LOCUS       NM_006408               1697 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens anterior gradient 2, protein disulphide isomerase
            family member (AGR2), mRNA.
ACCESSION   NM_006408
VERSION     NM_006408.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1697)
  AUTHORS   Martisova,A., Faktor,J., Sosolikova,T., Klemesova,I., Kolarova,T.,
            Holcakova,J. and Hrstka,R.
  TITLE     Characterization of the AGR2-NPM3 axis uncovers the AGR2
            involvement in PD-L1 regulation in colorectal cancer
  JOURNAL   Sci Rep 14 (1), 21926 (2024)
   PUBMED   39300184
  REMARK    GeneRIF: Characterization of the AGR2-NPM3 axis uncovers the AGR2
            involvement in PD-L1 regulation in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1697)
  AUTHORS   Wambach,M., Montani,M., Runz,J., Stephan,C., Jung,K., Moch,H.,
            Eberli,D., Bernhardt,M., Hommerding,O., Kreft,T., Cronauer,M.V.,
            Kremer,A., Mayr,T., Hauser,S. and Kristiansen,G.
  TITLE     Clinical implications of AGR2 in primary prostate cancer: Results
            from a large-scale study
  JOURNAL   APMIS 132 (4), 256-266 (2024)
   PUBMED   38288749
  REMARK    GeneRIF: Clinical implications of AGR2 in primary prostate cancer:
            Results from a large-scale study.
REFERENCE   3  (bases 1 to 1697)
  AUTHORS   Kosykh,A.V., Tereshina,M.B. and Gurskaya,N.G.
  TITLE     Potential Role of AGR2 for Mammalian Skin Wound Healing
  JOURNAL   Int J Mol Sci 24 (9), 7895 (2023)
   PUBMED   37175601
  REMARK    GeneRIF: Potential Role of AGR2 for Mammalian Skin Wound Healing.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1697)
  AUTHORS   Yan,T., Wang,H., Ma,X., Cao,J., Tong,Y., Guo,L. and Lu,R.
  TITLE     Clinical value of serum and tissue AGR2 for diagnosis and prognosis
            in epithelial ovarian cancer
  JOURNAL   Biomark Med 17 (6), 325-336 (2023)
   PUBMED   37284743
  REMARK    GeneRIF: Clinical value of serum and tissue AGR2 for diagnosis and
            prognosis in epithelial ovarian cancer.
REFERENCE   5  (bases 1 to 1697)
  AUTHORS   Adilay,H.U., Evran,S., Katar,S., Ozdemir,A., Kayhan,A.,
            Avcikurt,A.S., Gunaldi,O., Guclu,B. and Tanriverdi,O.
  TITLE     AGR2 Gene Expression in Glioblastoma: A Novel Molecular Potential
            Target for Diagnosis and Treatment
  JOURNAL   Turk Neurosurg 33 (2), 265-271 (2023)
   PUBMED   36622190
  REMARK    GeneRIF: AGR2 Gene Expression in Glioblastoma: A Novel Molecular
            Potential Target for Diagnosis and Treatment.
REFERENCE   6  (bases 1 to 1697)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   7  (bases 1 to 1697)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1697)
  AUTHORS   Fletcher,G.C., Patel,S., Tyson,K., Adam,P.J., Schenker,M.,
            Loader,J.A., Daviet,L., Legrain,P., Parekh,R., Harris,A.L. and
            Terrett,J.A.
  TITLE     hAG-2 and hAG-3, human homologues of genes involved in
            differentiation, are associated with oestrogen receptor-positive
            breast tumours and interact with metastasis gene C4.4a and
            dystroglycan
  JOURNAL   Br J Cancer 88 (4), 579-585 (2003)
   PUBMED   12592373
  REMARK    GeneRIF: hAG-2 and hAG-3, human homologues of genes involved in
            differentiation, are associated with oestrogen receptor-positive
            breast tumours and interact with metastasis gene C4.4a and
            dystroglycan.
REFERENCE   9  (bases 1 to 1697)
  AUTHORS   Petek,E., Windpassinger,C., Egger,H., Kroisel,P.M. and Wagner,K.
  TITLE     Localization of the human anterior gradient-2 gene (AGR2) to
            chromosome band 7p21.3 by radiation hybrid mapping and
            fluorescencein situ hybridisation
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 141-142 (2000)
   PUBMED   10965104
REFERENCE   10 (bases 1 to 1697)
  AUTHORS   Thompson,D.A. and Weigel,R.J.
  TITLE     hAG-2, the human homologue of the Xenopus laevis cement gland gene
            XAG-2, is coexpressed with estrogen receptor in breast cancer cell
            lines
  JOURNAL   Biochem Biophys Res Commun 251 (1), 111-116 (1998)
   PUBMED   9790916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF088867.1 and AC073333.5.
            
            On Nov 23, 2018 this sequence version replaced NM_006408.3.
            
            Summary: This gene encodes a member of the disulfide isomerase
            (PDI) family of endoplasmic reticulum (ER) proteins that catalyze
            protein folding and thiol-disulfide interchange reactions. The
            encoded protein has an N-terminal ER-signal sequence, a
            catalytically active thioredoxin domain, and a C-terminal
            ER-retention sequence. This protein plays a role in cell migration,
            cellular transformation and metastasis and is as a p53 inhibitor.
            As an ER-localized molecular chaperone, it plays a role in the
            folding, trafficking, and assembly of cysteine-rich transmembrane
            receptors and the cysteine-rich intestinal gylcoprotein mucin. This
            gene has been implicated in inflammatory bowel disease and cancer
            progression. [provided by RefSeq, Mar 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115926.1, SRR5189667.313185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419304.7/ ENSP00000391490.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-868               AF088867.1         76-943
            869-1697            AC073333.5         96357-97185         c
FEATURES             Location/Qualifiers
     source          1..1697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.1"
     gene            1..1697
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="anterior gradient 2, protein disulphide isomerase
                     family member"
                     /db_xref="GeneID:10551"
                     /db_xref="HGNC:HGNC:328"
                     /db_xref="MIM:606358"
     exon            1..65
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            66..211
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..600
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="protein disulfide isomerase family A, member 17;
                     anterior gradient protein 2 homolog; secreted cement gland
                     homolog; secreted cement gland protein XAG-2 homolog;
                     anterior gradient homolog 2; epididymis secretory protein
                     Li 116"
                     /codon_start=1
                     /product="anterior gradient protein 2 homolog precursor"
                     /protein_id="NP_006399.1"
                     /db_xref="CCDS:CCDS5364.1"
                     /db_xref="GeneID:10551"
                     /db_xref="HGNC:HGNC:328"
                     /db_xref="MIM:606358"
                     /translation="MEKIPVSAFLLLVALSYTLARDTTVKPGAKKDTKDSRPKLPQTL
                     SRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAE
                     QFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALL
                     LDNMKKALKLLKTEL"
     exon            212..275
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..328
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..402
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            403..466
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..550
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..1697
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      835..840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="hexamer: AATAAA"
     polyA_site      868
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="major polyA site"
     regulatory      1676..1681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="hexamer: GATAAA"
     polyA_site      1697
                     /gene="AGR2"
                     /gene_synonym="AG-2; AG2; GOB-4; HAG-2; HEL-S-116; HPC8;
                     PDIA17; RIFTD; XAG-2"
                     /note="major polyA site"
ORIGIN      
        1 actcagaagc ttggaccgca tcctagccgc cgactcacac aaggcaggtg ggtgaggaaa
       61 tccagagttg ccatggagaa aattccagtg tcagcattct tgctccttgt ggccctctcc
      121 tacactctgg ccagagatac cacagtcaaa cctggagcca aaaaggacac aaaggactct
      181 cgacccaaac tgccccagac cctctccaga ggttggggtg accaactcat ctggactcag
      241 acatatgaag aagctctata taaatccaag acaagcaaca aacccttgat gattattcat
      301 cacttggatg agtgcccaca cagtcaagct ttaaagaaag tgtttgctga aaataaagaa
      361 atccagaaat tggcagagca gtttgtcctc ctcaatctgg tttatgaaac aactgacaaa
      421 cacctttctc ctgatggcca gtatgtcccc aggattatgt ttgttgaccc atctctgaca
      481 gttagagccg atatcactgg aagatattca aatcgtctct atgcttacga acctgcagat
      541 acagctctgt tgcttgacaa catgaagaaa gctctcaagt tgctgaagac tgaattgtaa
      601 agaaaaaaaa tctccaagcc cttctgtctg tcaggccttg agacttgaaa ccagaagaag
      661 tgtgagaaga ctggctagtg tggaagcata gtgaacacac tgattaggtt atggtttaat
      721 gttacaacaa ctatttttta agaaaaacaa gttttagaaa tttggtttca agtgtacatg
      781 tgtgaaaaca atattgtata ctaccatagt gagccatgat tttctaaaaa aaaaaataaa
      841 tgttttgggg gtgttctgtt ttctccaact tggtctttca cagtggttcg tttaccaaat
      901 aggattaaac acacacaaaa tgctcaagga agggacaaga caaaaccaaa actagttcaa
      961 atgatgaaga ccaaagacca agttatcatc tcaccacacc acaggttctc actagatgac
     1021 tgtaagtaga cacgagctta atcaacagaa gtatcaagcc atgtgcttta gcataaaaga
     1081 atatttagaa aaacatccca agaaaatcac atcactacct agagtcaact ctggccagga
     1141 actctaaggt acacactttc atttagtaat taaattttag tcagattttg cccaacctaa
     1201 tgctctcagg gaaagcctct ggcaagtagc tttctccttc agaggtctaa tttagtagaa
     1261 aggtcatcca aagaacatct gcactcctga acacaccctg aagaaatcct gggaattgac
     1321 cttgtaatcg atttgtctgt caaggtccta aagtactgga gtgaaataaa ttcagccaac
     1381 atgtgactaa ttggaagaag agcaaagggt ggtgacgtgt tgatgaggca gatggagatc
     1441 agaggttact agggtttagg aaacgtgaaa ggctgtggca tcagggtagg ggagcattct
     1501 gcctaacaga aattagaatt gtgtgttaat gtcttcactc tatacttaat ctcacattca
     1561 ttaatatatg gaattcctct actgcccagc ccctcctgat ttctttggcc cctggactat
     1621 ggtgctgtat ataatgcttt gcagtatctg ttgcttgtct tgattaactt ttttggataa
     1681 aacctttttt gaacaga
//
