LOCUS       NM_024852              19660 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens argonaute RISC catalytic component 3 (AGO3),
            transcript variant 1, mRNA.
ACCESSION   NM_024852
VERSION     NM_024852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 19660)
  AUTHORS   Pan,L., Xu,C., Mei,J., Chen,Y. and Wang,D.
  TITLE     Argonaute 3 (AGO3) promotes malignancy potential of cervical cancer
            via regulation of Wnt/beta-catenin signaling pathway
  JOURNAL   Reprod Biol 21 (1), 100479 (2021)
   PUBMED   33444963
  REMARK    GeneRIF: Argonaute 3 (AGO3) promotes malignancy potential of
            cervical cancer via regulation of Wnt/beta-catenin signaling
            pathway.
REFERENCE   2  (bases 1 to 19660)
  AUTHORS   Park,M.S., Sim,G., Kehling,A.C. and Nakanishi,K.
  TITLE     Human Argonaute2 and Argonaute3 are catalytically activated by
            different lengths of guide RNA
  JOURNAL   Proc Natl Acad Sci U S A 117 (46), 28576-28578 (2020)
   PUBMED   33122430
  REMARK    GeneRIF: Human Argonaute2 and Argonaute3 are catalytically
            activated by different lengths of guide RNA.
REFERENCE   3  (bases 1 to 19660)
  AUTHORS   Park,M.S., Phan,H.D., Busch,F., Hinckley,S.H., Brackbill,J.A.,
            Wysocki,V.H. and Nakanishi,K.
  TITLE     Human Argonaute3 has slicer activity
  JOURNAL   Nucleic Acids Res 45 (20), 11867-11877 (2017)
   PUBMED   29040713
  REMARK    GeneRIF: Data show that recombinant AGO3 loaded with miR-20a
            cleaves complementary target RNAs.
REFERENCE   4  (bases 1 to 19660)
  AUTHORS   Bridge,K.S., Shah,K.M., Li,Y., Foxler,D.E., Wong,S.C.K.,
            Miller,D.C., Davidson,K.M., Foster,J.G., Rose,R., Hodgkinson,M.R.,
            Ribeiro,P.S., Aboobaker,A.A., Yashiro,K., Wang,X., Graves,P.R.,
            Plevin,M.J., Lagos,D. and Sharp,T.V.
  TITLE     Argonaute Utilization for miRNA Silencing Is Determined by
            Phosphorylation-Dependent Recruitment of LIM-Domain-Containing
            Proteins
  JOURNAL   Cell Rep 20 (1), 173-187 (2017)
   PUBMED   28683311
REFERENCE   5  (bases 1 to 19660)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   6  (bases 1 to 19660)
  AUTHORS   Wu,L., Fan,J. and Belasco,J.G.
  TITLE     Importance of translation and nonnucleolytic ago proteins for
            on-target RNA interference
  JOURNAL   Curr Biol 18 (17), 1327-1332 (2008)
   PUBMED   18771919
  REMARK    GeneRIF: The specificity of RNA interference depends on the
            concentration of Ago1, Ago3, and Ago4 relative to Ago2.
REFERENCE   7  (bases 1 to 19660)
  AUTHORS   Meister,G., Landthaler,M., Patkaniowska,A., Dorsett,Y., Teng,G. and
            Tuschl,T.
  TITLE     Human Argonaute2 mediates RNA cleavage targeted by miRNAs and
            siRNAs
  JOURNAL   Mol Cell 15 (2), 185-197 (2004)
   PUBMED   15260970
REFERENCE   8  (bases 1 to 19660)
  AUTHORS   Sasaki,T., Shiohama,A., Minoshima,S. and Shimizu,N.
  TITLE     Identification of eight members of the Argonaute family in the
            human genome
  JOURNAL   Genomics 82 (3), 323-330 (2003)
   PUBMED   12906857
REFERENCE   9  (bases 1 to 19660)
  AUTHORS   Doi,N., Zenno,S., Ueda,R., Ohki-Hamazaki,H., Ui-Tei,K. and Saigo,K.
  TITLE     Short-interfering-RNA-mediated gene silencing in mammalian cells
            requires Dicer and eIF2C translation initiation factors
  JOURNAL   Curr Biol 13 (1), 41-46 (2003)
   PUBMED   12526743
REFERENCE   10 (bases 1 to 19660)
  AUTHORS   Carmell,M.A., Xuan,Z., Zhang,M.Q. and Hannon,G.J.
  TITLE     The Argonaute family: tentacles that reach into RNAi, developmental
            control, stem cell maintenance, and tumorigenesis
  JOURNAL   Genes Dev 16 (21), 2733-2742 (2002)
   PUBMED   12414724
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BF979526.1, AL139286.13,
            AL138787.11, AK303929.1, BX104163.1 and AA251146.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024852.3.
            
            Summary: This gene encodes a member of the Argonaute family of
            proteins which play a role in RNA interference. The encoded protein
            is highly basic, contains a PAZ domain and a PIWI domain, and may
            play a role in short-interfering-RNA-mediated gene silencing. This
            gene is located on chromosome 1 in a tandem cluster of closely
            related family members including argonaute 4 and eukaryotic
            translation initiation factor 2C, 1. Two transcript variants
            encoding distinct isoforms have been identified for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.136680.1,
                                           SRR1803612.186539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373191.9/ ENSP00000362287.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BF979526.1         29-98
            71-341              AL139286.13        66595-66865         c
            342-513             AL139286.13        52177-52348         c
            514-634             AL139286.13        30965-31085         c
            635-843             AL139286.13        25808-26016         c
            844-980             AL139286.13        24529-24665         c
            981-1115            AL138787.11        121593-121727       c
            1116-1203           AL138787.11        117291-117378       c
            1204-1351           AL138787.11        117024-117171       c
            1352-1471           AL138787.11        116474-116593       c
            1472-1594           AL138787.11        112316-112438       c
            1595-1728           AL138787.11        112020-112153       c
            1729-1913           AL138787.11        98770-98954         c
            1914-2073           AL138787.11        91735-91894         c
            2074-2164           AL138787.11        89801-89891         c
            2165-2359           AL138787.11        86084-86278         c
            2360-2494           AL138787.11        85627-85761         c
            2495-2594           AL138787.11        82522-82621         c
            2595-3151           AK303929.1         1902-2458
            3152-3410           BX104163.1         14-272              c
            3411-3622           AA251146.1         23-234              c
            3623-19660          AL138787.11        53568-69605         c
FEATURES             Location/Qualifiers
     source          1..19660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..19660
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="argonaute RISC catalytic component 3"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:HGNC:18421"
                     /db_xref="MIM:607355"
     exon            1..341
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2905
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /EC_number="3.1.26.n2"
                     /note="isoform a is encoded by transcript variant 1;
                     hAgo3; argonaute 3, RISC catalytic component; eukaryotic
                     translation initiation factor 2C, 3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform a"
                     /protein_id="NP_079128.2"
                     /db_xref="CCDS:CCDS399.1"
                     /db_xref="GeneID:192669"
                     /db_xref="HGNC:HGNC:18421"
                     /db_xref="MIM:607355"
                     /translation="MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKI
                     DVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVAT
                     TGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPV
                     HAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNI
                     DVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTM
                     RRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQE
                     QKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETD
                     PFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIK
                     MWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRH
                     LKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCL
                     KINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPS
                     RYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLY
                     YELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTD
                     ITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSV
                     SIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRT
                     MYFA"
     exon            342..513
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            514..634
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            635..843
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..980
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1115
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1203
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1351
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1471
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1594
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1728
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1913
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2073
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2164
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2359
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2494
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2596
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2796
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..19660
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      19178..19183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="hexamer: AATAAA"
     polyA_site      19197
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="major polyA site"
     regulatory      19640..19645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
                     /note="hexamer: AAGAAA"
     polyA_site      19660
                     /gene="AGO3"
                     /gene_synonym="EIF2C3"
ORIGIN      
        1 aggtcggcgg cggcggcccg cagtcgtgga ggagcggtgg gagcgtcggc ggccgcgggc
       61 gatgcaactt ccggacggga ctcccctctg tccgcgcctc acatctcccc ttcctctcgc
      121 ctagtcctgt gccgttttcc gtccgcgact cttccggccc agagctttcg gagtgcggtt
      181 gctcagggga agccgtcgcc gcccccgcct cggggccgag tgagagtgcc cgtcgcgtcg
      241 cgccgcgtcg ccccccgggc cgcctccttg ccgccagtgg cgggctccgt tctccctcga
      301 agcactcccc ccagctccat gaatggaaat cggctccgca ggacccgctg gggcccagcc
      361 cctactcatg gtgcccagaa gacctggcta tggcaccatg ggcaaaccca ttaaactgct
      421 ggctaactgt tttcaagttg aaatcccaaa gattgatgtc tacctctatg aggtagatat
      481 taaaccagac aagtgtccta ggagagtgaa cagggaggtg gttgactcaa tggttcagca
      541 ttttaaagta actatatttg gagaccgtag accagtttat gatggaaaaa gaagtcttta
      601 caccgccaat ccacttcctg tggcaactac aggggtagat ttagacgtta ctttacctgg
      661 ggaaggtgga aaagatcgac ctttcaaggt gtcaatcaaa tttgtctctc gggtgagttg
      721 gcacctactg catgaagtac tgacaggacg gaccttgcct gagccactgg aattagacaa
      781 gccaatcagc actaaccctg tccatgccgt tgatgtggtg ctacgacatc tgccctccat
      841 gaaatacaca cctgtggggc gttcattttt ctccgctcca gaaggatatg accaccctct
      901 gggagggggc agggaagtgt ggtttggatt ccatcagtct gttcggcctg ccatgtggaa
      961 aatgatgctt aatatcgatg tttctgccac tgccttctac aaagcacaac ctgtaattca
     1021 gttcatgtgt gaagttcttg atattcataa tattgatgag caaccaagac ctctgactga
     1081 ttctcatcgg gtaaaattca ccaaagagat aaaaggtttg aaggttgaag tgactcattg
     1141 tggaacaatg agacggaaat accgtgtttg taatgtaaca aggaggcctg ccagtcatca
     1201 aacctttcct ttacagttag aaaacggcca aactgtggag agaacagtag cgcagtattt
     1261 cagagaaaag tatactcttc agctgaagta cccgcacctt ccctgtctgc aagtcgggca
     1321 ggaacagaaa cacacctacc tgccactaga agtctgtaat attgtggcag ggcaacgatg
     1381 tatcaagaag ctaacagaca atcagacttc cactatgatc aaggcaacag caagatctgc
     1441 accagataga caagaggaaa ttagcagatt ggtaagaagt gcaaattatg aaacagatcc
     1501 atttgttcag gagtttcaat ttaaagttcg ggatgaaatg gctcatgtaa ctggacgcgt
     1561 acttccagca cctatgctcc agtatggagg acggaatcgg acagtagcaa caccgagcca
     1621 tggagtatgg gacatgcgag ggaaacaatt ccacacagga gttgaaatca aaatgtgggc
     1681 tatcgcttgt tttgccacac agaggcagtg cagagaagaa atattgaagg gtttcacaga
     1741 ccagctgcgt aagatttcta aggatgcagg gatgcccatc cagggccagc catgcttctg
     1801 caaatatgca cagggggcag acagcgtaga gcccatgttc cggcatctca agaacacata
     1861 ttctggccta cagcttatta tcgtcatcct gccggggaag acaccagtgt atgcggaagt
     1921 gaaacgtgta ggagacacac ttttgggtat ggctacacaa tgtgttcaag tcaagaatgt
     1981 aataaaaaca tctcctcaaa ctctgtcaaa cttgtgccta aagataaatg ttaaactcgg
     2041 agggatcaat aatattcttg tacctcatca aagaccttct gtgttccagc aaccagtgat
     2101 ctttttggga gccgatgtca ctcatccacc tgctggtgat ggaaagaagc cttctattgc
     2161 tgctgttgta ggtagtatgg atgcacaccc aagcagatac tgtgccacag taagagttca
     2221 gagaccccga caggagatca tccaggactt ggcctccatg gtccgggaac ttcttattca
     2281 attttataag tcaactcggt tcaagcctac tcgtatcatc ttttatcggg atggtgtttc
     2341 agaggggcag tttaggcagg tattatatta tgaactacta gcaattcgag aagcctgcat
     2401 cagtttggag aaagactatc aacctggaat aacctacatt gtagttcaga agagacatca
     2461 cactcgatta ttttgtgctg ataggacaga aagggttgga agaagtggca atatcccagc
     2521 tggaacaaca gttgatacag acattacaca cccatatgag ttcgattttt acctctgtag
     2581 ccatgctgga atacagggta ccagtcgtcc ttcacactat catgttttat gggatgataa
     2641 ctgctttact gcagatgaac ttcagctgct aacttaccag ctctgccaca cttacgtacg
     2701 ctgtacacga tctgtttcta tacctgcacc agcgtattat gctcacctgg tagcatttag
     2761 agccagatat catcttgtgg acaaagaaca tgacagtgct gaaggaagtc acgtttcagg
     2821 acaaagcaat gggcgagatc cacaagctct tgccaaggct gtacagattc accaagatac
     2881 cttacgcaca atgtacttcg cttaaatagt ccaagtatat tctctgagag gaagtactga
     2941 aagatgaatt gacatacaac gtatgtttcc agtgaagtca attgagtaag gacacctcca
     3001 gccatacaga aaccaacact gtgtgggggc caaggtctga tccttatgtt aatacaagga
     3061 agattgttta cttcatcaag gaacacagca tcattatgca atatgaaacc agccaactgc
     3121 tttttgtgcg gtctcctata ggaagtatcg caattgtttt gttttcattt cttgtagtct
     3181 aaccctttta atgcctttac ctcaagttgc ttggcagcac aactatcttt gcaaaaaaaa
     3241 gtaaagaaaa agtaaatgat ggtttaaaaa atacacacct tcatgaataa tcaaagtgat
     3301 ttttcagaat tatgtgtgca aaaaattaat gtgcattcat atattcttgt aaaaggtgtc
     3361 tgtgtatttt taaaatatat acatccatac ttcatatgca tatatatcta gatctggatt
     3421 gataatagat atatatgtgt ctgttatata ttttagagtt cattccattg gggaattttc
     3481 tttccctttt attctacccc cactaccgcc tttatttctc tatttccctt gccttcatca
     3541 cctacatttt tttcccagtc ctaccagtga cattcaaatg ttgatgtatc tggttcgttt
     3601 gaatataaaa tatggcaaac tagaattcta cttttatttt gcatacccta ctcctgactc
     3661 ctatctcata cacaattctg agttctcaac tcttgatatt gctgtcttaa gaaacaaaat
     3721 tttatatata tatgtataca tacatacaca gacacagaca cacacatata tatacataaa
     3781 ataactttct gtgagagtgc gtctctcccc tcccactcag aacatacatt taccatttgc
     3841 gcaatttgta tataagcagt agcaacctga actattcttt ttcttttttc tttttctttt
     3901 ctttcttttt tttttttaat gagacagagc ctcgctctgt caccaggctg gagtgcagtg
     3961 gcgagatctc ggctcactgc aacttccgcc tctcgggttc aagcaattct cctgcctcag
     4021 cctcccgagt agctgggttt acaggcatgt gccaccacac ccagctaatt tttgtatttt
     4081 tagtagagac ggggtttcac cgtgttggcc aggatggtct cgatctcttg accttgtgat
     4141 ccacccgcct cgacctccca aagtgctggg attacaggca tgagccaccg cacccggcct
     4201 actattcttt ttctttagtg agtttgttaa agctgctata aatataaaac ctgtcagaag
     4261 ttgtaacttt ctctctggta agtgatgtgt attctgaagc cttctgtttc tatgggttat
     4321 acatggaaat tctttaaagg ttttataaag ggtaaatatt ttaaaagatt agagctctgt
     4381 agggttgaga cctctgaaat tgagtagaga gaagagtttg ttgagggatt tttttgtttt
     4441 gttttttgat agtttacttg ctgcctctca taccttaatg tgattttcat atatttttta
     4501 tatatatata tgtatgtgtg tgtatataaa cacatatgta tgtgtttgga agtatagctt
     4561 ccttttcttt tatatttatt agaatagtgc tttaataatt atagaattgt attggcagca
     4621 tcttttatag aaatataatc atgtttattt taagaactga caacttgttt ttgctatctt
     4681 ttagtgcaat aagcagtttt aaaggaaagt tgtgtctgca tctttaccat ggatagtagg
     4741 aggaacaggc acctccatag tttaaaaggg caaagaatac agccttaatt tcagaaggaa
     4801 agttttgtaa ttttcagttt taaagcatat cttttaaaat tcatcatgat aaaaggctgg
     4861 acgcggtggc tcatgcctgt aatcctagca ctttgggagg ctgagacagg tatatcaccg
     4921 gagctcagga gtttgagacc agcctggcca acgtggtgaa accccgtctc tactaaaaat
     4981 acaaaaatta gctgggcgtg gtagtgggca cctctaatcc cagctactcg ggaggctgag
     5041 gcaggattgc ttgaacctag gaggcggaag ttacagtgag ccaagactgc accattgcac
     5101 tccagcctgg gcaacaaaac caaaactccg tctcaaaaga aaaaaaaatc ataatgaaaa
     5161 tgaagtgaaa ttgcctaaat gagtccaact tgaatattag aaataaagtt gaacttttat
     5221 ataattgtga atagcttaac atatttaaat tatttgcaaa tagattgtgt ttattgaaga
     5281 atcatattgg ctagatgccc attttcattt actaaaatga atcaggaaaa tgcaagatga
     5341 tattttaaaa cttttgctaa tgtatcacca gtataacttt ccttttaaaa ttaaggtgat
     5401 agtaacaaag gaagttagga ctttgatcat tttaaatcag ttaaatcact gaaacgtggg
     5461 aaattgtttt acaaaacttt tattgattac actttaaggt attaaaaagt actataaagc
     5521 tatcaaaact gagtttatca gtaacattgg attcagggga gctttgcact ttgtaactca
     5581 tgaaaattgc attttgattt tttttttttt tgcactggtt cagagtatag atactacaga
     5641 ttgtttccag tgggcattgt tgttagcctt tcagaattcc atctgcacgt gaaacctaat
     5701 ggatttagat ctttagtttc tctcttacct gtaatccact attattgcca attcactgta
     5761 ttttgagcct aaaatctgag cccatgtcct ctgacaggca tgaaatcttt tgtccctctg
     5821 ccagaaaact aagaaagtac tgtattttgt atgtttatta ttttgaagtg tctgaaatgc
     5881 aatttacaac actgttgcaa agaactttac aaaaggtaat atttgtatcg tatatacatt
     5941 ttttctccca gccttctccc atctcctcca gaaaaatttc ctataaagat ggattttttt
     6001 acactgaaat tttactgaat atagtcagga tcatgggcaa gagaagaaaa tagtataccc
     6061 aagatgataa aaatttaatt cgtctatgct tgatcagtgt gagtaaaaca tcttccttta
     6121 tcatgggagc tgcacagatt catgtgggaa actttaggga atgactgtag ataccctttc
     6181 tctatgtact ctctcaccta attttcagtc actcatatat gctagagtgg agcccttaat
     6241 ttaaatctat ttggaaggac ttttttaaga ggaaaaatat tttttctaaa ttataaagct
     6301 ttaccttttg agtgatttct tttttagagt gctcttacac tagtcagcat tgctagttta
     6361 aagttgatta acttgaaaga gtatgtatac tatatttcta ttttgctaac aaattggtat
     6421 attaattacc attggttctt aattacaaga aaacttgtgc ttagaatttt aagataaaag
     6481 gctaagtgac aaatgcttct tgaaatttgt cctatttatt gttgcatttc tggtgtagaa
     6541 tttctaatct tttttatttt aaaaaagttt ttttttttaa gttaaacatg aaattcacag
     6601 tgacccttct gctcctgccc ttgctcacta actatatcat gaatgctaga ttttggtctt
     6661 cttttttctg tgatgtatct tacgagactg actgtaaaat atcagtctgg caactagata
     6721 attgattttc atatgaagaa gagttgggag tttaatgtat attcttgatg gttaatgtgt
     6781 ctacataaag tgctgataca tgtattatat cacagtatca ggttactggc atggaggacc
     6841 atacacttac aatattgtag ctgctatatt tatttaagta gattctgaca gttactgcac
     6901 taaacagtaa ggagataagc aggattcaag gctagtgtta gacccttttt tttcctaaga
     6961 gtaaggacac ggaatatcaa agtaacaaag ggtgctgcca ttttagtttc aatttaatat
     7021 caggatattc tttgttttag aaatgtagat tttgactttt acagtttgaa aaagggtacc
     7081 tcagcctctt cagtactggt tttttggcac atttcaacag aaatattaga ttccctttct
     7141 ttttcttaat agtgatcttc taacaagttt cttggaaaaa ctatcattct aagggaaatc
     7201 cctgtttata acctattaat atatttctat tcctagaaga gagtctagca gggattctag
     7261 taggaattac tgagtgtttt ggaaggcact tgatagaggc atctctgctt tccagcacag
     7321 ggattctcag ccttctaaag atctagacca gtttccaagc tagcttctcc acagcccacc
     7381 actgcctagt gtttgcttgt gtattctcta atggatttta ggaggatagg ccttctgaca
     7441 gagtcatgaa agactgaagg catgtctagg gaaataaaac ctgacttgcc cttcagcagg
     7501 aatgactggc agcggatctc tgtgttcaag gaaagggtga gcgctaagca tgccagtgat
     7561 ggatccgaag tatttagatg gattgcagac caggaattag agaccgtttg tgactcaagg
     7621 aacttgatgg atctgtttag agccctacat gaatttgcca agggcagtga tttttatgaa
     7681 attcaagaag caaacgactt cgatacagct agaatatgtt gcagtcttcc tatttcaaac
     7741 ttgattttaa tatttttacc aagaagttta actgacaact ctgcaaaatt ttcattcagt
     7801 atcattaaac ctgagttaaa tgtttgctta gcttatcctc ttagatgttc ttctgttgaa
     7861 caggcaggtt gcccttaaca gtaacttgct acttaaatta ccttttatta gttagtcaag
     7921 ctgcaaaaat atcattagtg tggcgtcttt attttggctt tatccatatg aagtattcat
     7981 tattttcatt ctttttgaga attcataaat gtcttaaagc ttcagtaaga attgttggga
     8041 ggtttgacat caagtaacgc cttcctgtgt agcagtataa ccctaattta gaactcttgt
     8101 tttcctattt cagtcctcat atttgatcat agaaaagcac ttttgtgatt ctataggagt
     8161 caaaaaatca gccaagagta ggtaagtcag tcagcacaga aatcagaaag tgagaatttt
     8221 ctccaaaaaa tctttttaaa aaagtcctgc ttatactaag aacattcttg atccgttgca
     8281 gtgttagaaa tgacactgtg attagtgaaa gccaagctga gtcccaggaa gcagggaggg
     8341 ggagtgtgtg tgtgtgtata tgtatgagtg tgtatatata taatctcaca cacacacaca
     8401 aagggaaaaa ttattttgac ttttttccta cttttaaaat ggtacattta agtttataat
     8461 tttccatgtc agtcaacata attttttaaa ctaaggtata atggtcaagg cttgtgctaa
     8521 tattacctac tactcattga aatttatatt actttaccca tcaaaactag tactccagat
     8581 gtttacatca ttgattaaat ctcaagaatc ttttgttctt aaaatatgga agttaaagat
     8641 tttaatttga attaaagata gaaggatggt aaattcaata tagagggttg agatttacca
     8701 gtgagaaacc ctgttgaagt atcaggtaaa tggtgtgaca aaattagaat cctgtcaaat
     8761 cacctatcca gccatcgggg tcccttcctt ttttagacta atttctaagg taaccagaat
     8821 ctaatgtatc tatgttaggg tctcagtaaa gcaaagacgt ttgtcagggc gtagactctt
     8881 gagttaaatt ttttaatcat tttttaaagc aaggcggttc ttagaaagtg ccttttcaga
     8941 agatggtgct gtagattttt atttttcaag tagcacgaag ctaagaattt taaagataaa
     9001 ttattttaga actccaagag tgtgacagtt tcataaaaat aatgttagtt gttgtcttga
     9061 atctcgtcca agggaaccaa ggaaagcttt tatgcagtaa agtatctagg taaatgctca
     9121 ccaaatttat tttgtaaatt tgaaaacaaa atatttagta gaattacctc ttttaattcc
     9181 caactgtgtt ggaggaaatc cataatgcac ataaaacagc aaacctactt aactttttaa
     9241 caagattatg ggtatagtac caatgtccaa agggaaatgt aacttgcctg gaatcatagg
     9301 caacattttc taattaatct tttttttttt tttttttttt gagacaaagt cttgctctgt
     9361 cacctaggct ggagtgcagt ggctcaatct cagcttactg caaactccgc ctcccgggtt
     9421 caagtgattc tcgtgcctca gcctcccaag tagctgggat tacaggcatg caccaccaca
     9481 cccggcccta attagtcatt attaaggagg actgctcata aaggcagtac caaatcatca
     9541 ttcagatcag cttaagtgag aaagcaaaat gataatctct attgttagag aaattttctt
     9601 ttctagacac caaggaatat tttaaatgat tttttatttt ttctaggatg caggaactat
     9661 gaaaaatgat gacaaggcat ttaaaagggt atgatcagtt aaatagaagt agggtctgca
     9721 aattgtgctt aaggggaaat aagcaaaaga aaggaaaata gtagaacctt tcatactaat
     9781 tagaaatgta gttacctacc agagggcaat tttgctccat accaggaagc agtaaatagc
     9841 agtaaatgat cacctaggca cttctttcct gtgaatttgg tgagcattct tccagaaaag
     9901 aagactaaaa gcaaacaaca acaacaacaa aaaataccac acctcagtaa ccttgtatgc
     9961 tgcattatat aataatgata gtaaaattat attgtttgga gtgtactgtg tctgtttgca
    10021 aatatacatg cacattaaac ttttttgttt ttataatgtc ttaatagcaa ttatgagttt
    10081 atttttgtta agattaattt ttctattgtg atgtttatat ttattggcaa tttgtatgca
    10141 acttttatat tttgcttgtc ggttttaagg tattttattt ttatagatat ttctagcttt
    10201 cctcattctt tgtaatagca gcaaagatta agatggagtg ttaatatacc aaccaaacta
    10261 cgaattccat aaactctaga gtttggattt ttaccaataa accattaaca ctattttgta
    10321 acttagaata tttaatgttg tttatatagt gggcattaaa gacagtcttt agacagattt
    10381 ctacatgtgg aggggaggtg gggctttcct gtaagtttga tccttttttt cccctttagt
    10441 agcaaactaa cataacagat tggatttatt ttacctgact acagttttgg ggaaacctgt
    10501 caaataaata attgttacat gccttttttt tttaaattta agcacattga aactgcttaa
    10561 atggtcacat ttttcagcat taggattaag ataccatttt tgtaggcctg gaaaacaaat
    10621 agcaaatgat tcaaaattca ttgaattgac tttgaaatga aacttttccc ccataatttg
    10681 ttatatggaa gatttgctac cctgatcttt tccctagcat acttctaaag ttgattgaat
    10741 ccctgagtat caatgaagaa atcagagttt aagtggctag ggagagccag gtataaagac
    10801 tgattaatag agtacttcag ctaattaaaa atttaaatag taataattta tgaatgtgaa
    10861 taaattggaa ggcagcaaaa agcatgatta tagaatatta agttcaatta tatatagaca
    10921 gtccagtttc ctagtgaata ggtcaagatt atttgttttg ttttgtggca ctatcatagt
    10981 tcactataac ttcaaactcc tgggctcagg ctatcctccc acctcagcct ctgaagtagc
    11041 tgggactact cacatgcgcc accatgccca gctaatggtt tttttcttta gagatggggg
    11101 tcactatact gcccaggctg gtcttgaact cctaagctca agtgcttctc ccacatcagc
    11161 ctcccaaagt gctgggatta cagccatgag ccactgcatc tggccaagat caagattatg
    11221 gatattggta tgttaacttt taaaataaaa gtacatgggc tgggcgcagt ggctaacgcc
    11281 tgtaatccca gcaatttggg aggccgaggc aggcagacca cctgaggtca ggggttcgtg
    11341 accagcctgg ccaacatggc gaaaccccgt ctctactaaa catacaaaaa ttagctgggc
    11401 atggtggcac atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcacttga
    11461 actcgggagg cggaggttgc agtgagccaa gatcgcgcca ttgcactcca gcctgggcaa
    11521 caagagtgaa actccatctc agaaaataaa aataaaaata aataaaagta catgaaaaaa
    11581 gtatattccc ttaagcaggt aaaatacttg cattgtattt ttacatcatg aatttgcttg
    11641 ttaagaaatt tcttttctgt aagtggttaa aagataaact gtattccatc ctctgggttt
    11701 tcaattctaa attattggag ctcaatgtat gacattttac tgtagtgtat tccactgaga
    11761 ggcaaggaaa tgggaaagtg tcaggtaatt ataaatggga aaattttatt tttatatgat
    11821 gtaaagtttt acagtttaaa atagatcagc atgtgatttc ttgtagagat tagccatttc
    11881 atttcttttt gcatttttgc cagttacatt agtttgccct atgatatact attctgagat
    11941 acttcagccc cgcacacatc aagtactaat tgtatacaga tagtacagat ttgtactctg
    12001 attataagaa tttgttacta ctaattaaaa gcaaattaat gtggctgggc gtggtagctc
    12061 acacctgtaa tcccagcact ttgggtgggc ggctgaggcg ggcggatcac gaggtcagga
    12121 gttggagacc agcctgccca atatggtgaa accctgtctc tactaaaatt acaaaaatta
    12181 gctgggcttg gcggtacgtg cctgtaatcc cagctactgg gaaggccgag gcaggagaat
    12241 ggcttgaacc caggaggcgg aggttgcagt gagccaagat cacaccactg cactccagcc
    12301 tgggcgacag agcaagactc cgtctcaaaa aaaaaaaaag caaaatattt ttgctgtgat
    12361 tgtatgtccc cttttaagga tatttattgc gcttataacc ttaatagttg tattcattac
    12421 atttcaacat gtccaaggtt agcagacatg tagttcctga aaaccaacat tttaaaagtt
    12481 gcctctgggc tgggcatggt ggctcacgcc tgtaatccct gcactttggg aggccgaggt
    12541 gggcggatca cgaggtcaag agatggagac catcctggcc aacatgctga aaccccatct
    12601 ctactaaaaa tacaaaaatt agctgggtgt ggtggcacac gcctgtagtc ccagctactt
    12661 gggaggctga ggcaggagaa tcacttgaac ctgggaggcg gaggttgcag tgagccaaga
    12721 ttgcaccgct gcactccagc ctggcaacag agcaagactc catctcaaaa caaacataca
    12781 aacaaaaaaa ggtgcctctg gtcctgtgtt ttctttttcc ttctgaaagt tcatagaaac
    12841 ctggcatata gagcttattt tgctgtttta actggttggc tccacaaatc ctgctacctg
    12901 acatcagtac agcttgaccg cagtgaagta cttgatggct tgttcatgtt tagttcacct
    12961 ctttagaaag aaagctttgt ggccaggtgc agtggctcac acctgtaatc ccaacacttt
    13021 gggcagctga ggtgagcaga tcacctgagg tcaggagttc aagaccagcc tggccaacat
    13081 ggcaaaaccc tgtctcttct aaaaatacaa aaattagccg ggtgtggtgg cggaggatgc
    13141 agtgagccaa gatcgtgcca ctgcactcca gcctgggcaa cagagtgaga ctctgtctca
    13201 aaaaaaaaaa aaaatcgttg tgcagtaata gatcatccca aaaaagaatt gccatgaaca
    13261 gcgttatgcg tagaaaacag atggaagtgt tggtcattag agccttgctt tttaaatttt
    13321 attctttcca aaaattggcg gtatgctatc tataatttta tgtttgatgt tgaagaggca
    13381 acaccagaga ctagagaggg agattactct gatatttagt gcctaaaact ttcatcttgg
    13441 ccgggcacgg tggctcacac ctgtaatccc agcacttcgg gaggccgagg caggctgatt
    13501 acctgaggtc aggagttcga gaccagcctg gacaacatgg caaaacccgt ctctactaaa
    13561 aatacaaaaa ttagccaggc atggtggtgg gcgcctgtaa tcccagctac tcgggaggct
    13621 gaggcgagag aatcgtttga acccggtagg cggaggttgc agtgagccga gatcatgcca
    13681 ctgcactcca gcctgggcga caagagtgaa actccgtctc aaaaaataat aataatttta
    13741 aaaataaaag acaaaacttt catctttatt tcatggcttt atttcatctt tatttcattt
    13801 ttggttggga aaacaaacaa aaatctctta agttagtcct ttaatagtct ttttagaacc
    13861 aaagaaggaa agactgcaaa aatgttgcat acgtgactct ttattgtcag aatctgtaga
    13921 aactggaggt ctttgtaaag aaatagacta gtaggattgt gagaatatat agtgaggggg
    13981 gatttaggat aaggcttcct tgctgggatc cttggacaga aaccttacaa ttgtttaata
    14041 tttgcagagt aaaagagcag ctattgctat ttgaacctac agaagagacc taagacgagc
    14101 gtctctgtaa tctaaattta tatgataatg ttgtcccaga cccaaaggca cacctattct
    14161 cagtaactta gagaagtctt ggaagttgct tctgaattac agtaaagaaa ttaaatgaag
    14221 tctttatcct taaatagggc caggcattgc tatcaacata gtgtctttgg ttttcccctt
    14281 taaatagaaa acaccaagca gggcctttcc agacaatgta gtctttcctg taaagaaaat
    14341 ggttttggtg tgggatttgg taaaaacact ggttagtttg taatgaagaa agaattttgg
    14401 catagacagt ccgacccagt tcatggatac agtttgatcc cagggagttt aacaaaagga
    14461 agctttggtt ttgctagcaa cagacttgat cttctatagt aattaattgc aattaaggtt
    14521 ttccaggagc tttctcattt cttagcccag ggtccaaccc cattccctct ttaaaaaaga
    14581 aagaataggc cgggagcagt ggctcatgcc tgcaatccca gcactttggg aggccaaggc
    14641 aggtggatca caaggtcagg agtttgagac cagcgtggcc aatatggtga aaccctgtct
    14701 ctactaaaaa tacaaaatta gctaggcgtg gtggcaggcg cctgaggctg aggcaggaga
    14761 atcctgctag tctgaattac aataaggaaa ttaaatgaag gatttatctt taatagagcc
    14821 aggcattgct atcaacataa catgtttggt tttccccttt aaatagaaaa caccaagcag
    14881 ggcctttcca gacaaggtag tctggaaccc aggaggcgga ggttgcagtg agccgagatc
    14941 ccaccattgc actccagcct gggtggcaga gtgagactcc gtctcaaaaa aaaaaaaaag
    15001 aaggaatagg aaaaggactt agaggcagtt gatatagaat tctactgggg gtaaatgaca
    15061 ctctcaaaat acttgggaaa gaagaatcac atgccacaag ctatagcttg attaatattt
    15121 tagcatgttt tccatgtttg tattctaaag tttgtttcct ttgacattcc attatcttac
    15181 ttactagagt gccaccattc ttatttgtaa tacaatcagt gttttatgcc atttgtgaat
    15241 cacacaattg ttcttttttc cccatcacac acactcacac acaaacacac acactgttaa
    15301 aaataaaaga ggggaaggat aaaacaaaaa tagatagaat gatgattatt acaatgtaac
    15361 tttaacatat atgaagagaa attctaactc agttaagtga gaattaagat tgaaagtatt
    15421 aatgttgcaa gtattatctc tagccatgga attttttgct ggctatagaa tgctaatgtg
    15481 aacagagtat atatcaggaa tatgatgtat tatggcacag tgataatatt attgttgata
    15541 ttagccagat gtggtggttt gcacctgtag tccgaacttc tcaggaggat gaggcaggag
    15601 gatagttgag cccaggagtt taaagcaagc ctgggcaata cagcaagacc ccaatcttta
    15661 aaataaataa ataaataaga attattcttg aaagtaatat tctaaccttc tgccaaccaa
    15721 cagagatcct catattctta aagaaaatta atatagctta tggttttgat aaattggact
    15781 ctgatttaaa ctttaaaatg ttatgacttt tattctgata catggcttct aaaatatgta
    15841 aaaaattata ttgaatgaat taatacttaa cctgttcatt tctcttaatt tatgtattta
    15901 ttctgacttt attatacagc ttatgtctca catctgcctt cttgatatgt gcaaaatatt
    15961 gtgtaaaaat agtttaaaac tcatcccagt tcctagtcaa gcgtgggcta taagagagaa
    16021 ggcttaaggt gttctttaat ggaggaactt ttgaaagatc acaaatggaa aaagcctatt
    16081 gagaatttat tgcctttgag agtagaaagg gctctagaat atgagccaga gacttggaat
    16141 ttagtaatag gtctcccact gatttgctcc gtgtccttag gcaattcgtt taatctctgt
    16201 gtgcctagtt tccccttgta aataagagtg gtaatacctg tcctcaccta cctcactaaa
    16261 ttgttggagt tcttttgttc tgagtcaggg tctcactctg ttgcccaggc tgaactacag
    16321 tagtgtgatc atagctcact acagcctcca actcctgggc ccaaactatc ctcctgcttc
    16381 agcctcccaa gtagctggga ctagaggtac atgccaccac acccagctaa ttattttctt
    16441 ttattgcaga gatggggtct cacatgttgc caaggctgat ctctaactcc tgagctcaag
    16501 cagtcctcct gcctcagcca cccaaagtgc tgggattata ggcatgatca ctaaattgtt
    16561 gtaagaataa gataatgttt gcggaagcat ttgagttctc caaaggaaaa gctattcaga
    16621 cgttcaagat aatagaagag tgttgtgtga aggattcctt tccagtttgc ctctgtgaaa
    16681 atgtctttgt tgtagatcat tttatgaaat aggaataaga gaaacatagg ccttatcatg
    16741 gtgtagtgtt cacttacaaa catatcctgt tgtttcttcc ctgcaagata tccagcacac
    16801 aggctgaatt tttctttata ataatccttg gcaaaagcat aacttttcaa aaaccaaatg
    16861 attttagtgg tgctatggca gctgcagttt tgagttagat taatgtggtg aaaaccatca
    16921 aatacttaga aattgactgg gtgcggtggc tcatgcctgt aatcccagca ctttgggagg
    16981 ccgaggtagg tggatcactt gaggtcagga gttcgagacc agcctggcca acatggcaaa
    17041 accccgtctc tactaaagat acaaaaatta gctgggcacg atggagggtg cctgtaatcc
    17101 cagctactcg ggaggctaag gtgggagaat tgcttggacc caggtggcag aggttgcagt
    17161 gagccaagat tgtgccactg cactccagcc tgggcaacaa agcgaagctc tgtctcaata
    17221 aaaaaaaaaa taataataat aaaatacaaa tacttagaaa ttaacttcgc ctttgccttc
    17281 aggcactttt gctacatgtt agcatcagag gctattgtac aactagatgg ttattccctg
    17341 tttcttggcc gatttttggt acctttcttt gaagaagagg gttagatttt aagaaagaaa
    17401 gtgtgcttat ttcactcatg tctttgcaga atttaacttt gctttacttt aaaaattcca
    17461 atcatcatgt acctataaag gttaaaatat agtgaaagtt tctgcttcat gtgaattcaa
    17521 ttctgagcac ctgcaggtca tatcaggtgt ctgatgcagt tacctttata gatcgtggca
    17581 ggtccttaca tttcaacagg cttatgcatt tccatggggg gaagagattc tgtttctagg
    17641 aaattacaaa gggcacacca ctgcagggag tgtaaacaat tctttgttgc aacagacaag
    17701 atttttttta aaaaaagaaa aaaggatgca ttttaggtac acagggtatg gacgcattca
    17761 acatttactt ttatctccac agatgccaac ctccccttgt tgcaggcagt tgggcttttc
    17821 caactcattg ctaacaaagc tggcatctgc attaatttca atgagaattt caagtactga
    17881 agatgaaaag ttggggagat tcatgtttga aaaatgaaaa atgaacaaaa aatccacctt
    17941 gtgcagtgag atagctaacg ctgatatatc aggaataatt ttaaactatt tttgctgtaa
    18001 tgtgtagctt taatgtctct tttcagttat ggacccataa aagtattcct atatcttgtg
    18061 aataaagatc attcttgtgg actagtacgt ggatgcattc ataggctttg ggaagcagtg
    18121 gtgtgcgtat gtgtgtctat atcaatattt tatgtttata actctgcgta ttaagtttat
    18181 atagaaaaaa ataatgtctt tctttagtgt ttgggggact caatggtaat atgaccattg
    18241 cagtgtaatc tgactgctca ctctagagaa cacttctgtt atacacaatg cacatacaaa
    18301 catacacccc taaagcgtag ctaactgctc ccactagata attgctgcta aaaacaaaac
    18361 aaaacaaaac aatacaaaac aaaaaaaacc ctaagtaatg gaggaagaaa tagcattctt
    18421 ttaaaagggg cttttctgaa gagtaaaatg taaatacagg acatgtgggg agggtggggc
    18481 cgcctgcaaa atgtcctgaa gatggacaaa tagcctttta aattctactt tttaaccatc
    18541 tttaccgtgt gtgcctattt gtattgcaga tgtgaactac tatttttgga ggttgatatc
    18601 agtatgtttt gaaactgaat tattacataa aatcagagta acctctttct ccatcctcct
    18661 tttccacact attcttgcca aatatttcta ctgaaaccca gtttcagcaa ggcaaaatga
    18721 tgggactctc aaacctccct cctcatcttc ccttcccctc tgtcttatgc ctggcctggc
    18781 cttttttgtt gttgttggct tttcataagt aagaaaaatt tattgtagta tttcaagact
    18841 gcagaatttc aagtgtatat ctataaatct ttttttaaaa tcttcggcta cacagtaaca
    18901 tcaattaaaa cagaagagtg agtctaagtc tgtaatatgc tgtaggacca gataagattt
    18961 tgaatgagac taaacttgac tgccatattt taagaggaaa ttgaaacttt atggtggaga
    19021 atggatgaga gcaagtctat gatatatatg tagtcattgt ataattagaa acaccaaatg
    19081 ctgaatccta tcactgtgtt cttgggggcc aggccttgga tttggttgtc atttaaactc
    19141 cttgaagatt atatgtaatt ataatgagca gaaggcaaat aaagtttttg aacaaaagtc
    19201 cttgttttca gtatttaaaa tttggtaata tattttcttt ttcagttaaa ctatcttccc
    19261 cacaaaaaat attatacttc agttaaacta tcttccccac agaaattatt atactacgaa
    19321 caagttatga gtgagactga gaagcttgaa gaagctggtt tttaagcagc tcatataata
    19381 ttttgtgtta aagaaagtgt cattgtttcc tgttgggagg caaataacaa caacaacaaa
    19441 agaaattgtc atgattcttt ctgagccaaa ctgtcacgaa atgttctgtg acagaaccac
    19501 tactcttttt tctgccattc tgcctactgg agagttctat gttgtatttg tttttaatcc
    19561 ttgattttaa aaatattaat ggttttagtg ttgcttagct tcagtttgaa gtataacttt
    19621 cactaataac tgcaataaaa agaaaagctt tgctcttaaa
//
