LOCUS       NM_001004320            2476 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens alkylglycerol monooxygenase (AGMO), mRNA.
ACCESSION   NM_001004320 XM_374406
VERSION     NM_001004320.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2476)
  AUTHORS   Okur,V., Watschinger,K., Niyazov,D., McCarrier,J., Basel,D.,
            Hermann,M., Werner,E.R. and Chung,W.K.
  TITLE     Biallelic variants in AGMO with diminished enzyme activity are
            associated with a neurodevelopmental disorder
  JOURNAL   Hum Genet 138 (11-12), 1259-1266 (2019)
   PUBMED   31555905
  REMARK    GeneRIF: Biallelic variants in AGMO with diminished enzyme activity
            are associated with a neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 2476)
  AUTHORS   Marquet,S., Bucheton,B., Reymond,C., Argiro,L., El-Safi,S.H.,
            Kheir,M.M., Desvignes,J.P., Beroud,C., Mergani,A., Hammad,A. and
            Dessein,A.J.
  TITLE     Exome Sequencing Identifies Two Variants of the Alkylglycerol
            Monooxygenase Gene as a Cause of Relapses in Visceral Leishmaniasis
            in Children, in Sudan
  JOURNAL   J Infect Dis 216 (1), 22-28 (2017)
   PUBMED   28586473
  REMARK    GeneRIF: We identified homozygous and heterozygous mutations of the
            alkylglycerol monooxygenase (AGMO) gene (MIM 613738) as the likely
            cause of visceral leishmaniasis relapse in 3 families.
REFERENCE   4  (bases 1 to 2476)
  AUTHORS   Alrayes,N., Mohamoud,H.S., Ahmed,S., Almramhi,M.M., Shuaib,T.M.,
            Wang,J., Al-Aama,J.Y., Everett,K., Nasir,J. and Jelani,M.
  TITLE     The alkylglycerol monooxygenase (AGMO) gene previously involved in
            autism also causes a novel syndromic form of primary microcephaly
            in a consanguineous Saudi family
  JOURNAL   J Neurol Sci 363, 240-244 (2016)
   PUBMED   27000257
  REMARK    GeneRIF: An AGMO mutation was found in a Saudi family underlying
            primary microcephaly and intellectual disability.
REFERENCE   5  (bases 1 to 2476)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2476)
  AUTHORS   Watschinger,K., Fuchs,J.E., Yarov-Yarovoy,V., Keller,M.A.,
            Golderer,G., Hermetter,A., Werner-Felmayer,G., Hulo,N. and
            Werner,E.R.
  TITLE     Catalytic residues and a predicted structure of
            tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase
  JOURNAL   Biochem J 443 (1), 279-286 (2012)
   PUBMED   22220568
  REMARK    GeneRIF: Among all of the acidic residues within the
            eight-histidine motif, only mutation of Glu137 to alanine led to an
            18-fold increase in the Michaelis-Menten constant for
            tetrahydrobiopterin, suggesting a role in tetrahydrobiopterin
            interaction
REFERENCE   7  (bases 1 to 2476)
  AUTHORS   Akiyama,K., Narita,A., Nakaoka,H., Cui,T., Takahashi,T., Yasuno,K.,
            Tajima,A., Krischek,B., Yamamoto,K., Kasuya,H., Hata,A. and
            Inoue,I.
  TITLE     Genome-wide association study to identify genetic variants present
            in Japanese patients harboring intracranial aneurysms
  JOURNAL   J Hum Genet 55 (10), 656-661 (2010)
   PUBMED   20613766
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 2476)
  AUTHORS   Watschinger,K., Keller,M.A., Golderer,G., Hermann,M., Maglione,M.,
            Sarg,B., Lindner,H.H., Hermetter,A., Werner-Felmayer,G., Konrat,R.,
            Hulo,N. and Werner,E.R.
  TITLE     Identification of the gene encoding alkylglycerol monooxygenase
            defines a third class of tetrahydrobiopterin-dependent enzymes
  JOURNAL   Proc Natl Acad Sci U S A 107 (31), 13672-13677 (2010)
   PUBMED   20643956
  REMARK    GeneRIF: Transmembrane protein 195 has
            tetrahydrobiopterin-dependent alkylglycerol monooxygenase activity
            (also known as glyceryl-ether monooxygenase activity, E.C.
            1.14.16.5).
REFERENCE   9  (bases 1 to 2476)
  AUTHORS   Boesgaard,T.W., Grarup,N., Jorgensen,T., Borch-Johnsen,K.,
            Hansen,T. and Pedersen,O.
  CONSRTM   Meta-Analysis of Glucose and Insulin-Related Trait Consortium
            (MAGIC)
  TITLE     Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are
            associated with reduced glucose-stimulated beta cell function in
            middle-aged Danish people
  JOURNAL   Diabetologia 53 (8), 1647-1655 (2010)
   PUBMED   20419449
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2476)
  AUTHORS   Dupuis,J., Langenberg,C., Prokopenko,I., Saxena,R., Soranzo,N.,
            Jackson,A.U., Wheeler,E., Glazer,N.L., Bouatia-Naji,N., Gloyn,A.L.,
            Lindgren,C.M., Magi,R., Morris,A.P., Randall,J., Johnson,T.,
            Elliott,P., Rybin,D., Thorleifsson,G., Steinthorsdottir,V.,
            Henneman,P., Grallert,H., Dehghan,A., Hottenga,J.J., Franklin,C.S.,
            Navarro,P., Song,K., Goel,A., Perry,J.R., Egan,J.M., Lajunen,T.,
            Grarup,N., Sparso,T., Doney,A., Voight,B.F., Stringham,H.M., Li,M.,
            Kanoni,S., Shrader,P., Cavalcanti-Proenca,C., Kumari,M., Qi,L.,
            Timpson,N.J., Gieger,C., Zabena,C., Rocheleau,G., Ingelsson,E.,
            An,P., O'Connell,J., Luan,J., Elliott,A., McCarroll,S.A., Payne,F.,
            Roccasecca,R.M., Pattou,F., Sethupathy,P., Ardlie,K., Ariyurek,Y.,
            Balkau,B., Barter,P., Beilby,J.P., Ben-Shlomo,Y., Benediktsson,R.,
            Bennett,A.J., Bergmann,S., Bochud,M., Boerwinkle,E., Bonnefond,A.,
            Bonnycastle,L.L., Borch-Johnsen,K., Bottcher,Y., Brunner,E.,
            Bumpstead,S.J., Charpentier,G., Chen,Y.D., Chines,P., Clarke,R.,
            Coin,L.J., Cooper,M.N., Cornelis,M., Crawford,G., Crisponi,L.,
            Day,I.N., de Geus,E.J., Delplanque,J., Dina,C., Erdos,M.R.,
            Fedson,A.C., Fischer-Rosinsky,A., Forouhi,N.G., Fox,C.S.,
            Frants,R., Franzosi,M.G., Galan,P., Goodarzi,M.O., Graessler,J.,
            Groves,C.J., Grundy,S., Gwilliam,R., Gyllensten,U., Hadjadj,S.,
            Hallmans,G., Hammond,N., Han,X., Hartikainen,A.L., Hassanali,N.,
            Hayward,C., Heath,S.C., Hercberg,S., Herder,C., Hicks,A.A.,
            Hillman,D.R., Hingorani,A.D., Hofman,A., Hui,J., Hung,J.,
            Isomaa,B., Johnson,P.R., Jorgensen,T., Jula,A., Kaakinen,M.,
            Kaprio,J., Kesaniemi,Y.A., Kivimaki,M., Knight,B., Koskinen,S.,
            Kovacs,P., Kyvik,K.O., Lathrop,G.M., Lawlor,D.A., Le Bacquer,O.,
            Lecoeur,C., Li,Y., Lyssenko,V., Mahley,R., Mangino,M.,
            Manning,A.K., Martinez-Larrad,M.T., McAteer,J.B., McCulloch,L.J.,
            McPherson,R., Meisinger,C., Melzer,D., Meyre,D., Mitchell,B.D.,
            Morken,M.A., Mukherjee,S., Naitza,S., Narisu,N., Neville,M.J.,
            Oostra,B.A., Orru,M., Pakyz,R., Palmer,C.N., Paolisso,G.,
            Pattaro,C., Pearson,D., Peden,J.F., Pedersen,N.L., Perola,M.,
            Pfeiffer,A.F., Pichler,I., Polasek,O., Posthuma,D., Potter,S.C.,
            Pouta,A., Province,M.A., Psaty,B.M., Rathmann,W., Rayner,N.W.,
            Rice,K., Ripatti,S., Rivadeneira,F., Roden,M., Rolandsson,O.,
            Sandbaek,A., Sandhu,M., Sanna,S., Sayer,A.A., Scheet,P.,
            Scott,L.J., Seedorf,U., Sharp,S.J., Shields,B., Sigurethsson,G.,
            Sijbrands,E.J., Silveira,A., Simpson,L., Singleton,A., Smith,N.L.,
            Sovio,U., Swift,A., Syddall,H., Syvanen,A.C., Tanaka,T.,
            Thorand,B., Tichet,J., Tonjes,A., Tuomi,T., Uitterlinden,A.G., van
            Dijk,K.W., van Hoek,M., Varma,D., Visvikis-Siest,S., Vitart,V.,
            Vogelzangs,N., Waeber,G., Wagner,P.J., Walley,A., Walters,G.B.,
            Ward,K.L., Watkins,H., Weedon,M.N., Wild,S.H., Willemsen,G.,
            Witteman,J.C., Yarnell,J.W., Zeggini,E., Zelenika,D., Zethelius,B.,
            Zhai,G., Zhao,J.H., Zillikens,M.C., Borecki,I.B., Loos,R.J.,
            Meneton,P., Magnusson,P.K., Nathan,D.M., Williams,G.H.,
            Hattersley,A.T., Silander,K., Salomaa,V., Smith,G.D.,
            Bornstein,S.R., Schwarz,P., Spranger,J., Karpe,F., Shuldiner,A.R.,
            Cooper,C., Dedoussis,G.V., Serrano-Rios,M., Morris,A.D., Lind,L.,
            Palmer,L.J., Hu,F.B., Franks,P.W., Ebrahim,S., Marmot,M., Kao,W.H.,
            Pankow,J.S., Sampson,M.J., Kuusisto,J., Laakso,M., Hansen,T.,
            Pedersen,O., Pramstaller,P.P., Wichmann,H.E., Illig,T., Rudan,I.,
            Wright,A.F., Stumvoll,M., Campbell,H., Wilson,J.F., Bergman,R.N.,
            Buchanan,T.A., Collins,F.S., Mohlke,K.L., Tuomilehto,J.,
            Valle,T.T., Altshuler,D., Rotter,J.I., Siscovick,D.S.,
            Penninx,B.W., Boomsma,D.I., Deloukas,P., Spector,T.D.,
            Frayling,T.M., Ferrucci,L., Kong,A., Thorsteinsdottir,U.,
            Stefansson,K., van Duijn,C.M., Aulchenko,Y.S., Cao,A., Scuteri,A.,
            Schlessinger,D., Uda,M., Ruokonen,A., Jarvelin,M.R.,
            Waterworth,D.M., Vollenweider,P., Peltonen,L., Mooser,V.,
            Abecasis,G.R., Wareham,N.J., Sladek,R., Froguel,P., Watanabe,R.M.,
            Meigs,J.B., Groop,L., Boehnke,M., McCarthy,M.I., Florez,J.C. and
            Barroso,I.
  CONSRTM   DIAGRAM Consortium; GIANT Consortium; Global BPgen Consortium;
            Anders Hamsten on behalf of Procardis Consortium; MAGIC
            investigators
  TITLE     New genetic loci implicated in fasting glucose homeostasis and
            their impact on type 2 diabetes risk
  JOURNAL   Nat Genet 42 (2), 105-116 (2010)
   PUBMED   20081858
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet.2010 May;42(5):464]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK131284.1 and AC091789.5.
            
            On Nov 23, 2018 this sequence version replaced NM_001004320.1.
            
            Summary: The protein encoded by this gene is a tetrahydrobiopterin-
            and iron-dependent enzyme that cleaves the ether bond of
            alkylglycerols. Sequence comparisons distinguish this protein as
            forming a third, distinct class of tetrahydrobiopterin-dependent
            enzymes. Variations in this gene have been associated with
            decreased glucose-stimulated insulin response, type 2 diabetes, and
            susceptibility to intracranial aneurysms. [provided by RefSeq, Aug
            2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131284.1, SRR1660809.224668.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342526.8/ ENSP00000341662.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2475              AK131284.1         1-2475
            2476-2476           AC091789.5         30804-30804         c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..2476
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /note="alkylglycerol monooxygenase"
                     /db_xref="GeneID:392636"
                     /db_xref="HGNC:HGNC:33784"
                     /db_xref="MIM:613738"
     exon            1..296
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1508
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /EC_number="1.14.16.5"
                     /note="transmembrane protein 195; glyceryl-ether
                     monooxygenase"
                     /codon_start=1
                     /product="alkylglycerol monooxygenase"
                     /protein_id="NP_001004320.1"
                     /db_xref="CCDS:CCDS34604.1"
                     /db_xref="GeneID:392636"
                     /db_xref="HGNC:HGNC:33784"
                     /db_xref="MIM:613738"
                     /translation="MKNPEAQQDVSVSQGFRMLFYTMKPSETSFQTLEEVPDYVKKAT
                     PFFISLMLLELVVSWILKGKPPGRLDDALTSISAGVLSRLPSLFFRSIELTSYIYIWE
                     NYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDYNLSTAL
                     RQSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVINNLGPLELILNTP
                     SHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFEPIKVQFH
                     HLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSSSSSQL
                     LKIYTVVQFALMLAFYEETFADTAALSQVTLLLRVCFIILTLTSIGFLLDQRPKAAIM
                     ETLRCLMFLMLYRFGHLKPLVPSLSSAFEIVFSICIAFWGVRSMKQLTSHPWK"
     exon            297..427
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            428..579
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            580..683
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            684..779
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            780..846
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            847..912
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            913..992
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1127
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1244
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1327
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1433
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..2476
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1625..1630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /note="hexamer: AGTAAA"
     polyA_site      1645
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /note="major polyA site"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /note="hexamer: ATTAAA"
     polyA_site      1692
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
                     /note="hexamer: AATAAA"
     polyA_site      2476
                     /gene="AGMO"
                     /gene_synonym="TMEM195"
ORIGIN      
        1 ctctctacac agaatcggct gttgagtgtg ctctcagtgg agctttggtt ttagctgttc
       61 tctgacaaag agcttgttct gagctgcaca tctcgtcctc tttgttcagc ctcaggcttc
      121 aagcattgaa tcctaaatat tctccagctg ggaatcagac aagggcagaa atgaagaacc
      181 cagaagccca gcaggatgtt tcagtttccc agggatttcg catgttgttt tacacgatga
      241 aacccagtga aacttcattc caaacattag aagaggtgcc tgattatgta aaaaaggcaa
      301 ctccattttt catttctttg atgctgcttg aacttgttgt cagctggatt ctcaaaggaa
      361 agccaccagg tcgcctggat gatgctttaa cgtcaatctc agctggtgtt ctgtctcgac
      421 ttccaagtct atttttcagg agcattgaac tgaccagtta tatttatatc tgggagaact
      481 acaggctgtt caatttgcct tgggattctc catggacttg gtattcagcc ttcttaggag
      541 ttgactttgg ctactactgg ttccatcgta tggctcatga agttaatatt atgtgggccg
      601 gacaccaaac acatcatagt tctgaagact ataacttatc cacagcactg agacagtctg
      661 tcctccagat atatacttcc tggattttct actctcccct ggccctcttc ataccccctt
      721 cagtatatgc tgttcatctt caattcaatc ttctttacca attttggatc catacagagg
      781 tcatcaataa ccttggtcct ttggaactga ttcttaatac tcctagccat catagggttc
      841 atcatggcag aaatcgttat tgcatagaca aaaattatgc tggtgttctt attatttggg
      901 ataaaatttt tgggacattt gaagcagaaa atgaaaaagt tgtatatggc ttaacacatc
      961 ccattaatac atttgaacca atcaaagtgc agttccatca cttattttcc atatggacta
     1021 cattctgggc cacacctgga ttcttcaata agttttctgt catatttaag ggaccgggat
     1081 ggggtccagg taaaccaaga cttggtctca gtgaagaaat tccagaggtc accggcaaag
     1141 aagttccctt ctcatcatct tcatctcagc tattaaagat atatacagtt gtacagtttg
     1201 ctctgatgtt ggcattttat gaagagacct ttgcagatac agctgcactg tcgcaagtta
     1261 ctctccttct gagggtttgc ttcattatcc tgaccttgac ttccattgga tttcttctgg
     1321 atcaaagacc caaggcagct attatggaaa ctctccgttg cttgatgttc ttaatgctgt
     1381 accgatttgg tcacctgaag cctcttgtcc cttcattgtc atctgctttt gagattgttt
     1441 tttccatttg cattgctttc tggggagtta gaagcatgaa acaactcacc tctcaccctt
     1501 ggaaataacc tgaatttgta cataattctc ttcttttaat gagttgtcca cacgcatatt
     1561 atgactgcat attaaaatgt aattatttta tgtaatgctt atatgaacta tttcttcaat
     1621 gaaaagtaaa attacttatt tactattgtt tgcctttcac atttgttatt ttctattaaa
     1681 aattaaagtc agttttggtt acttcccccc tttactacaa ttaaaaaaag atttcaaata
     1741 taatgatgtt atattaactg atagccttat atgacaagta taaaaagaag ggatgaaact
     1801 taaaaacagt aaaaacaaga aggaatattg cctttacatc aatttgaaaa caatgtttcc
     1861 tttgatgttt gctaaaatta tgcatagata catgtttgta gtcataaaaa tgtattacat
     1921 tggttgtctt cctaaggcca cagttacctt tgcaatccat ataacctaag aagctgcatt
     1981 ccagaaaaag acatcactga ggccaggcgc ggtggctcac ccctgtaatc ccagcacttt
     2041 gtggggctga ggtgggcgga tcatgaggtc cagagataga gaccatcctg gccaacatgg
     2101 tgaagtcctg tctctactaa aaatataaaa atttagctgg acatggtggt gtgcgcctgt
     2161 agtcccagct actctggagg ctgaggcagg agaatcgctt gaacctggga ggcagaagtt
     2221 ggagtgagtg gagattgcac cactgcactc cagcctgggc gacagagcga gactccgtct
     2281 caaagaaaaa agacatcact gaaagaaaaa tgaacagaat ttgtcagaat tagttttttc
     2341 aacaggttac tttgtcatac atttctctaa tatgcttggt caatttgttt tggcagactg
     2401 ggcagcatgc agcaattctg cattatttaa agttatcaga acaatgttaa ttctctaaat
     2461 aaaattaccc aaggtg
//
