LOCUS       NM_000687               2150 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens adenosylhomocysteinase (AHCY), transcript variant 1,
            mRNA.
ACCESSION   NM_000687
VERSION     NM_000687.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Boczki,P., Colombo,M., Weiner,J., Rapohn,I., Lacher,M., Kiess,W.,
            Hanschkow,M., Korner,A. and Landgraf,K.
  TITLE     Inhibition of AHCY impedes proliferation and differentiation of
            mouse and human adipocyte progenitor cells
  JOURNAL   Adipocyte 13 (1), 2290218 (2024)
   PUBMED   38064408
  REMARK    GeneRIF: Inhibition of AHCY impedes proliferation and
            differentiation of mouse and human adipocyte progenitor cells.
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Pavicic,I., Rokic,F. and Vugrek,O.
  TITLE     Effects of S-Adenosylhomocysteine Hydrolase Downregulation on Wnt
            Signaling Pathway in SW480 Cells
  JOURNAL   Int J Mol Sci 24 (22), 16102 (2023)
   PUBMED   38003292
  REMARK    GeneRIF: Effects of S-Adenosylhomocysteine Hydrolase Downregulation
            on Wnt Signaling Pathway in SW480 Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Vande Voorde,J., Steven,R.T., Najumudeen,A.K., Ford,C.A.,
            Dexter,A., Gonzalez-Fernandez,A., Nikula,C.J., Xiang,Y., Ford,L.,
            Maneta Stavrakaki,S., Gilroy,K., Zeiger,L.B., Pennel,K.,
            Hatthakarnkul,P., Elia,E.A., Nasif,A., Murta,T., Manoli,E.,
            Mason,S., Gillespie,M., Lannagan,T.R.M., Vlahov,N., Ridgway,R.A.,
            Nixon,C., Raven,A., Mills,M., Athineos,D., Kanellos,G., Nourse,C.,
            Gay,D.M., Hughes,M., Burton,A., Yan,B., Sellers,K., Wu,V., De
            Ridder,K., Shokry,E., Huerta Uribe,A., Clark,W., Clark,G.,
            Kirschner,K., Thienpont,B., Li,V.S.W., Maddocks,O.D.K., Barry,S.T.,
            Goodwin,R.J.A., Kinross,J., Edwards,J., Yuneva,M.O., Sumpton,D.,
            Takats,Z., Campbell,A.D., Bunch,J. and Sansom,O.J.
  TITLE     Metabolic profiling stratifies colorectal cancer and reveals
            adenosylhomocysteinase as a therapeutic target
  JOURNAL   Nat Metab 5 (8), 1303-1318 (2023)
   PUBMED   37580540
  REMARK    GeneRIF: Metabolic profiling stratifies colorectal cancer and
            reveals adenosylhomocysteinase as a therapeutic target.
REFERENCE   4  (bases 1 to 2150)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2150)
  AUTHORS   Liu,Z., Wang,A., Pu,Y., Li,Z., Xue,R., Zhang,C., Xiang,X., E,J.Y.,
            Bu,Z., Bai,F. and Ji,J.
  TITLE     Genomic and transcriptomic profiling of hepatoid adenocarcinoma of
            the stomach
  JOURNAL   Oncogene 40 (38), 5705-5717 (2021)
   PUBMED   34326469
  REMARK    GeneRIF: Genomic and transcriptomic profiling of hepatoid
            adenocarcinoma of the stomach.
REFERENCE   6  (bases 1 to 2150)
  AUTHORS   Coulter-Karis,D.E. and Hershfield,M.S.
  TITLE     Sequence of full length cDNA for human S-adenosylhomocysteine
            hydrolase
  JOURNAL   Ann Hum Genet 53 (2), 169-175 (1989)
   PUBMED   2596825
REFERENCE   7  (bases 1 to 2150)
  AUTHORS   Arredondo-Vega,F.X., Charlton,J.A., Edwards,Y.H., Hopkinson,D.A.
            and Whitehouse,D.B.
  TITLE     Isozyme and DNA analysis of human S-adenosyl-L-homocysteine
            hydrolase (AHCY)
  JOURNAL   Ann Hum Genet 53 (2), 157-167 (1989)
   PUBMED   2574561
REFERENCE   8  (bases 1 to 2150)
  AUTHORS   Bissbort,S., Bender,K., Wienker,T.F. and Grzeschik,K.H.
  TITLE     Genetics of human S-adenosylhomocysteine hydrolase. A new
            polymorphism in man
  JOURNAL   Hum Genet 65 (1), 68-71 (1983)
   PUBMED   6580258
REFERENCE   9  (bases 1 to 2150)
  AUTHORS   Hershfield,M.S.
  TITLE     Apparent suicide inactivation of human lymphoblast
            S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine and adenine
            arabinoside. A basis for direct toxic effects of analogs of
            adenosine
  JOURNAL   J Biol Chem 254 (1), 22-25 (1979)
   PUBMED   309884
REFERENCE   10 (bases 1 to 2150)
  AUTHORS   Hershfield,M.S. and Krodich,N.M.
  TITLE     S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a
            target for adenosine toxicity
  JOURNAL   Science 202 (4369), 757-760 (1978)
   PUBMED   715439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290422.1, AK097610.1 and
            AI057366.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000687.3.
            
            Summary: S-adenosylhomocysteine hydrolase belongs to the
            adenosylhomocysteinase family. It catalyzes the reversible
            hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado)
            and L-homocysteine (Hcy). Thus, it regulates the intracellular
            S-adenosylhomocysteine (SAH) concentration thought to be important
            for transmethylation reactions. Deficiency in this protein is one
            of the different causes of hypermethioninemia. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.232100.1,
                                           SRR3476690.1038970.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217426.7/ ENSP00000217426.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1675              AK290422.1         1-1675
            1676-2148           AK097610.1         1883-2355
            2149-2150           AI057366.1         13-14               c
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..2150
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="adenosylhomocysteinase"
                     /db_xref="GeneID:191"
                     /db_xref="HGNC:HGNC:343"
                     /db_xref="MIM:180960"
     exon            1..113
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1384
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /EC_number="3.13.2.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     S-adenosylhomocysteine hydrolase;
                     S-adenosyl-L-homocysteine hydrolase; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="adenosylhomocysteinase isoform 1"
                     /protein_id="NP_000678.1"
                     /db_xref="CCDS:CCDS13233.1"
                     /db_xref="GeneID:191"
                     /db_xref="HGNC:HGNC:343"
                     /db_xref="MIM:180960"
                     /translation="MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKP
                     LKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAW
                     KGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTG
                     VHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVV
                     AGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTT
                     GCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGR
                     RIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDE
                     AVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY"
     exon            114..304
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            305..380
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            381..530
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            531..643
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            644..851
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            852..939
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1057
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1252
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..2150
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="hexamer: AATAAA"
     polyA_site      2150
                     /gene="AHCY"
                     /gene_synonym="adoHcyase; SAHH"
                     /note="major polyA site"
ORIGIN      
        1 ccctgctcgg cgctgcccgc ccagttcctg ttcccagact gaggcccagc ccccttcgcc
       61 cgtttccatc acgagtgccg ccagcatgtc tgacaaactg ccctacaaag tcgccgacat
      121 cggcctggct gcctggggac gcaaggccct ggacattgct gagaacgaga tgccgggcct
      181 gatgcgtatg cgggagcggt actcggcctc caagccactg aagggcgccc gcatcgctgg
      241 ctgcctgcac atgaccgtgg agacggccgt cctcattgag accctcgtca ccctgggtgc
      301 tgaggtgcag tggtccagct gcaacatctt ctccacccag gaccatgcgg cggctgccat
      361 tgccaaggct ggcattccgg tgtatgcctg gaagggcgaa acggacgagg agtacctgtg
      421 gtgcattgag cagaccctgt acttcaagga cgggcccctc aacatgattc tggacgacgg
      481 gggcgacctc accaacctca tccacaccaa gtacccgcag cttctgccag gcatccgagg
      541 catctctgag gagaccacga ctggggtcca caacctctac aagatgatgg ccaatgggat
      601 cctcaaggtg cctgccatca atgtcaatga ctccgtcacc aagagcaagt ttgacaacct
      661 ctatggctgc cgggagtccc tcatagatgg catcaagcgg gccacagatg tgatgattgc
      721 cggcaaggta gcggtggtag caggctatgg tgatgtgggc aagggctgtg cccaggccct
      781 gcggggtttc ggagcccgcg tcatcatcac cgagattgac cccatcaacg cactgcaggc
      841 tgccatggag ggctatgagg tgaccaccat ggatgaggcc tgtcaggagg gcaacatctt
      901 tgtcaccacc acaggctgta ttgacatcat ccttggccgg cactttgagc agatgaagga
      961 tgatgccatt gtgtgtaaca ttggacactt tgacgtggag atcgatgtca agtggctcaa
     1021 cgagaacgcc gtggagaagg tgaacatcaa gccgcaggtg gaccggtatc ggttgaagaa
     1081 tgggcgccgc atcatcctgc tggccgaggg tcggctggtc aacctgggtt gtgccatggg
     1141 ccaccccagc ttcgtgatga gtaactcctt caccaaccag gtgatggcgc agatcgagct
     1201 gtggacccat ccagacaagt accccgttgg ggttcatttc ctgcccaaga agctggatga
     1261 ggcagtggct gaagcccacc tgggcaagct gaatgtgaag ttgaccaagc taactgagaa
     1321 gcaagcccag tacctgggca tgtcctgtga tggccccttc aagccggatc actaccgcta
     1381 ctgagagcca ggtctgcgtt tcaccctcca gctgctgtcc ttgcccaggc cccacctctc
     1441 ctccctaaga gctaatggca ccaactttgt gattggtttg tcagtgtccc ccatcgactc
     1501 tctggggctg atcacttagt ttttggcctc tgctgcagcc gtcatactgt tccaaatgtg
     1561 gcagcgggaa cagagtaccc tcttcaagcc ccggtcatga tggaggtccc agccacaggg
     1621 aaccatgagc tcagtggtct tggaacagct cactaagtca gtccttcctt agcctggaag
     1681 tcagtagtgg agtcacaaag cccatgtgtt ttgccatcta ggccttcacc tggtctgtgg
     1741 acttatacct gtgtgcttgg tttacaggtc cagtggttct tcagcccatg acagatgaga
     1801 aggggctata ttgaagggca aagaggaact gttgtttgaa ttttcctgag agcctggctt
     1861 agtgctgggc cttctcttaa acctcattac aatgaggtta gtacttttag tccctgtttt
     1921 acaggggtta gaatagactg ttaaggggca actgagaaag aacagagaag tgacagctag
     1981 gggttgagag gggccagaaa aacatgaatg caggcagatt tcgtgaaatc tgccaccact
     2041 ttataaccag atggttcctt tcacaaccct gggtcaaaaa gagaataatt tggcctataa
     2101 tgttaaaaga aagcaggaag gtgggtaaat aaaaatcttg gtgcctggaa
//
