LOCUS       NM_000685               2324 bp    mRNA    linear   PRI 03-DEC-2024
DEFINITION  Homo sapiens angiotensin II receptor type 1 (AGTR1), transcript
            variant 1, mRNA.
ACCESSION   NM_000685
VERSION     NM_000685.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Tchio,C., Heydarpour,M., Pojoga,L., Taylor,H., Williams,G.,
            Williams,J.S. and Seely,E.W.
  TITLE     AGTR1 variant rs2638355 is associated with increased salt
            sensitivity of blood pressure: a female-specific effect in
            individuals from the HyperPath cohort
  JOURNAL   J Hypertens 42 (12), 2180-2186 (2024)
   PUBMED   39288250
  REMARK    GeneRIF: AGTR1 variant rs2638355 is associated with increased salt
            sensitivity of blood pressure: a female-specific effect in
            individuals from the HyperPath cohort.
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Liu,J.Y., Yi,Y.Z., Guo,Q.W., Jia,K.X., Li,X.C., Cai,J.J.,
            Shen,Y.L., Su,G.M., Chen,X., Zhang,X.Y., Fang,D.Z., Hong,H. and
            Lin,J.
  TITLE     Associations of ACE I/D and AGTR1 rs5182 polymorphisms with
            diabetes and their effects on lipids in an elderly Chinese
            population
  JOURNAL   Lipids Health Dis 23 (1), 231 (2024)
   PUBMED   39080710
  REMARK    GeneRIF: Associations of ACE I/D and AGTR1 rs5182 polymorphisms
            with diabetes and their effects on lipids in an elderly Chinese
            population.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Ihsan,M., Khan,N.U., Asim,N., Ismail,M., Almutairi,M.H., Ali,I. and
            Adams,B.D.
  TITLE     Significant Association of Candidate Genes (AGTR1 and TGF-Beta1)
            Polymorphism with Diabetic Nephropathy in Diabetes Mellitus Type 2
            Patients
  JOURNAL   Cell Physiol Biochem 58 (3), 203-211 (2024)
   PUBMED   38852191
  REMARK    GeneRIF: Significant Association of Candidate Genes (AGTR1 and
            TGF-Beta1) Polymorphism with Diabetic Nephropathy in Diabetes
            Mellitus Type 2 Patients.
REFERENCE   4  (bases 1 to 2324)
  AUTHORS   Forrester,S.J., Booz,G.W., Sigmund,C.D., Coffman,T.M., Kawai,T.,
            Rizzo,V., Scalia,R. and Eguchi,S.
  TITLE     Angiotensin II Signal Transduction: An Update on Mechanisms of
            Physiology and Pathophysiology
  JOURNAL   Physiol Rev 98 (3), 1627-1738 (2018)
   PUBMED   29873596
  REMARK    Review article
REFERENCE   5  (bases 1 to 2324)
  AUTHORS   Kawai,T., Forrester,S.J., O'Brien,S., Baggett,A., Rizzo,V. and
            Eguchi,S.
  TITLE     AT1 receptor signaling pathways in the cardiovascular system
  JOURNAL   Pharmacol Res 125 (Pt A), 4-13 (2017)
   PUBMED   28527699
  REMARK    Review article
REFERENCE   6  (bases 1 to 2324)
  AUTHORS   Takezako,T., Unal,H., Karnik,S.S. and Node,K.
  TITLE     Current topics in angiotensin II type 1 receptor research: Focus on
            inverse agonism, receptor dimerization and biased agonism
  JOURNAL   Pharmacol Res 123, 40-50 (2017)
   PUBMED   28648738
  REMARK    Review article
REFERENCE   7  (bases 1 to 2324)
  AUTHORS   Martin,M.M., Willardson,B.M., Burton,G.F., White,C.R.,
            McLaughlin,J.N., Bray,S.M., Ogilvie,J.W. Jr. and Elton,T.S.
  TITLE     Human angiotensin II type 1 receptor isoforms encoded by messenger
            RNA splice variants are functionally distinct
  JOURNAL   Mol Endocrinol 15 (2), 281-293 (2001)
   PUBMED   11158334
REFERENCE   8  (bases 1 to 2324)
  AUTHORS   Guo,D.F., Furuta,H., Mizukoshi,M. and Inagami,T.
  TITLE     The genomic organization of human angiotensin II type 1 receptor
  JOURNAL   Biochem Biophys Res Commun 200 (1), 313-319 (1994)
   PUBMED   8166699
REFERENCE   9  (bases 1 to 2324)
  AUTHORS   Mauzy,C.A., Hwang,O., Egloff,A.M., Wu,L.H. and Chung,F.Z.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   10 (bases 1 to 2324)
  AUTHORS   Curnow,K.M., Pascoe,L. and White,P.C.
  TITLE     Genetic analysis of the human type-1 angiotensin II receptor
  JOURNAL   Mol Endocrinol 6 (7), 1113-1118 (1992)
   PUBMED   1508224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024897.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 10, 2020 this sequence version replaced NM_000685.4.
            
            Summary: Angiotensin II is a potent vasopressor hormone and a
            primary regulator of aldosterone secretion. It is an important
            effector controlling blood pressure and volume in the
            cardiovascular system. It acts through at least two types of
            receptors. This gene encodes the type 1 receptor which is thought
            to mediate the major cardiovascular effects of angiotensin II. This
            gene may play a role in the generation of reperfusion arrhythmias
            following restoration of blood flow to ischemic or infarcted
            myocardium. It was previously thought that a related gene, denoted
            as AGTR1B, existed; however, it is now believed that there is only
            one type 1 receptor gene in humans. Alternative splicing of this
            gene results in multiple transcript variants. [provided by RefSeq,
            Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068494.1, S77410.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349243.8/ ENSP00000273430.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            regulatory uORF        :: PMID: 16504375
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC024897.23        151303-151527       c
            226-309             AC024897.23        141403-141486       c
            310-2324            AC024897.23        106427-108441       c
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..2324
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="angiotensin II receptor type 1"
                     /db_xref="GeneID:185"
                     /db_xref="HGNC:HGNC:336"
                     /db_xref="MIM:106165"
     exon            1..225
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            226..309
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      253..276
                     /regulatory_class="uORF"
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16504375]"
                     /note="this uORF is predicted to encode a 7 aa peptide
                     (PMID:16504375)"
     regulatory      284..319
                     /regulatory_class="uORF"
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16504375]"
                     /note="this uORF is predicted to encode a 11 aa peptide
                     (PMID:16504375)"
     exon            310..2324
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="hexamer: AATAAA"
     polyA_site      2324
                     /gene="AGTR1"
                     /gene_synonym="AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR;
                     AT1R; AT2R1; ATR1; HAT1R"
                     /note="major polyA site"
ORIGIN      
        1 attccagcgc ctgacagcca ggaccccagg cagcagcgag tgacaggacg tctggaccgg
       61 cgcgccgcta gcagctctgc cgggccgcgg cggtgatcga tggggagcgg ctggagcgga
      121 cccagcgagt gagggcgcac agccgggacg ccgaggcggc gggcgggaga cccgcaccag
      181 cgcagccggc cctcggcggg acgtgacgca gcgcccgggg cgcgggtttg atatttgaca
      241 aattgatcta aaatggctgg gtttttatct gaataactca ctgatgccat cccagaaagt
      301 cggcaccagg tgtatttgat atagtgtttg caacaaattc gacccaggtg atcaaaatga
      361 ttctcaactc ttctactgaa gatggtatta aaagaatcca agatgattgt cccaaagctg
      421 gaaggcataa ttacatattt gtcatgattc ctactttata cagtatcatc tttgtggtgg
      481 gaatatttgg aaacagcttg gtggtgatag tcatttactt ttatatgaag ctgaagactg
      541 tggccagtgt ttttcttttg aatttagcac tggctgactt atgcttttta ctgactttgc
      601 cactatgggc tgtctacaca gctatggaat accgctggcc ctttggcaat tacctatgta
      661 agattgcttc agccagcgtc agtttcaacc tgtacgctag tgtgtttcta ctcacgtgtc
      721 tcagcattga tcgatacctg gctattgttc acccaatgaa gtcccgcctt cgacgcacaa
      781 tgcttgtagc caaagtcacc tgcatcatca tttggctgct ggcaggcttg gccagtttgc
      841 cagctataat ccatcgaaat gtatttttca ttgagaacac caatattaca gtttgtgctt
      901 tccattatga gtcccaaaat tcaaccctcc cgatagggct gggcctgacc aaaaatatac
      961 tgggtttcct gtttcctttt ctgatcattc ttacaagtta tactcttatt tggaaggccc
     1021 taaagaaggc ttatgaaatt cagaagaaca aaccaagaaa tgatgatatt tttaagataa
     1081 ttatggcaat tgtgcttttc tttttctttt cctggattcc ccaccaaata ttcacttttc
     1141 tggatgtatt gattcaacta ggcatcatac gtgactgtag aattgcagat attgtggaca
     1201 cggccatgcc tatcaccatt tgtatagctt attttaacaa ttgcctgaat cctctttttt
     1261 atggctttct ggggaaaaaa tttaaaagat attttctcca gcttctaaaa tatattcccc
     1321 caaaagccaa atcccactca aacctttcaa caaaaatgag cacgctttcc taccgcccct
     1381 cagataatgt aagctcatcc accaagaagc ctgcaccatg ttttgaggtt gagtgacatg
     1441 ttcgaaacct gtccataaag taattttgtg aaagaaggag caagagaaca ttcctctgca
     1501 gcacttcact accaaatgag cattagctac ttttcagaat tgaaggagaa aatgcattat
     1561 gtggactgaa ccgacttttc taaagctctg aacaaaagct tttctttcct tttgcaacaa
     1621 gacaaagcaa agccacattt tgcattagac agatgacggc tgctcgaaga acaatgtcag
     1681 aaactcgatg aatgtgttga tttgagaaat tttactgaca gaaatgcaat ctccctagcc
     1741 tgcttttgtc ctgttatttt ttatttccac ataaaggtat ttagaatata ttaaatcgtt
     1801 agaggagcaa caggagatga gagttccaga ttgttctgtc cagtttccaa agggcagtaa
     1861 agttttcgtg ccggttttca gctattagca actgtgctac acttgcacct ggtactgcac
     1921 attttgtaca aagatatgct aagcagtagt cgtcaagttg cagatctttt tgtgaaattc
     1981 aacctgtgtc ttataggttt ccactgccaa aacaatgccc gtaagatggc ttatttgtat
     2041 aatggtgtta ctaaagtcac atataaaagt taaactactt gtaaaggtgc tgcactggtc
     2101 ccaagtagta gtgtcttcct agtatattag tttgatttaa tatctgagaa gtgtatatag
     2161 tttgtggtaa aaagattata tatcataaag tatgccttcc tgtttaaaaa aagtatatat
     2221 tctacacata tatgtatatg tatatctata tctctaaact gctgttaatt gattaaaatc
     2281 tggcaaagtt atatttactt taaaataaaa taattttatt gcaa
//
