LOCUS       NM_004504               8677 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens ArfGAP with FG repeats 1 (AGFG1), transcript variant
            2, mRNA.
ACCESSION   NM_004504 XM_941338
VERSION     NM_004504.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8677)
  AUTHORS   Chen,J., Wang,H. and Tang,M.
  TITLE     CircAGFG1 absence decreases PKM2 expression to enhance oxaliplatin
            sensitivity in colorectal cancer in a miR-7-5p-dependent manner
  JOURNAL   J Chemother 36 (3), 208-221 (2024)
   PUBMED   37691430
  REMARK    GeneRIF: CircAGFG1 absence decreases PKM2 expression to enhance
            oxaliplatin sensitivity in colorectal cancer in a
            miR-7-5p-dependent manner.
REFERENCE   2  (bases 1 to 8677)
  AUTHORS   Luo,J., Zhong,H., Guo,M., Xiao,P., Cao,R., Zhao,M. and Jing,Y.
  TITLE     CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3
            p/ZEB1 Axis
  JOURNAL   Technol Cancer Res Treat 23, 15330338241252423 (2024)
   PUBMED   38752261
  REMARK    GeneRIF: CircAGFG1 Promotes Ovarian Cancer Progression Through the
            miR-409-3 p/ZEB1 Axis.
REFERENCE   3  (bases 1 to 8677)
  AUTHORS   Chen,S., Liu,Z., Feng,Q., Zhou,J., Huang,J. and Yu,J.
  TITLE     Circular RNA circ-AGFG1 contributes to esophageal squamous cell
            carcinoma progression and glutamine catabolism by targeting
            microRNA-497-5p/solute carrier family 1 member 5 axis
  JOURNAL   Anticancer Drugs 34 (2), 195-206 (2023)
   PUBMED   36206112
  REMARK    GeneRIF: Circular RNA circ-AGFG1 contributes to esophageal squamous
            cell carcinoma progression and glutamine catabolism by targeting
            microRNA-497-5p/solute carrier family 1 member 5 axis.
REFERENCE   4  (bases 1 to 8677)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 8677)
  AUTHORS   Wang,X.H. and Li,J.
  TITLE     CircAGFG1 aggravates the progression of cervical cancer by
            downregulating p53
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (4), 1704-1711 (2020)
   PUBMED   32141537
  REMARK    GeneRIF: CircAGFG1 aggravates the progression of cervical cancer by
            downregulating p53.
REFERENCE   6  (bases 1 to 8677)
  AUTHORS   Stutz,F., Izaurralde,E., Mattaj,I.W. and Rosbash,M.
  TITLE     A role for nucleoporin FG repeat domains in export of human
            immunodeficiency virus type 1 Rev protein and RNA from the nucleus
  JOURNAL   Mol Cell Biol 16 (12), 7144-7150 (1996)
   PUBMED   8943370
REFERENCE   7  (bases 1 to 8677)
  AUTHORS   Fritz,C.C. and Green,M.R.
  TITLE     HIV Rev uses a conserved cellular protein export pathway for the
            nucleocytoplasmic transport of viral RNAs
  JOURNAL   Curr Biol 6 (7), 848-854 (1996)
   PUBMED   8805303
REFERENCE   8  (bases 1 to 8677)
  AUTHORS   Fridell,R.A., Bogerd,H.P. and Cullen,B.R.
  TITLE     Nuclear export of late HIV-1 mRNAs occurs via a cellular protein
            export pathway
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4421-4424 (1996)
   PUBMED   8633082
REFERENCE   9  (bases 1 to 8677)
  AUTHORS   Bogerd,H.P., Fridell,R.A., Madore,S. and Cullen,B.R.
  TITLE     Identification of a novel cellular cofactor for the Rev/Rex class
            of retroviral regulatory proteins
  JOURNAL   Cell 82 (3), 485-494 (1995)
   PUBMED   7634337
REFERENCE   10 (bases 1 to 8677)
  AUTHORS   Fritz,C.C., Zapp,M.L. and Green,M.R.
  TITLE     A human nucleoporin-like protein that specifically interacts with
            HIV Rev
  JOURNAL   Nature 376 (6540), 530-533 (1995)
   PUBMED   7637788
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097662.5, DB456989.1,
            BC096273.3, AC105286.5 and BQ016135.1.
            
            On May 20, 2020 this sequence version replaced NM_004504.4.
            
            Summary: The protein encoded by this gene is related to
            nucleoporins, a class of proteins that mediate nucleocytoplasmic
            transport. The encoded protein binds the activation domain of the
            human immunodeficiency virus Rev protein when Rev is assembled onto
            its RNA target, and is required for the nuclear export of
            Rev-directed RNAs. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon and uses an alternate in-frame splice site in the 3' coding
            region, compared to variant 1, resulting in a shorter protein
            (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2577967.1, BC030592.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310078.13/ ENSP00000312059.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC097662.5         201246-201261
            17-440              DB456989.1         1-424
            441-1681            BC096273.3         225-1465
            1682-1682           AC105286.5         76462-76462
            1683-2005           BC096273.3         1467-1789
            2006-8287           AC105286.5         79012-85293
            8288-8677           BQ016135.1         24-413              c
FEATURES             Location/Qualifiers
     source          1..8677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..8677
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="ArfGAP with FG repeats 1"
                     /db_xref="GeneID:3267"
                     /db_xref="HGNC:HGNC:5175"
                     /db_xref="MIM:600862"
     exon            1..433
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1955
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleoporin-like protein RIP; arf-GAP domain and FG
                     repeats-containing protein 1; Rab, Rev/Rex activation
                     domain-binding protein; hRIP, Rev interacting protein;
                     HIV-1 Rev-binding protein; rev/Rex activation
                     domain-binding protein; rev-interacting protein; arf-GAP
                     domain and FG repeat-containing protein 1"
                     /codon_start=1
                     /product="arf-GAP domain and FG repeat-containing protein
                     1 isoform 2"
                     /protein_id="NP_004495.2"
                     /db_xref="CCDS:CCDS2467.1"
                     /db_xref="GeneID:3267"
                     /db_xref="HGNC:HGNC:5175"
                     /db_xref="MIM:600862"
                     /translation="MAASAKRKQEEKHLKMLRDMTGLPHNRKCFDCDQRGPTYVNMTV
                     GSFVCTSCSGSLRGLNPPHRVKSISMTTFTQQEIEFLQKHGNEVCKQIWLGLFDDRSS
                     AIPDFRDPQKVKEFLQEKYEKKRWYVPPEQAKVVASVHASISGSSASSTSSTPEVKPL
                     KSLLGDSAPTLHLNKGTPSQSPVVGRSQGQQQEKKQFDLLSDLGSDIFAAPAPQSTAT
                     ANFANFAHFNSHAAQNSANADFANFDAFGQSSGSSNFGGFPTASHSPFQPQTTGGSAA
                     SVNANFAHFDNFPKSSSADFGTFNTSQSHQTASAVSKVSTNKAGLQTADKYAALANLD
                     NIFSAGQGGDQGSGFGTTGKAPVGSVVSVPSQSSASSDKYAALAELDSVFSSAATSSN
                     AYTSTSNASSNVFGTVPVVASAQTQPASSSVPAPFGATPSTNPFVAAAGPSVASSTNP
                     FQTNARGATAATFGTASMSMPTGFGTPAPYSLPTSFSGSFQQPAFPAQAAFPQQTAFS
                     QQPNGAGFAAFGQTKPVVTPFGQVAAAGVSSNPFMTGAPTGQFPTGSSSTNPFL"
     exon            434..527
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            528..643
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            644..806
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            807..960
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1080
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1290
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1471
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1551
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1644
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1803
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1895
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..8677
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="hexamer: AATAAA"
     polyA_site      2582
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="major polyA site"
     regulatory      4105..4110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="hexamer: ATTAAA"
     polyA_site      4128
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="major polyA site"
     regulatory      8651..8656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="hexamer: AATAAA"
     polyA_site      8677
                     /gene="AGFG1"
                     /gene_synonym="HRB; RAB; RIP"
                     /note="major polyA site"
ORIGIN      
        1 cccctcagga gaagtcggga aggtggcggc ggcggcggcg gttgtcccgg ctgtgccggt
       61 tggtgtggcc cgtcagcccg cgtaccacag cgcccgggcc gcgtcgagcc cagtacagcc
      121 aagccgctgc ggccgggtcc ggcgcgggcg gcgcgcgcag acggagggcg gcggccgcgg
      181 ccagggcggc ccgtgggacc gcgggccccc ggcgcagcgc tgcccggctc ccggccctgc
      241 cggcctcctc ccttggcgcc gcggccatgg cggccagcgc gaagcggaag caggaggaga
      301 agcacctgaa gatgctgcgg gacatgaccg gcctcccgca caaccgaaag tgcttcgact
      361 gcgaccagcg cggccccacc tacgttaaca tgacggtcgg ctccttcgtg tgtacctcct
      421 gctccggcag cctgcgagga ttaaatccac cacacagggt gaaatctatc tccatgacaa
      481 cattcacaca acaggaaatt gaattcttac aaaaacatgg aaatgaagtc tgtaaacaga
      541 tttggctagg attatttgat gatagatctt cagcaattcc agacttcagg gatccacaaa
      601 aagtgaaaga gtttctacaa gaaaagtatg aaaagaaaag atggtatgtc ccgccagaac
      661 aagccaaagt cgtggcatca gttcatgcat ctatttcagg gtcctctgcc agtagcacaa
      721 gcagcacacc tgaggtcaaa ccactgaaat ctcttttagg ggattctgca ccaacactgc
      781 acttaaataa gggcacacct agtcagtccc cagttgtagg tcgttctcaa gggcagcagc
      841 aggagaagaa gcaatttgac cttttaagtg atctcggctc agacatcttt gctgctccag
      901 ctcctcagtc aacagctaca gccaattttg ctaactttgc acatttcaac agtcatgcag
      961 ctcagaattc tgcaaatgca gattttgcaa actttgatgc atttggacag tctagtggtt
     1021 cgagtaattt tggaggtttc cccacagcaa gtcactctcc ttttcagccc caaactacag
     1081 gtggaagtgc tgcatcagta aatgctaatt ttgctcattt tgataacttc cccaaatcct
     1141 ccagtgctga ttttggaacc ttcaatactt cccagagtca tcaaacagca tcagctgtta
     1201 gtaaagtttc aacgaacaaa gctggtttac agactgcaga caaatatgca gcacttgcta
     1261 atttagacaa tatcttcagt gccgggcaag gtggtgatca gggaagtggc tttgggacca
     1321 caggtaaagc tcctgttggt tctgtggttt cagttcccag tcagtcaagt gcatcttcag
     1381 acaagtatgc agctctggca gaactagaca gcgttttcag ttctgcagcc acctccagta
     1441 atgcgtatac ttccacaagt aatgctagca gcaatgtttt tggaacagtg ccagtggttg
     1501 cttctgcaca gacacagcct gcttcatcaa gtgtgcctgc tccatttgga gctacgcctt
     1561 ccacaaatcc atttgttgct gctgctggtc cttctgtggc atcttctaca aacccatttc
     1621 agaccaatgc cagaggagca acagcggcaa cctttggcac tgcatccatg agcatgccca
     1681 caggattcgg cactcctgct ccctacagtc ttcccaccag ctttagtggc agctttcagc
     1741 agcctgcctt tccagcccaa gcagctttcc ctcaacagac agctttttct caacagccca
     1801 atggtgcagg ttttgcagca tttggacaaa caaagccagt agtaacccct tttggtcaag
     1861 ttgcagctgc tggagtatct agtaatcctt ttatgactgg tgcaccaaca ggacaatttc
     1921 caacaggaag ctcatcaacc aatcctttct tatagcctta tatagacaat ttactggaac
     1981 gaacttttat gtggtcacat tacatctctc cacctcttgc actgttgtct tgtttcactg
     2041 atcttagctt taaacacaag agaagtcttt aaaaagcctg cattgtgtat taaacaccag
     2101 gtaatatgtg caaaaccgag ggctccagta acaccttcta acctgtgaat tggcagaaaa
     2161 gggtagcggt atcatgtata ttaaaattgg ctaatattaa gttattgcag ataccacatt
     2221 cattatgctg cagtactgta catatttttc ttagaaatta gctatttgtg catatcagta
     2281 tttgtaactt taacacattg ttatgtgaga aatgttactg gggaaataga tcagccactt
     2341 ttaaggtgct gtcatatatc ttggaatgaa tgacctaaaa tcattttaac cattgctact
     2401 ggaaagtaac agagtcaaaa ttggaaggtt ttattcattc ttgaattttt cctttctaaa
     2461 gagctcttct atttatacat gcctaaattc ttttaaaatg tagagggata cctgtctgca
     2521 taataaagct gatcatgttt tgctacagtt tgcaggtgaa aaaaaataaa tattataaaa
     2581 tatgctattg tttttgtgtt cttgctgcaa tgcctttacc aaagtggcct taaatatgag
     2641 tagtgaattg agaacatctt gaattcttaa aagacttctt agtgactttt tataaaaagg
     2701 ccatgtagaa aatttattaa aactactatg actgctacat tcaggaatat gccagtggta
     2761 aagcatttaa atgtagcttg tcagatttac cataatccta ctaatttctt tgcagcttat
     2821 taattttgtg aaatttgtat atatgaagaa tttgcatgta tgtgtattta caaatttttc
     2881 taagtatctt gaattctcag actgcaaaag gcctatttta actattgatt ttttttaaaa
     2941 aaaattgtct ttgaatgtat tggaagtaga catgcattaa ctgtgacatt attgcacctc
     3001 agtttttttc tttctttttt tgggcaaact gatattatct ataggatatt tgtttatgtt
     3061 tgttttttgg gggaaagaaa ctggaactca gtgttacctt aaagttacgg aatactttgt
     3121 tttaaaggaa aagataataa gtttagttat atctttttgt taatattcaa atgaacttgt
     3181 ttaagtatct atgtacagta atgcctcatt catctagagg taatctggca gtcttgtgaa
     3241 aaccgaacac aactcagaaa cttggaatcg ttttttttaa aaatgcctct gagcaaccca
     3301 tataagtcac aaagtctgtg tgttagagct tatgcatttg tttttatgag agattttaat
     3361 aaatttaatt atttgcttgt ccagactata gcatattagc tgtttagaag ggatggcttg
     3421 aaaggaagga gactgaaaaa cactctgaga gcatacactg tccaaggcca ttagtgtaag
     3481 gaccgctacc cagcctagag gacatcacta tactacatca tctgatgatt attctttatt
     3541 atgcctctag gtaattaagt aaaggtgaaa ttgcatacac agatatgtag tacatatttt
     3601 aaaagtttta tcttaaattg attaaaactt tttaaaaagc tttggtatta aaagaggtaa
     3661 acatcagttt cctcaaacat tttattcatg ttgaatgcct ttttgcaatg atgactgagt
     3721 tgttatcata gtattttaaa acctgtatag tgttttagac ttgttaaaac attgctgtct
     3781 agtgtacatc tagctaaaag tgtggtttat ctaaaccgtt ttaataagca agatgactgg
     3841 gaaatctctg ccccttttct gagcagtatg cctcttcttt tagaattaaa tgaatgctgc
     3901 acaggtccag atgtgtgttg atgtagactt gaaatgtctc cacattttgg aggacttcct
     3961 cagccctttt cattgaggga aaatatattt gaatttctgt tttagattgt atcgggtccc
     4021 agttgattca tgtgtacaaa gttatgctac ctaattacag accattaccc aaatatccta
     4081 ccaggctttc catctgaata gtaaattaaa cagttgttat caaaatgatt ttaaagacta
     4141 tttctttttc tgggtaacta ttgaagtttg taattaaatg ggggctctta ctgactttaa
     4201 attagcgctt ataaaataaa aatgtttagt tcaagaagag acccaagctg ggtatggtgg
     4261 tgtgagagcc tgtgagtcct agctacctgg aggtgaggtg ggaacatcac ttgagcccag
     4321 gagttggagg ctgcagtgcg ctacgatcac accactgcac accagcctgg ggatagagtg
     4381 agatcccatc tctaaaaaat gaaaaaaaga agagaggtag ctttaaagtg gtttttctca
     4441 tgatattcac tgtttattat taaagaaaat cagctttcgt tagactttta catttagatt
     4501 tattctagtt ttatatagac catcaaaatt atgttgagta ctaaaaagga gaaaaaatcc
     4561 tggaaggtaa caaggctgaa gaccttcaaa tttcctggct tactggttta gtcacatcat
     4621 ttttcctgtt caggtatctg cagatatccc tgttcaggaa agatcttttt tcaggatggc
     4681 aaacttttga catagtttaa agacattttt tccccatttt ttgaaataga gaatatttta
     4741 ttatttttgt gaaaatagag ttttggtaat cactttcttc ctcaaaataa gtccttctgt
     4801 taatttgtaa aagcacatta gtgctttacc tgtgaaattc cccgcccccc tgcacacaca
     4861 cccactttag tacagttcct gtcaattggc aacatggaga gggtgacctg gctgctggtt
     4921 taccactgta ccaacatctc tggagcattt tagtttcaga accttaacac tccccaacag
     4981 ctttgttgat gtagcttgta tctctgagaa tttattgtat taaaattaat actgagatat
     5041 ttttaaaaca tgtttattta tttaagtata acagtaataa actaataact tgctaacata
     5101 aataccattt ttgataaaaa taacttttcc aaaacaaaaa ctaatgagaa caggaacatt
     5161 gttttacatt ttatgcattt aaatctggct taataaaagc agtgagattt tcatgctgct
     5221 tttgcattcc aacttaaaaa ttacacagca tacacacgct ggaaaactcc actgtgcact
     5281 tgtgagatca ggagaatgaa aactatgtaa tatctcagta gtacaatgaa aatagtttga
     5341 cttttcacag cctttcaaag aaagggttgt agggaccatt aagggtctcc agactctttg
     5401 agaaccacta tactttaaat ttgtgtattt ctagaacagt atttacttgc agggcaaaca
     5461 taactattcc ctgggttttt tttgtttgct agtgagaact gaaattgcag actttttaac
     5521 actacttcaa ggtaataata gcagtggtat tatgggctgt gtatgagata gtcatttgta
     5581 aaacaatttt catatttcat ctcttacaat ccctgcagtg gacctatact tttaggatga
     5641 aagaagcaaa gcatagagag gttaagctag tggcagcttt ttgctctggg gaacagattt
     5701 ggattaaatg ctatcacatt tatatatgaa tgcattcttt cttaatattt tgaaattctg
     5761 aacaagttaa cgttcttgtc ttgtatatct aaaaaaactt taatcacttg aattcctttc
     5821 ataatttgat gaaatcagta cagtttattc ttggtttttt tttttaactt tagaagtaaa
     5881 ttaatatggt aactagtgga gcgtgcttta gattgaagac tcatctgaag tatcacagac
     5941 tcctattttg taaagcattc cacctttatt gatacagttt gtggcctata cacttttaaa
     6001 atttattttt taaaaggtga tattaaaatt tgtatttaac ctgttgtatt catcctcatt
     6061 agttaagttt ttctttttat gttttaaaac ttagtgacat taaacttttc acgtggttgt
     6121 ttgtgaacag atgaatatat aaccacgatg taatccagtg ttgtgctgct gaatgtttaa
     6181 caaccatctt tcatgaaaga aaaaaggccc tgttttgtag catttactaa tatttatggt
     6241 ataaatactg tcttcatggt gattttacct gccaatctga tgtcattaaa tgcagtttga
     6301 tgaaagagat agccaaccag tggctttccc aagccttggc aaaccagctt cagcacagca
     6361 aaggacatac aattccacaa ctcattaatt aaatgtattg gtcatttgat gattatatcc
     6421 agtatttgga gagcttttat attgttaatt catttagcaa gcatttgaac acttgtttat
     6481 ttttagagat atactgggca ctgaggtatt taatctgcaa agacccaagt atcgtgaacc
     6541 ttggttttaa aaagtccaat tattgtgctc ttataggggt tgcacattca aggcttacac
     6601 tgaattctgt ctgcagttct gttttgtgtg accagcacag tgttttaaaa cgttgcattc
     6661 tgaatccatc tttttgaaat ggggcatgta ctcttaaggt ggccactagc ttaccattcc
     6721 caatttttct tagtctcaaa cattcacatg tttttcaagg ccttggagtt ggcaaatcct
     6781 gaatatatag tgaaggtagg aaatagctct tcttatgcca catcttagtc tgattttgaa
     6841 gtcagttgtg taagtttggg ctgacagtgg tattttccag tgaagactat cgccaagaat
     6901 gcatatcatt ctgcttattt tattctagtg gataaaaatt caacgtatat ttaagtgtat
     6961 ttttgacatc tgtgcttgtc caacacaggg ctgtagggac tgatgaaaag agaatgttgt
     7021 gatttgagct tttataaaaa aagataagtg atcctagata aaatatttta gatggtgatt
     7081 aaaatgccca tagattaatt ttttaatcgg ttctctgaaa tcttgagatg ttatccaagt
     7141 tacaatttaa gcaatgagag taaaatttga attctaaatt ctcagcatct tccctcattc
     7201 ttgagtggag agacagagga agcaaacgcc aaggagcctt ctaattttga ctatatgatc
     7261 attaactaaa ggcagcaagg gattgtaaac taatcttaca tagtcaatgt ttcatagaat
     7321 gctttggtta caatcaggtt ttttaaagac tttaaaggtt ttttgtatgc tataatatat
     7381 gcttatgatt tctaaaaatt atgcagtata cacaaagggc ataaagtcaa aaagtgtgtc
     7441 tccctctgtg actttattct cataccccag aggcatataa tttcttgtat tcttgtgtag
     7501 tctttaagaa atgttatcgt ttattttata tatggctctc tctctgtatg cctcttcctg
     7561 ttcttatttt aaatgttcaa gtttgtgact tggttcttgt ttaacttggt tgtctttcca
     7621 tattgccacc ttccagctct aacattaatg tctccaggat tccattatat ggatgtccct
     7681 ttgggagaac atttgtttat agacttttct actaaaaata ttgttataat gataatatcc
     7741 ttatgcatat atgaagatta ctcttgattc tgcctgactg gaaactttat taataaagta
     7801 gacattattc tattttgagg ctcaccagct gtgtaggtat gatcttgtgc ttccatttaa
     7861 gaaattcttc catttaaaga agaaaaaaaa tctctctgac tatctgaaga tatatgaaaa
     7921 agcctatgct tttaaattaa actgttaaga cagtccattg aaagattgtg gaagttcaca
     7981 tctattttgc accttaattt tttcattgtc cctactcatg actctaaaaa gtgcatggct
     8041 tggggctata ctttgttttg cagtttgttg gtatcgtgcc tttccttatc tacattagct
     8101 tagactatac cttattttta agaagagaaa gtggaaatta actgtggcaa aacctatttt
     8161 ggcacaacca catttgttca ttatacaaaa ttagcttcct atgctttaga aaaaatgtga
     8221 gttattactc tgaaagttgt gattctgatt cctcatggtt tggagctcag aaatttctta
     8281 acatgtcttt gctgttagtc aagcacagga tttgttttct gcaaaagttt attttcaatg
     8341 aagaatactt gtcctaatag ctcataaaaa gtacctttgc actttaaatc ctaggaatag
     8401 ggaacaagga aacttactgg gaagttcaaa agaaagaata acaggacctt ctagtcagca
     8461 gggcatgttt ggaaaatgtt aatacgccat gatttttgaa gaccaatttt agttcaggag
     8521 gtggttttaa atattggatg aaaacttaca ggctgttttc aatattcatt tctgaaatac
     8581 tttagtatga tagataaatt tggttaagtt cttgttcatt gtgaaatact gttggaagaa
     8641 tttttttcaa aataaagact tctgaatttg tgtacca
//
