LOCUS       NM_001136               1420 bp    mRNA    linear   PRI 06-JUL-2024
DEFINITION  Homo sapiens advanced glycosylation end-product specific receptor
            (AGER), transcript variant 1, mRNA.
ACCESSION   NM_001136
VERSION     NM_001136.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Monu, Agnihotri,P., Saquib,M. and Biswas,S.
  TITLE     Targeting TNF-alpha-induced expression of TTR and RAGE in
            rheumatoid arthritis: Apigenin's mediated therapeutic approach
  JOURNAL   Cytokine 179, 156616 (2024)
   PUBMED   38626647
  REMARK    GeneRIF: Targeting TNF-alpha-induced expression of TTR and RAGE in
            rheumatoid arthritis: Apigenin's mediated therapeutic approach.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Rezaei Arnesa,A., Hajian,S., Salemi Bazargani,S.,
            Salahshourifar,I., Moghbelinejad,S., Abdolvahabi,Z.,
            Yaghoobzadeh,H., Fathi,M. and Piri,H.
  TITLE     Association Between the G82S Polymorphism of the Receptor Gene for
            Advanced Glycation End-products and Soluble Serum Levels RAGE with
            Diabetic Nephropathy in the White (Asian) Race
  JOURNAL   Iran J Kidney Dis 18 (3), 179-186 (2024)
   PUBMED   38904338
  REMARK    GeneRIF: Association Between the G82S Polymorphism of the Receptor
            Gene for Advanced Glycation End-products and Soluble Serum Levels
            RAGE with Diabetic Nephropathy in the White (Asian) Race.
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Guo,W., Luo,J., Zhao,S., Li,L., Xing,W. and Gao,R.
  TITLE     The critical role of RAGE in severe influenza infection: A target
            for control of inflammatory response in the disease
  JOURNAL   Clin Immunol 262, 110178 (2024)
   PUBMED   38460892
  REMARK    GeneRIF: The critical role of RAGE in severe influenza infection: A
            target for control of inflammatory response in the disease.
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Held,M., Kozmar,A., Sestan,M., Turudic,D., Kifer,N., Srsen,S.,
            Gagro,A., Frkovic,M. and Jelusic,M.
  TITLE     Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and PCDH1 in IgA
            Vasculitis (IgAV)
  JOURNAL   Int J Mol Sci 25 (8), 4383 (2024)
   PUBMED   38673968
  REMARK    GeneRIF: Insight into the Interplay of Gd-IgA1, HMGB1, RAGE and
            PCDH1 in IgA Vasculitis (IgAV).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Hudson,B.I., Carter,A.M., Harja,E., Kalea,A.Z., Arriero,M.,
            Yang,H., Grant,P.J. and Schmidt,A.M.
  TITLE     Identification, classification, and expression of RAGE gene splice
            variants
  JOURNAL   FASEB J 22 (5), 1572-1580 (2008)
   PUBMED   18089847
  REMARK    GeneRIF: RAGE_v1 variant is the primary secreted soluble isoform of
            RAGE. identification of functional splice variants of RAGE
            underscores biological diversity of the RAGE gene & will aid in
            understanding of the gene in the normal & pathological state.
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Nozaki,I., Watanabe,T., Kawaguchi,M., Akatsu,H., Tsuneyama,K.,
            Yamamoto,Y., Ohe,K., Yonekura,H., Yamada,M. and Yamamoto,H.
  TITLE     Reduced expression of endogenous secretory receptor for advanced
            glycation endproducts in hippocampal neurons of Alzheimer's disease
            brains
  JOURNAL   Arch Histol Cytol 70 (5), 279-290 (2007)
   PUBMED   18431028
  REMARK    GeneRIF: low expression of endogenous secretory RAGE in the
            hippocampus would be associated with the development of Alzheimer's
            disease
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Ritthaler,U., Deng,Y., Zhang,Y., Greten,J., Abel,M., Sido,B.,
            Allenberg,J., Otto,G., Roth,H., Bierhaus,A. et al.
  TITLE     Expression of receptors for advanced glycation end products in
            peripheral occlusive vascular disease
  JOURNAL   Am J Pathol 146 (3), 688-694 (1995)
   PUBMED   7887450
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Vissing,H., Aagaard,L., Tommerup,N. and Boel,E.
  TITLE     Localization of the human gene for advanced glycosylation end
            product-specific receptor (AGER) to chromosome 6p21.3
  JOURNAL   Genomics 24 (3), 606-608 (1994)
   PUBMED   7713518
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Sugaya,K., Fukagawa,T., Matsumoto,K., Mita,K., Takahashi,E.,
            Ando,A., Inoko,H. and Ikemura,T.
  TITLE     Three genes in the human MHC class III region near the junction
            with the class II: gene for receptor of advanced glycosylation end
            products, PBX2 homeobox gene and a notch homolog, human counterpart
            of mouse mammary tumor gene int-3
  JOURNAL   Genomics 23 (2), 408-419 (1994)
   PUBMED   7835890
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Neeper,M., Schmidt,A.M., Brett,J., Yan,S.D., Wang,F., Pan,Y.C.,
            Elliston,K., Stern,D. and Shaw,A.
  TITLE     Cloning and expression of a cell surface receptor for advanced
            glycosylation end products of proteins
  JOURNAL   J Biol Chem 267 (21), 14998-15004 (1992)
   PUBMED   1378843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL662884.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_001136.4.
            
            Summary: The advanced glycosylation end product (AGE) receptor
            encoded by this gene is a member of the immunoglobulin superfamily
            of cell surface receptors. It is a multiligand receptor, and
            besides AGE, interacts with other molecules implicated in
            homeostasis, development, and inflammation, and certain diseases,
            such as diabetes and Alzheimer's disease. Many alternatively
            spliced transcript variants encoding different isoforms, as well as
            non-protein-coding variants, have been described for this gene
            (PMID:18089847). [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1, also known as RAGE) represents
            the predominant transcript, and encodes isoform 1.
            
            Sequence Note: This Refseq, containing two in-frame translation
            initiation codons (at nt 8-10 and nt 101-103), is annotated with a
            CDS starting from the downstream AUG (dAUG) because the AGE
            receptor encoded by this gene is a known type 1 transmembrane
            protein requiring signal peptide for its function, and a signal
            peptide of 22 aa is predicted for the dAUG initiated protein.
            Translation initiation from the upstream AUG (uAUG) will add an
            extra 31 aa to the N-terminus, and no signal peptide is predicted
            for the uAUG initiated protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279847.2396.1, AK298100.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375076.9/ ENSP00000364217.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL662884.11        96998-97080         c
            84-190              AL662884.11        96708-96814         c
            191-386             AL662884.11        96382-96577         c
            387-451             AL662884.11        96151-96215         c
            452-539             AL662884.11        95941-96028         c
            540-722             AL662884.11        95668-95850         c
            723-853             AL662884.11        95395-95525         c
            854-995             AL662884.11        95074-95215         c
            996-1022            AL662884.11        94433-94459         c
            1023-1149           AL662884.11        94178-94304         c
            1150-1420           AL662884.11        93796-94066         c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1420
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /note="advanced glycosylation end-product specific
                     receptor"
                     /db_xref="GeneID:177"
                     /db_xref="HGNC:HGNC:320"
                     /db_xref="MIM:600214"
     exon            1..83
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1246
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; receptor for advanced glycation end-products"
                     /codon_start=1
                     /product="advanced glycosylation end product-specific
                     receptor isoform 1 precursor"
                     /protein_id="NP_001127.1"
                     /db_xref="CCDS:CCDS4746.1"
                     /db_xref="GeneID:177"
                     /db_xref="HGNC:HGNC:320"
                     /db_xref="MIM:600214"
                     /translation="MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKK
                     PPQRLEWKLNTGRTEAWKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAM
                     NRNGKETKSNYRVRVYQIPGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLD
                     GKPLVPNEKGVSVKEQTRRHPETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHR
                     ALRTAPIQPRVWEPVPLEEVQLVVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGV
                     PLPLPPSPVLILPEIGPQDQGTYSCVATHSSHGPQESRAVSISIIEPGEEGPTAGSVG
                     GSGLGTLALALGILGGLGTAALLIGVILWQRRQRRGEERKAPENQEEEEERAELNQSE
                     EPEAGESSTGGP"
     exon            84..190
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            191..386
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            387..451
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            452..539
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            540..722
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            723..853
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            854..995
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1022
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1149
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1420
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1399..1404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /note="hexamer: ATTAAA"
     polyA_site      1420
                     /gene="AGER"
                     /gene_synonym="RAGE; SCARJ1; sRAGE"
                     /note="major polyA site"
ORIGIN      
        1 agacagagcc aggaccctgg aaggaagcag gatggctgcc ggaacagcag ttggagcctg
       61 ggtgctggtc ctcagtctgt ggggggcagt agtaggtgct caaaacatca cagcccggat
      121 tggcgagcca ctggtgctga agtgtaaggg ggcccccaag aaaccacccc agcggctgga
      181 atggaaactg aacacaggcc ggacagaagc ttggaaggtc ctgtctcccc agggaggagg
      241 cccctgggac agtgtggctc gtgtccttcc caacggctcc ctcttccttc cggctgtcgg
      301 gatccaggat gaggggattt tccggtgcca ggcaatgaac aggaatggaa aggagaccaa
      361 gtccaactac cgagtccgtg tctaccagat tcctgggaag ccagaaattg tagattctgc
      421 ctctgaactc acggctggtg ttcccaataa ggtggggaca tgtgtgtcag agggaagcta
      481 ccctgcaggg actcttagct ggcacttgga tgggaagccc ctggtgccta atgagaaggg
      541 agtatctgtg aaggaacaga ccaggagaca ccctgagaca gggctcttca cactgcagtc
      601 ggagctaatg gtgaccccag cccggggagg agatccccgt cccaccttct cctgtagctt
      661 cagcccaggc cttccccgac accgggcctt gcgcacagcc cccatccagc cccgtgtctg
      721 ggagcctgtg cctctggagg aggtccaatt ggtggtggag ccagaaggtg gagcagtagc
      781 tcctggtgga accgtaaccc tgacctgtga agtccctgcc cagccctctc ctcaaatcca
      841 ctggatgaag gatggtgtgc ccttgcccct tccccccagc cctgtgctga tcctccctga
      901 gatagggcct caggaccagg gaacctacag ctgtgtggcc acccattcca gccacgggcc
      961 ccaggaaagc cgtgctgtca gcatcagcat catcgaacca ggcgaggagg ggccaactgc
     1021 aggctctgtg ggaggatcag ggctgggaac tctagccctg gccctgggga tcctgggagg
     1081 cctggggaca gccgccctgc tcattggggt catcttgtgg caaaggcggc aacgccgagg
     1141 agaggagagg aaggccccag aaaaccagga ggaagaggag gagcgtgcag aactgaatca
     1201 gtcggaggaa cctgaggcag gcgagagtag tactggaggg ccttgagggg cccacagaca
     1261 gatcccatcc atcagctccc ttttcttttt cccttgaact gttctggcct cagaccaact
     1321 ctctcctgta taatctctct cctgtataac cccaccttgc caagctttct tctacaacca
     1381 gagcccccca caatgatgat taaacacctg acacatcttg
//
