LOCUS       NM_006411               2196 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens 1-acylglycerol-3-phosphate O-acyltransferase 1
            (AGPAT1), transcript variant 1, mRNA.
ACCESSION   NM_006411
VERSION     NM_006411.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Vessby,J., Wisniewski,J.R., Lindskog,C., Eriksson,N., Gabrysch,K.,
            Zettl,K., Wanders,A., Carlson,M., Rorsman,F. and Aberg,M.
  TITLE     AGPAT1 as a Novel Colonic Biomarker for Discriminating Between
            Ulcerative Colitis With and Without Primary Sclerosing Cholangitis
  JOURNAL   Clin Transl Gastroenterol 13 (5), e00486 (2022)
   PUBMED   35363634
  REMARK    GeneRIF: AGPAT1 as a Novel Colonic Biomarker for Discriminating
            Between Ulcerative Colitis With and Without Primary Sclerosing
            Cholangitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Guan,W., Steffen,B.T., Lemaitre,R.N., Wu,J.H.Y., Tanaka,T.,
            Manichaikul,A., Foy,M., Rich,S.S., Wang,L., Nettleton,J.A.,
            Tang,W., Gu,X., Bandinelli,S., King,I.B., McKnight,B., Psaty,B.M.,
            Siscovick,D., Djousse,L., Chen,Y.I., Ferrucci,L., Fornage,M.,
            Mozafarrian,D., Tsai,M.Y. and Steffen,L.M.
  TITLE     Genome-wide association study of plasma N6 polyunsaturated fatty
            acids within the cohorts for heart and aging research in genomic
            epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 7 (3), 321-331 (2014)
   PUBMED   24823311
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Aguado,B. and Campbell,R.D.
  TITLE     Characterization of a human lysophosphatidic acid acyltransferase
            that is encoded by a gene located in the class III region of the
            human major histocompatibility complex
  JOURNAL   J Biol Chem 273 (7), 4096-4105 (1998)
   PUBMED   9461603
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Aguado,B. and Campbell,R.D.
  TITLE     Human lysophosphatidic acid acyltransferase is encoded by a gene
            located in the major histocompatibility complex
  JOURNAL   Biochem Soc Trans 25 (4), S597 (1997)
   PUBMED   9450025
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Stamps,A.C., Elmore,M.A., Hill,M.E., Kelly,K., Makda,A.A. and
            Finnen,M.J.
  TITLE     A human cDNA sequence with homology to non-mammalian
            lysophosphatidic acid acyltransferases
  JOURNAL   Biochem J 326 (Pt 2) (Pt 2), 455-461 (1997)
   PUBMED   9291118
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   West,J., Tompkins,C.K., Balantac,N., Nudelman,E., Meengs,B.,
            White,T., Bursten,S., Coleman,J., Kumar,A., Singer,J.W. and
            Leung,D.W.
  TITLE     Cloning and expression of two human lysophosphatidic acid
            acyltransferase cDNAs that enhance cytokine-induced signaling
            responses in cells
  JOURNAL   DNA Cell Biol 16 (6), 691-701 (1997)
   PUBMED   9212163
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Lehner,R. and Kuksis,A.
  TITLE     Biosynthesis of triacylglycerols
  JOURNAL   Prog Lipid Res 35 (2), 169-201 (1996)
   PUBMED   8944226
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA529681.1, BC004310.1 and
            AI193422.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006411.3.
            
            Summary: This gene encodes an enzyme that converts lysophosphatidic
            acid (LPA) into phosphatidic acid (PA). LPA and PA are two
            phospholipids involved in signal transduction and in lipid
            biosynthesis in cells. This enzyme localizes to the endoplasmic
            reticulum. This gene is located in the class III region of the
            human major histocompatibility complex. Alternative splicing
            results in two transcript variants encoding the same protein.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR, and
            uses a downstream start codon compared to variant 3. The encoded
            isoform (1) is shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090849.1, BC004310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375107.8/ ENSP00000364248.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA529681.1         56-56
            2-2184              BC004310.1         1-2183
            2185-2196           AI193422.1         9-20                c
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..2196
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 1"
                     /db_xref="GeneID:10554"
                     /db_xref="HGNC:HGNC:324"
                     /db_xref="MIM:603099"
     exon            1..271
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            272..480
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1132
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /EC_number="2.3.1.51"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lysophosphatidic acid acyltransferase alpha;
                     1-AGP acyltransferase 1; lysophospholipid acyltransferase;
                     1-acyl-sn-glycerol-3-phosphate acyltransferase alpha;
                     1-acylglycerol-3-phosphate O-acyltransferase 1
                     (acetoacetly Coenzyme A thiolase); 1-AGPAT 1; epididymis
                     secretory sperm binding protein; lysophospholipid
                     acyltransferase l; 1-acylglycerol-3-phosphate
                     O-acyltransferase 1 (lysophosphatidic acid
                     acyltransferase, alpha)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     alpha isoform 1 precursor"
                     /protein_id="NP_006402.1"
                     /db_xref="CCDS:CCDS4744.1"
                     /db_xref="GeneID:10554"
                     /db_xref="HGNC:HGNC:324"
                     /db_xref="MIM:603099"
                     /translation="MDLWPGAWMLLLLLFLLLLFLLPTLWFCSPSAKYFFKMAFYNGW
                     ILFLAVLAIPVCAVRGRNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVS
                     NHQSSLDLLGMMEVLPGRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMS
                     EVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYC
                     KKERRFTSGQCQVRVLPPVPTEGLTPDDVPALADRVRHSMLTVFREISTDGRGGGDYL
                     KKPGGGG"
     exon            481..614
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..790
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..886
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            887..959
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2196
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="AGPAT1"
                     /gene_synonym="1-AGPAT1; G15; LPAAT-alpha; LPAATA; LPLAT1"
                     /note="major polyA site"
ORIGIN      
        1 agcggcggca gcagccccag ccctcagaga gacagcagaa agggagggag ggagggtgct
       61 ggggggacag ccccccacca ttcctaccgc tatgggccca acctcccact cccacctccc
      121 ctccatcggc cggggctagg acacccccaa atcccgtcgc ccccttggca ccgacacccc
      181 gacagagaca gagacacagc catccgccac caccgctgcc gcagcctggc tggggagggg
      241 gccagccccc caggccccct acccctctga ggtggccaga atggatttgt ggccaggggc
      301 atggatgctg ctgctgctgc tcttcctgct gctgctcttc ctgctgccca ccctgtggtt
      361 ctgcagcccc agtgccaagt acttcttcaa gatggccttc tacaatggct ggatcctctt
      421 cctggctgtg ctcgccatcc ctgtgtgtgc cgtgcgagga cgcaacgtcg agaacatgaa
      481 gatcttgcgt ctaatgctgc tccacatcaa atacctgtac gggatccgag tggaggtgcg
      541 aggggctcac cacttccctc cctcgcagcc ctatgttgtt gtctccaacc accagagctc
      601 tctcgatctg cttgggatga tggaggtact gccaggccgc tgtgtgccca ttgccaagcg
      661 cgagctactg tgggctggct ctgccgggct ggcctgctgg ctggcaggag tcatcttcat
      721 cgaccggaag cgcacggggg atgccatcag tgtcatgtct gaggtcgccc agaccctgct
      781 cacccaggac gtgagggtct gggtgtttcc tgagggaacg agaaaccaca atggctccat
      841 gctgcccttc aaacgtggcg ccttccatct tgcagtgcag gcccaggttc ccattgtccc
      901 catagtcatg tcctcctacc aagacttcta ctgcaagaag gagcgtcgct tcacctcggg
      961 acaatgtcag gtgcgggtgc tgcccccagt gcccacggaa gggctgacac cagatgacgt
     1021 cccagctctg gctgacagag tccggcactc catgctcact gttttccggg aaatctccac
     1081 tgatggccgg ggtggtggtg actatctgaa gaagcctggg ggcggtgggt gaaccctggc
     1141 tctgagctct cctcccatct gtccccatct tcctccccac acctacccac ccagtgggcc
     1201 ctgaagcagg gccaaaccct cttccttgtc tcccctctcc ccacttattc tcctctttgg
     1261 aatcttcaac ttctgaagtg aatgtggata cagcgccact cctgccccct cttggcccca
     1321 tccatggact cttgcctcgg tgcagtctcc actcttgacc cccacctcct actgtcttgt
     1381 ctgtgggaca gttgcctccc cctcatctcc agtgactcag cctacacaag ggaggggaac
     1441 attccatccc cagtggagtc tcttcctatg tggtcttctc tacccctcta ccccacattg
     1501 gccagtggac tcatccattc tttggaacaa atccccccca ctccaaagtc catggattca
     1561 atggactcat ccatttgtga ggaggacttc tcgccctctg gctggaagct gatacctgaa
     1621 gcactcccag gctcatcatg ggagctttcc tcagcacctt caccttccct cccagtgtag
     1681 cctcctgtca gtgggggctg gacccttcta attcagaggt ctcatgcctg cccttgccca
     1741 gatgcccagg gtcgtgcact ctctgggata ccagttcagt ctccacattt ctggttttct
     1801 gtccccatag tacagttctt cagtggacat gaccccaccc agccccctgc agccctgctg
     1861 caccatctca ccagacacaa ggggaagaag cagacatcag gtgctgcact cacttctgcc
     1921 ccctggggag ttggggaaag gaacgaaccc tggctggagg ggataggagg gcttttaatt
     1981 tatttctttt tctgttgagg cttccccctc tctgagccag ttttcatttc ttcctggtgg
     2041 cattagccac tccctgcctc tcactccaga cctgttccca caactgggga ggtaggctgg
     2101 gagcaaaagg agagggtggg acccagtttt gcgtggttgg tttttattaa ttatctggat
     2161 aacagcaaaa aaactgaaaa taaagagaga gagaga
//
