LOCUS       NM_001077665            2684 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH
            domain 6 (AGAP6), transcript variant 1, mRNA.
ACCESSION   NM_001077665 XM_001713643
VERSION     NM_001077665.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2684)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL442003.8.
            
            On Feb 5, 2021 this sequence version replaced NM_001077665.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131545.1, SRR14038193.4067248.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000412531.7/ ENSP00000500374.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               AL442003.8         25251-25783
            534-602             AL442003.8         26153-26221
            603-671             AL442003.8         28521-28589
            672-706             AL442003.8         31240-31274
            707-807             AL442003.8         38841-38941
            808-843             AL442003.8         41530-41565
            844-895             AL442003.8         44870-44921
            896-2684            AL442003.8         45556-47344
FEATURES             Location/Qualifiers
     source          1..2684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..2684
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /note="ArfGAP with GTPase domain, ankyrin repeat and PH
                     domain 6"
                     /db_xref="GeneID:414189"
                     /db_xref="HGNC:HGNC:23466"
     exon            1..533
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2371
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /note="centaurin-gamma-like family member 3"
                     /codon_start=1
                     /product="arf-GAP with GTPase, ANK repeat and PH
                     domain-containing protein 6"
                     /protein_id="NP_001071133.2"
                     /db_xref="CCDS:CCDS44397.1"
                     /db_xref="GeneID:414189"
                     /db_xref="HGNC:HGNC:23466"
                     /translation="MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAP
                     MAAAVQPAEVTVEVGEDLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFN
                     PSANPEASTIFQRNSQTDVVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYL
                     TMTIISVTLEIPHHITQRDADRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSI
                     PSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTI
                     GSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQ
                     TSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPP
                     PSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCE
                     SSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRS
                     LGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSIWEGSSQGQTKPSEKSTREEKERW
                     IRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDG
                     CTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCP
                     DECV"
     exon            534..602
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            603..671
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            672..706
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..807
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            808..843
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            844..895
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     exon            896..2684
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2660..2665
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /note="hexamer: AATAAA"
     polyA_site      2684
                     /gene="AGAP6"
                     /gene_synonym="AGAP-6; CTGLF3"
                     /note="major polyA site"
ORIGIN      
        1 tgttctctct tcaggcagtt gttgtgtctc tcagcgcttg ttggtttcac aacctattaa
       61 ataagccggc tggtcttcac cctcccagac aagtcaactc aggggaggca gcagggtgcg
      121 ggccttggcc cgcagcccta gccggggccg gggccagggc tggtgcccgg ggcctcgctg
      181 tgaggtgggc aggcgaggag cgggaagacc atctctgcaa gtgcagcata gcctcggcct
      241 aggacagcgg gagtgcgtgg ccaaagctgt gagcagaggc acaggtggtg gcagacagta
      301 gaggcgcccc atggggaaca tactgacctg tcgtgtgcac cctagcgtca gcctcgagtt
      361 tgaccagcag caggggtcgg tgtgtccctc tgaatctgag acctatgagg caggagctag
      421 ggacaggatg gcaggagcgc ccatggctgc tgctgtacag cctgctgagg tgactgttga
      481 agttggtgag gacctccaca tgcaccacgt tcgtgaccgg gagatgcctg aagctttgga
      541 gtttaacctt tctgccaatc cagagtcaag cacaatattc cagaggaact ctcaaacaga
      601 agctttggag tttaaccctt ctgccaatcc agaggcaagc acaatattcc agaggaactc
      661 tcaaacagat gttgtagaaa taagaagaag caactgtaca aaccatgtat ctgctgtgcg
      721 tttcagtcaa caatacagct tgtgttcgac aatattcctt gatgacagca cagccatcca
      781 gcattatctt acaatgacaa taatatctgt gaccttggag atacctcatc atatcacaca
      841 aagagatgca gatagaactt tgagcatacc tgatgaacag ttacactcat ttgcggtttc
      901 caccgtgcac attatgaaga aaagaaatgg aggtgggagt ttaaataact attcctcctc
      961 cattccatcg actcccagca ccagccagga ggaccctcag ttcagtgttc ctcccactgc
     1021 caacacaccc acgcccgttt gcaagcggtc catgcgctgg tccaacctgt ttacatctga
     1081 gaaagggagt gacccagaca aagagaggaa agccccggag aatcatgctg acaccatcgg
     1141 gagcggtaga gccatcccca ttaaacaggg catgctctta aagcgaagtg ggaaatggct
     1201 gaagacatgg aaaaagaaat acgtcaccct gtgttccaat ggcatgctca cctattattc
     1261 aagcttaggt gattatatga agaatattca taaaaaagag attgaccttc agacatctac
     1321 catcaaagtc ccaggaaagt ggccatccct agccacatcg gcctgcacac ccatctccag
     1381 ctctaaaagc aatggcctat ccaaggacat ggacaccggg ctgggtgact ccatatgctt
     1441 cagccccagt atctccagca ccaccagccc caagctcaac ccgcccccct ctcctcatgc
     1501 taataaaaag aaacacctaa agaagaaaag caccaacaac tttatgattg tgtctgccac
     1561 tggccaaacg tggcactttg aagccacgac gtatgaggag cgggatgcct gggtccaagc
     1621 catccagagc cagatcctgg ccagcctgca gtcatgcgag agcagtaaaa gcaagtccca
     1681 gctgaccagc cagagcgagg ccatggccct gcagtcgatc caaaacatgc gtgggaacgc
     1741 ccactgtgtg gactgtgaga cccagaatcc taagtgggcc agtttgaact tgggagtcct
     1801 catgtgtatt gaatgctcag gtatccaccg cagtcttggc ccccaccttt cccgtgtgcg
     1861 atctctggag ctggatgact ggccagttga gctcaggaag gttatgtcat ctattgtcaa
     1921 tgacctagcc aacagcatct gggaagggag cagccagggg cagacaaaac cctcagaaaa
     1981 gtccacgagg gaagagaagg aacggtggat ccgttccaaa tatgaggaga agctctttct
     2041 ggccccacta ccctgcactg agctgtccct gggccagcag ctgctgcggg ccaccgctga
     2101 tgaggacctg cagacagcca tcctgctgct ggcacatggc tcctgtgagg aggtgaacga
     2161 gacctgtggg gagggagacg gctgcacggc gctccatctg gcctgccgca aggggaatgt
     2221 ggtcctggcg cagctcctga tctggtacgg ggtggacgtc atggcccgag atgcccacgg
     2281 gaacacagcg ctgacctacg cccggcaggc ctccagccag gagtgcatca acgtgcttct
     2341 gcagtacggc tgccccgacg agtgtgtgta gtatctgttt tatttgactg cagtctcctt
     2401 ggtgcaaaaa caaaatggga aaaataagga taactcagaa tttcaaaagg aaatcacaaa
     2461 ttcagctaat attagcattt tcagtacttt tcgtaaacta agtaaataca caaaatgttg
     2521 atttttctga ccataagacg tattttatgt ccttctgcca aggtggattt gttagtctca
     2581 ggccctcctg gccacattgc ccaagtcaca caggcttctg tattatgtat ttagataaaa
     2641 tgtgtgaaaa catatttgaa ataaagttca taaatatgca ttga
//
