgggtgt ggtggctcac ccctgtagtc
      721 ccagcacttt gagaggccga ggtgggcgaa tcacttgagg tcaagagttc gagaccagcc
      781 tggccaacgt ggtgaaacgc tatctctacc aaaaatacaa aaactagctg ggcgtggtgg
      841 cgggcgcctt cattcccagc tactcgggag gctgaggcag gaggactgtt tgagccgggg
      901 agacggaggt tgcagtgagc cgagattgca ccaccacgct ccaacctggg caacagagca
      961 agaccctgtc tcaaaaaaaa aaaacaaaca aaaaaagaca ctattaagtc tggagaatgc
     1021 catccacatt tatggaaaca cttgctgtat atctggtgat ttacgtgtgt ttacacaata
     1081 atcttcatag aggtggacgt aatcccgtta tatagagcat gaaactgagg cccttgggag
     1141 gtgacttgca aagattctgt tgaagtagtt catcaagttg ctaccagagt agactgtctc
     1201 cattgtgtgg atgctgaaac tgaacccaga aagccgacat cggcctggct gcctggggac
     1261 gcaaggccct ggacattgct gagaacgaga tgccgggcct gatgcgtatg cgggagcggt
     1321 actcggcctc caagccactg aagggcgccc gcatcgctgg ctgcctgcac atgaccgtgg
     1381 agacggccgt cctcattgag accctcgtca ccctgggtgc tgaggtgcag tggtccagct
     1441 gcaacatctt ctccacccag gaccatgcgg cggctgccat tgccaaggct ggcattccgg
     1501 tgtatgcctg gaagggcgaa acggacgagg agtacctgtg gtgcattgag cagaccctgt
     1561 acttcaagga cgggcccctc aacatgattc tggacgacgg gggcgacctc accaacctca
     1621 tccacaccaa gtacccgcag cttctgccag gcatccgagg catctctgag gagaccacga
     1681 ctggggtcca caacctctac aagatgatgg ccaatgggat cctcaaggtg cctgccatca
     1741 atgtcaatga ctccgtcacc aagagcaagt ttgacaacct ctatggctgc cgggagtccc
     1801 tcatagatgg catcaagcgg gccacagatg tgatgattgc cggcaaggta gcggtggtag
     1861 caggctatgg tgatgtgggc aagggctgtg cccaggccct gcggggtttc ggagcccgcg
     1921 tcatcatcac cgagattgac cccatcaacg cactgcaggc tgccatggag ggctatgagg
     1981 tgaccaccat ggatgaggcc tgtcaggagg gcaacatctt tgtcaccacc acaggctgta
     2041 ttgacatcat ccttggccgg cactttgagc agatgaagga tgatgccatt gtgtgtaaca
     2101 ttggacactt tgacgtggag atcgatgtca agtggctcaa cgagaacgcc gtggagaagg
     2161 tgaacatcaa gccgcaggtg gaccggtatc ggttgaagaa tgggcgccgc atcatcctgc
     2221 tggccgaggg tcggctggtc aacctgggtt gtgccatggg ccaccccagc ttcgtgatga
     2281 gtaactcctt caccaaccag gtgatggcgc agatcgagct gtggacccat ccagacaagt
     2341 accccgttgg ggttcatttc ctgcccaaga agctggatga ggcagtggct gaagcccacc
     2401 tgggcaagct gaatgtgaag ttgaccaagc taactgagaa gcaagcccag tacctgggca
     2461 tgtcctgtga tggccccttc aagccggatc actaccgcta ctgagagcca ggtctgcgtt
     2521 tcaccctcca gctgctgtcc ttgcccaggc cccacctctc ctccctaaga gctaatggca
     2581 ccaactttgt gattggtttg tcagtgtccc ccatcgactc tctggggctg atcacttagt
     2641 ttttggcctc tgctgcagcc gtcatactgt tccaaatgtg gcagcgggaa cagagtaccc
     2701 tcttcaagcc ccggtcatga tggaggtccc agccacaggg aaccatgagc tcagtggtct
     2761 tggaacagct cactaagtca gtccttcctt agcctggaag tcagtagtgg agtcacaaag
     2821 cccatgtgtt ttgccatcta ggccttcacc tggtctgtgg acttatacct gtgtgcttgg
     2881 tttacaggtc cagtggttct tcagcccatg acagatgaga aggggctata ttgaagggca
     2941 aagaggaact gttgtttgaa ttttcctgag agcctggctt agtgctgggc cttctcttaa
     3001 acctcattac aatgaggtta gtacttttag tccctgtttt acaggggtta gaatagactg
     3061 ttaaggggca actgagaaag aacagagaag tgacagctag gggttgagag gggccagaaa
     3121 aacatgaatg caggcagatt tcgtgaaatc tgccaccact ttataaccag atggttcctt
     3181 tcacaaccct gggtcaaaaa gagaataatt tggcctataa tgttaaaaga aagcaggaag
     3241 gtgggtaaat aaaaatcttg gtgcctggaa
//
