LOCUS       NM_018361               5237 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 5
            (AGPAT5), mRNA.
ACCESSION   NM_018361
VERSION     NM_018361.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5237)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 5237)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5237)
  AUTHORS   Prasad,S.S., Garg,A. and Agarwal,A.K.
  TITLE     Enzymatic activities of the human AGPAT isoform 3 and isoform 5:
            localization of AGPAT5 to mitochondria
  JOURNAL   J Lipid Res 52 (3), 451-462 (2011)
   PUBMED   21173190
  REMARK    GeneRIF: enzymatic properties, tissue distribution, and subcellular
            localization of human AGPAT3 and AGPAT5
REFERENCE   4  (bases 1 to 5237)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5237)
  AUTHORS   Agarwal,A.K., Barnes,R.I. and Garg,A.
  TITLE     Functional characterization of human 1-acylglycerol-3-phosphate
            acyltransferase isoform 8: cloning, tissue distribution, gene
            structure, and enzymatic activity
  JOURNAL   Arch Biochem Biophys 449 (1-2), 64-76 (2006)
   PUBMED   16620771
REFERENCE   6  (bases 1 to 5237)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 5237)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
  REMARK    GeneRIF: This publication describes the molecular cloning, tissue
            distribution, and enzyme characterization of the mouse homolog,
            mAGPAT5.
REFERENCE   8  (bases 1 to 5237)
  AUTHORS   Leung,D.W.
  TITLE     The structure and functions of human lysophosphatidic acid
            acyltransferases
  JOURNAL   Front Biosci 6, D944-D953 (2001)
   PUBMED   11487472
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5237)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF287957.6.
            
            On Aug 31, 2019 this sequence version replaced NM_018361.4.
            
            Summary: This gene encodes a member of the
            1-acylglycerol-3-phosphate O-acyltransferase family. This integral
            membrane protein converts lysophosphatidic acid to phosphatidic
            acid, the second step in de novo phospholipid biosynthesis. A
            pseudogene of this gene is present on the Y chromosome. [provided
            by RefSeq, Aug 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.600484.1,
                                           SRR14038194.1611913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285518.11/ ENSP00000285518.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               AF287957.6         114135-114380
            247-316             AF287957.6         130363-130432
            317-432             AF287957.6         136204-136319
            433-522             AF287957.6         138054-138143
            523-613             AF287957.6         147154-147244
            614-772             AF287957.6         153163-153321
            773-896             AF287957.6         160544-160667
            897-5237            AF287957.6         162656-166996
FEATURES             Location/Qualifiers
     source          1..5237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..5237
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 5"
                     /db_xref="GeneID:55326"
                     /db_xref="HGNC:HGNC:20886"
                     /db_xref="MIM:614796"
     exon            1..246
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1122
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /EC_number="2.3.1.51"
                     /note="1-AGP acyltransferase 5; 1-AGPAT 5;
                     lysophosphatidic acid acyltransferase epsilon;
                     1-acylglycerol-3-phosphate O-acyltransferase 5
                     (lysophosphatidic acid acyltransferase, epsilon);
                     testicular tissue protein Li 144; lysophospholipid
                     acyltransferase 5"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     epsilon"
                     /protein_id="NP_060831.2"
                     /db_xref="CCDS:CCDS34796.1"
                     /db_xref="GeneID:55326"
                     /db_xref="HGNC:HGNC:20886"
                     /db_xref="MIM:614796"
                     /translation="MLLSLVLHTYSMRYLLPSVVLLGTAPTYVLAWGVWRLLSAFLPA
                     RFYQALDDRLYCVYQSMVLFFFENYTGVQILLYGDLPKNKENIIYLANHQSTVDWIVA
                     DILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYV
                     DAGTPMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCM
                     KNYLDAIYDVTVVYEGKDDGGQRRESPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEH
                     MRRWLHERFEIKDKMLIEFYESPDPERRKRFPGKSVNSKLSIKKTLPSMLILSGLTAG
                     MLMTDAGRKLYVNTWIYGTLLGCLWVTIKA"
     exon            247..316
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            317..432
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            433..522
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            523..613
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            614..772
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            773..896
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            897..5237
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3376..3381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /note="hexamer: AATAAA"
     polyA_site      3399
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /note="major polyA site"
     regulatory      5160..5165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /note="hexamer: AATAAA"
     polyA_site      5184
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
     regulatory      5211..5216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
                     /note="hexamer: AATAAA"
     polyA_site      5237
                     /gene="AGPAT5"
                     /gene_synonym="1AGPAT5; LPAATE; LPLAT5"
ORIGIN      
        1 ggagctcgct gccgccgagc tgagaagatg ctgctgtccc tggtgctcca cacgtactcc
       61 atgcgctacc tgctgcccag cgtcgtgctc ctgggcacgg cgcccaccta cgtgttggcc
      121 tggggggtct ggcggctgct ctccgccttc ctgcccgccc gcttctacca agcgctggac
      181 gaccggctct actgcgtcta ccagagcatg gtgctcttct tcttcgagaa ttacaccggg
      241 gtccagatat tgctatatgg agatttgcca aaaaataaag aaaatataat atatttagca
      301 aatcatcaaa gcacagttga ctggattgtt gctgacatct tggccatcag gcagaatgcg
      361 ctaggacatg tgcgctacgt gctgaaagaa gggttaaaat ggctgccatt gtatgggtgt
      421 tactttgctc agcatggagg aatctatgta aagcgcagtg ccaaatttaa cgagaaagag
      481 atgcgaaaca agttgcagag ctacgtggac gcaggaactc caatgtatct tgtgattttt
      541 ccagaaggta caaggtataa tccagagcaa acaaaagtcc tttcagctag tcaggcattt
      601 gctgcccaac gtggccttgc agtattaaaa catgtgctaa caccacgaat aaaggcaact
      661 cacgttgctt ttgattgcat gaagaattat ttagatgcaa tttatgatgt tacggtggtt
      721 tatgaaggga aagacgatgg agggcagcga agagagtcac cgaccatgac ggaatttctc
      781 tgcaaagaat gtccaaaaat tcatattcac attgatcgta tcgacaaaaa agatgtccca
      841 gaagaacaag aacatatgag aagatggctg catgaacgtt tcgaaatcaa agataagatg
      901 cttatagaat tttatgagtc accagatcca gaaagaagaa aaagatttcc tgggaaaagt
      961 gttaattcca aattaagtat caagaagact ttaccatcaa tgttgatctt aagtggtttg
     1021 actgcaggca tgcttatgac cgatgctgga aggaagctgt atgtgaacac ctggatatat
     1081 ggaaccctac ttggctgcct gtgggttact attaaagcat agacaagtag ctgtctccag
     1141 acagtgggat gtgctacatt gtctattttt ggcggctgca catgacatca aattgtttcc
     1201 tgaatttatt aaggagtgta aataaagcct tgttgattga agattggata atagaatttg
     1261 tgacgaaagc tgatatgcaa tggtcttggg caaacatacc tggttgtaca actttagcat
     1321 cggggctgct ggaagggtaa aagctaaatg gagtttctcc tgctctgtcc atttcctatg
     1381 aactaatgac aacttgagaa ggctgggagg attgtgtatt ttgcaagtca gatggctgca
     1441 tttttgagca ttaatttgca gcgtatttca ctttttctgt tattttcaat ttattacaac
     1501 ttgacagctc caagctctta ttactaaagt atttagtatc ttgcagctag ttaatatttc
     1561 atcttttgct tatttctaca agtcagtgaa ataaattgta tttaggaagt gtcaggatgt
     1621 tcaaaggaaa gggtaaaaag tgttcatggg gaaaaagctc tgtttagcac atgattttat
     1681 tgtattgcgt tattagctga ttttactcat tttatatttg caaaataaat ttctaatatt
     1741 tattgaaatt gcttaatttg cacaccctgt acacacagaa aatggtataa aatatgagaa
     1801 cgaagtttaa aattgtgact ctgattcatt atagcagaac tttaaatttc ccagcttttt
     1861 gaagatttaa gctacactat tagtacttcc ctttgtctgt gccataagtg cttgaaaacg
     1921 ttaaggtttt ctgttttgtt ttgttttttt aatatcaaaa gagtcggtgt gaaccttggt
     1981 tggaccccaa gttcacaaga tttttaaggt gatgagagcc tgcagacatt ctgcctagat
     2041 ttactagcgt gtgccttttg cctgcttctc tttgatttca cagaatattc attcagaagt
     2101 cgcgtttctg tagtgtggtg gattcccact gggctctggt ccttcccttg gatcccgtca
     2161 gtggtgctgc tcagcggctt gcacgcagac ttgctaggaa gaaatgcaga gccagcctgt
     2221 gctgcccact ttcagagttg aactctttaa gcccttgtga gtgggcttca ccagctactg
     2281 cagaggcatt ttgcatttgt ctgtgtcaag aagttcacct tctcaagcca gtgaaataca
     2341 gacttaattt gtcatgactg aacgaatttg tttatttccc attaggttta gtggagctac
     2401 acattaatat gtatcgcctt agagcaagag ctgtgttcca ggaaccagat cacgattttt
     2461 agccatggaa caatatatcc catgggagaa gacctttcag tgtgaactgt tctatttttg
     2521 tgttataatt taaacttcga tttcctcata gtcctttaag ttgacatttc tgcttactgc
     2581 tactggattt ttgctgcaga aatatatcag tggcccacat taaacatacc agttggatca
     2641 tgataagcaa aatgaaagaa ataatgatta agggaaaatt aagtgactgt gttacactgc
     2701 ttctcccatg ccagagaata aactctttca agcatcatct ttgaagagtc gtgtggtgtg
     2761 aattggtttg tgtacattag aatgtatgca cacatccatg gacactcagg atatagttgg
     2821 cctaataatc ggggcatggg taaaacttat gaaaatttcc tcatgctgaa ttgtaatttt
     2881 ctcttacctg taaagtaaaa tttagatcaa ttccatgtct ttgttaagta cagggattta
     2941 atatattttg aatataatgg gtatgttcta aatttgaact ttgagaggca atactgttgg
     3001 aattatgtgg attctaactc attttaacaa ggtagcctga cctgcataag atcacttgaa
     3061 tgttaggttt catagaacta tactaatctt ctcacaaaag gtctataaaa tacagtcgtt
     3121 gaaaaaaatt ttgtatcaaa atgtttggaa aattagaagc ttctccttaa cctgtattga
     3181 tactgacttg aattattttc taaaattaag agccgtatac ctacctgtaa gtcttttcac
     3241 atatcattta aacttttgtt tgtattatta ctgatttaca gcttagttat taatttttct
     3301 ttataagaat gccgtcgatg tgcatgcttt tatgtttttc agaaaagggt gtgtttggat
     3361 gaaagtaaaa aaaaaaataa aatctttcac tgtctctaat ggctgtgctg tttaacattt
     3421 tttgacccta aaattcacca acagtctccc agtacataaa ataggcttaa tgactggccc
     3481 tgcattcttc acaatatttt tccctaagct ttgagcaaag ttttaaaaaa atacactaaa
     3541 ataatcaaaa ctgttaagca gtatattagt ttggttatat aaattcatct gcaatttata
     3601 agatgcatgg ccgatgttaa tttgcttggc aattctgtaa tcattaagtg atctcagtga
     3661 aacatgtcaa atgccttaaa ttaactaagt tggtgaataa aagtgccgat ctggctaact
     3721 cttacaccat acatactgat agtttttcat atgtttcatt tccatgtgat ttttaaaatt
     3781 tagagtggca acaattttgc ttaatatggg ttacataagc tttatttttt cctttgttca
     3841 taattatatt ctttgaatag gtctgtgtca atcaagtgat ctaactagac tgatcataga
     3901 tagaaggaaa taaggccaag ttcaagacca gcctgggcaa catatcgaga acctgtctac
     3961 aaaaaaatta aaaaaaatta gccaggcatg gtggcgtaca ctgagtagtt tgtcccagct
     4021 actcgggagg gtgaggtggg aggatcgctt cagcccagga ggttgagatt gcagtgagcc
     4081 atggacatac cactgcacta cagcctaggt aacagcacga gaccccaact cttagaaaat
     4141 gaaaaggaaa tatagaaata taaaatttgc ttattataga cacacagtaa ctcccagata
     4201 tgtaccacaa aaaatgtgaa aagagagaga aatgtctacc aaagcagtat tttgtgtgta
     4261 taattgcaag cgcatagtaa aataatttta accttaattt gtttttagta gtgtttagat
     4321 tgaagattga gtgaaatatt ttcttggcag atattccgta tctggtggaa agctacaatg
     4381 caatgtcgtt gtagttttgc atggcttgct ttataaacaa gattttttct ccctcctttt
     4441 gggccagttt tcattacgag taactcacac tttttgatta aagaacttga aattacgtta
     4501 tcacttagta taattgacat tatatagaga ctatgtaaca tgcaatcatt agaatcaaaa
     4561 ttagtacttt ggtcaaaata tttacaacat tcacatactt gtcaaatatt catgtaatta
     4621 actgaattta aaaccttcaa ctattatgaa gtgctcgtct gtacaatcgc taatttactc
     4681 agtttagagt agctacaact cttcgatact atcatcaata tttgacatct tttccaattt
     4741 gtgtatgaaa agtaaatcta ttcctgtagc aactggggag tcatatatga ggtcaaagac
     4801 atataccttg ttattataat atgtatacta taataatagc tggttatcct gagcagggga
     4861 aaaggttatt tttaggaaaa ccacttcaaa tagaaagctg aagtacttct aatatactga
     4921 gggaagtata atatgtggaa caaactctca acaaaatgtt tattgatgtt gatgaaacag
     4981 atcagttttt ccatccggat tattattggt tcatgatttt atatgtgaat atgtaagata
     5041 tgttctgcaa ttttataaat gttcatgtct ttttttaaaa aaggtgctat tgaaattctg
     5101 tgtctccagc aggcaagaat acttgactaa ctctttttgt ctctttatgg tattttcaga
     5161 ataaagtctg acttgtgttt ttgagattat tggtgcctca ttaattcagc aataaaggaa
     5221 aatatgcatc tcaaaaa
//
