LOCUS       NM_024783               3586 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens AGBL carboxypeptidase 2 (AGBL2), mRNA.
ACCESSION   NM_024783
VERSION     NM_024783.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Peterfi,L., Banyai,D., Yusenko,M.V., Bjercke,T. and Kovacs,G.
  TITLE     Expression of RARRES1 and AGBL2 and progression of conventional
            renal cell carcinoma
  JOURNAL   Br J Cancer 122 (12), 1818-1824 (2020)
   PUBMED   32307444
  REMARK    GeneRIF: Expression of RARRES1 and AGBL2 and progression of
            conventional renal cell carcinoma.
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Wang,L.L., Jin,X.H., Cai,M.Y., Li,H.G., Chen,J.W., Wang,F.W.,
            Wang,C.Y., Hu,W.W., Liu,F. and Xie,D.
  TITLE     AGBL2 promotes cancer cell growth through IRGM-regulated autophagy
            and enhanced Aurora A activity in hepatocellular carcinoma
  JOURNAL   Cancer Lett 414, 71-80 (2018)
   PUBMED   29126912
  REMARK    GeneRIF: Findings suggest that ATP/GTP binding protein like 2
            (AGBL2) plays a critical oncogenic role in the pathogenesis of
            hepatocellular carcinoma (HCC) through modulation on
            immunity-related GTPase family, M protein (IRGM)-regulated
            autophagy and aurora kinase A (Aurora A) activity.
            Erratum:[Cancer Lett. 2022 Jul 28;539:215700. doi:
            10.1016/j.canlet.2022.215700.. PMID: 35525812]
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Zhu,H., Zheng,Z., Zhang,J., Liu,X., Liu,Y., Yang,W., Liu,Y.,
            Zhang,T., Zhao,Y., Liu,Y., Su,X. and Gu,X.
  TITLE     Effects of AGBL2 on cell proliferation and chemotherapy resistance
            of gastric cancer
  JOURNAL   Hepatogastroenterology 62 (138), 497-502 (2015)
   PUBMED   25916089
  REMARK    GeneRIF: Suggest role for AGBL2 in cell proliferation and
            chemotherapy resistance in gastric cancer.
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Hysi,P.G., Cheng,C.Y., Springelkamp,H., Macgregor,S.,
            Bailey,J.N.C., Wojciechowski,R., Vitart,V., Nag,A., Hewitt,A.W.,
            Hohn,R., Venturini,C., Mirshahi,A., Ramdas,W.D., Thorleifsson,G.,
            Vithana,E., Khor,C.C., Stefansson,A.B., Liao,J., Haines,J.L.,
            Amin,N., Wang,Y.X., Wild,P.S., Ozel,A.B., Li,J.Z., Fleck,B.W.,
            Zeller,T., Staffieri,S.E., Teo,Y.Y., Cuellar-Partida,G., Luo,X.,
            Allingham,R.R., Richards,J.E., Senft,A., Karssen,L.C., Zheng,Y.,
            Bellenguez,C., Xu,L., Iglesias,A.I., Wilson,J.F., Kang,J.H., van
            Leeuwen,E.M., Jonsson,V., Thorsteinsdottir,U., Despriet,D.D.G.,
            Ennis,S., Moroi,S.E., Martin,N.G., Jansonius,N.M., Yazar,S.,
            Tai,E.S., Amouyel,P., Kirwan,J., van Koolwijk,L.M.E., Hauser,M.A.,
            Jonasson,F., Leo,P., Loomis,S.J., Fogarty,R., Rivadeneira,F.,
            Kearns,L., Lackner,K.J., de Jong,P.T.V.M., Simpson,C.L.,
            Pennell,C.E., Oostra,B.A., Uitterlinden,A.G., Saw,S.M.,
            Lotery,A.J., Bailey-Wilson,J.E., Hofman,A., Vingerling,J.R.,
            Maubaret,C., Pfeiffer,N., Wolfs,R.C.W., Lemij,H.G., Young,T.L.,
            Pasquale,L.R., Delcourt,C., Spector,T.D., Klaver,C.C.W.,
            Small,K.S., Burdon,K.P., Stefansson,K., Wong,T.Y., Viswanathan,A.,
            Mackey,D.A., Craig,J.E., Wiggs,J.L., van Duijn,C.M., Hammond,C.J.
            and Aung,T.
  CONSRTM   BMES GWAS Group; NEIGHBORHOOD Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide analysis of multi-ancestry cohorts identifies new loci
            influencing intraocular pressure and susceptibility to glaucoma
  JOURNAL   Nat Genet 46 (10), 1126-1130 (2014)
   PUBMED   25173106
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Zhang,H., Ren,Y., Pang,D. and Liu,C.
  TITLE     Clinical implications of AGBL2 expression and its inhibitor latexin
            in breast cancer
  JOURNAL   World J Surg Oncol 12, 142 (2014)
   PUBMED   24884516
  REMARK    GeneRIF: High AGBL2 expression is associated with breast cancer.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   Rodriguez de la Vega Otazo,M., Lorenzo,J., Tort,O., Aviles,F.X. and
            Bautista,J.M.
  TITLE     Functional segregation and emerging role of cilia-related cytosolic
            carboxypeptidases (CCPs)
  JOURNAL   FASEB J 27 (2), 424-431 (2013)
   PUBMED   23085998
REFERENCE   8  (bases 1 to 3586)
  AUTHORS   Sahab,Z.J., Hall,M.D., Me Sung,Y., Dakshanamurthy,S., Ji,Y.,
            Kumar,D. and Byers,S.W.
  TITLE     Tumor suppressor RARRES1 interacts with cytoplasmic
            carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination
            cycle
  JOURNAL   Cancer Res 71 (4), 1219-1228 (2011)
   PUBMED   21303978
  REMARK    GeneRIF: RARRES1, its interacting partners AGBL2, Eg5/KIF11,
            another EEY-bearing protein (EB1), and the microtubule tyrosination
            cycle are important in tumorigenesis.
REFERENCE   9  (bases 1 to 3586)
  AUTHORS   Jahn,J.E., Ricketts,S.L. and Coleman,W.B.
  TITLE     Identification of candidate liver tumor suppressor genes from human
            11p11.2 by transcription mapping of microcell hybrid cell lines
  JOURNAL   Int J Oncol 22 (6), 1303-1310 (2003)
   PUBMED   12738998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021443.27 and BC036234.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024783.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525123.6/ ENSP00000435582.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC021443.27        67844-67856         c
            14-2307             BC036234.1         5-2298
            2308-2308           AC021443.27        32463-32463         c
            2309-3586           BC036234.1         2300-3577
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..3586
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /note="AGBL carboxypeptidase 2"
                     /db_xref="GeneID:79841"
                     /db_xref="HGNC:HGNC:26296"
                     /db_xref="MIM:617345"
     exon            1..195
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            196..328
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..3004
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /note="cytoplasmic carboxypeptidase 2; testis tissue
                     sperm-binding protein Li 96mP; ATP/GTP binding protein
                     like 2; protein deglutamylase CCP2"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 2"
                     /protein_id="NP_079059.2"
                     /db_xref="CCDS:CCDS7944.1"
                     /db_xref="GeneID:79841"
                     /db_xref="HGNC:HGNC:26296"
                     /db_xref="MIM:617345"
                     /translation="MFPALETHLKQTIPDPYEDFMYRHLQYYGYFKAQRGSLPNSATH
                     QHVRKNNPQCLLNGSLGEKDDLIPDTLQKEKLLWPISLSSAVHRQIEAINRDFHSCLG
                     WMQWRGLSSLQPPPPRFKDSPASAFRVAGITDSHMLSLPHLRSRQLLYDELDEVNPRL
                     REPQELFSILSTKRPLQAPRWPIECEVIKENIHHIEWAPPQPEYFYQPKGNEKVPEIV
                     GEKKGTVVYQLDSVPIEGSYFTSSRVGGKRGIVKELAVTLQGPEDNTLLFESRFESGN
                     LQKAVRVDTYEYELTLRTDLYTNKHTQWFYFRVQNTRKDATYRFTIVNLLKPKSLYTV
                     GMKPLLYSQLDANTRNIGWRREGNEIKYYKNNTDDGQQPFYCLTWTIQFPYDQDTCFF
                     AHFYPYTYTDLQCYLLSVANNPIQSQFCKLQTLCRSLAGNTVYLLTITNPSQTPQEAA
                     AKKAVVLSARVHPGESNGSWVMKGFLDFILSNSPDAQLLRDIFVFKVLPMLNPDGVIV
                     GNYRCSLAGRDLNRHYKTILKESFPCIWYTRNMIKRLLEEREVLLYCDFHGHSRKNNI
                     FLYGCNNNNRKYWLHERVFPLMLCKNAPDKFSFHSCNFKVQKCKEGTGRVVMWRMGIL
                     NSYTMESTFGGSTLGNKRDTHFTIEDLKSLGYHVCDTLLDFCDPDQMKFTQCLAELKE
                     LLRQEIHKKFHELGQDVDLEGSWSDISLSDIESSTSGSDSSLSDGLPVHLANIADELT
                     QKKKMFKKKKKKSLQTRKQRNEQYQKKNLMQKLKLTEDTSEKAGFASTLQKQPTFFKN
                     SENSSFLPMKNENPRLNETNLNRRDKDTPLDPSMATLILPKNKGRMQNKKPGFTVSCS
                     PKRTINSSQEPAPGMKPNWPRSRYPATKRGCAAMAAYPSLHIYTYP"
     exon            329..392
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            393..527
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            528..581
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..695
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..881
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..989
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1143
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1926
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2083
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2210
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2311
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2442
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2509
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2635
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2743
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2830
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..3586
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3566..3571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3586
                     /gene="AGBL2"
                     /gene_synonym="CCP2"
                     /note="major polyA site"
ORIGIN      
        1 agactacccg ggccctcaca gaaggcggtg gcgggcgggt gcagcgagtt tgtccccttg
       61 cccgcacact gcttggcctc tgtacttaag tgcggtggcc gcctgcctcg ctggagcttc
      121 tctgccgcag ccatccgtgc tgcttgggac gggccggggc gcgaaggcgg tcgcatccat
      181 cgctctgccc tcctgcttct cttgtgtaat cagctgccta tttggaaatt gggcagggtt
      241 tgcgactgga tgctaatgtc actgactagt tttcagccta ccatccagaa gtaacatgtt
      301 cccagctttg gaaacgcacc taaagcagac tattcctgat ccttatgaag actttatgta
      361 ccgtcacctc caatattatg gctactttaa agctcagaga ggcagtttac caaactctgc
      421 tacgcatcag catgttcgga agaataaccc tcaatgcctg ttgaatggct ctcttgggga
      481 aaaagatgat ttgataccag acaccctgca aaaggagaag cttctatggc ctatcagttt
      541 atcttcagct gtgcacagac agatagaagc catcaacaga gactttcact cttgcctggg
      601 ctggatgcag tggcgcggcc tcagctcact gcaacctcca cctcccagat tcaaggattc
      661 tcctgcctca gctttccgag tagctgggat tacagattca catatgctga gtttaccaca
      721 tcttaggagc agacagcttc tttatgatga gttggatgaa gtaaacccac gtcttcgaga
      781 accccaagag ctcttttcca ttttgtctac caagaggcca ctgcaggctc caagatggcc
      841 aattgaatgt gaggtcatca aggaaaacat ccatcatatt gagtgggctc cacctcaacc
      901 agaatatttc tatcagccta aaggaaatga aaaggtacca gagattgtag gagagaaaaa
      961 aggaacagtt gtctatcaat tagattcagt gcctatagaa ggttcctatt ttaccagttc
     1021 cagagtggga ggcaaacgag gaattgtcaa ggaacttgct gtcacgttgc aaggaccaga
     1081 agataatact ctactgtttg aatcaaggtt tgagagtggg aatctgcaaa aagctgtcag
     1141 agtagacacc tatgagtatg aactcacctt gcgaactgac ctctacacta acaaacacac
     1201 tcagtggttt tattttcgtg ttcagaacac cagaaaagat gctacctatc gcttcaccat
     1261 tgtcaacttg ctaaaaccca agagtcttta tactgtaggg atgaagccac tcttgtactc
     1321 ccaattggat gccaacaccc gcaatattgg ctggaggaga gaaggaaatg aaatcaagta
     1381 ctacaagaac aacacggatg atgggcagca gcccttctac tgtctcacgt ggaccattca
     1441 gtttccatat gaccaggaca cttgcttctt tgcacacttc tacccatata catacactga
     1501 tttgcaatgc tacctcctgt cagtggcaaa caaccctatc cagtctcagt tctgcaagct
     1561 ccaaacttta tgcaggagcc tagcaggaaa taccgtttac ttgctcacca tcaccaaccc
     1621 atcccagacc cctcaagagg cagctgcaaa gaaagctgtg gtcttgagtg ccagagttca
     1681 ccctggagaa agtaatggct cctgggttat gaaaggcttt ttggacttca tccttagcaa
     1741 ctccccagat gcccagctcc tcagagatat ttttgtcttc aaggtgcttc ccatgttaaa
     1801 tccagatggt gtgattgtgg ggaattatcg gtgttccttg gccggaaggg atttgaacag
     1861 gcattataaa accattctga aggagtcttt cccttgtatt tggtacacca ggaacatgat
     1921 caaaagactt cttgaagaaa gagaggttct gttgtattgt gatttccatg gccacagtcg
     1981 taagaataat atcttcctgt atggctgtaa taacaacaat cgcaaatact ggcttcatga
     2041 acgagtcttt cctttaatgt tatgcaaaaa tgcaccagat aagttctctt ttcacagttg
     2101 taattttaag gtccaaaaat gcaaagaagg aacaggacga gttgttatgt ggcggatggg
     2161 aatcctaaac agctacacca tggagtctac ctttggcggg tccaccctgg gtaataaaag
     2221 agacacccac tttaccatcg aagatctgaa gtccttaggt tatcatgtct gtgacaccct
     2281 tctggacttt tgtgatcctg accaaatgaa gttcactcag tgtctagcag agcttaagga
     2341 gcttttacga caggaaatcc acaagaaatt ccatgaactt ggacaagatg tagatttaga
     2401 aggaagttgg agtgacatct ctttgtctga cattgaatcc agcaccagtg gctctgacag
     2461 ttctctctca gatggtcttc ctgttcacct agcaaacata gcagatgagc tgactcagaa
     2521 aaagaagatg tttaagaaga aaaaaaagaa gtcacttcag actaggaaac agcgaaatga
     2581 gcagtatcag aaaaaaaatt tgatgcagaa gttaaagtta acagaagata cctcagaaaa
     2641 ggcaggattt gcttctactc tgcaaaagca gccaaccttt ttcaaaaact cagagaattc
     2701 cagtttttta ccaatgaaaa atgaaaaccc aaggttaaat gagacaaatt taaatagaag
     2761 agacaaagac acccccctgg acccatcaat ggccaccctg attctgccta agaataaagg
     2821 gagaatgcag aataagaagc caggctttac agtatcatgc tctccaaaga gaaccataaa
     2881 ctccagccaa gagccagctc caggtatgaa gccaaactgg cctaggagca gatatcctgc
     2941 cacaaagaga ggctgtgctg ccatggcggc atacccatcc ttgcacatat acacataccc
     3001 gtaggtgagc ctgggctgtg ccacacaagc acttcatcgg gggttttgag attagacaca
     3061 ttttataatg ggggagatgt atgactggga actgcattta cttgtggtat actgtgttgt
     3121 gcactcatgc actgacctta cactttgtac ttacactgtg ggcatgtggt caagatgcat
     3181 acctcatgaa ttcaactatt ttttcataaa atgaaatttt attatgatgt gtaaaaatgc
     3241 tttatcagaa actgaagtgt gttctcatgg cacacttcat ggcagcacag atatacctca
     3301 ttttaaccaa tagatattct ctctaaaatt atgtgcaaat caatttttaa aaatcaaaat
     3361 ctatgttaaa cacattttgg cagtgtgcta taataaaaaa aagtgttgtg tcaaagcttt
     3421 ctagtgacgg tcagtcctac tgctgtatgt caggtttgct cacaatgagg tattcccaca
     3481 tagaaataac aatgcatgta ttacccagaa tttaatgttg cgtaccttat gttcaatgag
     3541 gttttgtaat ttttttaggc tgatgattaa aattctttct ctctaa
//
