LOCUS       NM_009585               2240 bp    mRNA    linear   PRI 03-DEC-2024
DEFINITION  Homo sapiens angiotensin II receptor type 1 (AGTR1), transcript
            variant 2, mRNA.
ACCESSION   NM_009585
VERSION     NM_009585.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Tchio,C., Heydarpour,M., Pojoga,L., Taylor,H., Williams,G.,
            Williams,J.S. and Seely,E.W.
  TITLE     AGTR1 variant rs2638355 is associated with increased salt
            sensitivity of blood pressure: a female-specific effect in
            individuals from the HyperPath cohort
  JOURNAL   J Hypertens 42 (12), 2180-2186 (2024)
   PUBMED   39288250
  REMARK    GeneRIF: AGTR1 variant rs2638355 is associated with increased salt
            sensitivity of blood pressure: a female-specific effect in
            individuals from the HyperPath cohort.
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Liu,J.Y., Yi,Y.Z., Guo,Q.W., Jia,K.X., Li,X.C., Cai,J.J.,
            Shen,Y.L., Su,G.M., Chen,X., Zhang,X.Y., Fang,D.Z., Hong,H. and
            Lin,J.
  TITLE     Associations of ACE I/D and AGTR1 rs5182 polymorphisms with
            diabetes and their effects on lipids in an elderly Chinese
            population
  JOURNAL   Lipids Health Dis 23 (1), 231 (2024)
   PUBMED   39080710
  REMARK    GeneRIF: Associations of ACE I/D and AGTR1 rs5182 polymorphisms
            with diabetes and their effects on lipids in an elderly Chinese
            population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Ihsan,M., Khan,N.U., Asim,N., Ismail,M., Almutairi,M.H., Ali,I. and
            Adams,B.D.
  TITLE     Significant Association of Candidate Genes (AGTR1 and TGF-Beta1)
            Polymorphism with Diabetic Nephropathy in Diabetes Mellitus Type 2
            Patients
  JOURNAL   Cell Physiol Biochem 58 (3), 203-211 (2024)
   PUBMED   38852191
  REMARK    GeneRIF: Significant Association of Candidate Genes (AGTR1 and
            TGF-Beta1) Polymorphism with Diabetic Nephropathy in Diabetes
            Mellitus Type 2 Patients.
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Forrester,S.J., Booz,G.W., Sigmund,C.D., Coffman,T.M., Kawai,T.,
            Rizzo,V., Scalia,R. and Eguchi,S.
  TITLE     Angiotensin II Signal Transduction: An Update on Mechanisms of
            Physiology and Pathophysiology
  JOURNAL   Physiol Rev 98 (3), 1627-1738 (2018)
   PUBMED   29873596
  REMARK    Review article
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Kawai,T., Forrester,S.J., O'Brien,S., Baggett,A., Rizzo,V. and
            Eguchi,S.
  TITLE     AT1 receptor signaling pathways in the cardiovascular system
  JOURNAL   Pharmacol Res 125 (Pt A), 4-13 (2017)
   PUBMED   28527699
  REMARK    Review article
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Takezako,T., Unal,H., Karnik,S.S. and Node,K.
  TITLE     Current topics in angiotensin II type 1 receptor research: Focus on
            inverse agonism, receptor dimerization and biased agonism
  JOURNAL   Pharmacol Res 123, 40-50 (2017)
   PUBMED   28648738
  REMARK    Review article
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Martin,M.M., Willardson,B.M., Burton,G.F., White,C.R.,
            McLaughlin,J.N., Bray,S.M., Ogilvie,J.W. Jr. and Elton,T.S.
  TITLE     Human angiotensin II type 1 receptor isoforms encoded by messenger
            RNA splice variants are functionally distinct
  JOURNAL   Mol Endocrinol 15 (2), 281-293 (2001)
   PUBMED   11158334
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Guo,D.F., Furuta,H., Mizukoshi,M. and Inagami,T.
  TITLE     The genomic organization of human angiotensin II type 1 receptor
  JOURNAL   Biochem Biophys Res Commun 200 (1), 313-319 (1994)
   PUBMED   8166699
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Mauzy,C.A., Hwang,O., Egloff,A.M., Wu,L.H. and Chung,F.Z.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Curnow,K.M., Pascoe,L. and White,P.C.
  TITLE     Genetic analysis of the human type-1 angiotensin II receptor
  JOURNAL   Mol Endocrinol 6 (7), 1113-1118 (1992)
   PUBMED   1508224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024897.23.
            
            On May 20, 2020 this sequence version replaced NM_009585.3.
            
            Summary: Angiotensin II is a potent vasopressor hormone and a
            primary regulator of aldosterone secretion. It is an important
            effector controlling blood pressure and volume in the
            cardiovascular system. It acts through at least two types of
            receptors. This gene encodes the type 1 receptor which is thought
            to mediate the major cardiovascular effects of angiotensin II. This
            gene may play a role in the generation of reperfusion arrhythmias
            following restoration of blood flow to ischemic or infarcted
            myocardium. It was previously thought that a related gene, denoted
            as AGTR1B, existed; however, it is now believed that there is only
            one type 1 receptor gene in humans. Alternative splicing of this
            gene results in multiple transcript variants. [provided by RefSeq,
            Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022447.1, X65699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC024897.23        151303-151527       c
            226-2240            AC024897.23        106427-108441       c
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2240
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="angiotensin II receptor type 1"
                     /db_xref="GeneID:185"
                     /db_xref="HGNC:HGNC:336"
                     /db_xref="MIM:106165"
     exon            1..225
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            226..2240
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1352
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="type-1B angiotensin II receptor; AT1 receptor"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor"
                     /protein_id="NP_033611.1"
                     /db_xref="CCDS:CCDS3137.1"
                     /db_xref="GeneID:185"
                     /db_xref="HGNC:HGNC:336"
                     /db_xref="MIM:106165"
                     /translation="MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIF
                     GNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCK
                     IASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLAS
                     LPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLI
                     WKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRI
                     ADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKM
                     STLSYRPSDNVSSSTKKPAPCFEVE"
     regulatory      2220..2225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="hexamer: AATAAA"
     polyA_site      2240
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="major polyA site"
ORIGIN      
        1 attccagcgc ctgacagcca ggaccccagg cagcagcgag tgacaggacg tctggaccgg
       61 cgcgccgcta gcagctctgc cgggccgcgg cggtgatcga tggggagcgg ctggagcgga
      121 cccagcgagt gagggcgcac agccgggacg ccgaggcggc gggcgggaga cccgcaccag
      181 cgcagccggc cctcggcggg acgtgacgca gcgcccgggg cgcgggtgta tttgatatag
      241 tgtttgcaac aaattcgacc caggtgatca aaatgattct caactcttct actgaagatg
      301 gtattaaaag aatccaagat gattgtccca aagctggaag gcataattac atatttgtca
      361 tgattcctac tttatacagt atcatctttg tggtgggaat atttggaaac agcttggtgg
      421 tgatagtcat ttacttttat atgaagctga agactgtggc cagtgttttt cttttgaatt
      481 tagcactggc tgacttatgc tttttactga ctttgccact atgggctgtc tacacagcta
      541 tggaataccg ctggcccttt ggcaattacc tatgtaagat tgcttcagcc agcgtcagtt
      601 tcaacctgta cgctagtgtg tttctactca cgtgtctcag cattgatcga tacctggcta
      661 ttgttcaccc aatgaagtcc cgccttcgac gcacaatgct tgtagccaaa gtcacctgca
      721 tcatcatttg gctgctggca ggcttggcca gtttgccagc tataatccat cgaaatgtat
      781 ttttcattga gaacaccaat attacagttt gtgctttcca ttatgagtcc caaaattcaa
      841 ccctcccgat agggctgggc ctgaccaaaa atatactggg tttcctgttt ccttttctga
      901 tcattcttac aagttatact cttatttgga aggccctaaa gaaggcttat gaaattcaga
      961 agaacaaacc aagaaatgat gatattttta agataattat ggcaattgtg cttttctttt
     1021 tcttttcctg gattccccac caaatattca cttttctgga tgtattgatt caactaggca
     1081 tcatacgtga ctgtagaatt gcagatattg tggacacggc catgcctatc accatttgta
     1141 tagcttattt taacaattgc ctgaatcctc ttttttatgg ctttctgggg aaaaaattta
     1201 aaagatattt tctccagctt ctaaaatata ttcccccaaa agccaaatcc cactcaaacc
     1261 tttcaacaaa aatgagcacg ctttcctacc gcccctcaga taatgtaagc tcatccacca
     1321 agaagcctgc accatgtttt gaggttgagt gacatgttcg aaacctgtcc ataaagtaat
     1381 tttgtgaaag aaggagcaag agaacattcc tctgcagcac ttcactacca aatgagcatt
     1441 agctactttt cagaattgaa ggagaaaatg cattatgtgg actgaaccga cttttctaaa
     1501 gctctgaaca aaagcttttc tttccttttg caacaagaca aagcaaagcc acattttgca
     1561 ttagacagat gacggctgct cgaagaacaa tgtcagaaac tcgatgaatg tgttgatttg
     1621 agaaatttta ctgacagaaa tgcaatctcc ctagcctgct tttgtcctgt tattttttat
     1681 ttccacataa aggtatttag aatatattaa atcgttagag gagcaacagg agatgagagt
     1741 tccagattgt tctgtccagt ttccaaaggg cagtaaagtt ttcgtgccgg ttttcagcta
     1801 ttagcaactg tgctacactt gcacctggta ctgcacattt tgtacaaaga tatgctaagc
     1861 agtagtcgtc aagttgcaga tctttttgtg aaattcaacc tgtgtcttat aggtttccac
     1921 tgccaaaaca atgcccgtaa gatggcttat ttgtataatg gtgttactaa agtcacatat
     1981 aaaagttaaa ctacttgtaa aggtgctgca ctggtcccaa gtagtagtgt cttcctagta
     2041 tattagtttg atttaatatc tgagaagtgt atatagtttg tggtaaaaag attatatatc
     2101 ataaagtatg ccttcctgtt taaaaaaagt atatattcta cacatatatg tatatgtata
     2161 tctatatctc taaactgctg ttaattgatt aaaatctggc aaagttatat ttactttaaa
     2221 ataaaataat tttattgcaa
//
