LOCUS       NM_001384479            2116 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens angiotensinogen (AGT), transcript variant 1, mRNA.
ACCESSION   NM_001384479
VERSION     NM_001384479.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   Patel,P., Sanghavi,D.K., Morris,D.L. and Kahwaji,C.I.
  TITLE     Angiotensin II
  JOURNAL   (in) ? (Ed.);
            STATPEARLS;
            (2025)
   PUBMED   29763087
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Buonfiglio,F., Pfeiffer,N. and Gericke,A.
  TITLE     Glaucoma and the ocular renin-angiotensin-aldosterone system:
            Update on molecular signalling and treatment perspectives
  JOURNAL   Cell Signal 122, 111343 (2024)
   PUBMED   39127136
  REMARK    GeneRIF: Glaucoma and the ocular renin-angiotensin-aldosterone
            system: Update on molecular signalling and treatment perspectives.
            Review article
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Labandeira-Garcia,J.L., Labandeira,C.M., Guerra,M.J. and
            Rodriguez-Perez,A.I.
  TITLE     The role of the brain renin-angiotensin system in Parkinson s
            disease
  JOURNAL   Transl Neurodegener 13 (1), 22 (2024)
   PUBMED   38622720
  REMARK    GeneRIF: The role of the brain renin-angiotensin system in
            Parkinson s disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Alvarado-Ojeda,Z.A., Trejo-Moreno,C., Ferat-Osorio,E.,
            Mendez-Martinez,M., Fragoso,G. and Rosas-Salgado,G.
  TITLE     Role of Angiotensin II in Non-Alcoholic Steatosis Development
  JOURNAL   Arch Med Res 55 (3), 102986 (2024)
   PUBMED   38492325
  REMARK    GeneRIF: Role of Angiotensin II in Non-Alcoholic Steatosis
            Development.
            Review article
REFERENCE   5  (bases 1 to 2116)
  AUTHORS   Xu,Y., Rong,J. and Zhang,Z.
  TITLE     The emerging role of angiotensinogen in cardiovascular diseases
  JOURNAL   J Cell Physiol 236 (1), 68-78 (2021)
   PUBMED   32572956
  REMARK    Review article
REFERENCE   6  (bases 1 to 2116)
  AUTHORS   Lu,H., Cassis,L.A., Kooi,C.W. and Daugherty,A.
  TITLE     Structure and functions of angiotensinogen
  JOURNAL   Hypertens Res 39 (7), 492-500 (2016)
   PUBMED   26888118
  REMARK    Review article
            Erratum:[Hypertens Res. 2016 Nov;39(11):827. doi:
            10.1038/hr.2016.106. PMID: 27818490]
REFERENCE   7  (bases 1 to 2116)
  AUTHORS   Wu,C., Lu,H., Cassis,L.A. and Daugherty,A.
  TITLE     Molecular and Pathophysiological Features of Angiotensinogen: A
            Mini Review
  JOURNAL   N Am J Med Sci (Boston) 4 (4), 183-190 (2011)
   PUBMED   22389749
REFERENCE   8  (bases 1 to 2116)
  AUTHORS   Fukamizu,A., Takahashi,S., Seo,M.S., Tada,M., Tanimoto,K.,
            Uehara,S. and Murakami,K.
  TITLE     Structure and expression of the human angiotensinogen gene.
            Identification of a unique and highly active promoter
  JOURNAL   J Biol Chem 265 (13), 7576-7582 (1990)
   PUBMED   1692023
REFERENCE   9  (bases 1 to 2116)
  AUTHORS   Odya,C.E., Marinkovic,D.V., Hammon,K.J., Stewart,T.A. and
            Erdos,E.G.
  TITLE     Purification and properties of prolylcarboxypeptidase
            (angiotensinase C) from human kidney
  JOURNAL   J Biol Chem 253 (17), 5927-5931 (1978)
   PUBMED   28321
REFERENCE   10 (bases 1 to 2116)
  AUTHORS   Koida,M. and Walter,R.
  TITLE     Post-proline cleaving enzyme. Purification of this endopeptidase by
            affinity chromatography
  JOURNAL   J Biol Chem 251 (23), 7593-7599 (1976)
   PUBMED   12173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512328.16 and AL158214.33.
            
            Summary: The protein encoded by this gene, pre-angiotensinogen or
            angiotensinogen precursor, is expressed in the liver and is cleaved
            by the enzyme renin in response to lowered blood pressure. The
            resulting product, angiotensin I, is then cleaved by angiotensin
            converting enzyme (ACE) to generate the physiologically active
            enzyme angiotensin II. The protein is involved in maintaining blood
            pressure, body fluid and electrolyte homeostasis, and in the
            pathogenesis of essential hypertension and preeclampsia. Mutations
            in this gene are associated with susceptibility to essential
            hypertension, and can cause renal tubular dysgenesis, a severe
            disorder of renal tubular development. Defects in this gene have
            also been associated with non-familial structural atrial
            fibrillation, and inflammatory bowel disease. [provided by RefSeq,
            Nov 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222815.1, K02215.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            coronavirus related              :: relevant for disease process
            MANE Ensembl match               :: ENST00000366667.6/
                                                ENSP00000355627.5
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL512328.16        12454-12490         c
            38-896              AL512328.16        8363-9221           c
            897-1164            AL512328.16        4301-4568           c
            1165-1309           AL512328.16        2561-2705           c
            1310-2116           AL158214.33        180066-180872       c
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..2116
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="angiotensinogen"
                     /db_xref="GeneID:183"
                     /db_xref="HGNC:HGNC:333"
                     /db_xref="MIM:106150"
     exon            1..37
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /inference="alignment:Splign:2.1.0"
     exon            38..896
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1498
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="alpha-1 antiproteinase, antitrypsin; angiotensin
                     II; pre-angiotensinogen; serine (or cysteine) proteinase
                     inhibitor; serpin A8; serpin peptidase inhibitor, clade A,
                     member 8; fetal-liver predominant transporter 1"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_001371408.1"
                     /db_xref="CCDS:CCDS1585.2"
                     /db_xref="GeneID:183"
                     /db_xref="HGNC:HGNC:333"
                     /db_xref="MIM:106150"
                     /translation="MAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQ
                     LAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLAN
                     FLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDK
                     NCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGL
                     ALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVDSTLAFNTYVHFQ
                     GKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVPFTESACLL
                     LIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAEL
                     PAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRP
                     FLFAVYDQSATALHFLGRVANPLSTA"
     exon            897..1164
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1309
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..2116
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="hexamer: ATTAAA"
     polyA_site      1909
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="major polyA site"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="hexamer: AATAAA"
     polyA_site      2116
                     /gene="AGT"
                     /gene_synonym="ANHU; hFLT1; SERPINA8"
                     /note="major polyA site"
ORIGIN      
        1 gaagaagctg ccgttgttct gggtactaca gcagaagggt atgcggaagc gagcacccca
       61 gtctgagatg gctcctgccg gtgtgagcct gagggccacc atcctctgcc tcctggcctg
      121 ggctggcctg gctgcaggtg accgggtgta catacacccc ttccacctcg tcatccacaa
      181 tgagagtacc tgtgagcagc tggcaaaggc caatgccggg aagcccaaag accccacctt
      241 catacctgct ccaattcagg ccaagacatc ccctgtggat gaaaaggccc tacaggacca
      301 gctggtgcta gtcgctgcaa aacttgacac cgaagacaag ttgagggccg caatggtcgg
      361 gatgctggcc aacttcttgg gcttccgtat atatggcatg cacagtgagc tatggggcgt
      421 ggtccatggg gccaccgtcc tctccccaac ggctgtcttt ggcaccctgg cctctctcta
      481 tctgggagcc ttggaccaca cagctgacag gctacaggca atcctgggtg ttccttggaa
      541 ggacaagaac tgcacctccc ggctggatgc gcacaaggtc ctgtctgccc tgcaggctgt
      601 acagggcctg ctagtggccc agggcagggc tgatagccag gcccagctgc tgctgtccac
      661 ggtggtgggc gtgttcacag ccccaggcct gcacctgaag cagccgtttg tgcagggcct
      721 ggctctctat acccctgtgg tcctcccacg ctctctggac ttcacagaac tggatgttgc
      781 tgctgagaag attgacaggt tcatgcaggc tgtgacagga tggaagactg gctgctccct
      841 gatgggagcc agtgtggaca gcaccctggc tttcaacacc tacgtccact tccaagggaa
      901 gatgaagggc ttctccctgc tggccgagcc ccaggagttc tgggtggaca acagcacctc
      961 agtgtctgtt cccatgctct ctggcatggg caccttccag cactggagtg acatccagga
     1021 caacttctcg gtgactcaag tgcccttcac tgagagcgcc tgcctgctgc tgatccagcc
     1081 tcactatgcc tctgacctgg acaaggtgga gggtctcact ttccagcaaa actccctcaa
     1141 ctggatgaag aaactatctc cccggaccat ccacctgacc atgccccaac tggtgctgca
     1201 aggatcttat gacctgcagg acctgctcgc ccaggctgag ctgcccgcca ttctgcacac
     1261 cgagctgaac ctgcaaaaat tgagcaatga ccgcatcagg gtgggggagg tgctgaacag
     1321 catttttttt gagcttgaag cggatgagag agagcccaca gagtctaccc aacagcttaa
     1381 caagcctgag gtcttggagg tgaccctgaa ccgcccattc ctgtttgctg tgtatgatca
     1441 aagcgccact gccctgcact tcctgggccg cgtggccaac ccgctgagca cagcatgagg
     1501 ccagggcccc agaacacagt gcctggcaag gcctctgccc ctggcctttg aggcaaaggc
     1561 cagcagcaga taacaacccc ggacaaatca gcgatgtgtc acccccagtc tcccaccttt
     1621 tcttctaatg agtcgacttt gagctggaaa gcagccgttt ctccttggtc taagtgtgct
     1681 gcatggagtg agcagtagaa gcctgcagcg gcacaaatgc acctcccagt ttgctgggtt
     1741 tattttagag aatgggggtg gggaggcaag aaccagtgtt tagcgcggga ctactgttcc
     1801 aaaaagaatt ccaaccgacc agcttgtttg tgaaacaaaa aagtgttccc ttttcaagtt
     1861 gagaacaaaa attgggtttt aaaattaaag tatacatttt tgcattgcct tcggtttgta
     1921 tttagtgtct tgaatgtaag aacatgacct ccgtgtagtg tctgtaatac cttagttttt
     1981 tccacagatg cttgtgattt ttgaacaata cgtgaaagat gcaagcacct gaatttctgt
     2041 ttgaatgcgg aaccatagct ggttatttct cccttgtgtt agtaataaac gtcttgccac
     2101 aataagcctc caaaaa
//
