LOCUS       NM_178563               3533 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens AGBL carboxypeptidase 3 (AGBL3), transcript variant 1,
            mRNA.
ACCESSION   NM_178563 XM_371952
VERSION     NM_178563.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3533)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK302827.1, AC090497.2, AC083862.2 and AA707617.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178563.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436302.6/ ENSP00000388275.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-616               AK302827.1         1-616
            617-617             AC090497.2         53843-53843
            618-849             AK302827.1         618-849
            850-1462            AC083862.2         8860-9472
            1463-3069           AK302827.1         1463-3069
            3070-3124           AC083862.2         109988-110042
            3125-3533           AA707617.1         10-418              c
FEATURES             Location/Qualifiers
     source          1..3533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..3533
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /note="AGBL carboxypeptidase 3"
                     /db_xref="GeneID:340351"
                     /db_xref="HGNC:HGNC:27981"
                     /db_xref="MIM:617346"
     exon            1..194
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            195..316
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..3016
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /note="isoform a is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 3; protein deglutamylase CCP3;
                     ATP/GTP binding protein like 3"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 3 isoform a"
                     /protein_id="NP_848658.3"
                     /db_xref="CCDS:CCDS47718.1"
                     /db_xref="GeneID:340351"
                     /db_xref="HGNC:HGNC:27981"
                     /db_xref="MIM:617346"
                     /translation="MSEDSEKEDYSDRTISDEDESDEDMFMKFVSEDLHRCALLTADS
                     FGDPFFPRTTQILLEYQLGRWVPRLREPRDLYGVSSSGPLSPTRWPYHCEVIDEKVQH
                     IDWTPSCPEPVYIPTGLETEPLYPDSKEATVVYLAEDAYKEPCFVYSRVGGNRTPLKQ
                     PVDYRDNTLMFEARFESGNLQKVVKVAEYEYQLTVRPDLFTNKHTQWYYFQVTNMRAG
                     IVYRFTIVNFTKPASLYSRGMRPLFYSEKEAKAHHIGWQRIGDQIKYYRNNPGQDGRH
                     YFSLTWTFQFPHNKDTCYFAHCYPYTYTNLQEYLSGINNDPVRSKFCKIRVLCHTLAR
                     NMVYILTITTPLKNSDSRKRKAVILTARVHPGETNSSWIMKGFLDYILGNSSDAQLLR
                     DTFVFKVVPMLNPDGVIVGNYRCSLAGRDLNRNYTSLLKESFPSVWYTRNMVHRLMEK
                     REVILYCDLHGHSRKENIFMYGCDGSDRSKTLYLQQRIFPLMLSKNCPDKFSFSACKF
                     NVQKSKEGTGRVVMWKMGIRNSFTMEATFCGSTLGNKRGTHFSTKDLESMGYHFCDSL
                     LDYCDPDRTKYYRCLKELEEMERHITLEKVFEDSDTPVIDITLDVESSSRGSDSSESI
                     DSLTYLLKLTSQKKHLKTKKERNSTIASHQNARGQEVYDRGHLLQRHTQSNSDVKDTR
                     PNEPDDYMVDYFRRQLPNQGLDLHHNLKSKIKECISFQSKKTGINWTDDEKRSYKDKG
                     IVQTQEILQYLLPIVHSTKNMQTTQIKQLFNPRTNFQIQHQLNPATCRNIKKYSTSWT
                     APRNHPFVIQGDVMANSSEWVQSKPHRSLESLSPLKGPKKNKHSQIWAIKNEDIKPLS
                     SKWETASSSFGMDANVLKYKSLQAEETNQQSSKHTALHLTKNKDEQANKNDGQPTLYL
                     KFQRES"
     exon            317..377
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            378..563
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..671
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..810
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1590
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1753
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1880
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1981
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2094
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2161
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2233
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2291
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2363
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2595
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..3533
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3511..3516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /note="hexamer: AATAAA"
     polyA_site      3533
                     /gene="AGBL3"
                     /gene_synonym="CCP3"
                     /note="major polyA site"
ORIGIN      
        1 gttgcctgat gacgagagtt gggagtgtgg ctggggctgc ggatctccag cagtggcgtt
       61 acttctagcg gctggatacc gggttctccg cgagatcgcg agatcccgag atattctccc
      121 cgcacggaag cgacgactgg cctggccaga ggactcgcgt gggagcgagg tgccggcccc
      181 gacaggacgg tgagaaattg ttttacagcc tacccgtata ttacaagaaa tctcaagtca
      241 aacactggaa aagatgtcag aagattcaga aaaggaagac tattcagaca gaacaatcag
      301 tgatgaagat gaatcggatg aggatatgtt catgaaattt gtaagtgaag atcttcatcg
      361 gtgtgcactt ttaacagctg actcttttgg tgatcccttc ttcccccgga ctacacagat
      421 actattagaa tatcagctag ggagatgggt gccacgtctt cgtgaaccaa gggatttata
      481 tggtgtctct tcttctggtc cattgagccc aacacggtgg ccataccatt gtgaagtcat
      541 cgatgaaaaa gtccagcata ttgattggac tccttcttgt cctgagccag tgtatatccc
      601 aacgggctta gaaacggaac ccctttatcc agactccaag gaagctactg tggtttatct
      661 agctgaagat gcttacaaag agccctgttt tgtgtattcc cgagttgggg gtaaccgaac
      721 acctttgaag cagcctgtgg attaccgtga caatactttg atgtttgaag caaggtttga
      781 gagtggtaat ctacagaagg tagtcaaagt ggcagaatac gaataccaat tgactgtacg
      841 ccctgacctc ttcacaaata aacacaccca gtggtactat ttccaagtca ctaatatgcg
      901 agcaggaata gtctacagat tcactattgt caacttcacc aaacctgcta gtctttacag
      961 tcggggtatg cgcccactgt tctattctga aaaagaggcc aaggctcatc acattggctg
     1021 gcagagaata ggagaccaaa tcaagtatta taggaacaac ccaggccaag atgggcgcca
     1081 ttatttctct cttacatgga catttcaatt tccacacaac aaagatacct gctactttgc
     1141 tcattgctat ccatacactt acaccaacct gcaagaatac ctttctggca tcaataatga
     1201 tccagtacgg tcaaagtttt gtaaaatacg tgttttgtgc cacacgcttg ctaggaacat
     1261 ggtgtatatt ttaacaatca ctaccccctt gaagaactct gactcaagaa agcggaaggc
     1321 tgtgattctg actgcaaggg tccatccagg ggaaaccaac agctcttgga tcatgaaagg
     1381 cttcctagat tatattttag gaaactcaag tgatgcacag ttgcttcggg acacttttgt
     1441 cttcaaggtg gtacccatgc tcaatccaga tggtgtgatt gtgggaaatt atcgctgttc
     1501 cttagctgga cgggatttaa accgtaatta tacatctctc ctgaaggaat cttttccttc
     1561 tgtatggtat acccggaaca tggttcatag actgatggag aaacgagagg ttattttata
     1621 ctgtgatctt catggccata gtaggaaaga gaacatcttc atgtatggct gtgatggtag
     1681 tgacagatct aagacattat acttacagca acgaatcttc ccacttatgc taagcaaaaa
     1741 ttgtccagat aaattttcat tctcagcttg caagtttaat gtccagaaga gcaaagaagg
     1801 aacaggaagg gtggtaatgt ggaaaatggg aatcaggaac agctttacca tggaggccac
     1861 cttctgtgga tctactctgg gtaacaaacg aggcactcat ttcagcacga aagacctgga
     1921 atcaatggga tatcattttt gtgattctct cttggattat tgtgatcccg accggaccaa
     1981 gtattatcgg tgcctgaaag aattagaaga aatggaaaga catataaccc tggaaaaagt
     2041 ctttgaggat tcagacacac ctgtgataga cattacattg gatgtagagt ctagtagccg
     2101 aggctctgac agttcagaat ccattgactc tctgacttac cttctcaagt taacttctca
     2161 gaaaaaacat ttgaaaacaa agaaggaaag gaattctacc atagcaagcc accaaaatgc
     2221 cagaggacaa gaggtttatg atagagggca tttgctgcaa agacacacac aatcaaattc
     2281 tgatgtgaaa gatacaaggc caaatgaacc agatgattat atggttgatt atttcagaag
     2341 acaattacct aatcaaggtt tggatctgca ccacaactta aaaagcaaaa taaaagaatg
     2401 catatctttc caaagcaaga agactggcat aaattggaca gatgatgaaa aaagaagcta
     2461 caaggataaa ggaatagttc aaactcaaga aatattgcag tatttgctcc ccatcgtgca
     2521 tagcactaaa aacatgcaaa ccactcagat aaaacagcta ttcaatccaa gaaccaactt
     2581 ccaaatccaa catcaactaa atccggctac ttgcagaaat ataaagaaat acagcacatc
     2641 ttggacagca cccagaaatc acccttttgt aatccaaggg gatgttatgg caaactcttc
     2701 agaatgggtc cagtctaagc cccacaggtc attggaaagt ttatcacctc tcaaaggccc
     2761 caagaagaat aaacattctc aaatctgggc cataaagaat gaagacataa aacctctcag
     2821 cagcaagtgg gagactgctt cttcaagctt tggaatggat gcaaatgttc taaaatataa
     2881 gagtcttcaa gctgaagaaa ctaaccagca aagctctaag catacagccc tccatctaac
     2941 taaaaataag gatgagcagg ccaataagaa tgatggacaa cccaccttat atctgaagtt
     3001 ccaaagggag agttaatcta gctttatact gctctgagaa ctgtgaatga aggataacat
     3061 atgcttatgt agtaaaaaga aaaaaaggaa agccctcccc ttcccctttc cctatctctc
     3121 cccttacaca tgcatatgca taaactaaaa attttagata tcccatcttc tgtagtggga
     3181 acatctttca gagatttaaa aagaaatcca gagaaaatat ggaaaaatat taaagcagat
     3241 atttatattt agtttttatc agcatggaaa aaaatctctg aagttttgat ttcttccaaa
     3301 actacttaca cattcgacac caaaaaaact taagaactca aagtaggaat gacatataat
     3361 atgtcactga ttttaacctc cctactagac actttaatca attagtcaac aaacatcatt
     3421 tcctgatttt ctgttatatc attagtgtgc taggaaccat ttctctctac taggagatta
     3481 ccacataatt gtacagataa aacatacctg aataaaatga ttacagaata aga
//
