LOCUS       NM_020350               1130 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens angiotensin II receptor associated protein (AGTRAP),
            transcript variant 1, mRNA.
ACCESSION   NM_020350
VERSION     NM_020350.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1130)
  AUTHORS   Wang,D., Jin,X., Lei,M., Jiang,Y., Liu,Y., Yu,F., Guo,Y., Han,B.,
            Yang,Y., Sun,W., Liu,Y., Zeng,G., Liu,F., Hu,J. and Chen,X.
  TITLE     USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant
            Phenotype by Activating AKT/mTOR Signaling
  JOURNAL   Int J Biol Sci 18 (6), 2452-2471 (2022)
   PUBMED   35414770
  REMARK    GeneRIF: USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and
            Malignant Phenotype by Activating AKT/mTOR Signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1130)
  AUTHORS   Guo,T., Dai,Z., You,K., Battaglia-Hsu,S.F., Feng,J., Wang,F.,
            Li,B., Yang,J. and Li,Z.
  TITLE     S-adenosylmethionine upregulates the angiotensin receptor-binding
            protein ATRAP via the methylation of HuR in NAFLD
  JOURNAL   Cell Death Dis 12 (4), 306 (2021)
   PUBMED   33753727
  REMARK    GeneRIF: S-adenosylmethionine upregulates the angiotensin
            receptor-binding protein ATRAP via the methylation of HuR in NAFLD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1130)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1130)
  AUTHORS   Wakui,H.
  TITLE     The pathophysiological role of angiotensin receptor-binding protein
            in hypertension and kidney diseases: Oshima Award Address 2019
  JOURNAL   Clin Exp Nephrol 24 (4), 289-294 (2020)
   PUBMED   32112267
  REMARK    GeneRIF: The pathophysiological role of angiotensin
            receptor-binding protein in hypertension and kidney diseases:
            Oshima Award Address 2019.
            Review article
REFERENCE   5  (bases 1 to 1130)
  AUTHORS   Yamaji,T., Yamashita,A., Wakui,H., Azushima,K., Uneda,K.,
            Fujikawa,Y., Haku,S., Kobayashi,R., Ohki,K., Haruhara,K.,
            Kinguchi,S., Ishii,T., Yamada,T., Urate,S., Suzuki,T., Abe,E.,
            Tanaka,S., Kamimura,D., Ishigami,T., Toya,Y., Takahashi,H. and
            Tamura,K.
  TITLE     Angiotensin II type 1 receptor-associated protein deficiency
            attenuates sirtuin1 expression in an immortalised human renal
            proximal tubule cell line
  JOURNAL   Sci Rep 9 (1), 16550 (2019)
   PUBMED   31719572
  REMARK    GeneRIF: Angiotensin II type 1 receptor-associated protein
            deficiency attenuates sirtuin1 expression in an immortalised human
            renal proximal tubule cell line.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1130)
  AUTHORS   Lopez-Ilasaca,M., Liu,X., Tamura,K. and Dzau,V.J.
  TITLE     The angiotensin II type I receptor-associated protein, ATRAP, is a
            transmembrane protein and a modulator of angiotensin II signaling
  JOURNAL   Mol Biol Cell 14 (12), 5038-5050 (2003)
   PUBMED   12960423
REFERENCE   7  (bases 1 to 1130)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1130)
  AUTHORS   Wang,W., Huang,Y., Zhou,Z., Tang,R., Zhao,W., Zeng,L., Xu,M.,
            Cheng,C., Gu,S., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Identification and characterization of AGTRAP, a human homolog of
            murine Angiotensin II Receptor-Associated Protein (Agtrap)
  JOURNAL   Int J Biochem Cell Biol 34 (1), 93-102 (2002)
   PUBMED   11733189
  REMARK    GeneRIF: cloned a new human gene cDNA that codes for a homolog of
            the murine Agtrap protein
REFERENCE   9  (bases 1 to 1130)
  AUTHORS   Cui,T., Nakagami,H., Iwai,M., Takeda,Y., Shiuchi,T., Tamura,K.,
            Daviet,L. and Horiuchi,M.
  TITLE     ATRAP, novel AT1 receptor associated protein, enhances
            internalization of AT1 receptor and inhibits vascular smooth muscle
            cell growth
  JOURNAL   Biochem Biophys Res Commun 279 (3), 938-941 (2000)
   PUBMED   11162453
REFERENCE   10 (bases 1 to 1130)
  AUTHORS   Daviet,L., Lehtonen,J.Y., Tamura,K., Griese,D.P., Horiuchi,M. and
            Dzau,V.J.
  TITLE     Cloning and characterization of ATRAP, a novel protein that
            interacts with the angiotensin II type 1 receptor
  JOURNAL   J Biol Chem 274 (24), 17058-17062 (1999)
   PUBMED   10358057
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI117521.1, AF312374.1,
            BC017328.2, AI741916.1 and BQ672962.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020350.4.
            
            Summary: This gene encodes a transmembrane protein localized to the
            plasma membrane and perinuclear vesicular structures. The gene
            product interacts with the angiotensin II type I receptor and
            negatively regulates angiotensin II signaling. Alternative splicing
            of this gene generates multiple transcript variants encoding
            different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant represents the most common
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP355708.1, AK290042.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314340.10/ ENSP00000319713.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BI117521.1         24-42
            20-548              AF312374.1         2-530
            549-977             BC017328.2         517-945
            978-1069            AI741916.1         65-156              c
            1070-1130           BQ672962.1         605-665
FEATURES             Location/Qualifiers
     source          1..1130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..1130
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /note="angiotensin II receptor associated protein"
                     /db_xref="GeneID:57085"
                     /db_xref="HGNC:HGNC:13539"
                     /db_xref="MIM:608729"
     exon            1..100
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..553
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /note="isoform a is encoded by transcript variant 1;
                     angiotensin II, type I receptor-associated protein; ATI
                     receptor-associated protein; type-1 angiotensin II
                     receptor-associated protein; AT1 receptor-associated
                     protein"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor-associated
                     protein isoform a"
                     /protein_id="NP_065083.3"
                     /db_xref="CCDS:CCDS136.1"
                     /db_xref="GeneID:57085"
                     /db_xref="HGNC:HGNC:13539"
                     /db_xref="MIM:608729"
                     /translation="MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWA
                     VAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLS
                     CCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY"
     exon            101..135
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            136..241
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            242..437
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            438..1130
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /note="hexamer: ATTAAA"
     polyA_site      1130
                     /gene="AGTRAP"
                     /gene_synonym="ATRAP"
                     /note="major polyA site"
ORIGIN      
        1 aagtttgttc cccgagttcg gagcctagga gccccccgcg gctgcggcgc aggtgccctc
       61 ggcctgagtc gggatggagc tgcctgctgt gaacctgaag gtgattctcc taggtcactg
      121 gctgctgaca acctggggct gcattgtatt ctcaggctcc tatgcctggg ccaacttcac
      181 catcctggcc ttgggcgtgt gggctgtggc tcagcgggac tccatcgacg ccataagcat
      241 gtttctgggt ggcttgctgg ccaccatctt cctggacatc gtgcacatca gcatcttcta
      301 cccgcgggtc agcctcacgg acacgggccg ctttggcgtg ggcatggcca tcctcagctt
      361 gctgctcaag ccgctctcct gctgcttcgt ctaccacatg taccgggagc gcgggggtga
      421 gctcctggtc cacactggtt tccttgggtc ttctcaggac cgtagtgcct accagacgat
      481 tgactcagca gaggcgcccg cagatccctt tgcagtccca gagggcagga gtcaagatgc
      541 ccgagggtac tgaagccagc cacgctgcgc ccggccctgc cccgggcctt cctcgtgcct
      601 gggaggtcgt tctagggatg ctcctgacct ccgtctcttg gacctaagat ggaatgtgtc
      661 cccagctcag ggattgcctg aaccaagagg ccaggagccc ccatgggccg cccagtacca
      721 tgcacactcc tgtcccgaac tccctgaggc ctcccctccc ttcagggcac ccactggttc
      781 ccaggctgga accagggtct ctctttacct cctaccccat ggtggcacca cagaggccct
      841 cagccgagtc ctgcctgagt gttgcaagct caggccttta aggactgctg atgccccctc
      901 aggcctcccc caagtttgct gggctttggt ggaagccctg agagcttcag gtcctgctca
      961 gcccgaggag cagtctggca tgggagtgag gccccgtcct tctcactgcc tggtcacatg
     1021 gtgcctaggg atgcagggct ggaggccaga ggtgtcagca acactgtgtc ccaccacaac
     1081 ctccagcctc ccttttcaga gcacagcatt aaagtttggg gaattctgta
//
