LOCUS       NM_001330701            4464 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens ATP/GTP binding carboxypeptidase 1 (AGTPBP1),
            transcript variant 4, mRNA.
ACCESSION   NM_001330701 XM_005251847
VERSION     NM_001330701.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4464)
  AUTHORS   Li,D.Z., Yang,Z.Y., Leng,A., Zhang,Q., Zhang,X.D., Bian,Y.C.,
            Xiao,R. and Ren,J.J.
  TITLE     Targeting AGTPBP1 inhibits pancreatic cancer progression via
            regulating microtubules and ERK signaling pathway
  JOURNAL   Mol Med 30 (1), 119 (2024)
   PUBMED   39129004
  REMARK    GeneRIF: Targeting AGTPBP1 inhibits pancreatic cancer progression
            via regulating microtubules and ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4464)
  AUTHORS   Lin,Y.H., Wang,Y.Y., Lai,T.H., Teng,J.L., Lin,C.W., Ke,C.C.,
            Yu,I.S., Lee,H.L., Chan,C.C., Tung,C.H., Conrad,D.F., O'Bryan,M.K.
            and Lin,Y.H.
  TITLE     Deleterious genetic changes in AGTPBP1 result in teratozoospermia
            with sperm head and flagella defects
  JOURNAL   J Cell Mol Med 28 (2), e18031 (2024)
   PUBMED   37937809
  REMARK    GeneRIF: Deleterious genetic changes in AGTPBP1 result in
            teratozoospermia with sperm head and flagella defects.
REFERENCE   3  (bases 1 to 4464)
  AUTHORS   Lalonde,R. and Strazielle,C.
  TITLE     The AGTPBP1 gene in neurobiology
  JOURNAL   Gene 809, 146001 (2022)
   PUBMED   34637898
  REMARK    GeneRIF: The AGTPBP1 gene in neurobiology.
REFERENCE   4  (bases 1 to 4464)
  AUTHORS   Turay,S., Eroz,R. and Basak,A.N.
  TITLE     A novel pathogenic variant in the 3' end of the AGTPBP1 gene gives
            rise to neurodegeneration without cerebellar atrophy: an expansion
            of the disease phenotype?
  JOURNAL   Neurogenetics 22 (2), 127-132 (2021)
   PUBMED   33909173
  REMARK    GeneRIF: A novel pathogenic variant in the 3' end of the AGTPBP1
            gene gives rise to neurodegeneration without cerebellar atrophy: an
            expansion of the disease phenotype?
            Review article
REFERENCE   5  (bases 1 to 4464)
  AUTHORS   Sheffer,R., Gur,M., Brooks,R., Salah,S., Daana,M., Fraenkel,N.,
            Eisenstein,E., Rabie,M., Nevo,Y., Jalas,C., Elpeleg,O.,
            Edvardson,S. and Harel,T.
  TITLE     Biallelic variants in AGTPBP1, involved in tubulin deglutamylation,
            are associated with cerebellar degeneration and motor neuropathy
  JOURNAL   Eur J Hum Genet 27 (9), 1419-1426 (2019)
   PUBMED   30976113
  REMARK    GeneRIF: We conclude that complete loss-of-function of AGTPBP1 in
            humans, just like in mice and sheep, is associated with cerebellar
            and motor neuron disease, reminiscent of Pontocerebellar Hypoplasia
            Type 1 (PCH1).
REFERENCE   6  (bases 1 to 4464)
  AUTHORS   Berezniuk,I., Vu,H.T., Lyons,P.J., Sironi,J.J., Xiao,H., Burd,B.,
            Setou,M., Angeletti,R.H., Ikegami,K. and Fricker,L.D.
  TITLE     Cytosolic carboxypeptidase 1 is involved in processing alpha- and
            beta-tubulin
  JOURNAL   J Biol Chem 287 (9), 6503-6517 (2012)
   PUBMED   22170066
REFERENCE   7  (bases 1 to 4464)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 4464)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4464)
  AUTHORS   Fernandez-Gonzalez,A., La Spada,A.R., Treadaway,J., Higdon,J.C.,
            Harris,B.S., Sidman,R.L., Morgan,J.I. and Zuo,J.
  TITLE     Purkinje cell degeneration (pcd) phenotypes caused by mutations in
            the axotomy-induced gene, Nna1
  JOURNAL   Science 295 (5561), 1904-1906 (2002)
   PUBMED   11884758
  REMARK    Erratum:[Science 2002 Jul 19;297(5580):337]
REFERENCE   10 (bases 1 to 4464)
  AUTHORS   Harris,A., Morgan,J.I., Pecot,M., Soumare,A., Osborne,A. and
            Soares,H.D.
  TITLE     Regenerating motor neurons express Nna1, a novel ATP/GTP-binding
            protein related to zinc carboxypeptidases
  JOURNAL   Mol Cell Neurosci 16 (5), 578-596 (2000)
   PUBMED   11083920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295774.1, DA326833.1, CN354118.1, CN354120.1, DB078109.1,
            AL157882.5, AL833359.1 and CA449535.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001330701.1.
            
            Summary: NNA1 is a zinc carboxypeptidase that contains nuclear
            localization signals and an ATP/GTP-binding motif that was
            initially cloned from regenerating spinal cord neurons of the
            mouse.[supplied by OMIM, Jul 2002].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.28208.1,
                                           SRR14038195.553804.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357081.8/ ENSP00000349592.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AK295774.1         76-149
            75-739              DA326833.1         1-665
            740-1190            CN354118.1         259-709
            1191-1380           CN354120.1         393-582
            1381-1659           DB078109.1         293-571
            1660-2228           AL157882.5         39501-40069         c
            2229-2312           AL157882.5         28041-28124         c
            2313-2348           AL157882.5         26105-26140         c
            2349-4459           AL833359.1         896-3006
            4460-4464           CA449535.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..4464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.33"
     gene            1..4464
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /note="ATP/GTP binding carboxypeptidase 1"
                     /db_xref="GeneID:23287"
                     /db_xref="HGNC:HGNC:17258"
                     /db_xref="MIM:606830"
     exon            1..180
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..245
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..3894
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /EC_number="3.4.17.24"
                     /note="isoform d is encoded by transcript variant 4;
                     cytosolic carboxypeptidase 1; nervous system nuclear
                     protein induced by axotomy protein 1 homolog;
                     carboxypeptidase-tubulin; soluble carboxypeptidase;
                     tyrosine carboxypeptidase; tubulinyl-Tyr carboxypeptidase;
                     ATP/GTP binding protein 1; protein deglutamylase CCP1"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 1 isoform d"
                     /protein_id="NP_001317630.1"
                     /db_xref="CCDS:CCDS83382.1"
                     /db_xref="GeneID:23287"
                     /db_xref="HGNC:HGNC:17258"
                     /db_xref="MIM:606830"
                     /translation="MSKLKVIPEKSLTNNSRIVGLLAQLEKINAEPSESDTARYVTSK
                     ILHLAQSQEKTRREMTAKGSTGMEILLSTLENTKDLQTTLNILSILVELVSAGGGRRV
                     SFLVTKGGSQILLQLLMNASKESPPHEDLMVQIHSILAKIGPKDKKFGVKARINGALN
                     ITLNLVKQNLQNHRLVLPCLQLLRVYSANSVNSVSLGKNGVVELMFKIIGPFSKKNSS
                     LIKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSL
                     KSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLP
                     TIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDVEAENETENEDDLDQ
                     NFKNDDIETDINKLKPQQEPGRTIEDLKMYEHLFPELVDDFQDYDLISKEPKPFVFEG
                     KVRGPIVVPTAGEETSGNSGNLRKVVMKENISSKGDEGEKKSTFMDLAKEDIKDNDRT
                     LQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPSQTAPGFTAEMKKDCSLPLTVLT
                     CAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESNSSVEQASVEVPDGPTL
                     HDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERL
                     IHQSDIIDRVVYDLDNPNYTIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDI
                     NSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWI
                     RMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQ
                     MHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNYYEHICHFRNRPYVF
                     LSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCS
                     LSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGC
                     SIKETVWHTNDNATSCDVVEDTGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVV
                     VWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEY
                     NLPSSLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVG
                     DYEPSAQEEVLSDSELSRTYLP"
     exon            246..370
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..438
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..502
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..649
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..781
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..875
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..913
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1122
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1300
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1398
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1515
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..2228
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2312
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2399
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2400..2548
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2636
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2781
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2935
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3116
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3246
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3378
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3555
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3716
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..4464
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4432..4437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /note="hexamer: ATTAAA"
     regulatory      4440..4445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /note="hexamer: AATAAA"
     polyA_site      4452
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
     polyA_site      4464
                     /gene="AGTPBP1"
                     /gene_synonym="CCP1; CONDCA; NNA1"
                     /note="major polyA site"
ORIGIN      
        1 aggttccgcc gcctccagcg ccgccgccgc agctgccgcc gccgccgcct ccgcctcgcc
       61 tgccaccggg gtttgtatga aaacaccggg cggcgggcgg cgagggatcc gccgtgatcc
      121 aggtgctgag ccgggtgctg cggctctgcg cggtccccgc cagcgcccca tcctgagccg
      181 attatctgca attatgaaat gaagtaactc aagatgagca agttaaaagt gataccagaa
      241 aaaagcctta ccaataattc taggatcgta ggactcctgg ctcaactgga gaagatcaat
      301 gctgagcctt cagaatcaga cactgcccga tatgttacat caaaaattct tcatctggct
      361 cagagtcaag aaaaaacaag gagagaaatg acagccaaag gttctacagg aatggaaatt
      421 ctgctgtcaa cattagagaa cacaaaagat cttcaaacta cacttaatat cttaagcatt
      481 cttgttgagc tggtgtcagc tggtggaggt cgaagagtga gtttcttagt caccaaaggt
      541 ggttcacaaa tattgttgca gttacttatg aatgccagca aagaatctcc cccacatgag
      601 gacttaatgg tacagattca ttctattctt gcaaagattg gaccaaaaga taaaaaattt
      661 ggagtaaagg ctagaattaa tggggctctg aatataaccc tgaatttggt caagcagaat
      721 ttgcagaatc atcgcttggt tctaccttgc cttcagcttt tacgagtata ttctgccaac
      781 tctgtgaatt cagtatcctt agggaaaaat ggagttgtgg aactgatgtt taaaatcatt
      841 ggaccattta gtaagaagaa ttccagtctt ataaaggttg ctttagacac tcttgctgca
      901 ttgctaaaat caaaaacaaa tgccaggaga gctgtagaca gaggatatgt ccaagtgctt
      961 ttaacaattt atgtagattg gcaccgccat gataaccggc atagaaacat gctcattcgg
     1021 aaaggaattt tacagagttt aaaaagtgtt acaaacatca agttgggaag aaaagcattt
     1081 attgatgcca atgggatgaa aattctgtat aatacttcgc aagaatgtct ggcagtcagg
     1141 actctggatc ctcttgtcaa tacctccagt ctgataatga ggaagtgttt cccaaaaaat
     1201 cgactgccac tcccaacaat taaaagttct tttcatttcc agttgcctgt tattcctgtg
     1261 actggtcctg tggctcagct ctacagctta cctcctgaag tggatgacgt agtagatgaa
     1321 agtgatgaca acgatgatat tgatgtagaa gctgaaaacg aaactgagaa tgaagatgac
     1381 ctagatcaaa attttaagaa tgatgatatt gaaacagata ttaacaaact aaaaccccag
     1441 caagaaccgg gacgaacaat agaagatcta aaaatgtatg aacacctttt ccctgagctt
     1501 gttgatgatt ttcaggacta tgatttaatc tccaaagaac caaagccttt tgtatttgag
     1561 ggaaaagtac gtggtcctat tgttgttcct acggcaggcg aggaaacatc tgggaattct
     1621 ggcaatttaa gaaaagttgt aatgaaggag aacatatctt ctaaaggaga tgaaggtgaa
     1681 aagaagtcta cctttatgga tctagcaaaa gaagatatta aagataatga tagaacatta
     1741 caacagcagc caggtgatca aaatagaact atttcatcag tccatggttt aaacaatgat
     1801 attgtaaagg ccttggaccg aattacattg cagaatattc cttctcaaac agccccaggt
     1861 tttactgcag aaatgaagaa ggactgcagt cttcctctta ctgtccttac ctgtgctaaa
     1921 gcatgtccac acatggctac ttgtggaaat gttctgtttg agggaagaac agttcagcta
     1981 gggaagcttt gctgcactgg agttgaaact gaagatgatg aagatactga gtcaaattca
     2041 tcggtagaac aagcatcggt tgaagtacct gatggaccaa cactccatga cccagacctc
     2101 tatattgaga ttgtgaaaaa tacgaagtct gtcccagaat attcagaggt ggcttatccc
     2161 gattattttg gtcacattcc gcctccattc aaagagccta ttttagaaag gccttatggt
     2221 gtacaaagga caaaaattgc tcaagatatt gaaaggctaa tacatcagag tgatatcata
     2281 gatcgtgtgg tatatgactt ggataaccca aattacacca ttccagaaga gggagatatt
     2341 ttgaaattta actccaaatt tgagtctggg aatctgcgca aagtaattca aattagaaaa
     2401 aatgaatatg atcttattct gaactcagac ataaacagca atcattatca tcagtggttt
     2461 tactttgaag tcagtggaat gcgaccaggt gttgcttaca ggtttaacat cattaactgt
     2521 gaaaagtcca acagtcagtt taattatggt atgcaaccac tcatgtattc ggttcaggaa
     2581 gcattaaatg ccagaccatg gtggattcgt atggggactg acatttgtta ctataaaaat
     2641 catttctcaa gaagttcagt tgctgcaggt gggcaaaagg gaaaatccta ctatacaatt
     2701 acatttactg tcaattttcc acataaagat gatgtttgct actttgctta tcactatcca
     2761 tatacgtatt caactttaca gatgcatctt caaaaattgg aatcagcaca caatcctcag
     2821 caaatctatt ttcggaaaga tgtgttatgt gaaaccctgt ctggaaacag ctgccccttg
     2881 gtgactataa cagcaatgcc agagtctaat tattatgaac atatctgcca tttcagaaat
     2941 cgcccttacg ttttcttgtc tgctcgggta catcctggag aaactaatgc aagttgggtt
     3001 atgaaaggaa cgttggaata tctcatgagc aataacccca ctgctcagag cttacgagaa
     3061 tcttatattt ttaaaattgt ccctatgtta aatccagatg gtgtcatcaa tggaaatcat
     3121 cgctgttctt taagtggaga ggatttgaat aggcagtggc aaagtccaag tccggattta
     3181 catcctacaa tttaccatgc taaggggctg ttgcaatact tggctgcagt gaagcgttta
     3241 cccttggttt attgtgatta tcatggccat tcccgaaaga agaatgtatt tatgtatggt
     3301 tgcagcatca aagagacagt gtggcatacc aatgataatg caacttcatg tgatgttgtg
     3361 gaggatacgg gatacaggac attgcctaag atactgagcc atatcgcccc agcattttgc
     3421 atgagcagct gtagcttcgt agtggaaaaa tctaaagaat ccacagcacg tgttgtagtt
     3481 tggagggaaa taggagtaca aagaagttat accatggaga gtactttatg tggctgtgat
     3541 cagggaaaat acaagggttt acagattggt acccgagaac tggaagagat gggagcaaaa
     3601 ttttgtgttg gtcttttacg tttgaaaaga ctgacctctc cattggagta taatctgcct
     3661 tccagcctgc ttgactttga aaatgattta attgaatcaa gctgcaaagt aactagccct
     3721 accacttatg tcttggatga agatgaacct cgattccttg aagaagttga ttacagtgca
     3781 gaaagtaatg atgagttaga tattgagttg gctgaaaatg taggagatta tgaaccttct
     3841 gctcaagaag aagtactttc tgactctgaa ttatcaagaa catacctacc ttgagcccgc
     3901 tgccatctct tgttaactgc aaagaataaa tgaaatatct tggtttttat ttcccaggaa
     3961 gcttgagaga aatgagttta tacagagctg actcaaaaag acaaaaagta acttgggcca
     4021 gtttggtttc aagataataa atgtgttatt aattaatgat aaaattggcg cttgttttat
     4081 tttcgatatt caatgcactt tatgtagcat tgaatgatca aatattggat ttacctttaa
     4141 aaaaaaaacc tgagtatcat tgcatgaatt tttatctccc tatggttata tcctgcatca
     4201 agtggataat tttgaagtgt gttcagaata taaaattgaa attttagagt tgttgaaaat
     4261 cctgacttgt tgaaaactaa tatatatgta catggatttc tatagatgtg tttgtttaga
     4321 agtgggtaga tattgcagat aagactgttc ttcagaatca tgttaactat tgggttgtga
     4381 ctgaagtagt ccagggtttg ccttgaaacc attacattct acatttacca aattaaacaa
     4441 ataaaaactg tattaaatgt tgca
//
