LOCUS       NM_006076               4819 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ArfGAP with FG repeats 2 (AGFG2), mRNA.
ACCESSION   NM_006076
VERSION     NM_006076.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4819)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 4819)
  AUTHORS   Doria,M., Salcini,A.E., Colombo,E., Parslow,T.G., Pelicci,P.G. and
            Di Fiore,P.P.
  TITLE     The eps15 homology (EH) domain-based interaction between eps15 and
            hrb connects the molecular machinery of endocytosis to that of
            nucleocytosolic transport
  JOURNAL   J Cell Biol 147 (7), 1379-1384 (1999)
   PUBMED   10613896
REFERENCE   3  (bases 1 to 4819)
  AUTHORS   Glockner,G., Scherer,S., Schattevoy,R., Boright,A., Weber,J.,
            Tsui,L.C. and Rosenthal,A.
  TITLE     Large-scale sequencing of two regions in human chromosome 7q22:
            analysis of 650 kb of genomic sequence around the EPO and CUTL1
            loci reveals 17 genes
  JOURNAL   Genome Res 8 (10), 1060-1073 (1998)
   PUBMED   9799793
REFERENCE   4  (bases 1 to 4819)
  AUTHORS   Salcini,A.E., Confalonieri,S., Doria,M., Santolini,E., Tassi,E.,
            Minenkova,O., Cesareni,G., Pelicci,P.G. and Di Fiore,P.P.
  TITLE     Binding specificity and in vivo targets of the EH domain, a novel
            protein-protein interaction module
  JOURNAL   Genes Dev 11 (17), 2239-2249 (1997)
   PUBMED   9303539
REFERENCE   5  (bases 1 to 4819)
  AUTHORS   Wong,W.T., Schumacher,C., Salcini,A.E., Romano,A., Castagnino,P.,
            Pelicci,P.G. and Di Fiore,P.P.
  TITLE     A protein-binding domain, EH, identified in the receptor tyrosine
            kinase substrate Eps15 and conserved in evolution
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9530-9534 (1995)
   PUBMED   7568168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069281.6, BF310674.1,
            AK314954.1, BC017329.2, AK090744.1 and BC047227.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006076.4.
            
            Summary: This gene is a member of the HIV-1 Rev binding protein
            (HRB) family and encodes a protein with one Arf-GAP zinc finger
            domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF)
            motifs. This protein interacts with Eps15 homology (EH) domains and
            plays a role in the Rev export pathway, which mediates the
            nucleocytoplasmic transfer of proteins and RNAs. Alternatively
            spliced transcript variants have been described, but their
            biological validity has not been determined. [provided by RefSeq,
            Feb 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.162403.1,
                                           SRR3476690.1060030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300176.9/ ENSP00000300176.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC069281.6         63957-63964         c
            9-22                BF310674.1         1-14
            23-1590             AK314954.1         1-1568
            1591-2247           BC017329.2         1535-2191
            2248-2488           AK090744.1         7-247
            2489-2506           BC047227.1         31-48
            2507-4551           AK090744.1         265-2309
            4552-4819           BC047227.1         2093-2360
FEATURES             Location/Qualifiers
     source          1..4819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..4819
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /note="ArfGAP with FG repeats 2"
                     /db_xref="GeneID:3268"
                     /db_xref="HGNC:HGNC:5177"
                     /db_xref="MIM:604019"
     exon            1..365
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1590
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /note="Rev/Rex activation domain binding protein-related;
                     arf-GAP domain and FG repeats-containing protein 2;
                     nucleoporin; HIV-1 Rev-binding protein-like protein;
                     rev/Rex activation domain-binding protein related"
                     /codon_start=1
                     /product="arf-GAP domain and FG repeat-containing protein
                     2"
                     /protein_id="NP_006067.3"
                     /db_xref="CCDS:CCDS5697.1"
                     /db_xref="GeneID:3268"
                     /db_xref="HGNC:HGNC:5177"
                     /db_xref="MIM:604019"
                     /translation="MVMAAKKGPGPGGGVSGGKAEAEAASEVWCRRVRELGGCSQAGN
                     RHCFECAQRGVTYVDITVGSFVCTTCSGLLRGLNPPHRVKSISMTTFTEPEVVFLQSR
                     GNEVCRKIWLGLFDARTSLVPDSRDPQKVKEFLQEKYEKKRWYVPPDQVKGPTYTKGS
                     ASTPVQGSIPEGKPLRTLLGDPAPSLSVAASTSSQPVSQSHARTSQARSTQPPPHSSV
                     KKASTDLLADIGGDPFAAPQMAPAFAAFPAFGGQTPSQGGFANFDAFSSGPSSSVFGS
                     LPPAGQASFQAQPTPAGSSQGTPFGATPLAPASQPNSLADVGSFLGPGVPAAGVPSSL
                     FGMAGQVPPLQSVTMGGGGGSSTGLAFGAFTNPFTAPAAQSPLPSTNPFQPNGLAPGP
                     GFGMSSAGPGFPQAVPPTGAFASSFPAPLFPPQTPLVQQQNGSSFGDLGSAKLGQRPL
                     SQPAGISTNPFMTGPSSSPFASKPPTTNPFL"
     exon            366..459
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            460..575
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            576..729
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            730..895
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1021
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1142
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1231
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1315
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1444
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1530
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..4819
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2596
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /note="major polyA site"
     regulatory      4460..4465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /note="hexamer: AATAAA"
     polyA_site      4485
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
     regulatory      4797..4802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
                     /note="hexamer: AATAAA"
     polyA_site      4819
                     /gene="AGFG2"
                     /gene_synonym="HRBL; RABR"
ORIGIN      
        1 ggtggacggc gaagtctcct gcggatgccg cccgctcccg agcttctgtc aggggagccg
       61 ggcgtgcgga ggcggctgag gaggcgggaa ggcggcagtg gttgaagggg tgattgctga
      121 ctagcgggga gggagtgggc agcgatggtg atggcggcga agaagggccc gggcccgggc
      181 ggcggggtca gcgggggcaa ggcggaggcg gaggcggcct cggaggtgtg gtgccgtcgg
      241 gtgcgggagc tgggtggctg cagccaggcc gggaaccgcc actgcttcga gtgcgcccag
      301 cgcggggtca cctacgtgga tatcaccgtg ggcagcttcg tgtgcaccac ctgctccggc
      361 ctcctgagag ggctgaaccc ccctcatcgt gtcaagtcaa tctccatgac aactttcact
      421 gagcctgaag tagtattcct gcaatcccgt ggaaatgagg tttgccggaa gatttggttg
      481 ggtctgtttg atgctcggac atctttagta ccagattcca gggatcctca gaaagtgaag
      541 gagtttctcc aggaaaaata tgagaagaag agatggtatg tccccccaga ccaagtcaag
      601 gggcccactt ataccaaagg cagtgcctcc acccctgtgc agggctccat cccagaaggg
      661 aagccccttc ggacacttct gggtgatcct gcaccgtctc tctcagttgc tgcctccacc
      721 tcgagccagc ccgtcagtca gtctcacgct cggacatccc aggcccggag cactcagcca
      781 cctccccact cctctgtcaa aaaagccagt actgacctgc tggctgacat cggtggagac
      841 ccctttgctg caccccagat ggcaccagct tttgctgcat tccctgcctt tgggggccag
      901 acaccttccc aaggaggctt tgccaacttt gatgccttta gcagtggccc cagctcttct
      961 gtgtttggaa gcctccctcc agctggtcaa gcctcgttcc aggcccagcc aactcctgca
     1021 gggagcagcc aggggactcc atttggtgcc actcccctgg cacccgccag tcagccaaac
     1081 agcctcgcag acgtgggcag cttcctggga cccggggtgc ccgctgcagg tgttcctagc
     1141 agcctcttcg ggatggctgg ccaggtcccc ccgctccagt ctgtcacgat gggcggcggc
     1201 ggcggcagca gcacagggct ggcctttgga gccttcacta accctttcac agctcccgcc
     1261 gcccagtccc cgctgccttc caccaacccg ttccagccca atggcttggc gccagggccc
     1321 ggctttggga tgagcagtgc tgggcctggc ttcccccagg cagtgccacc cactggggcc
     1381 tttgccagct ccttcccagc accgctgttc cccccgcaga ccccgcttgt tcagcagcag
     1441 aatggctctt ccttcgggga cttaggatca gccaagttgg ggcagaggcc actgagccag
     1501 ccagctggga tctccaccaa ccccttcatg actggaccct catcaagccc attcgcctcc
     1561 aaacctccaa ccaccaaccc cttcttgtag cactgtgttt ttggggggcc tcttccctgc
     1621 cttctggggc ccctctgctc cctagagctc tggtgaccac ttgcctgtgg gcatttctat
     1681 gggccttggg gatggtggag gtgctaatgc tttgcttggg gcctacaggt gaaaggtggc
     1741 tgccctcaga ttccacaaag cctctctccc ctccctcgtc ccacccccac ccaggcagga
     1801 agcccaggag gagtgcgggc agggcctgac ctggaggagt gatggttgag ggggagggat
     1861 ttttttcaaa tgatcagtcc cctgtggaac agctcttccc tgggcctagc tcgccagcgc
     1921 tgtgctcctc atggacggga gcgcagtggg gaaggtaggg gaaagatgag gcacagtgtt
     1981 gatggggcag tgaccagaca gtcctgagac ccagaaggcc caggtggccc aagtgctctt
     2041 ggtggcccag cttggccagc acacactttc ctcctgcagc accccctgct gaaggggtcc
     2101 cccattgttt tgcttcccca gcgcccagga tgagcggttt accatcgagc ttacccgggc
     2161 ccggctcctg tcaagcactt tagttagctg ttggtgtcat gtttggatac cagtgtttta
     2221 tatttataca tagagaggat tttctaatat agcctattat atataaatag atctatctat
     2281 atgcacatac atacatatat acacacaccc agccgatctc ccgctcccag actgctctcg
     2341 tatgtgggga atgggatgaa tccccatctg tgcctcgacc atcaaagccg gagctccagg
     2401 gctggagggg gggcagccat gtgtcctgac ccccaccatc cccagagcct gggttttcca
     2461 gggaaaggct ttgtgcaatt gcctggtctt tttttttttt tttttttctc catgtgcctc
     2521 cctgtcccca aatctctgca ccaaagctca ttgcaggcaa tgttggaaaa gaactgcatt
     2581 tgaacgaaag agaaaacggc gcctgtggtt ttgcttcagg ccactttgag gggttgcagg
     2641 tcagtcaaca tgactgatcc ttgacctggc tctgctgggc tggactgcct gggccagtga
     2701 taatgctgcc attggccaga gacagggcag agcccgtccc tgtctgaaca agagtcccgc
     2761 attagcaatg agaagaagcg tggcgggaga ggagccacca ctgccgggga ctggagtttg
     2821 ttggatgtga ggggaatgcc cactggggcc agggtgggca aaggaggttg gtgccaatgt
     2881 ggtgctggaa gtagacccct cctgggtctg gaacattctc tgccccaggc tctttccacc
     2941 tggggatgtt gtgacaacat ccagctgtgg tgtctgggct atttgtgtgg tgacaagaca
     3001 gacctggtca gggggtgggt ggcaaacacc tcacctggct gggcagaggc caccttgctg
     3061 tttggcccaa ggccaggtga ggcccctccc tttccaccat tgccctggcc ccgtggccat
     3121 tcattcttgg ggtttgtctg agtcttccac agagagcagc aaagagatat gggagttggg
     3181 tgatcagtgt atttactttg cagatttttc tggaaataac ctctagctgc tgctatttgc
     3241 aaggctggga ttggcctccc tgtcttttcc aacaatcagg accccatcct gtctgttcct
     3301 gttcttctcc cagcctctgc cctccttctg tctcctgggt ggtctcccgc ttcgctcctg
     3361 gcctttgcat gttccatctc ttctctttct cccctcttcg ccaccctaga ttatctctgt
     3421 gtccctctac ctaattctct taccagttct ttcctttctg cttagagccg gagggaggga
     3481 agctggaatc tgttatggtg tattaggggg aggagccttt ctgttatttc cccccagctt
     3541 ccatcaccct tcccttaatg ccaggagcgc cgaggtttgg aactgaggct aaaccgaagg
     3601 gctttctcct gcttctgtca ccctgtgctg tctcccggca tctcctcact atctgggtcc
     3661 aggcccgggt cctccctgca gactccctcc cctccagccc acaaggactc cagcctgctg
     3721 gctggtgaga gctggatgag cagtaagaag ttaacgccag gtcagcctcg ggccccaggg
     3781 ttccctgggc acaggctgac actaggagct gctctccttg gccggggaca gctccagcag
     3841 ctcaggctcc agccctccag tgagccgcct ctcctggaga gtagcaaaga atggagaaag
     3901 gcctggcttg agaggaaatg gagaaaacat tgcctggtag ctgcagattc aaacccacca
     3961 cacacaccac ggggctagag tgactcacct gggctcacac caacttctgg ccaatgcagg
     4021 gaccatgctc tgcagacagc agtcctctag catggcccca gcattcagcc agtcggtcac
     4081 ctgtgggcca tccccatgtg tgaggaagca ggagtcagcc accaagtgtc tccacatcgg
     4141 agcttgcggg tcagacctgt gggccagggg atgggagcag ggctgagggt aggggctgaa
     4201 tgtgtggctc tgtccctgtg ttgccttcca cagaggagca aggcctcagg ctgaggaagg
     4261 aggggcacgc tggaacagcc tagtctcctc cccgtggatt cccccaaacc cataacattc
     4321 ttccataggg gctgagaacg cagtgccccg tccctgacag ggatgaaaag tgaacccctc
     4381 aggtcaggag aggcagagtt gaggttctgc cacttcctgt ccctggggag ccactcaagt
     4441 taccagggct accggctgaa ataaatcttt tccgggtagg gtcaagggca gtgtgttgcc
     4501 aaggcaactg atgtaggcca gttgcgtgac tccaggtttg tcctggtact cagtgggtcc
     4561 aatcacctgg cattgatcac ctggcattga tcagcaccca ccccacccct gaggcttgcc
     4621 cagcccccag gccctcagat ccctgctctt cctgcctttc ctgcccatgt gtcacccagc
     4681 acccaaggtt cagtgacaca gggtggtttg gagctggtca ctgtcatagc agctgtgatt
     4741 tcacaaggaa gggtgctgca gggggacctg gttgatgggg agtgggaagg ggaaggaata
     4801 aagagatctt cctcaggta
//
