LOCUS       NM_018046               4490 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens angiogenic factor with G-patch and FHA domains 1
            (AGGF1), mRNA.
ACCESSION   NM_018046
VERSION     NM_018046.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4490)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4490)
  AUTHORS   Wang,R., Zhao,J., Liu,C., Li,S., Liu,W. and Cao,Q.
  TITLE     Decreased AGGF1 facilitates the progression of placenta accreta
            spectrum via mediating the P53 signaling pathway under the
            regulation of miR-1296-5p
  JOURNAL   Reprod Biol 23 (1), 100735 (2023)
   PUBMED   36753931
  REMARK    GeneRIF: Decreased AGGF1 facilitates the progression of placenta
            accreta spectrum via mediating the P53 signaling pathway under the
            regulation of miR-1296-5p.
REFERENCE   3  (bases 1 to 4490)
  AUTHORS   Wang,J., Peng,H., Timur,A.A., Pasupuleti,V., Yao,Y., Zhang,T.,
            You,S.A., Fan,C., Yu,Y., Jia,X., Chen,J., Xu,C., Chen,Q. and
            Wang,Q.
  TITLE     Receptor and Molecular Mechanism of AGGF1 Signaling in Endothelial
            Cell Functions and Angiogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (11), 2756-2769 (2021)
   PUBMED   34551592
  REMARK    GeneRIF: Receptor and Molecular Mechanism of AGGF1 Signaling in
            Endothelial Cell Functions and Angiogenesis.
REFERENCE   4  (bases 1 to 4490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4490)
  AUTHORS   Si,W., Zhou,B., Xie,W., Li,H., Li,K., Li,S., Deng,W., Shi,P.,
            Yuan,C., Ke,T., Ren,X., Tu,X., Zeng,X., Weigelt,B., Rubin,B.P.,
            Chen,Q., Xu,C. and Wang,Q.K.
  TITLE     Angiogenic factor AGGF1 acts as a tumor suppressor by modulating
            p53 post-transcriptional modifications and stability via MDM2
  JOURNAL   Cancer Lett 497, 28-40 (2021)
   PUBMED   33069768
  REMARK    GeneRIF: Angiogenic factor AGGF1 acts as a tumor suppressor by
            modulating p53 post-transcriptional modifications and stability via
            MDM2.
REFERENCE   6  (bases 1 to 4490)
  AUTHORS   Gutierrez,S., Magano,L., Delicado,A., Mori,M.A., de Torres,M.L.,
            Fernandez,L., Palomares,M., Fernandez,E., Tarduchy,G.R., Molano,J.,
            Gracia,R., Pajares,I.L. and Lapunzina,P.
  TITLE     The G397A (E133K) change in the AGGF1 (VG5Q) gene is a single
            nucleotide polymorphism in the Spanish population
  JOURNAL   Am J Med Genet A 140 (24), 2832-2833 (2006)
   PUBMED   17103452
  REMARK    GeneRIF: Observational study of genotype prevalence and
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4490)
  AUTHORS   Kihiczak,G.G., Meine,J.G., Schwartz,R.A. and Janniger,C.K.
  TITLE     Klippel-Trenaunay syndrome: a multisystem disorder possibly
            resulting from a pathogenic gene for vascular and tissue overgrowth
  JOURNAL   Int J Dermatol 45 (8), 883-890 (2006)
   PUBMED   16911369
  REMARK    GeneRIF: This review describes the somatic mutation for angiogenic
            factor VG5Q, which may be the cause of the multisystem disorder
            Klippel-Trenaunay syndrome.
            Review article
REFERENCE   8  (bases 1 to 4490)
  AUTHORS   Barker,K.T., Foulkes,W.D., Schwartz,C.E., Labadie,C., Monsell,F.,
            Houlston,R.S. and Harper,J.
  TITLE     Is the E133K allele of VG5Q associated with Klippel-Trenaunay and
            other overgrowth syndromes?
  JOURNAL   J Med Genet 43 (7), 613-614 (2006)
   PUBMED   16443853
  REMARK    GeneRIF: VG5Q, E133K is a mutation that causes Klippel-Trenaunay
            and other overgrowth syndromes.
REFERENCE   9  (bases 1 to 4490)
  AUTHORS   Timur,A.A., Driscoll,D.J. and Wang,Q.
  TITLE     Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular
            anomalies and vascular morphogenesis
  JOURNAL   Cell Mol Life Sci 62 (13), 1434-1447 (2005)
   PUBMED   15905966
  REMARK    Review article
REFERENCE   10 (bases 1 to 4490)
  AUTHORS   Tian,X.L., Kadaba,R., You,S.A., Liu,M., Timur,A.A., Yang,L.,
            Chen,Q., Szafranski,P., Rao,S., Wu,L., Housman,D.E.,
            DiCorleto,P.E., Driscoll,D.J., Borrow,J. and Wang,Q.
  TITLE     Identification of an angiogenic factor that when mutated causes
            susceptibility to Klippel-Trenaunay syndrome
  JOURNAL   Nature 427 (6975), 640-645 (2004)
   PUBMED   14961121
  REMARK    GeneRIF: results define VG5Q as an angiogenic factor, establish
            VG5Q as a susceptibility gene for Klippel-Trenaunay syndrome, and
            show that increased angiogenesis is a molecular pathogenic
            mechanism of KTS
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI561566.1, AY500994.1,
            AC008581.11, DR157679.1, BX648120.1 and AI453097.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018046.4.
            
            Summary: This gene encodes an angiogenic factor that promotes
            proliferation of endothelial cells. Mutations in this gene are
            associated with a susceptibility to Klippel-Trenaunay syndrome.
            Pseudogenes of this gene are found on chromosomes 3, 4, 10 and
            16.[provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.112465.1,
                                           SRR1660803.183314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312916.12/ ENSP00000316109.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BI561566.1         24-85
            63-1577             AY500994.1         1-1515
            1578-1578           AC008581.11        62996-62996
            1579-2766           AY500994.1         1517-2704
            2767-3078           DR157679.1         477-788
            3079-4469           BX648120.1         1907-3297
            4470-4490           AI453097.1         6-26                c
FEATURES             Location/Qualifiers
     source          1..4490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..4490
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="angiogenic factor with G-patch and FHA domains 1"
                     /db_xref="GeneID:55109"
                     /db_xref="HGNC:HGNC:24684"
                     /db_xref="MIM:608464"
     exon            1..573
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..2508
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="angiogenic factor VG5Q; vasculogenesis gene on 5q
                     protein; G patch domain-containing protein 7"
                     /codon_start=1
                     /product="angiogenic factor with G patch and FHA domains
                     1"
                     /protein_id="NP_060516.2"
                     /db_xref="CCDS:CCDS4035.1"
                     /db_xref="GeneID:55109"
                     /db_xref="HGNC:HGNC:24684"
                     /db_xref="MIM:608464"
                     /translation="MASEAPSPPRSPPPPTSPEPELAQLRRKVEKLERELRSCKRQVR
                     EIEKLLHHTERLYQNAESNNQELRTQVEELSKILQRGRNEDNKKSDVEVQTENHAPWS
                     ISDYFYQTYYNDVSLPNKVTELSDQQDQAIETSILNSKDHLQVENDAYPGTDRTENVK
                     YRQVDHFASNSQEPASALATEDTSLEGSSLAESLRAAAEAAVSQTGFSYDENTGLYFD
                     HSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYPTSSTKQSKDKKLKK
                     KRKDPDSSATNEEKDLNSEDQKAFSVEHTSCNEEENFANMKKKAKIGIHHKNSPPKVT
                     VPTSGNTIESPLHENISNSTSFKDEKIMETDSEPEEGEITDSQTEDSYDEAITSEGNV
                     TAEDSEDEDEDKIWPPCIRVIVIRSPVLQIGSLFIITAVNPATIGREKDMEHTLRIPE
                     VGVSKFHAEIYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIG
                     ETVLSFHIHPGSDTCDGCEPGQVRAHLRLDKKDESFVGPTLSKEEKELERRKELKKIR
                     VKYGLQNTEYEDEKTLKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGR
                     KMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKPSSFEDVHLLQNKNKKNW
                     DKARERFTENFPETKPQKDDPGTMPWVKGTLE"
     exon            574..676
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            677..879
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1044
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1233
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1564
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1676
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1728
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1830
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1996
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2079
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2207
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2307
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..4490
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2678..2683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="hexamer: AATAAA"
     polyA_site      2698
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="major polyA site"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="hexamer: AATAAA"
     polyA_site      3352
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="major polyA site"
     regulatory      4442..4447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="hexamer: ATTATA"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
                     /note="hexamer: CATAAA"
     polyA_site      4469
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
     polyA_site      4490
                     /gene="AGGF1"
                     /gene_synonym="GPATC7; GPATCH7; HSU84971; HUS84971; VG5Q"
ORIGIN      
        1 gccgttgttt ccggctcaac tggggagctg ctggagctct tctggcctct ggttttccga
       61 ctgcttatcc gacgctcctc cctctgtctc tgtagctgga gaaggtagtt tccaggaaag
      121 ttttccggtt tgcaggccgc gcacatcggg caggggccat cctcggtccc cttgctcgtt
      181 gctcgcagcc ccgttcggct acaagtgagt ttcagggcgt catggccagg ggccaccgcg
      241 gccagccggg tgtgaggctg cctttcgctg cccgcgcgct ccagtggtct ctgggtccgc
      301 cggcgtccgt ttcggcctga acgcagcccc tccgcggcga cgagcagtct cgcgccggag
      361 ctcatggcct cggaggcgcc gtccccgccg cggtcgccgc cgccgcccac ctcccccgag
      421 cctgagctgg cccagctaag gcggaaggtg gagaagttgg aacgtgaact gcggagctgc
      481 aagcggcagg tgcgggagat cgagaagctg ctgcatcaca cagaacggct gtaccagaac
      541 gcagaaagca acaaccagga gctccgcacg caggtggaag aactcagtaa aatactccaa
      601 cgtgggagaa atgaagataa taaaaagtct gatgtagaag tacaaacaga gaaccatgct
      661 ccttggtcaa tctcagatta tttttatcag acgtactaca atgacgttag tcttccaaat
      721 aaagtgactg aactgtcaga tcaacaagat caagctatcg aaacttctat tttgaattct
      781 aaagaccatt tacaagtaga aaatgatgct taccctggta ccgatagaac agaaaatgtt
      841 aaatatagac aagtggacca ttttgcctca aattcacagg agccagcatc tgcattagca
      901 acagaagata cctccttaga aggctcatca ttagctgaaa gtttgagagc tgcagcagaa
      961 gcggctgtat cacagactgg atttagttat gatgaaaata ctggactgta ttttgaccac
     1021 agcactggtt tctattatga ttctgaaaat caactctatt atgatccttc cactggaatt
     1081 tattactatt gtgatgtgga aagtggtcgt tatcagtttc attctcgagt agatttgcaa
     1141 ccttatccga cttctagcac aaaacaaagt aaagataaaa aattgaagaa gaaaagaaaa
     1201 gatccagatt cttctgcaac aaatgaggaa aaggatttga actcagagga tcaaaaagcc
     1261 ttcagtgttg aacatacaag ctgcaatgag gaagaaaatt tcgcaaatat gaaaaagaag
     1321 gccaaaatag gcattcatca caaaaatagt ccccccaaag tcactgttcc aactagtgga
     1381 aatactatag agtctcctct tcatgaaaac atctctaatt caacatcatt taaagatgag
     1441 aaaatcatgg agactgatag tgaaccagag gaaggtgaaa ttacagactc tcagactgag
     1501 gatagttatg acgaagccat taccagtgaa ggcaatgtaa ctgcagaaga tagtgaggat
     1561 gaagatgaag acaaaatttg gcccccatgt attagagtaa ttgtcattag atcacctgtg
     1621 ttgcagatag gatcactctt tatcattact gctgtaaacc ctgctacaat tggaagagaa
     1681 aaggatatgg aacatactct ccgaatccct gaagttggtg tcagtaagtt tcatgcagaa
     1741 atttattttg accatgactt acaaagttat gtccttgtgg atcaaggcag tcaaaatggc
     1801 acaattgtta atggaaaaca gattcttcag ccgaaaacta aatgtgaccc ttacgtactt
     1861 gagcatggag atgaagtcaa aattggagaa actgtcttat cctttcacat tcatcctggc
     1921 agtgatacct gtgatggctg tgaaccaggg caggttagag cccaccttcg ccttgataag
     1981 aaagatgaat cttttgttgg tccaacacta agtaaggagg aaaaagagtt ggaaagaaga
     2041 aaagaattaa agaaaatacg agtaaaatat ggtttacaga atacagaata cgaagatgaa
     2101 aagacattga agaatccaaa atataaagat agagctggaa aacgtaggga gcaggttgga
     2161 agtgaaggaa ctttccaaag agatgatgct cctgcatctg ttcattctga aattactgat
     2221 agcaacaaag gtcggaagat gttggagaag atgggttgga agaaaggaga gggcctgggg
     2281 aaggatggtg gaggaatgaa aacgccgatc cagcttcagc ttcggcgaac acatgcaggc
     2341 ttggggacag gcaaaccatc ctcatttgaa gatgttcacc ttctccaaaa caagaacaaa
     2401 aaaaactggg acaaagcacg agagcggttt actgaaaact tcccagaaac taagcctcaa
     2461 aaagatgacc cagggaccat gccttgggta aaagggactt tagagtgaag gctaatcata
     2521 gaaaaaaaac ctctagtttt tttaaaaata gaatttggaa acttattttt tctccccaaa
     2581 agaatcagca gcacagggga actatgtcac agtttacctc ttcctgattc agaaatgtgt
     2641 atggtttgca gcttttaaaa accatttttt taaaactaat aaatagtgac tgaaccaatt
     2701 tatgcagtaa atagactaaa gttcacaggg cacggatgag tttatcaaac ttcgttattt
     2761 tatcttgtca tttacaacat ccatataagc aactagccat ataagcaaaa ttcatagaac
     2821 tactaatgac ttaagtgtac atctgttctt gtctccatat attcatgtaa gatgcacaac
     2881 aaaagaaaca tcagaagttt ataaaaataa atctgactat atgcatcctc atttattccc
     2941 tttagaacct aggtaaaaaa tgttgcgaaa acatgggtag tggcgcatac attttgttat
     3001 ccttgaaata gcctaagtaa tgttattgaa gaactaatga acaggtaaca tattgtagaa
     3061 aattagtctt tcattgtttt cttctgtgaa gaatctgttg ctatgtactg tatattcagc
     3121 atttatattt ggtttgtttc atagctaatg aggtatttag atatgaacaa ctgaatacat
     3181 attgaaatag tgtgctggct tttgtagttt tgataaagac cattgcaggc aatggaattg
     3241 tgccagagaa atctgatttc tagtacaaaa ggaatactta gccagggcct caagctcaag
     3301 atacttattg aaaacatcct caattgcaat aaaaacatta taacatgaaa aagagtgatt
     3361 ttttgaaccg gtgatttaaa tgtattgatc tgctttgaat tttcaagcag ccagaatttt
     3421 ctagtttaaa ttggcagagt tataacaaag gagagcctca aatattagac aattgcagtg
     3481 cggctttctg ggcacaggtg tcactgctct gccacctatc actattcttt ttctgttcag
     3541 tttttctctc aggtgtttgc tgggaaatta acactggaac tgaccctttt ctggcagtga
     3601 atgtaagctc tagctccccc atctactata aagaaatgtc ttcgagatgt agaaataagg
     3661 aatattctga aaataaaaat tatacagtag taaagataat tcagaaagaa aaagctacct
     3721 gttagaattt ccagtctaaa tggcacaggg tagttacgga gaaaagggga tggagaagga
     3781 gaaactatga ctaaagatga gaggtatgaa cgagttgtca ggttcctatg ggcttaagct
     3841 aggacaatca ggccctaaac tccaaatttg gataaaatat ctctttgcat tcttcttggc
     3901 cacctgcata gtctgacaca tacgtatgta cagttagact tgcaggctgc aggagtgccc
     3961 tgcattgttt tcttttaatt agaaataaaa agtattagtc taaatgtggt tctggtgctg
     4021 gtgccctgta tatatgtaac aatataggac ccctccaaat aggttttgct tctggtgaat
     4081 cttggtcatt gggttagtat atgactgtct ataatatttt ccatttgtat tattatattg
     4141 gggaaaacat tttttatcat tttctattaa gaaaatggaa aacttaaata tggtgttaaa
     4201 aatggaaata tatgtgatat ttgcattatt aaaccccttt gcagatctaa agtctcaggg
     4261 ttccactatt agtggttaaa gtactgaata atgtctgggt ctatttccat ctgtaaaata
     4321 agaatatttg tctcacgtgt ctgtcatgaa tagcaaatga gaaaatgtat ataaaagcac
     4381 tttgtaaatt gtaaaagtag tacagatgtg agcttctatt tgtttagaag cataaatgtg
     4441 aattatatac agtttgaatt ttgcataaat tttttgtgtc taattttaaa
//
