LOCUS       NM_032785               2989 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens AGBL carboxypeptidase 4 (AGBL4), transcript variant 1,
            mRNA.
ACCESSION   NM_032785
VERSION     NM_032785.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Zhang,S., Cheng,L., Su,Y., Qian,Z., Wang,Z., Chen,C., Li,R.,
            Zhang,A., He,J., Mao,J., Wang,H. and Chen,J.
  TITLE     AGBL4 promotes malignant progression of glioblastoma via modulation
            of MMP-1 and inflammatory pathways
  JOURNAL   Front Immunol 15, 1420182 (2024)
   PUBMED   39007144
  REMARK    GeneRIF: AGBL4 promotes malignant progression of glioblastoma via
            modulation of MMP-1 and inflammatory pathways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Wang,Y., Zhang,Y., Guo,X., Zheng,Y., Zhang,X., Feng,S. and Wu,H.Y.
  TITLE     CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis
  JOURNAL   BMC Biol 21 (1), 124 (2023)
   PUBMED   37226238
  REMARK    GeneRIF: CCP5 and CCP6 retain CP110 and negatively regulate
            ciliogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Rodriguez-Calado,S., Van Damme,P., Aviles,F.X., Candiota,A.P.,
            Tanco,S. and Lorenzo,J.
  TITLE     Proximity Mapping of CCP6 Reveals Its Association with Centrosome
            Organization and Cilium Assembly
  JOURNAL   Int J Mol Sci 24 (2), 1273 (2023)
   PUBMED   36674791
  REMARK    GeneRIF: Proximity Mapping of CCP6 Reveals Its Association with
            Centrosome Organization and Cilium Assembly.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Pan,H., Yang,M., Lu,L., Tao,B., He,X., Chen,H., Yi,H. and Tang,S.
  TITLE     Association of FAM65B, AGBL4, and CUX2 genetic polymorphisms with
            susceptibility to antituberculosis drug-induced hepatotoxicity:
            validation study in a Chinese Han population
  JOURNAL   Pharmacogenet Genomics 29 (4), 84-90 (2019)
   PUBMED   30720667
  REMARK    GeneRIF: this is the first study to explore and validate the
            relationships between seven SNPs in the FAM65B, AGBL4, and CUX2
            genes and ATDH in a Chinese population. On the basis of this
            case-control study, SNP rs10946737 in FAM65B may be associated with
            susceptibility to ATDH in Chinese Han anti-TB treatment patients.
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Guo,T., Yin,R.X., Yao,L.M., Huang,F., Pan,L., Lin,W.X., Yang,D.Z.
            and Pan,S.L.
  TITLE     Integrative mutation, haplotype and G x G interaction evidence
            connects ABGL4, LRP8 and PCSK9 genes to cardiometabolic risk
  JOURNAL   Sci Rep 6, 37375 (2016)
   PUBMED   27853278
  REMARK    GeneRIF: ABGL4, LRP8 and PCSK9 polymorphisms and gene interactions
            increase cardiometabolic risk.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Lin,P.C., Lin,J.K., Lin,C.H., Lin,H.H., Yang,S.H., Jiang,J.K.,
            Chen,W.S., Chou,C.C., Tsai,S.F. and Chang,S.C.
  TITLE     Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer
            Patients Identified by Using a Genome-Wide High-Resolution Array
  JOURNAL   Ann Surg Oncol 22 Suppl 3, S1419-S1427 (2015)
   PUBMED   25472652
  REMARK    GeneRIF: AGBL4 promoter hypermethylation is associated with
            Colorectal Cancer.
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Wu,H.Y., Rong,Y., Correia,K., Min,J. and Morgan,J.I.
  TITLE     Comparison of the enzymatic and functional properties of three
            cytosolic carboxypeptidase family members
  JOURNAL   J Biol Chem 290 (2), 1222-1232 (2015)
   PUBMED   25416787
  REMARK    GeneRIF: Nna1 and CCP4 remove the C-terminal glutamate from
            substrates with two or more glutamates, whereas CCP6 requires four
            or more glutamates. CCP4 behaves as a promiscuous glutamase with
            little preference for chain length or neighboring amino acid
            composition
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Rodriguez de la Vega Otazo,M., Lorenzo,J., Tort,O., Aviles,F.X. and
            Bautista,J.M.
  TITLE     Functional segregation and emerging role of cilia-related cytosolic
            carboxypeptidases (CCPs)
  JOURNAL   FASEB J 27 (2), 424-431 (2013)
   PUBMED   23085998
REFERENCE   9  (bases 1 to 2989)
  AUTHORS   Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C.,
            Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Bosch Grau,M., Bec,N.,
            Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and
            Janke,C.
  TITLE     A family of protein-deglutamylating enzymes associated with
            neurodegeneration
  JOURNAL   Cell 143 (4), 564-578 (2010)
   PUBMED   21074048
REFERENCE   10 (bases 1 to 2989)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645730.10, AL591602.7, AL390023.8, AL590432.9, AC099788.2,
            AL645507.7, AL355809.11 and AL391844.12.
            
            On Nov 22, 2018 this sequence version replaced NM_032785.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.228487.1,
                                           SRR1803616.196153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371839.6/ ENSP00000360905.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               AL645730.10        84126-84317         c
            193-315             AL591602.7         59747-59869         c
            316-440             AL390023.8         120964-121088       c
            441-535             AL590432.9         71073-71167         c
            536-752             AC099788.2         82092-82308         c
            753-792             AL645507.7         4442-4481           c
            793-882             AL355809.11        69625-69714         c
            883-997             AL355809.11        59810-59924         c
            998-1109            AL355809.11        40966-41077         c
            1110-1262           AL391844.12        93151-93303         c
            1263-1425           AL391844.12        89322-89484         c
            1426-1522           AL391844.12        41960-42056         c
            1523-1549           AL391844.12        37208-37234         c
            1550-2988           AL391844.12        35173-36611         c
            2989-2989           AL391844.12        35172-35172         c
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2989
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /note="AGBL carboxypeptidase 4"
                     /db_xref="GeneID:84871"
                     /db_xref="HGNC:HGNC:25892"
                     /db_xref="MIM:616476"
     exon            1..192
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1670
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /EC_number="3.4.17.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 6; ATP/GTP binding protein like
                     4; protein deglutamylase CCP6"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 6 isoform 1"
                     /protein_id="NP_116174.3"
                     /db_xref="CCDS:CCDS44137.1"
                     /db_xref="GeneID:84871"
                     /db_xref="HGNC:HGNC:25892"
                     /db_xref="MIM:616476"
                     /translation="MAEGSQSAPEAGNDMGNDDAIGGNVSKYIVLPTGYCGQPKKGHL
                     IFDACFESGNLGRVDQVSEFEYDLFIRPDTCNPRFRVWFNFTVENVKESQRVIFNIVN
                     FSKTKSLYRDGMAPMVKSTSRPKWQRLPPKNVYYYRCPDHRKNYVMSFAFCFDREEDI
                     YQFAYCYPYTYTRFQHYLDSLQKRNMDYFFREQLGQSVQQRKLDLLTITSPDNLREGA
                     EQKVVFITGRVHPGETPSSFVCQGIIDFLVSQHPIACVLREYLVFKIAPMLNPDGVYL
                     GNYRCSLMGFDLNRHWLDPSPWVHPTLHGVKQLIVQMYNDPKTSLEFYIDIHAHSTMM
                     NGFMYGNIFEDEERFQRQAIFPKLLCQNAEDFSYSSTSFNRDAVKAGTGRRFLGGLLD
                     HTSYCYTLEVSFYSYIISGTTAAVPYTEEAYMKLGRNVARTFLDYYRLNPVVEKVAIP
                     MPRLRNKEIEVQRRKEKSPPYKHPLLRGPASNYPNSKGDKKSSVNHKDPSTPF"
     exon            193..315
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            316..440
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            441..535
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            536..752
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            753..792
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            793..882
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            883..997
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1109
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1262
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1425
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1522
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1549
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..2989
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /note="hexamer: AATAAA"
     polyA_site      2989
                     /gene="AGBL4"
                     /gene_synonym="CCP6"
                     /note="major polyA site"
ORIGIN      
        1 agccgcgcgc cggccacccg cgcgcctgcc gcccgttgcc caggcaaccg tcgtgccgcg
       61 tcttcctgag gtagctcctg tcagcccact gatcccacca cccgctccct actgccccgc
      121 ggtcttcgcg tgagctcgga gactgaggga caacaaaaat ggcggagggg agccagtcgg
      181 cgcctgaggc aggcaatgat atgggaaatg atgatgccat tggagggaat gtgagcaaat
      241 atatagtgct tccaactggc tattgtggac agcccaagaa aggacatctt atctttgatg
      301 cttgctttga aagtggtaac ctgggccggg tggaccaggt ctctgagttt gagtatgatc
      361 tgttcattag gccggacacc tgtaatccac gcttccgagt ctggttcaac tttactgttg
      421 aaaatgtgaa agaatcacag agggtcattt tcaacattgt taacttcagt aaaaccaaga
      481 gtctctatag agatgggatg gcccctatgg tgaaatctac cagcagacca aaatggcaaa
      541 ggctgccacc caaaaatgtt tactactacc gctgcccgga ccataggaag aactatgtga
      601 tgtcctttgc cttttgtttt gaccgagaag aagatattta ccagtttgct tactgctacc
      661 catatacata cactcgcttc caacattacc ttgacagcct gcaaaagaga aacatggatt
      721 acttctttcg ggagcagctg ggccagagtg tgcaacaacg aaagcttgac ctcctgacga
      781 taaccagccc tgacaatctc cgggaagggg cagagcagaa ggtggtattc atcacaggac
      841 gagtccaccc aggggaaaca ccctcatcat ttgtgtgcca agggatcatt gacttccttg
      901 taagccagca ccctattgcc tgtgtcctcc gggaatacct ggtcttcaag atcgcaccaa
      961 tgctcaatcc tgatggagtc tacctgggca attacaggtg ttctctgatg ggatttgatc
     1021 tgaatcgtca ctggctggat ccctctccat gggtccatcc taccctgcat ggagtgaaac
     1081 aactcatcgt ccagatgtac aacgacccaa aaacaagcct ggagttttat attgacatcc
     1141 atgcccactc caccatgatg aatggcttca tgtatggcaa catctttgag gatgaggaac
     1201 ggttccagag gcaggccatt tttcccaagc tcctctgcca gaatgctgag gacttctcct
     1261 attccagcac atcctttaac cgggacgctg tgaaagcagg aactggccgt cgcttcctcg
     1321 gtggactcct ggaccacact tcctattgct acaccctaga ggtctccttc tacagctaca
     1381 tcatcagtgg caccacggct gctgtgccct acactgaaga agcctatatg aagctggggc
     1441 ggaatgtggc aagaaccttt ttggactatt atcggctgaa ccccgtggtt gaaaaggtgg
     1501 caattcccat gccgagactg cgaaataaag aaatagaagt ccagagaagg aaagaaaaat
     1561 cccctcctta caagcaccca ctcctgcggg gcccagccag caactacccc aacagcaaag
     1621 gggacaagaa gagctcagtg aaccacaaag acccttcaac ccctttttaa agacacggag
     1681 tcctgggagg tcttatgggg acaggagcat gcattttctg ctggggaatg aaattaatca
     1741 ctcttctcta gcttccaagg atttgtggat taatgcatag gctagtgaaa gggaagggat
     1801 acaatgagaa acttcatcac tgattttccc tttttccaat ggaaaatcaa ttgtaagcct
     1861 tcagctcaaa aagctcagga acaaaatagg agatcggaac caggtgagca cagatgctat
     1921 tttctacaac atagagatct tccaagatga ggaaaaccta cacatccctt ttaagagatt
     1981 tgacacatat caggtcagtt ctttcaaagc cactttacat ttttaagttt tatagttact
     2041 gcagatggtt accttttaaa taggcttggt tgtttacagc tttagaaatg cagtgtttgt
     2101 attttctgat ccaaaacaac agcaacaaca catgcaacca aagggcaaat gcatcctagg
     2161 gaacaatggg acagaatttt tgaaatcaac ggtggactta aatatatggt cactgtatct
     2221 aagctgcatg cttgctgatt ccctcaaacc ccagcatgca gatttagaaa actgttttga
     2281 gagctgtttc ccaatttcct cggtagttta attaaaattt tagctctaaa gacaaaaagc
     2341 actggtcact cattttaaaa ggtttattat ggttaaggtc tccagatccc aggtgacagg
     2401 gattaagcct ggcccctgaa gatgtaggca ttgctaatct gcaatgagga aagggtgatt
     2461 gccaggcaag gaagatgcaa aagacagaag gatgcaccct gaggcaggga ggaatgataa
     2521 aataaaacag tagtagcaat tcccaaggtg tggcaagcta aatattggca tttttgtgaa
     2581 gagtaaagtg cctttgtatg atgaatgggt ccaggggggt ctgctccctt cctgtctgtg
     2641 gaaacagcag gctgagtcac catgacagcc tgctaattaa aatgacctcc cggaaatgag
     2701 gattagaaca cagggagagg aagggaggct ccagggagga aaatccctta gcacagagct
     2761 ccactaaagc attttttgtt tgtttgtttg tttgtttgtt tgtttgagtt ggagattatt
     2821 gaagtttgct acaaaaatca aaaagaaaac ttgttctcct ttgcatgcta gttttcagaa
     2881 atgatgacaa agagccatat gttgattggc tacaaatgtc atgttgtata tacagcttct
     2941 cccctgggtt cgttttgccc agaggaacac aaataaagtg ttttgtgca
//
