LOCUS       NM_018238               3628 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens acylglycerol kinase (AGK), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_018238
VERSION     NM_018238.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Wu,C.W., Caha,M., Smoot,L., Harris,D.J., Roberts,A.E., Sacharow,S.
            and Bodamer,O.
  TITLE     Sengers syndrome and AGK-related disorders - Minireview of
            phenotypic variability and clinical outcomes in molecularly
            confirmed cases
  JOURNAL   Mol Genet Metab 139 (3), 107626 (2023)
   PUBMED   37354892
  REMARK    GeneRIF: Sengers syndrome and AGK-related disorders - Minireview of
            phenotypic variability and clinical outcomes in molecularly
            confirmed cases.
            Review article
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Meng,K., Lu,S., Li,Y.Y., Hu,L.L., Zhang,J., Cao,Y., Wang,Y.,
            Zhang,C.Z. and He,Q.Y.
  TITLE     LINC00493-encoded microprotein SMIM26 exerts anti-metastatic
            activity in renal cell carcinoma
  JOURNAL   EMBO Rep 24 (6), e56282 (2023)
   PUBMED   37009826
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Sun,F., Wei,Y., Liu,Z., Jie,Q., Yang,X., Long,P., Wang,J.,
            Xiong,Y., Li,Q., Quan,S. and Ma,Y.
  TITLE     Acylglycerol kinase promotes ovarian cancer progression and
            regulates mitochondria function by interacting with ribosomal
            protein L39
  JOURNAL   J Exp Clin Cancer Res 41 (1), 238 (2022)
   PUBMED   35934718
  REMARK    GeneRIF: Acylglycerol kinase promotes ovarian cancer progression
            and regulates mitochondria function by interacting with ribosomal
            protein L39.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Long,Y., Li,C. and Zhu,B.
  TITLE     Circ_0008068 facilitates the oral squamous cell carcinoma
            development by microRNA-153-3p/acylgycerol kinase (AGK) axis
  JOURNAL   Bioengineered 13 (5), 13055-13069 (2022)
   PUBMED   35635053
  REMARK    GeneRIF: Circ_0008068 facilitates the oral squamous cell carcinoma
            development by microRNA-153-3p/acylgycerol kinase (AGK) axis.
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Nouh,M.A., Wu,X.X., Okazoe,H., Tsunemori,H., Haba,R.,
            Abou-Zeid,A.M., Saleem,M.D., Inui,M., Sugimoto,M., Aoki,J. and
            Kakehi,Y.
  TITLE     Expression of autotaxin and acylglycerol kinase in prostate cancer:
            association with cancer development and progression
  JOURNAL   Cancer Sci 100 (9), 1631-1638 (2009)
   PUBMED   19549252
  REMARK    GeneRIF: High Expression of acylglycerol kinase is associated with
            development and progression of prostate cancer.
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   Epand,R.M., Shulga,Y.V., Timmons,H.C., Perri,A.L., Belani,J.D.,
            Perinpanathan,K., Johnson-McIntire,L.B., Bajjalieh,S., Dicu,A.O.,
            Elias,C., Rychnovsky,S.D. and Topham,M.K.
  TITLE     Substrate chirality and specificity of diacylglycerol kinases and
            the multisubstrate lipid kinase
  JOURNAL   Biochemistry 46 (49), 14225-14231 (2007)
   PUBMED   18004883
  REMARK    GeneRIF: The chiral specificity of diacylglycerol kinase alpha,
            zeta & epsilon mimics the substrate specificity, with MuLK being
            the least selective and the epsilon isoform of diacylglycerol
            kinase exhibiting the greatest selectivity.
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Spiegel,S. and Milstien,S.
  TITLE     Functions of the multifaceted family of sphingosine kinases and
            some close relatives
  JOURNAL   J Biol Chem 282 (4), 2125-2129 (2007)
   PUBMED   17135245
  REMARK    Review article
REFERENCE   8  (bases 1 to 3628)
  AUTHORS   Van Overloop,H., Gijsbers,S. and Van Veldhoven,P.P.
  TITLE     Further characterization of mammalian ceramide kinase: substrate
            delivery and (stereo)specificity, tissue distribution, and
            subcellular localization studies
  JOURNAL   J Lipid Res 47 (2), 268-283 (2006)
   PUBMED   16269826
REFERENCE   9  (bases 1 to 3628)
  AUTHORS   Bektas,M., Payne,S.G., Liu,H., Goparaju,S., Milstien,S. and
            Spiegel,S.
  TITLE     A novel acylglycerol kinase that produces lysophosphatidic acid
            modulates cross talk with EGFR in prostate cancer cells
  JOURNAL   J Cell Biol 169 (5), 801-811 (2005)
   PUBMED   15939762
REFERENCE   10 (bases 1 to 3628)
  AUTHORS   Waggoner,D.W., Johnson,L.B., Mann,P.C., Morris,V., Guastella,J. and
            Bajjalieh,S.M.
  TITLE     MuLK, a eukaryotic multi-substrate lipid kinase
  JOURNAL   J Biol Chem 279 (37), 38228-38235 (2004)
   PUBMED   15252046
  REMARK    GeneRIF: identification and characterization of a novel lipid
            kinase that phosphorylates multiple substrates, MuLK
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK001704.1, BC022777.1,
            AJ278150.1, AW961934.1 and BU740733.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 16, 2018 this sequence version replaced NM_018238.3.
            
            Summary: The protein encoded by this gene is a mitochondrial
            membrane protein involved in lipid and glycerolipid metabolism. The
            encoded protein is a lipid kinase that catalyzes the formation of
            phosphatidic and lysophosphatidic acids. Defects in this gene have
            been associated with mitochondrial DNA depletion syndrome 10.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: The variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.213505.1,
                                           SRR1660807.21362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000649286.2/
                                                  ENSP00000497280.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AK001704.1         1-14
            15-266              BC022777.1         1-252
            267-2019            AJ278150.1         255-2007
            2020-2793           BC022777.1         2006-2779
            2794-3155           AW961934.1         1-362               c
            3156-3505           BU740733.1         140-489             c
            3506-3628           BU740733.1         16-138              c
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3628
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="acylglycerol kinase"
                     /db_xref="GeneID:55750"
                     /db_xref="HGNC:HGNC:21869"
                     /db_xref="MIM:610345"
     exon            1..25
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            26..140
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1308
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /EC_number="2.7.1.107"
                     /EC_number="2.7.1.94"
                     /EC_number="2.7.1.138"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; multi-substrate lipid kinase; multiple
                     substrate lipid kinase; acylglycerol kinase,
                     mitochondrial; hAGK; hsMuLK"
                     /codon_start=1
                     /product="acylglycerol kinase, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_060708.1"
                     /db_xref="CCDS:CCDS5865.1"
                     /db_xref="GeneID:55750"
                     /db_xref="HGNC:HGNC:21869"
                     /db_xref="MIM:610345"
                     /translation="MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQ
                     EAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDY
                     EGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSL
                     SHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAG
                     VKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLY
                     RRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNIC
                     IEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEA
                     MPVEVKLLPRKLQFFCDPRKREQMLTSPTQ"
     exon            141..180
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            181..260
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            261..336
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            337..429
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            430..462
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            463..557
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            558..627
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            628..707
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            708..765
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            766..916
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1014
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1085
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1170
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..3628
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="hexamer: TATAAA"
     polyA_site      2529
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="major polyA site"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="hexamer: ATTAAA"
     polyA_site      2649
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
     regulatory      2759..2764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="hexamer: CATAAA"
     regulatory      2773..2778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="hexamer: AATAGA"
     polyA_site      2788
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
     polyA_site      2795
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
     regulatory      3607..3612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
                     /note="hexamer: TATAAA"
     polyA_site      3628
                     /gene="AGK"
                     /gene_synonym="CATC5; CTRCT38; MTDPS10; MULK"
ORIGIN      
        1 agagccgcga gctggaccag ccgtgcaaat ctctagaaga tgacggtgtt ctttaaaacg
       61 cttcgaaatc actggaagaa aactacagct gggctctgcc tgctgacctg gggaggccat
      121 tggctctatg gaaaacactg tgataacctc ctaaggagag cagcctgtca agaagctcag
      181 gtgtttggca atcaactcat tcctcccaat gcacaagtga agaaggccac tgtttttctc
      241 aatcctgcag cttgcaaagg aaaagccagg actctatttg aaaaaaatgc tgccccgatt
      301 ttacatttat ctggcatgga tgtgactatt gttaagacag attatgaggg acaagccaag
      361 aaactcctgg aactgatgga aaacacggat gtgatcattg ttgcaggagg agatgggaca
      421 ctgcaggagg ttgttactgg tgttcttcga cgaacagatg aggctacctt cagtaagatt
      481 cccattggat ttatcccact gggagagacc agtagtttga gtcataccct ctttgccgaa
      541 agtggaaaca aagtccaaca tattactgat gccacacttg ccattgtgaa aggagagaca
      601 gttccacttg atgtcttgca gatcaagggt gaaaaggaac agcctgtatt tgcaatgacc
      661 ggccttcgat ggggatcttt cagagatgct ggcgtcaaag ttagcaagta ctggtatctt
      721 gggcctctaa aaatcaaagc agcccacttt ttcagcactc ttaaggagtg gcctcagact
      781 catcaagcct ctatctcata cacgggacct acagagagac ctcccaatga accagaggag
      841 acccctgtac aaaggccttc tttgtacagg agaatattac gaaggcttgc gtcctactgg
      901 gcacaaccac aggatgccct ttcccaagag gtgagcccgg aggtctggaa agatgtgcag
      961 ctgtccacca ttgaactgtc catcacaaca cggaataatc agcttgaccc gacaagcaaa
     1021 gaagattttc tgaatatctg cattgaacct gacaccatca gcaaaggaga ctttataact
     1081 ataggaagtc gaaaggtgag aaaccccaag ctgcacgtgg agggcacgga gtgtctccaa
     1141 gccagccagt gcactttgct tatcccggag ggagcagggg gctcttttag cattgacagt
     1201 gaggagtatg aagcgatgcc tgtggaggtg aaactgctcc ccaggaagct gcagttcttc
     1261 tgtgatccta ggaagagaga acagatgctc acaagcccca cccagtgagc agcagaagac
     1321 aagcactctg agaccacact ttaggccacc ggtgggacca aaagggaaca ggtgcctcag
     1381 ccatcccaac agtgtcgtca gagggtcccc agggcatttt catggcaagt acccctctgc
     1441 ccccactcca gcagtgcttc ccaaagtgtg ctctgtcacc tgctttgcaa tcggcttcca
     1501 ttagcgcatg ttttattttg gtgtgacggt tggccctcct aaacacggac tttcctcagg
     1561 ctggttcaag acggaaaagg actttcttct gttttcttcc aaagtgcaac cacagtggag
     1621 agcccacggt gggcttagcc tgcctaggcc cttccatttc tcttctttga ccgtgctagg
     1681 aattccagga aagtgcattc ctgccctggt gaccttttcc tatgtctagg ctcctccaca
     1741 ggtgctgcta ttttgtgagc tccggctcct gtttagcttt tatttcagtt ctaacctcag
     1801 tccagaaaca tatgtgaggt tgtttccctc ttcagccacg gctacaatac cggaaaatgc
     1861 tagtttttat ttattttttt aagtagtgct tcctaaatgg tttgcatgag agccacctgg
     1921 ggtacatgtt gaaaacttat ttggggtcta ccccaaacct aataacccaa atttggggat
     1981 ggggcccagg aatatgcatt tttaaaaagt catctgccct tcccaggtga ttctgtaagt
     2041 tgtccctcaa ctgtacttgg agaaatcgtg ttttaaagca gtagtccaca aagtattctg
     2101 ctcatgtgcc cccaaaagta ttttgaaaaa tcatgtatac cctcacccat ctaagttgat
     2161 atctaaaatt ttatctaagt tggtatctaa aatttttcat gggaagttaa atagttgaca
     2221 aagtatgtat ttgctggtgt cgtgtaaata ttggtatttt aaaataaaaa ctgttacatc
     2281 actattttaa acatatccag tacaatttaa atatcacaac aatttgacac ccttcattca
     2341 tttataaaaa taaatgagct agttctttag tagttaaaca tttcaaattg gcttttctcc
     2401 ttctgtattt ccataccact tttcagccaa gaatcctatc ataatgtaat ctattatgcc
     2461 cgacatcttt taatcattca ccccattact tcttgtcaac aaaaaatata aatggaaatt
     2521 ttttttttag ctcttgcttt aagtgtttgt ttgttatctc agtccagaac caatattatc
     2581 gtaattaatt attggtatat aatgaaaacg gtattaattc ttggatgatt aaaagttttt
     2641 ttattagaat gttctttatc ctaattagtt catttatcca agaatacatg aatgtgattt
     2701 acagctgaga tggggttcaa cctcagctgt attccttgtt tctgtataga tgtaagcaca
     2761 taaattcgat ggaatagaat tacgttaaca atgtttttac agttctttgg attcctttgg
     2821 cattttgaca aagatcacag tgctctatca tcaagaatta ttaatgatga tctatcaact
     2881 aacaaacaac ttgattagat tctcctttag tctgttgaaa gcagagaact gaaatccacc
     2941 tgatttacca tggctttgcc agccagtcat tagcaccatt tacttttact atcgctgaca
     3001 ttttcctttg ttcagtggcc ctgaggttct tacactctag ggggcagtgc accacaggaa
     3061 gatagatcaa tgagggagga ttgcgagggg gaaggggagg aagcagagct ggcaggcctt
     3121 agctacaggc tctctctcag gcagatccct tttaagatac atacaccatg cccacacatc
     3181 ccatggagag agaccaatgc tttagtagat tacagaacag ctatgaaaag tccatgaatg
     3241 aagatcacaa aaaggaaggc tttcttattt catactgtat tcttcagggt ggtaaaattt
     3301 ctgcttttgg caaaaacata acagacggtt ccaaacatca gcataaagat cactcatccc
     3361 ataccaccca caggtaggga ggaaggatgc tgtagtatat gaaaacaaaa gttttcacct
     3421 gagctgagag catttagcat atcgtggttc tgtaacaata tcaaggacca gtgcagaatc
     3481 tggctttctt ttctgatagg ctaccagtgt gtgtttatgt gtgctcattt tgtggttcta
     3541 atcataatgg tacatataat tagggaagga tatggaagcc actttagaat cttattcatt
     3601 tttaaatata aatatgcctt gtttcaaa
//
