LOCUS       NM_001138                498 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens agouti related neuropeptide (AGRP), mRNA.
ACCESSION   NM_001138 NM_007316
VERSION     NM_001138.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 498)
  AUTHORS   Zapata,R.C., Zhang,D., Libster,A., Porcu,A., Montilla-Perez,P.,
            Nur,A., Xu,B., Zhang,Z., Correa,S.M., Liu,C., Telese,F. and
            Osborn,O.
  TITLE     Nuclear receptor 5A2 regulation of Agrp underlies
            olanzapine-induced hyperphagia
  JOURNAL   Mol Psychiatry 28 (5), 1857-1867 (2023)
   PUBMED   36765131
  REMARK    GeneRIF: Nuclear receptor 5A2 regulation of Agrp underlies
            olanzapine-induced hyperphagia.
            Review article
REFERENCE   2  (bases 1 to 498)
  AUTHORS   Sutton Hickey,A.K., Duane,S.C., Mickelsen,L.E., Karolczak,E.O.,
            Shamma,A.M., Skillings,A., Li,C. and Krashes,M.J.
  TITLE     AgRP neurons coordinate the mitigation of activity-based anorexia
  JOURNAL   Mol Psychiatry 28 (4), 1622-1635 (2023)
   PUBMED   36577844
  REMARK    GeneRIF: AgRP neurons coordinate the mitigation of activity-based
            anorexia.
REFERENCE   3  (bases 1 to 498)
  AUTHORS   Ericson,M.D., Haslach,E.M., Schnell,S.M., Freeman,K.T., Xiang,Z.M.,
            Portillo,F.P., Speth,R., Litherland,S.A. and Haskell-Luevano,C.
  TITLE     Discovery of Molecular Interactions of the Human Melanocortin-4
            Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous
            G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein
            (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at
            the hMC4R
  JOURNAL   ACS Chem Neurosci 12 (3), 542-556 (2021)
   PUBMED   33470098
  REMARK    GeneRIF: Discovery of Molecular Interactions of the Human
            Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the
            Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist
            Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse
            Agonist Pharmacology at the hMC4R.
REFERENCE   4  (bases 1 to 498)
  AUTHORS   Chiurazzi,M., Di Maro,M., Cozzolino,M. and Colantuoni,A.
  TITLE     Mitochondrial Dynamics and Microglia as New Targets in Metabolism
            Regulation
  JOURNAL   Int J Mol Sci 21 (10), 3450 (2020)
   PUBMED   32414136
  REMARK    GeneRIF: Mitochondrial Dynamics and Microglia as New Targets in
            Metabolism Regulation.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 498)
  AUTHORS   Freda,P.U., Reyes-Vidal,C., Jin,Z., Pugh,M., Panigrahi,S.K.,
            Bruce,J.N. and Wardlaw,S.L.
  TITLE     Plasma Agouti-Related Protein Levels in Acromegaly and Effects of
            Surgical or Pegvisomant Therapy
  JOURNAL   J Clin Endocrinol Metab 104 (11), 5453-5461 (2019)
   PUBMED   31361303
  REMARK    GeneRIF: The plasma AgRP levels were higher in those with active
            acromegaly than in the matched healthy subjects, and decreased
            after treatment with pegvisomant or with surgery.
REFERENCE   6  (bases 1 to 498)
  AUTHORS   Rossi,M., Kim,M.S., Morgan,D.G., Small,C.J., Edwards,C.M.,
            Sunter,D., Abusnana,S., Goldstone,A.P., Russell,S.H., Stanley,S.A.,
            Smith,D.M., Yagaloff,K., Ghatei,M.A. and Bloom,S.R.
  TITLE     A C-terminal fragment of Agouti-related protein increases feeding
            and antagonizes the effect of alpha-melanocyte stimulating hormone
            in vivo
  JOURNAL   Endocrinology 139 (10), 4428-4431 (1998)
   PUBMED   9751529
REFERENCE   7  (bases 1 to 498)
  AUTHORS   Bures,E.J., Hui,J.O., Young,Y., Chow,D.T., Katta,V., Rohde,M.F.,
            Zeni,L., Rosenfeld,R.D., Stark,K.L. and Haniu,M.
  TITLE     Determination of disulfide structure in agouti-related protein
            (AGRP) by stepwise reduction and alkylation
  JOURNAL   Biochemistry 37 (35), 12172-12177 (1998)
   PUBMED   9724530
REFERENCE   8  (bases 1 to 498)
  AUTHORS   Graham,M., Shutter,J.R., Sarmiento,U., Sarosi,I. and Stark,K.L.
  TITLE     Overexpression of Agrt leads to obesity in transgenic mice
  JOURNAL   Nat Genet 17 (3), 273-274 (1997)
   PUBMED   9354787
REFERENCE   9  (bases 1 to 498)
  AUTHORS   Ollmann,M.M., Wilson,B.D., Yang,Y.K., Kerns,J.A., Chen,Y., Gantz,I.
            and Barsh,G.S.
  TITLE     Antagonism of central melanocortin receptors in vitro and in vivo
            by agouti-related protein
  JOURNAL   Science 278 (5335), 135-138 (1997)
   PUBMED   9311920
  REMARK    Erratum:[Science 1998 Sep 11;281(5383):1615]
REFERENCE   10 (bases 1 to 498)
  AUTHORS   Shutter,J.R., Graham,M., Kinsey,A.C., Scully,S., Luthy,R. and
            Stark,K.L.
  TITLE     Hypothalamic expression of ART, a novel gene related to agouti, is
            up-regulated in obese and diabetic mutant mice
  JOURNAL   Genes Dev 11 (5), 593-602 (1997)
   PUBMED   9119224
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009061.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2019 this sequence version replaced NM_001138.1.
            
            Summary: This gene encodes an antagonist of the melanocortin-3 and
            melanocortin-4 receptor. It appears to regulate hypothalamic
            control of feeding behavior via melanocortin receptor and/or
            intracellular calcium regulation, and thus plays a role in weight
            homeostasis. Mutations in this gene have been associated with late
            on-set obesity. [provided by RefSeq, Dec 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88063.1, CD369732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2146411
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290953.3/ ENSP00000290953.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC009061.10        179921-179951       c
            32-164              AC009061.10        179673-179805       c
            165-250             AC009061.10        179429-179514       c
            251-498             AC009061.10        178975-179222       c
FEATURES             Location/Qualifiers
     source          1..498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..498
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /note="agouti related neuropeptide"
                     /db_xref="GeneID:181"
                     /db_xref="HGNC:HGNC:330"
                     /db_xref="MIM:602311"
     exon            1..31
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            32..164
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..433
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /note="agouti-related protein; agouti related protein
                     homolog"
                     /codon_start=1
                     /product="agouti-related protein precursor"
                     /protein_id="NP_001129.1"
                     /db_xref="CCDS:CCDS10839.1"
                     /db_xref="GeneID:181"
                     /db_xref="HGNC:HGNC:330"
                     /db_xref="MIM:602311"
                     /translation="MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPG
                     LGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCC
                     DPCATCYCRFFNAFCYCRKLGTAMNPCSRT"
     exon            165..250
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            251..498
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      480..485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /note="hexamer: AATAAA"
     polyA_site      498
                     /gene="AGRP"
                     /gene_synonym="AGRT; ART; ASIP2"
                     /note="major polyA site"
ORIGIN      
        1 aactctctag gcaagaatcc cggaggcaga ggccatgctg accgcagcgg tgctgagctg
       61 tgccctgctg ctggcactgc ctgccacgcg aggagcccag atgggcttgg cccccatgga
      121 gggcatcaga aggcctgacc aggccctgct cccagagctc ccaggcctgg gcctgcgggc
      181 cccactgaag aagacaactg cagaacaggc agaagaggat ctgttgcagg aggctcaggc
      241 cttggcagag gtactagacc tgcaggaccg cgagccccgc tcctcacgtc gctgcgtaag
      301 gctgcatgag tcctgcctgg gacagcaggt gccttgctgt gacccatgtg ccacgtgcta
      361 ctgccgcttc ttcaatgcct tctgctactg ccgcaagctg ggtactgcca tgaatccctg
      421 cagccgcacc tagctggcca acgtcagggt cggggctagg gtaggggcaa ggaaactcga
      481 ataaaggatg ggaccaac
//
