LOCUS       NM_024758               3095 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens agmatinase (putative) (AGMAT), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_024758 XR_108379 XR_112035 XR_114829
VERSION     NM_024758.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Xie,Y., Zhang,Y., Liu,X., Cao,L., Han,M., Wang,C., Chen,J. and
            Zhang,X.
  TITLE     miR-151a-5p promotes the proliferation and metastasis of colorectal
            carcinoma cells by targeting AGMAT
  JOURNAL   Oncol Rep 49 (3) (2023)
   PUBMED   36704851
  REMARK    GeneRIF: miR151a5p promotes the proliferation and metastasis of
            colorectal carcinoma cells by targeting AGMAT.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Sinn,M., Stanoppi,M., Hauth,F., Fleming,J.R., Funck,D., Mayans,O.
            and Hartig,J.S.
  TITLE     Guanidino acid hydrolysis by the human enzyme annotated as
            agmatinase
  JOURNAL   Sci Rep 12 (1), 22088 (2022)
   PUBMED   36543883
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Zhu,H.E., Yin,J.Y., Chen,D.X., He,S. and Chen,H.
  TITLE     Agmatinase promotes the lung adenocarcinoma tumorigenesis by
            activating the NO-MAPKs-PI3K/Akt pathway
  JOURNAL   Cell Death Dis 10 (11), 854 (2019)
   PUBMED   31699997
  REMARK    GeneRIF: Agmatinase promotes the lung adenocarcinoma tumorigenesis
            by activating the NO-MAPKs-PI3K/Akt pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Dallmann,K., Junker,H., Balabanov,S., Zimmermann,U., Giebel,J. and
            Walther,R.
  TITLE     Human agmatinase is diminished in the clear cell type of renal cell
            carcinoma
  JOURNAL   Int J Cancer 108 (3), 342-347 (2004)
   PUBMED   14648699
  REMARK    GeneRIF: Agmatinase is down-regulated in the clear cell type of
            renal cell carcinoma
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Morris,S.M. Jr.
  TITLE     Vertebrate agmatinases: what role do they play in agmatine
            catabolism?
  JOURNAL   Ann N Y Acad Sci 1009, 30-33 (2003)
   PUBMED   15028567
  REMARK    Review article
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Iyer,R.K., Kim,H.K., Tsoa,R.W., Grody,W.W. and Cederbaum,S.D.
  TITLE     Cloning and characterization of human agmatinase
  JOURNAL   Mol Genet Metab 75 (3), 209-218 (2002)
   PUBMED   11914032
REFERENCE   9  (bases 1 to 3095)
  AUTHORS   Mistry,S.K., Burwell,T.J., Chambers,R.M., Rudolph-Owen,L.,
            Spaltmann,F., Cook,W.J. and Morris,S.M. Jr.
  TITLE     Cloning of human agmatinase. An alternate path for polyamine
            synthesis induced in liver by hepatitis B virus
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 282 (2), G375-G381 (2002)
   PUBMED   11804860
  REMARK    GeneRIF: an alternative to ornithine decarboxylase for polyamine
            biosynthesis
REFERENCE   10 (bases 1 to 3095)
  AUTHORS   Chen,F.W., Davies,J.P. and Ioannou,Y.A.
  TITLE     Differential gene expression in apoptosis: identification of
            ribosomal protein 23K, a cell proliferation inhibitor
  JOURNAL   Mol Genet Metab 64 (4), 271-282 (1998)
   PUBMED   9758718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN996958.1, BC005090.1 and AL121992.24.
            
            On Nov 22, 2018 this sequence version replaced NM_024758.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.3467.1,
                                           SRR1163657.264987.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375826.4/ ENSP00000364986.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-661               DN996958.1         50-710
            662-1245            BC005090.1         721-1304
            1246-3095           AL121992.24        35875-37724         c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..3095
                     /gene="AGMAT"
                     /note="agmatinase (putative)"
                     /db_xref="GeneID:79814"
                     /db_xref="HGNC:HGNC:18407"
                     /db_xref="MIM:617887"
     exon            1..356
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1143
                     /gene="AGMAT"
                     /EC_number="3.5.3.1"
                     /EC_number="3.5.3.7"
                     /EC_number="3.5.3.17"
                     /note="agmatinase, mitochondrial; AUH; agmatine
                     ureohydrolase (agmatinase); arginase, mitochondrial;
                     guanidinobutyrase, mitochondrial; guanidinopropionase,
                     mitochondrial; guanidino acid hydrolase, mitochondrial"
                     /codon_start=1
                     /product="guanidino acid hydrolase, mitochondrial
                     precursor"
                     /protein_id="NP_079034.3"
                     /db_xref="CCDS:CCDS160.1"
                     /db_xref="GeneID:79814"
                     /db_xref="HGNC:HGNC:18407"
                     /db_xref="MIM:617887"
                     /translation="MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQP
                     PSPEFVARPVGVCSMMRLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESV
                     MLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGG
                     DHTITYPILQAMAKKHGPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKR
                     VVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFD
                     IDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALL
                     AANLLFEMLCALPKVTTV"
     exon            357..559
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            560..608
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            609..804
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            805..984
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1069
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..3095
                     /gene="AGMAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3070..3075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGMAT"
                     /note="hexamer: ATTAAA"
     polyA_site      3095
                     /gene="AGMAT"
                     /note="major polyA site"
ORIGIN      
        1 acactcgcct cgccgttcgg gaccagccag atcgcggcgg cctcgcgggc ggtttggtcg
       61 gtgaggtctt ggccgcgcgc ggcaatgctg aggctgctgg cgtccgggtg cgcccggggc
      121 ccggggcccg gcgtgggcgc gcgtcctgcc gcagggctct ttcatccggg gcgccgccag
      181 agccgccagg cttccgacgc gccccggaac cagcccccca gccccgagtt cgtggcccgg
      241 ccggtgggcg tctgctccat gatgcgcctg ccggtgcaga cctcccccga ggggctggac
      301 gctgccttca tcggggtgcc cctggatact gggacctcca accggcctgg ggcgagattc
      361 ggacctcgcc gcatccggga agaatcagtg atgcttggga cagtcaatcc tagcacgggg
      421 gccctcccct tccagtccct catggttgca gacctaggcg atgtgaatgt caatctttac
      481 aaccttcagg acagctgccg gcgaattcaa gaggcctatg agaaaattgt agcagctggc
      541 tgtattcctc tgaccttggg tggagatcac acaatcacat atcccatatt gcaagcgatg
      601 gcaaaaaagc atggcccagt ggggctgctg cacgtggatg cgcacacgga cacgaccgac
      661 aaggccctag gagagaagct ctaccacggg gcgcccttcc gccggtgtgt ggatgagggt
      721 ctcctggact gtaagcgtgt ggtgcagatt ggcatccggg gctcttccac gaccttggat
      781 ccctacagat acaaccggag ccagggcttc cgggtagtcc tggctgaaga ctgctggatg
      841 aagtcgctgg ttcctctgat gggggaagtc aggcagcaga tgggaggcaa acccatttat
      901 atcagctttg atattgacgc tctggatcct gcctatgcgc cagggacagg gacacctgaa
      961 attgctggtc tcactcctag tcaggctctg gagatcatca ggggttgtca aggcctgaac
     1021 gtgatgggct gtgatcttgt cgaagtttca ccaccgtatg atctttctgg gaacacagcc
     1081 ctgctggcgg ctaacctgct gtttgagatg ctatgtgctc tccccaaagt gacaaccgtc
     1141 tgagtcttgt gctcttcaag acaaaacaga ttgcgtcgct gacaagttct caagaagaac
     1201 ttatgagtaa gcagtctgag aactaaagag tttatgccaa gaaaactttc tgctgaaagt
     1261 gtcattgctg gctgtgaagt cgggataatc agtagaattc tcacccaaac agcaacattt
     1321 ctaaggaact tggattaatt gggggaaaaa aaaaggagta cttgtactgc tttgattttt
     1381 tttcctttga tgaaagatgg aggataaagg ggaagtgagg agaatttctt tcaagattat
     1441 ctaaacatta gaaacatgac atttaaaaaa actatgaaat aatactgtat aagcattcca
     1501 tatttctata tcttcctttt aaacattttt ttttttgaga tagagttttg cttgtcaccc
     1561 aggctggagt gcaatggcat gatctcggtt cattgcaacc tccgcctccc gagttcaatc
     1621 gattctcctg cctcagcctc ctgagtacct gggattacag gtgcctgcca ccacgcctgg
     1681 ctaatttttg tatttttagt agagacaggg tttcaccaca ttggccaggc tggtcttgaa
     1741 ctcctgacct aaggtgatcc gcccgcctca gcctccttaa agtgctggga ttacaggcat
     1801 gagccaccgc acccagccgc tttttaaaat tttgatgatc tgcttcctag agtattgagt
     1861 atcttccttt aaactacagc tcctcctcgg acgctgcagt gagctgagat cgcaccactg
     1921 cactccagcc tgggtgccag agcaagactc catctcaaaa aaaaaaaaaa aaaatacagc
     1981 ttctcctatg aggtgcttag ggctgcatct tggttttagg accactgtga acgtaagtaa
     2041 aaagtataaa gtaacacgga gagcctaatg aagaaacttc ttgctcagag gcctagaagg
     2101 gtacacaaaa tgtcttctaa actagaaaac ctaaggctgg acacggtggc tcatgcctgt
     2161 aatcccagca ctttgggggg cggaggtggg cagatcactt gaggtcagga gttcgagacc
     2221 agcctggcca acatggtgaa aacccatctc tactgaaaat acagaagtta gctgggcgtg
     2281 gtggcgcgtg cctatagtcc cagctactca ggaagctgag gcaggggcat tgcttgaacc
     2341 cgggaggtgg aggttgcagt gagctgaggt catgccacta cactccagcc tgggtgacag
     2401 agtgagactc cgtctccaaa aaaaaaaaaa aaaaaaaaaa agcaggccgg acccagtggc
     2461 tcacgcctgt aatcccaggc ctaggcggga ggatcacctg aggtcaggag ttcaagacca
     2521 gcctggccaa catggtgaaa ccccgtctct actaaaaaac aaaacaaaac aaaacaaaac
     2581 aaaaaaaccc cagaaaacaa aacaaaactg gaaaatgtca gctgggcttt tttttttttt
     2641 tttttttctg agatggagtc tcgctctgtc ccccaggctg gagtgcagtg gcccgatctt
     2701 agctcactgc aatctccgcc tcctgggttc aagcaattct gctgcctcag cctcctgagt
     2761 agctagaatt acagtcatgc gtcaccacgc ccggctaatt tttgtatttt tagtagagac
     2821 ggggtttcac catgttggcc aggctggcag ctgggctctt aatgttactt attgtaactc
     2881 acttcctgta agactcaatc tactcttcaa gttgatgtac cctctatgac tgtaattcct
     2941 gaaatctgca gttatgctgt ggtgatctta agcgtgtctt gagttccatg caaattcaat
     3001 tctgttgata atgtgtccat aatcaaatca tcatcttgca atgcaagggc taccccataa
     3061 ttatcagaca ttaaaatagt ttatttcttt ttcca
//
