LOCUS       NM_000686               2862 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens angiotensin II receptor type 2 (AGTR2), transcript
            variant 1, mRNA.
ACCESSION   NM_000686
VERSION     NM_000686.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Clark,C.R. and Khalil,R.A.
  TITLE     Regulation of vascular angiotensin II type 1 and type 2 receptor
            and angiotensin-(1-7)/MasR signaling in normal and hypertensive
            pregnancy
  JOURNAL   Biochem Pharmacol 220, 115963 (2024)
   PUBMED   38061417
  REMARK    GeneRIF: Regulation of vascular angiotensin II type 1 and type 2
            receptor and angiotensin-(1-7)/MasR signaling in normal and
            hypertensive pregnancy.
            Review article
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Schwartz,K.S., Lang,J.A. and Stanhewicz,A.E.
  TITLE     Angiotensin II type 2 receptor-mediated dilation is greater in the
            cutaneous microvasculature of premenopausal women compared with men
  JOURNAL   J Appl Physiol (1985) 135 (6), 1236-1242 (2023)
   PUBMED   37823205
  REMARK    GeneRIF: Angiotensin II type 2 receptor-mediated dilation is
            greater in the cutaneous microvasculature of premenopausal women
            compared with men.
            Erratum:[J Appl Physiol (1985). 2024 Feb 1;136(2):399. doi:
            10.1152/japplphysiol.00382.2023_COR.. PMID: 38324362]
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Wang,L., Rossi,R.M., Chen,X., Chen,J., Runyon,J., Chawla,M.,
            Miller,D., Forney,C., Lynch,A., Zhang,X., Kong,F., Jacobsson,B.,
            Kottyan,L.C., Weirauch,M.T., Zhang,G. and Muglia,L.J.
  TITLE     A functional mechanism for a non-coding variant near AGTR2
            associated with risk for preterm birth
  JOURNAL   BMC Med 21 (1), 258 (2023)
   PUBMED   37455310
  REMARK    GeneRIF: A functional mechanism for a non-coding variant near AGTR2
            associated with risk for preterm birth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Liu,J., Jin,B., Lu,J., Feng,Y., Li,N., Wan,C., Zhang,Q.Y. and
            Jiang,C.M.
  TITLE     Angiotensin II type 2 receptor prevents extracellular matrix
            accumulation in human peritoneal mesothelial cell by ameliorating
            lipid disorder via LOX-1 suppression
  JOURNAL   Ren Fail 44 (1), 1687-1697 (2022)
   PUBMED   36226438
  REMARK    GeneRIF: Angiotensin II type 2 receptor prevents extracellular
            matrix accumulation in human peritoneal mesothelial cell by
            ameliorating lipid disorder via LOX-1 suppression.
REFERENCE   5  (bases 1 to 2862)
  AUTHORS   Jevnikar,K., Lapajne,L., Petrovic,D., Meglic,A., Logar,M., Vidovic
            Valentincic,N., Globocnik Petrovic,M., Cilensek,I. and
            Mekjavic,P.J.
  TITLE     The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19 Severity
            and the Presence of COVID-19-Related Retinopathy
  JOURNAL   Genes (Basel) 13 (7), 1111 (2022)
   PUBMED   35885894
  REMARK    GeneRIF: The Role of ACE, ACE2, and AGTR2 Polymorphisms in COVID-19
            Severity and the Presence of COVID-19-Related Retinopathy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2862)
  AUTHORS   Ichiki,T., Labosky,P.A., Shiota,C., Okuyama,S., Imagawa,Y.,
            Fogo,A., Niimura,F., Ichikawa,I., Hogan,B.L. and Inagami,T.
  TITLE     Effects on blood pressure and exploratory behaviour of mice lacking
            angiotensin II type-2 receptor
  JOURNAL   Nature 377 (6551), 748-750 (1995)
   PUBMED   7477267
REFERENCE   7  (bases 1 to 2862)
  AUTHORS   Hein,L., Barsh,G.S., Pratt,R.E., Dzau,V.J. and Kobilka,B.K.
  TITLE     Behavioural and cardiovascular effects of disrupting the
            angiotensin II type-2 receptor in mice
  JOURNAL   Nature 377 (6551), 744-747 (1995)
   PUBMED   7477266
  REMARK    Erratum:[Nature 1996 Mar 28;380(6572):366]
REFERENCE   8  (bases 1 to 2862)
  AUTHORS   Lazard,D., Briend-Sutren,M.M., Villageois,P., Mattei,M.G.,
            Strosberg,A.D. and Nahmias,C.
  TITLE     Molecular characterization and chromosome localization of a human
            angiotensin II AT2 receptor gene highly expressed in fetal tissues
  JOURNAL   Recept Channels 2 (4), 271-280 (1994)
   PUBMED   7719706
REFERENCE   9  (bases 1 to 2862)
  AUTHORS   Takayanagi,R., Ohnaka,K., Sakai,Y., Nakao,R., Yanase,T., Haji,M.,
            Inagami,T., Furuta,H., Gou,D.F., Nakamuta,M. et al.
  TITLE     Molecular cloning, sequence analysis and expression of a cDNA
            encoding human type-1 angiotensin II receptor
  JOURNAL   Biochem Biophys Res Commun 183 (2), 910-916 (1992)
   PUBMED   1550596
REFERENCE   10 (bases 1 to 2862)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA538369.1, CR738498.1,
            U16957.1, BC095504.1, AL732602.5 and AI911273.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000686.4.
            
            Summary: The protein encoded by this gene belongs to the G-protein
            coupled receptor 1 family, and functions as a receptor for
            angiotensin II. It is an intergral membrane protein that is highly
            expressed in fetus and in neonates, but scantily in adult tissues,
            except brain, adrenal medulla, and atretic ovary. This receptor has
            been shown to mediate programmed cell death and this apoptotic
            function may play an important role in developmental biology and
            pathophysiology. Mutations in this gene are been associated with
            X-linked cognitive disability. Severe Acute Respiratory Syndrome
            Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in
            down-regulation of angiotensin converting enzyme-2 (ACE2)
            receptors, the effects of which, triggers serious inflammatory
            lesions in the tissues involved, primarily in the lungs. The
            inflammatory reaction appears to be mediated by angiotensin II
            derivatives, including the angiotensin AT2 receptor which has been
            found to be upregulated in bronchoalveolar lavage samples from
            Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq,
            Jul 2020].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA537585.1, SRR1660803.233098.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for disease process
            MANE Ensembl match     :: ENST00000371906.5/ ENSP00000360973.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA538369.1         42-42
            2-37                CR738498.1         9-44
            38-971              U16957.1           10-943
            972-1318            BC095504.1         1272-1618
            1319-2853           AL732602.5         129301-130835
            2854-2860           AI911273.1         8-14                c
            2861-2862           AL732602.5         130843-130844
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..2862
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /note="angiotensin II receptor type 2"
                     /db_xref="GeneID:186"
                     /db_xref="HGNC:HGNC:338"
                     /db_xref="MIM:300034"
     exon            1..73
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /inference="alignment:Splign:2.1.0"
     exon            74..133
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /inference="alignment:Splign:2.1.0"
     exon            134..2862
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1260
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /note="isoform 1 is encoded by transcript variant 1;
                     type-2 angiotensin II receptor; angiotensin II type-2
                     receptor; AT2 receptor"
                     /codon_start=1
                     /product="type-2 angiotensin II receptor isoform 1"
                     /protein_id="NP_000677.2"
                     /db_xref="CCDS:CCDS14569.1"
                     /db_xref="GeneID:186"
                     /db_xref="HGNC:HGNC:338"
                     /db_xref="MIM:300034"
                     /translation="MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHL
                     DAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWAT
                     YYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQA
                     SYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNIL
                     GFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLT
                     FLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
                     VPITWLQGKRESMSCRKSSSLREMETFVS"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /note="hexamer: AATAAA"
     polyA_site      2862
                     /gene="AGTR2"
                     /gene_synonym="AT2; ATGR2; MRX88"
                     /note="major polyA site"
ORIGIN      
        1 gctattacgt cccagcgtct gagagaacga gtaagcacag aattcaaagc attctgcagc
       61 ctgaattttg aaggagtgtg tttaggcact aagcaagctg atttatgata actgctttaa
      121 acttcaacaa ccaaaggcat aagaactagg agctgctgac atttcaatat gaagggcaac
      181 tccacccttg ccactactag caaaaacatt accagcggtc ttcacttcgg gcttgtgaac
      241 atctctggca acaatgagtc taccttgaac tgttcacaga aaccatcaga taagcattta
      301 gatgcaattc ctattcttta ctacattata tttgtaattg gatttctggt caatattgtc
      361 gtggttacac tgttttgttg tcaaaagggt cctaaaaagg tttctagcat atacatcttc
      421 aacctcgctg tggctgattt actccttttg gctactcttc ctctatgggc aacctattat
      481 tcttatagat atgactggct ctttggacct gtgatgtgca aagtttttgg ttcttttctt
      541 accctgaaca tgtttgcaag catttttttt atcacctgca tgagtgttga taggtaccaa
      601 tctgtcatct acccctttct gtctcaaaga agaaatccct ggcaagcatc ttatatagtt
      661 ccccttgttt ggtgtatggc ctgtttgtcc tcattgccaa cattttattt tcgagacgtc
      721 agaaccattg aatacttagg agtgaatgct tgcattatgg ctttcccacc tgagaaatat
      781 gcccaatggt cagctgggat tgccttaatg aaaaatatcc ttggttttat tatcccttta
      841 atattcatag caacatgcta ttttggaatt agaaaacact tactgaagac gaatagctat
      901 gggaagaaca ggataacccg tgaccaagtc ctgaagatgg cagctgctgt tgttctggcc
      961 ttcatcattt gctggcttcc cttccatgtt ctgaccttcc tggatgctct ggcctggatg
     1021 ggtgtcatta atagctgcga agttatagca gtcattgacc tggcacttcc ttttgccatc
     1081 ctcttgggat tcaccaacag ctgcgttaat ccgtttctgt attgttttgt tggaaaccgg
     1141 ttccaacaga agctccgcag tgtgtttagg gttccaatta cttggctcca agggaaaaga
     1201 gagagtatgt cttgccggaa aagcagttct cttagagaaa tggagacctt tgtgtcttaa
     1261 acgtgagagc aaaatgcatg taatcaacat ggctacttgc tttgaggctc accagaatta
     1321 tttttaagtg gttttaataa aataataaaa tttcccctaa tcttttctga atcttctgaa
     1381 accaaatgta actatgtttt atcgtccagt gactttcagg aattgcccat tgtttttctg
     1441 atatgtttgt acaagattgt cattagtgag acatatttac aacctagaag taactggtga
     1501 tatatctcaa attgtaatta ataatagatt gtgaataatg atttggggat tcagatttct
     1561 ctttgaaaca tgcttgtgtt tcttagtggg gttttatatc catttttatc aggatttcct
     1621 cttgaaccag aaccagtctt tcaactcatt gcatcattta caagacaaca ttgtaagaga
     1681 gatgagcact tctaagttga gtatattata atagattagt actggattat tcaggcttta
     1741 ggcatatgct tctttaaaaa agctataaat tatattcctc ttgcatttca cttgagtgga
     1801 ggtttatagt taatctataa ctacatattg aatagggcta ggaatataga ttaaatcata
     1861 ctcctatgct ttagcttatt tttacagtta tagaaagcaa gatgtactat aacatagaat
     1921 tgcaatctat aatatttgtg tgttcactaa actctgaata agcacttttt aaaaaacttt
     1981 ctactcattt taatgattgt ttaaaggttt ctattttctc tgatactttt ttgaaatcag
     2041 taaacactgt gtattgttgt aaaatgtaaa ggtcactttt cacatccttg actttttaga
     2101 tgtgctgctt tgatatatag gacattgatt tgatttttat tattaatgct ttggttctgg
     2161 gttgtttcct aaaatatctg ggtggcttaa aaaaaactct ttaacttgta ataaaccctt
     2221 aactggcata ggaaatggta tccagaatgg aattttgcta catggggtct gggtgggggc
     2281 aaagagaccc agtcaattac atgtttggta ccaagaaagg aacctgtcag ggcagtacaa
     2341 tgtgactttg aaaatatata ccgtgggggt agttttaccc tatatctata aacactgttt
     2401 gttccagaat ctgtatgatt ctatggagct attttaaacc aattgcaggt ctagatacct
     2461 ccttctcagc actattaaag ctcctaagtt agaggagtgc ctaaaactga gttacctaaa
     2521 gtttacttac attaaagtat gaatattaat tttagaaatt tgagacttta ttctgtacca
     2581 gccctgtata ataacaggtt atctaggacc ttcctctgag gtaggtctaa atactgatct
     2641 ctgaggcgga actaacgttt tggggactca gcatctctgc caggttccag gattatagac
     2701 agaagagtcc tgtcatacca ctttctggaa aagtcctaat ttcatgtaat ccttttattt
     2761 tcaataaaaa caaatagcta aatgtataac caactatgat gttatgtttt caataatttt
     2821 gtaaaacagc tcatataaat aaaattttta attggaagaa ca
//
