LOCUS       NM_001386094           12330 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens AGBL carboxypeptidase 1 (AGBL1), transcript variant 1,
            mRNA.
ACCESSION   NM_001386094 XM_011521226
VERSION     NM_001386094.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12330)
  AUTHORS   Zhang,L., Li,X., Quan,X., Tian,W., Yang,X. and Zhou,B.
  TITLE     A Case/Control Study: AGBL1 Polymorphism Related to Lung Cancer
            Risk in Chinese Nonsmoking Females
  JOURNAL   DNA Cell Biol 38 (12), 1452-1459 (2019)
   PUBMED   31603707
  REMARK    GeneRIF: rs4513061 in AGBL1 Gene is associated with decrease in the
            risk of lung cancer.
REFERENCE   2  (bases 1 to 12330)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J 14 (1), 35-40 (2014)
   PUBMED   23400010
REFERENCE   3  (bases 1 to 12330)
  AUTHORS   Riazuddin,S.A., Vasanth,S., Katsanis,N. and Gottsch,J.D.
  TITLE     Mutations in AGBL1 cause dominant late-onset Fuchs corneal
            dystrophy and alter protein-protein interaction with TCF4
  JOURNAL   Am J Hum Genet 93 (4), 758-764 (2013)
   PUBMED   24094747
  REMARK    GeneRIF: That AGBL1 interacts biochemically with the FCD-associated
            protein TCF4.
REFERENCE   4  (bases 1 to 12330)
  AUTHORS   Ikeda,M., Okahisa,Y., Aleksic,B., Won,M., Kondo,N., Naruse,N.,
            Aoyama-Uehara,K., Sora,I., Iyo,M., Hashimoto,R., Kawamura,Y.,
            Nishida,N., Miyagawa,T., Takeda,M., Sasaki,T., Tokunaga,K.,
            Ozaki,N., Ujike,H. and Iwata,N.
  TITLE     Evidence for shared genetic risk between methamphetamine-induced
            psychosis and schizophrenia
  JOURNAL   Neuropsychopharmacology 38 (10), 1864-1870 (2013)
   PUBMED   23594818
REFERENCE   5  (bases 1 to 12330)
  AUTHORS   Tang,W., Schwienbacher,C., Lopez,L.M., Ben-Shlomo,Y.,
            Oudot-Mellakh,T., Johnson,A.D., Samani,N.J., Basu,S., Gogele,M.,
            Davies,G., Lowe,G.D., Tregouet,D.A., Tan,A., Pankow,J.S.,
            Tenesa,A., Levy,D., Volpato,C.B., Rumley,A., Gow,A.J., Minelli,C.,
            Yarnell,J.W., Porteous,D.J., Starr,J.M., Gallacher,J.,
            Boerwinkle,E., Visscher,P.M., Pramstaller,P.P., Cushman,M.,
            Emilsson,V., Plump,A.S., Matijevic,N., Morange,P.E., Deary,I.J.,
            Hicks,A.A. and Folsom,A.R.
  TITLE     Genetic associations for activated partial thromboplastin time and
            prothrombin time, their gene expression profiles, and risk of
            coronary artery disease
  JOURNAL   Am J Hum Genet 91 (1), 152-162 (2012)
   PUBMED   22703881
REFERENCE   6  (bases 1 to 12330)
  AUTHORS   Clark,S.L., Adkins,D.E., Aberg,K., Hettema,J.M., McClay,J.L.,
            Souza,R.P. and van den Oord,E.J.
  TITLE     Pharmacogenomic study of side-effects for antidepressant treatment
            options in STAR*D
  JOURNAL   Psychol Med 42 (6), 1151-1162 (2012)
   PUBMED   22041458
REFERENCE   7  (bases 1 to 12330)
  AUTHORS   Kuparinen,T., Seppala,I., Jylhava,J., Marttila,S., Aittoniemi,J.,
            Kettunen,J., Viikari,J., Kahonen,M., Raitakari,O., Lehtimaki,T. and
            Hurme,M.
  TITLE     Genome-wide association study does not reveal major genetic
            determinants for anti-cytomegalovirus antibody response
  JOURNAL   Genes Immun 13 (2), 184-190 (2012)
   PUBMED   21993531
REFERENCE   8  (bases 1 to 12330)
  AUTHORS   Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C.,
            Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Bosch Grau,M., Bec,N.,
            Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and
            Janke,C.
  TITLE     A family of protein-deglutamylating enzymes associated with
            neurodegeneration
  JOURNAL   Cell 143 (4), 564-578 (2010)
   PUBMED   21074048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016180.14, AC107978.2, AC025842.11, AC069197.6, AC022817.8,
            AC012229.8 and AC016987.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 7, 2020 this sequence version replaced XM_011521226.3.
            
            Summary: Polyglutamylation is a reversible posttranslational
            modification catalyzed by polyglutamylases that results in the
            addition of glutamate side chains on the modified protein. This
            gene encodes a glutamate decarboxylase that catalyzes the
            deglutamylation of polyglutamylated proteins. Mutations in this
            gene result in dominant late-onset Fuchs corneal dystrophy.
            [provided by RefSeq, Nov 2013].
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2158800,
                              SAMN03465413 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000614907.3/ ENSP00000490608.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AC016180.14        114012-114164       c
            154-217             AC016180.14        51968-52031         c
            218-364             AC016180.14        50190-50336         c
            365-496             AC016180.14        39474-39605         c
            497-590             AC016180.14        35009-35102         c
            591-628             AC107978.2         63871-63908
            629-837             AC025842.11        119419-119627       c
            838-1003            AC025842.11        110280-110445       c
            1004-1071           AC025842.11        109267-109334       c
            1072-1188           AC025842.11        104404-104520       c
            1189-1769           AC025842.11        102460-103040       c
            1770-1853           AC025842.11        100841-100924       c
            1854-1940           AC025842.11        100222-100308       c
            1941-2089           AC025842.11        97231-97379         c
            2090-2177           AC025842.11        95592-95679         c
            2178-2322           AC025842.11        87515-87659         c
            2323-2476           AC025842.11        71890-72043         c
            2477-2657           AC069197.6         59700-59880
            2658-2787           AC022817.8         114437-114566
            2788-2919           AC022817.8         137629-137760
            2920-3096           AC022817.8         145988-146164
            3097-3260           AC012229.8         20439-20602         c
            3261-12330          AC016987.4         65155-74224
FEATURES             Location/Qualifiers
     source          1..12330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.3"
     gene            1..12330
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /note="AGBL carboxypeptidase 1"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
     exon            1..153
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..3468
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /EC_number="3.4.17.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic carboxypeptidase 4; ATP/GTP binding protein like
                     1; protein deglutamylase CCP4"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase 4 isoform 1"
                     /protein_id="NP_001373023.1"
                     /db_xref="CCDS:CCDS92052.1"
                     /db_xref="GeneID:123624"
                     /db_xref="HGNC:HGNC:26504"
                     /db_xref="MIM:615496"
                     /translation="MAEQEASGLQVLLHTLQSSSDKESILTILKVLGDLLSVGTDRRI
                     HYMISKGGSEALLQTLVDTARTAPPDYDILLPLFRLLAKVGLRDKKIGRKALELEALD
                     VTLILARKNLSHGQNLLHCLWALRVFASSVSMGAMLGINGAMELLFKVITPYTRKRTQ
                     AIRAATEVLAALLKSKSNGRRAVNRGYVTSLLGLHQDWHSHDTANAYVQIRRGLLLCL
                     RHIAALRSGREAFLAAQGMEILFSTTQNCLDDKSMEPVISVVLQILRQCYPTSPLPLV
                     TASSAYAFPVPGCITTEPPHDLPEEDFEDDGDDEVDKDSDTEDGKVEDDDLETDVNKL
                     SSKPGLDRPEEELMQYEVMCLELSYSFEELQSKLGDDLNSEKTQYANHHHIPAAASSK
                     QHCYSKDQSSCGQEREYAVQTSLLCRVKTGRSTVHLGSKKNPGVNLYQNVQSNSLRRD
                     SSESEIPDIQASPKADAWDVDAIFCPRMSASFSNSTRTREVVKVIDKLLQTHLKRVPF
                     HDPYLYMAKARRTSSVVDFKMMAFPDVWGHCPPPTTQPMLERKCGVQRIRIFEDIRRL
                     IQPSDVINKVVFSLDEPWPLQDNASNCLRFFSKFESGNLRKAIQVREFEYDLLVNADV
                     NSTQHQQWFYFKVSGMQAAIPYHFNIINCEKPNSQFNYGMQPTLYSVKEALLGKPTWI
                     RTGHEICYYKNHYRQSTAVAGGASGKCYYTLTFAVTFPHSEDVCYLAYHYPYTYTALM
                     THLDILEKSVNLKEVYFRQDVLCQTLGGNPCPLVTITAMPESNSDEHLEQFRHRPYQV
                     ITARVHPGESNASWVMKGTLEFLVSSDPVARLLRENFIFKIIPMLNPDGVINGNHRCS
                     LSGEDLNRQWLSPSAHLQPTIYHAKGLLYHLSSIGRSPVVFCDFHGHSQKKNVFLYGC
                     SIKETLWQAACTVGTSTILEEVNYRTLPKILDKLAPAFTMSSCSFLVEKSRASTARVV
                     VWREMGVSRSYTMESSYCGCNQGPYQGLQFGTRELEEMGAMFCLGLLILELKSASCSH
                     QLLAQAATLLSAEEDALDQHLQRCSSSSGSVPSELEDEPACLEEIDYSTDNSSDQEGS
                     LSELDRRIQECAFNKFEGEEEEEAPGQGGEAIP"
     exon            154..217
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            218..364
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            365..496
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            497..590
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            591..628
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            629..837
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1003
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1071
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1188
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1769
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1853
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1940
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2089
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2177
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2322
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2476
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2657
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2787
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2919
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3096
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3260
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..12330
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12304..12309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /note="hexamer: AATAAA"
     polyA_site      12330
                     /gene="AGBL1"
                     /gene_synonym="CCP4; FECD8"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtctcc tgcgaggcgg gcagcgaggt cagcttggca gccgctgcct ctccagcctg
       61 gatctggccg caggcagcgg ttccctagga cccgagaaaa ggatggccga acaagaagct
      121 agtgggctac aggtcctgct gcacacgctt cagagctcct ctgacaagga gtccatcctg
      181 accatcctca aggtcctcgg agatctgctt tctgttggca cagaccggag aattcactac
      241 atgatcagca agggtggcag tgaagctctt ctgcagaccc tggtagacac agcgaggaca
      301 gctcctccag actatgacat cctcctgcct ctcttccggc tgctggccaa agttggccta
      361 agagataaaa agattggacg gaaggcccta gaattggaag cacttgatgt gacattgatt
      421 ctggccagga agaacctatc ccatggccag aatctcctcc actgtctctg ggctctgcgt
      481 gtgtttgcct ccagtgtctc catgggagcc atgctgggaa ttaatggagc catggaactg
      541 cttttcaagg ttattactcc ttacacccga aagcgcaccc aagcaatcag ggcagccact
      601 gaagttttgg cagcattgct gaaatccaag tcgaacggcc gcagagcagt gaaccgaggc
      661 tacgtcacca gcctgctcgg gctgcaccag gactggcaca gccatgacac agccaacgcc
      721 tacgtgcaga tccgacgggg cttgctgctc tgcctcaggc acattgctgc cctccggtcc
      781 ggcagggagg ccttcctggc agcacagggc atggagatcc tcttcagcac cacacagaac
      841 tgcctggatg acaagagcat ggagcccgtc atctctgtgg tgcttcagat cctgaggcag
      901 tgctacccta cgagtccact tcccttggtc acagccagca gtgcctatgc cttcccggtc
      961 cccgggtgca tcaccactga acctccacat gatctacctg aagaggattt tgaagatgat
     1021 ggcgatgatg aagtggacaa agactctgat actgaagatg ggaaagtgga agatgatgac
     1081 ttggaaacag acgtgaacaa gctgagttcc aaacctggtc ttgaccgacc tgaagaggaa
     1141 ctgatgcaat atgaggtgat gtgtcttgag ctctcctata gctttgagga actgcagtcc
     1201 aaacttggag atgatttgaa ctctgaaaag actcagtatg ccaatcacca ccacattcca
     1261 gccgctgcct cctcaaaaca gcattgctac agcaaggacc aaagctcctg tgggcaagaa
     1321 agagaatatg ctgtccagac ttcccttctg tgcagggtga agacgggaag gtccactgtg
     1381 catctaggct ccaaaaaaaa tcctggagtg aacctgtacc aaaatgtgca atccaatagt
     1441 ctcaggagag attcttctga aagtgaaatc cctgacattc aggcttcccc gaaagcagat
     1501 gcctgggacg tagatgcaat tttctgccca aggatgagtg cctccttttc taattccact
     1561 aggactagag aagttgtcaa agtaatagat aagcttctgc agacacatct gaagcgtgtc
     1621 cctttccacg atccctatct ttatatggcc aaagccagaa gaaccagctc tgtggtggac
     1681 ttcaagatga tggcatttcc tgatgtctgg ggacactgtc cccctcccac cacccagcct
     1741 atgttggaac gaaaatgtgg agtccaaagg atcaggatat ttgaggatat tcggaggctc
     1801 atccagccaa gtgatgttat aaataaagtt gtcttcagtt tagatgagcc ttggcctttg
     1861 caagacaatg cttccaattg tttacggttc ttctccaaat ttgagtcagg aaatcttcgc
     1921 aaagccatcc aagtgcgtga gttcgagtat gacttgctgg tcaacgcaga tgtgaatagc
     1981 acccagcacc agcagtggtt ctatttcaaa gtgagcggta tgcaggcggc catcccttac
     2041 cacttcaaca tcatcaactg tgagaagccc aacagccagt ttaattatgg gatgcagccc
     2101 accctatatt ctgtgaagga ggctcttctt ggcaaaccca cctggataag gacaggccat
     2161 gaaatatgtt attacaaaaa tcattatcgc cagagtacag ctgttgcagg cggagcatct
     2221 gggaagtgct actataccct cacctttgct gtcaccttcc cacacagtga ggatgtctgc
     2281 tacctggcct accactatcc ctatacctac acagccctca tgactcatct tgacatcctg
     2341 gaaaagagtg tcaacctcaa agaggtctac ttccggcaag atgttctctg ccagacgctg
     2401 ggagggaatc cgtgtccctt ggtgaccatc acggccatgc ctgagtccaa cagtgatgag
     2461 catctagagc agttccgaca tcgtccatat caggtgatca ctgctcgagt tcatccagga
     2521 gagagcaatg ccagttgggt gatgaagggt accttggagt tcctggtcag cagtgaccct
     2581 gtggctaggc tcttgaggga aaacttcatc ttcaagatca tacccatgct caacccagat
     2641 ggtgtcatca acggcaacca cagatgctca ctgagcgggg aagatttgaa cagacaatgg
     2701 ctttctccca gtgctcatct gcagccaacc atttaccatg ccaaaggcct cctctaccac
     2761 ctgagcagca ttggccgaag tcccgtggtt ttctgtgact tccatggcca ctcccaaaag
     2821 aagaatgtgt tcctttatgg ctgtagcatc aaggaaacct tgtggcaagc agcatgcact
     2881 gtgggcacat ctactatcct agaggaggtc aactacagga ctcttcccaa aatccttgat
     2941 aagctagcac cagcattcac aatgagcagc tgcagctttc tcgtggagaa atctcgagct
     3001 tccacggccc gggtggtggt gtggagagag atgggggtgt ccagaagcta caccatggaa
     3061 agcagctact gtggctgcaa ccagggccct tatcagggtc tacagtttgg taccagagaa
     3121 ctggaggaga tgggagccat gttctgtttg ggcctcctca tcctggagct caaatctgcc
     3181 agctgcagcc atcagctcct ggctcaagct gcaactctgc tgagtgctga ggaggacgct
     3241 ctggaccagc acctccaacg gtgcagcagc agcagtggca gcgtcccttc ggaactggag
     3301 gatgaacctg cctgcttgga ggagattgat tacagtaccg acaacagctc agaccaggaa
     3361 gggagcttgt ctgagctgga ccggaggatc caggagtgtg ccttcaataa gtttgaggga
     3421 gaggaagaag aggaggcacc agggcaggga ggagaagcca tcccatagcc ccgaggttca
     3481 cagcaagttc tgtgtctcca accattggat tggactagca gctgtgttgc tgcttcttca
     3541 tcatcagaca cacacaatgt atatgtcagt gcaaaaagcc agcctgtgtg agctcagcaa
     3601 ccccatttcc agattttgtt ctagtttccc tatgcgtaga agctagccac tttataacat
     3661 tttatattag agttaggtag cccttggggc ctatgcaagc tgctattgta cttagaatgg
     3721 gacccaatgg gtagcctcaa gattaccatg gatcctttca agatttttct gagttattct
     3781 ccattcttgt gcttgaactg gagcaagctg gaagtagagg agttgggctt cttcttggct
     3841 tctcagccag aattctaagt ggttatttaa gttgttccat atacaagtgt tatcttccaa
     3901 tgttatctcc ccaccatagc atttgagcac cccagaacaa accactgaga ctctggggat
     3961 cctggcaggg tcttcaggtg ctggggcttg aacatgaaaa actgtgcatc caagtaattg
     4021 caggtttcat ctgtgatctt ctcaagcagc atatatttta catatgtggt acaggccaga
     4081 agctgcacta gactcttaga aataagacat tgtcactgat cttcacagat tttaagatcc
     4141 tatgtattca gatcaccaaa cataatgcta ggaagtacca gacctactgg aaaatttatt
     4201 catttcagaa tctgacagat atggttcata tgctagatct ggcagttgct tgttatgaca
     4261 atttaggcaa gtaattaaat tttcctaaac ttcagttttc ttatatataa aatgtggata
     4321 agtatatcta tatcataaaa ttattgtagg atgaaatgag atgatatata aaagtgtata
     4381 gcttagcatt tggtacacaa caacattggc ttatttttct tcataacaca aaagaacatt
     4441 ctatataaga attctgacag ttaagaaaaa attctcacca gcctggacaa catgatgaaa
     4501 ccctgtctct actaaacccc atctctacaa aaattagcca agtgtggtgg cgcacacctg
     4561 taatcccagc tacttgggag gctgagaaag gagaatcgct tgaacttggg aggtggaggt
     4621 tgccatgagc cgagattgca ccactgcatt ccagcccggc aacagagcaa gactctgtct
     4681 caaacaacaa caacaacaac gacgacaaac ccagaatcca gaattctctg gagtcacatg
     4741 gtaggaaata ggccctctta ctggaaggga gctgggaagg agattacaga ggagcagaat
     4801 ctaggaggct ggaatcactt aaaacaggtg aaaatggagc aaggcctttt agcattcgga
     4861 aggaagaggc ttagttattt gaataatgaa gtgtacgaga cctgcgaaga aaggatgaga
     4921 agggacgaca aaggcagtgg tagagtgaga gatagaatac gctaggtcaa acttaggctg
     4981 ttttagatgt catgtgtatt agttaggatt aggtttagct gcaagagatg gacaacttat
     5041 catagtagta gctttcataa ggcataagtc tatttctctt tcctgtggaa ttttacacac
     5101 tggaagacca gtcctagtgt catggctgca tggtgtcaga gacctggctt ctgcagtttt
     5161 ctggctctac tgtgtgtgct tctactcttg gtctagaatg gctgctgaag catcagtcac
     5221 tgcatctgca tcccaggcag tagcaagaag aacacaaaaa gaaatgcctg ttttctatct
     5281 ttccaaaagc tctacataat atttcttctt aatcccaccg gctgaaaaaa atgggcctat
     5341 agccacagga agctgcaaga gaggttagaa aacatagtct ttatttgagg tgggcccagc
     5401 taaaatttga agtttgaagt aaaagtctga atactaaggg aaaagataat aatacatatt
     5461 gggagattac atatctgcca aaagacttct cctgatgttc caaacaccac caagggagtt
     5521 ttggatatat cagaataatc tcagatgaca ctcatagcac acacctcttg accagcagaa
     5581 agccacagaa caaaacagga ttagctccaa ggcatagaag aaaggcatct gtgttgtgat
     5641 tttgggagtt gataacatta ttaatagtct cttatttttt taactctttt ccaagtttcc
     5701 attttgtagt tcagaaattg tatatccatt cttcatatta agacatgtat gtttatgtaa
     5761 catatgcaag aaatttgaag actattagca aagataatga aagtgaaacc caaacgctat
     5821 atagctctta actcctccca tatttaatct ttccactctt aaataaaggc tagcataatg
     5881 gtgctgattt ctctttgctt tgaggattca agaagataat attgaaatgt aattgctgag
     5941 agaggtggga atgatgctag cttatcatta attattattt cagcccaaat tagttttggg
     6001 ggttagcttc tggtcatgag gcatgtttct taaaaaacgt gaccatgaca gataagtttt
     6061 tatgtggcat gttcagaaaa agccaggaac atgaagtatt tgttgatcca tctatgtaac
     6121 aaatgtatat ttaaccccta actgtgggtc atgcacttta ctaagctcta cggatgcaga
     6181 taagaaagac ctattttgtg ccctcagtaa ccagacaaag aagaacaata aacattctaa
     6241 gttaatgcag tatggcccat gccattatgg aactctgcaa agaatattac aaaaacgcct
     6301 aatctaatgg gggtggcagt tgtggtaaaa gtctaccaaa agaaggtcat aatttgggtg
     6361 attcttgaag aatatgcagg agttttcaag tataaaggga gaaaagacat gcgaaggagt
     6421 ggaaagattt tgtgcaaagg ccctgtggta gagttagagc ttgaaataaa atgttcagtg
     6481 tgactggttt aaaagatgtg tttgtatgtg aggaaaggag gagagtgaca agagatgaaa
     6541 tggaaaaact agacagcagt cagataaagc tgcatttggc attccttgat gaaaaggctg
     6601 aatttaattc tgaatgtaat gggggagact taaagagctt tcagcagagg catgcccgtg
     6661 actgatatca gcgccatttt tcccttgttt atggctgagg gtttggtgct cctgctatgc
     6721 tggttgttca gtagtttgag gagtgcccca ggtgtgatac tactatattt gaagagcaga
     6781 acgtttgcat tcaggtcaaa gataataagt gcagtttggg gacatgttaa atgttggtgg
     6841 cctacatgat agcccgttcg aaaggtttcc tagaaatcag aggtacctca ggaagcagaa
     6901 ggagaacaaa gagaggtgta cctaacactt ggtgattttg gggacacagg tgaatgtcct
     6961 gagcacctaa gcccaggtgt cagtgagttg ggaaggcaat tgattggagg gaagagggga
     7021 cttgggagca gacctctctc ctttcctgct aggactgaag gctatcttgt gtcaaatctc
     7081 accagtcttc catccagagt tagagggtac ttacttgaga gttaactctc aatagttata
     7141 agagccattc ttccagtcaa gccaggactt tctcttgctg gccagaccac ttcagtgaat
     7201 tgttgggata aaacgtgttc taccaaattc aaagccaaac taagatgacc caagaattcc
     7261 aaggagttgt aggccataat gggaagcaaa tgtggtccaa aatgtgcaga ggagagagga
     7321 gagtccagag aggcgatgtt ggggcaggcc aagtgcatgc tgtcctgtac caactgtcat
     7381 ccggtgctct gcatgcagga ctggaactgg ggctgagggg ctgtgggggc ctgcagcttc
     7441 atgggacagc ctggtaaaac ttctctgatg ggcaaaggtt gggagctttc tgatttcacc
     7501 tttaagatag tcccattgtt agaatagaag cccaagactt gccacccacg agccctcaag
     7561 ggtggaaact actgacccct tcgtaacact tccctctggc aagaggcttt gtggcttcac
     7621 atttccttca gaaggaagtc taaatgtctc aacagatccc tttatagcct ggccccaatc
     7681 tccttgacag cctcaggttc tgacattctt tgttctcttt gatttgccac agaacatacc
     7741 ctctttctct ctcatcgcac ttatgcttgt gagtgtctac acacatatgc acatgcacag
     7801 tgcaataggg gcatggaagg gcacttctta agccacacag ctccctaaat gtactttttg
     7861 atttttctaa cattttcaca tttttcctct gcctctgata agaatctccc attctctcat
     7921 ttgggaatat caaaactcag ttcaaatatc acctttcttc tataaaactt gtcctcatca
     7981 cccaatgcca agttatatat aatctctctt ccatgcccct gttgcactgt ttatatatct
     8041 cttttatact atgcttattt ttaacttgat aaatatgtct tttataccca cacccccatt
     8101 caccattgaa tagtgagctc taaagtgcac aaacctgcta ttatcttggc atctgtccct
     8161 atacctatca tacttcttaa cacattgcag gtgttcaaaa atgtgtcttc ccctcagctt
     8221 caaactcaga catccaatgt ttcaatgaaa tctcacttat tttccttaaa tccctccgtt
     8281 ttccatctca aagaagagtt tgtgttatag acagggaaac acaaagaaga gtttgtgttg
     8341 tagtttcact aaaaggacgt gtagcacaag tgcagcctgg cctctcaagc tggtggttgc
     8401 catggaagag ttcccagtgc gaggcgagct taacaagggg cagggtgtcc ttttccttac
     8461 ctgtgttgtg caaatgctta gagtggtgat aatggagggg tggcatctcc aagggttccc
     8521 aggagctgcc acatttaccc aggggctctg cctcctatgc tccctttggt gagaactgtc
     8581 tgtgcagctc catggatatc atgccaactt ggctgcctgg gctctccttg caatcccatc
     8641 aataagaatc agcatccaag aattccatac attggcttca gtttccttcc agaaagagga
     8701 ttcagagcca ccaagaatat ttgaaattaa cctgctccct gagttacaag ctcaccttga
     8761 gggctgccaa cacaaggaag gtcatattac accctttcat ttatcagcct ggaaaatggt
     8821 gccgtagagt cgatttcata tgctaagggc agcctctgcc ctatgccaag agaaggagct
     8881 cccaggaaat gcctgacata agtcatcctt gttagggcca cagaagaatg actcgcatgg
     8941 tggatctcag catttggatt tgcattaaaa tgatggattt gttttgcctt gctggtacag
     9001 ctcaccccag ctccccaaac tctctagtct tggaaagaca tgcatagtag cctggtgccc
     9061 accaggaggg cttttctggg caaaaataat tcatcagctc tggagcctgc tgctgtcttc
     9121 ccaacagatg tcctcttttg tttgtgttgc agtttggttc atgctaccaa tgcttgataa
     9181 aaagtgttct ttagaaaaga aaaaatagag tggtaaaagg gaattttgag ataaaaatgg
     9241 attctattac aacctttcag tgcctaataa taaaaagata caattgcata taacttaaaa
     9301 tcatctatta cacacacaca attcaacata atggagctga agctgagttt gagttcccca
     9361 ccacacacac acatacacac acacacacac acacacacac acggcacagg gctttaagca
     9421 taacaatgag tgagggaagg ttgatcctca gacacatgac acatgttcat acaggtgagg
     9481 ggcagctggt tgatgatttt aggctctact gtcacacaga tgtcaagatg aaggcctttt
     9541 gggcagaaga cgggactcat ctctcattag catgtgacat aaactgtact tgaagtgtgt
     9601 atatattctg ggccagttcc aatgcaaagt aaaatgggtt cagtatcatt ggtagagaac
     9661 acagtctatg agagaattac caaatgagcc acatttagtt cttatgacaa gtagttaaac
     9721 agaggagagc actgactgtt tacaaggctg aagcaggcaa ggcgtggtgg ctcacaactg
     9781 taatcccaga attatgggag gccaagctgg gaggatccct tgagcccagg agtttgagac
     9841 cagcctgggc aacatagtta gaccctgaat ctacaaaaaa taaagaaaaa aaatagccag
     9901 gcgtgatggt gcatgcctgt agtcccagct actagggagg ctgaggcagg aggatcacct
     9961 gagcctggaa gtggaaggtt gaggctacgg tgagtcgtga tcgcacaact gcactcctgc
    10021 ctaggtggca gagtgagacc ctgtactctg tctaaaagta aataaaaagg ctgaagcaaa
    10081 gatgattcta catgggggga tttcaatgat cttttatagt ctctaggctc ttatggggtt
    10141 aaaatgattt cttggtatca gacaagtatt atgaccagct cctggcaaaa taagtaacac
    10201 ttaagcataa ttatttggag ctattcagtt aaagtgtctg agtgtagccc tggtcttgaa
    10261 gggcagggca agacatggca ttgagttcaa ttgtctctac tggctgtggg acgggacagg
    10321 aagcagagaa gccgacaggt ctgccatcca aacatccagg gtatgggggt taaatgaatg
    10381 aatgtcctgg ggtagaagac tatcaaccag accccaccca cacttcattc tgaagaggaa
    10441 gttattttgg gaggtattag aggaggaaaa atctgcctgt gtttctgctc tgctcagaca
    10501 atcacataag tgactcattt cactctcagt accagctctg tgggataaat ggacattatg
    10561 attgccattt taaaaatgaa gtgcacccat acttaaagag acacgtttag taaatgatag
    10621 agctggaatc tgttcccggg gaaatctgac ttcctaactc atgctccctc cacttcccca
    10681 gaggaggtga atatgaacca taacacagtt acagctaacg tggtaattag caacacttag
    10741 tatctataat agtctaagac catcgcaggt gtcatcatgt ttaagcctaa aacttcagcc
    10801 caacgagcta aactctgttg ttatgctcac tttataaatg agggcattaa gaatttaagg
    10861 gctagcctaa gatgatacag gtagtaagta gcagatcaca accttaactc aggcaatcgg
    10921 actcttaaac ttgctctcca aggaaaaaca tctttcttca aagaccccta agggccctct
    10981 gagaggttat ggagcaagtc tccatttcta ggaaagtgtg ttgttcttgt agatccttga
    11041 ctcaaataca agtaactcct actggccatt tctgcataac ttcctgctcc ttttcaaact
    11101 caacaggttc aaagtcaaaa tctcctccca acaaaatctc tacctccaaa ttcctaaact
    11161 tgattatgcc gatagtaaac cggcgttgtt tgatttattt gtgtgccaga tgcagagctc
    11221 actgtctggc cgaggcaggt actcagatct tcactaaata gatgaatctg caatgttgtt
    11281 gagtgtgaat cttagctttg gttggagtcc aaagctaaga atcagactcg gtaacactgt
    11341 tctcacctgg acttcaagtt ttcttaccac tcttctcacc tttggttgtg cttcctttcc
    11401 aaccctttca tccctgtgca gcctgatagt attaggaagg aaaaccggct tctactttcg
    11461 cagtttataa tttgtcagtg acctcccatg gtcttaagga taaaatgcag acaggaccta
    11521 gtgcttgagc cttttcagat ccagccacta cgtaattttc tggtctcttc tcttgacatc
    11581 agcccctgtt aaagtcataa aaacttactt tcaattctca gaaagcacct tactcttctg
    11641 ttccctcttc ttccatccat gtgcctagat ctatccatta tgtgcttaaa tgtaggctcc
    11701 tccaagaagt ctcccatgat ctgattctga gttcctactg tcatcttgga gaaacccagt
    11761 cacagctttt gttgtatggc attgcctgtg gactttgctg tcccctcttc acctcccccc
    11821 caccgcccca ctgcaccaag actgtaatat cttggagaac aaagacaatt ttgttcactg
    11881 ctacatcctg agagcctagc atcgtgccca agatgtggtg ggacttccat aaatatgtgt
    11941 tgaatggttg agatcttaat ttctgttaga acggtctcct gagaatgacc tcctacccgt
    12001 tgcctcagta acctcttacg catggagagc agagctgcag gaaagcagga cacacgtgag
    12061 tccagccaac tcagagcttc aaggaggcgt ccaggagaaa cctccctcag ccccgtttgc
    12121 ggtgcctcct ggtcggtaat tttccagaag caatttcttg tttcctccaa atggcctgta
    12181 gaggtcagaa aagggccttg ttttccaatc accgactgtc ctgtctacat tagcattcac
    12241 cccgggtgtc tataattaag caagcctaag ctgggcacat aggaacggaa atgcattgac
    12301 tttaataaaa cagagtgtaa aacaacttta
//
