LOCUS       NM_001144000            2719 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH
            domain 5 (AGAP5), mRNA.
ACCESSION   NM_001144000 XM_001722569 XM_001722765
VERSION     NM_001144000.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2719)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022400.9 and AC073389.10.
            
            On Aug 30, 2020 this sequence version replaced NM_001144000.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2089918.1,
                                           SRR14243140.5512840.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374094.9/ ENSP00000363207.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AC022400.9         30244-30820         c
            578-646             AC022400.9         29806-29874         c
            647-715             AC022400.9         27447-27515         c
            716-750             AC022400.9         24754-24788         c
            751-851             AC073389.10        1549-1649
            852-887             AC073389.10        4237-4272
            888-939             AC073389.10        7573-7624
            940-2719            AC073389.10        8269-10048
FEATURES             Location/Qualifiers
     source          1..2719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..2719
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /note="ArfGAP with GTPase domain, ankyrin repeat and PH
                     domain 5"
                     /db_xref="GeneID:729092"
                     /db_xref="HGNC:HGNC:23467"
     exon            1..577
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..2415
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /note="centaurin, gamma-like family, member 2; AGAP-5"
                     /codon_start=1
                     /product="arf-GAP with GTPase, ANK repeat and PH
                     domain-containing protein 5"
                     /protein_id="NP_001137472.1"
                     /db_xref="CCDS:CCDS44439.1"
                     /db_xref="GeneID:729092"
                     /db_xref="HGNC:HGNC:23467"
                     /translation="MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAP
                     MAAAVQPAEVTVEVGEDLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFN
                     PSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYL
                     TMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSI
                     PSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTI
                     GSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLR
                     TSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPP
                     PSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCE
                     SSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRS
                     LGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERW
                     IRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDG
                     CTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCP
                     DECV"
     exon            578..646
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            647..715
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..750
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..851
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..887
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..939
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..2719
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /note="hexamer: AATATA"
     polyA_site      2719
                     /gene="AGAP5"
                     /gene_synonym="CTGLF2"
                     /note="major polyA site"
ORIGIN      
        1 agtctgtagg tgactacaga aggaggagga gctccgtctg ttctctcttc aggcagttgt
       61 tgtgtctctc agcgcttgtt gggttcacaa cctattaaat aagccagctg gtcttcaccc
      121 tcccagacaa gtcaactcag gggaggcagc agggtgtggg ccttgacccg cagccctagc
      181 cggggccggg gccggggcca gggatggtgc ccggggccgc gctgtgaggt gggcaggcga
      241 ggagcgggaa gaccatctct gcaagtgcag catagcctcg gcctaggaca gtgggagtgt
      301 gtggccaaag ctgtgagcag aggcacaggt ggtggcagac agtagaggcg ccccatgggg
      361 aacatactga cctgttgtgt gcaccctagc gtcagcctcg agtttgacca gcaacagggg
      421 tcggtgtgtc cctctgaatc tgagatctat gaggcaggag ctggggacag gatggcagga
      481 gcgcccatgg ctgctgctgt gcagcctgct gaggtgaccg ttgaagttgg tgaggacctc
      541 cacatgcacc acattcgtga ccaggagatg cctgaagctt tggagtttag cctttctgcc
      601 aatccagagg caagcacaat attccagagg aactctcaaa cagatgcttt ggagtttaac
      661 ccttctgcca atccagaggc aagcacaata ttccagagga actctcaaac agatgttgta
      721 gaaataagaa gaagcaactg tacaaaccat gtatctactg agcgtttcag tcaacaatac
      781 agctcgtgtt cgacaatatt ccttgatgac agcacagcca gccagcatta tcttacaatg
      841 acaataatat ctgtgacctt ggagatacct catcatatca cacaaagaga tgcagataga
      901 tctttgagca tacctgatga acagttacac tcatttgcgg tttccaccgt gcacattacg
      961 aagaacagaa atggaggtgg gagtttaaat aactattcct cctccattcc atcgactccc
     1021 agcaccagcc aggaggaccc tcagttcagt gttcctccca ctgccaacac acccaccccc
     1081 gtttgcaagc ggtccatgcg ctggtccaac ctgtttacat ctgagaaagg gagtcaccca
     1141 gacaaagaga ggaaagcccc ggagaatcat gctgacacca tcgggagcgg cagagccatc
     1201 cccattaaac agggcatgct cttaaagcga agtgggaaat ggctgaagac atggaaaaag
     1261 aaatacgtca ccctgtgttc caatggcgtg ctcacctatt attcaagctt aggtgattat
     1321 atgaagaata ttcataaaaa agagattgac cttcggacat ctaccatcaa agtcccagga
     1381 aagtggccat ccctagccac atcggcctgt gcacccatct ccagctctaa aagcaatggc
     1441 ctatccaagg acatggacac cgggctgggt gactccatat gcttcagccc cagtatctcc
     1501 agcaccacca gccccaagct caacccgccc ccctctcctc atgccaataa aaagaaacac
     1561 ctaaagaaga aaagcaccaa caactttatg attgtgtctg ccactggcca aacatggcac
     1621 tttgaagcca cgacgtatga ggagcgggat gcctgggtcc aagccatcca gagccagatc
     1681 ctggccagcc tgcagtcatg cgagagcagt aaaagcaagt cccagctgac cagccagagc
     1741 gaggccatgg ccctgcagtc gatccaaaac atgcgtggga acgcccactg tgtggactat
     1801 gagacccaga atcctaagtg ggccagtttg aacttgggag tcctcatgtg tattgaatgc
     1861 tcaggaatcc accgcagtct tggcacccgc ctttcccgtg tgcgatctct ggagctggat
     1921 gactggccag ttgagctcag gaaggttatg tcatctattg gcaatgacct agccaacagc
     1981 atctgggaag ggagcagcca ggggcagaca aaaccctcag taaagtccac gagggaagag
     2041 aaggaacggt ggatccgttc caaatatgag gagaagctct ttctggcccc actaccctgc
     2101 actgagctgt ccctgggcca gcacctgctg cgggccaccg ctgatgagga cctgcagaca
     2161 gccatcctgc tgctggcaca tggctcccgt gaggaggtga acgagacctg tggggaggga
     2221 gacggctgca cggcgctcca tctggcctgc cgcaagggga atgtggtcct ggcacagctc
     2281 ctgatctggt acggggtgga cgtcatggcc cgagatgccc acgggaacac agcgctgacc
     2341 tacgcccggc aggcctccag ccaggagtgc atcaacgtgc ttctgcagta cggctgcccc
     2401 gacgagtgcg tgtagtatct gttttatttg actgcagtct ccttggtgca aaaacaaaat
     2461 gggaaaaata aggataactc agaatttcaa aaggaaatca caaattcagc tagtaatagc
     2521 attttcagta cttttcataa actaagtaaa tacacaaaat gttgattttt ctgaccataa
     2581 gacatatttt atgtcctttt gccaaggtgg atgtgttagt ctcaggccct cctggccaca
     2641 ttgcccaagt cacacaggct tctgtattat gtatttagat aaaatgtgtg aaaatatatt
     2701 tgaaaaaaaa gttcataaa
//
