LOCUS       NM_001122772            5430 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH
            domain 2 (AGAP2), transcript variant 1, mRNA.
ACCESSION   NM_001122772
VERSION     NM_001122772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5430)
  AUTHORS   Sun,M., Sheng,H., Wu,T., Song,J., Sun,H., Wang,Y., Wang,J., Li,Z.,
            Zhao,H., Tan,J., Li,Y., Chen,G., Huang,Q., Zhang,Y., Lan,B.,
            Liu,S., Shan,C. and Zhang,S.
  TITLE     PIKE-A promotes glioblastoma growth by driving PPP flux through
            increasing G6PD expression mediated by phosphorylation of STAT3
  JOURNAL   Biochem Pharmacol 192, 114736 (2021)
   PUBMED   34411567
  REMARK    GeneRIF: PIKE-A promotes glioblastoma growth by driving PPP flux
            through increasing G6PD expression mediated by phosphorylation of
            STAT3.
REFERENCE   2  (bases 1 to 5430)
  AUTHORS   Yu,L., Gui,S., Liu,Y., Qiu,X., Zhang,G., Zhang,X., Pan,J., Fan,J.,
            Qi,S. and Qiu,B.
  TITLE     Exosomes derived from microRNA-199a-overexpressing mesenchymal stem
            cells inhibit glioma progression by down-regulating AGAP2
  JOURNAL   Aging (Albany NY) 11 (15), 5300-5318 (2019)
   PUBMED   31386624
  REMARK    GeneRIF: Exosomes derived from microRNA-199a-overexpressing
            mesenchymal stem cells inhibit glioma progression by
            down-regulating AGAP2.
REFERENCE   3  (bases 1 to 5430)
  AUTHORS   Navarro-Corcuera,A., Lopez-Zabalza,M.J., Martinez-Irujo,J.J.,
            Alvarez-Sola,G., Avila,M.A., Iraburu,M.J., Ansorena,E. and
            Montiel-Duarte,C.
  TITLE     Role of AGAP2 in the profibrogenic effects induced by TGFbeta in
            LX-2 hepatic stellate cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (4), 673-685 (2019)
   PUBMED   30660615
  REMARK    GeneRIF: The role of AGAP2 in the pro-fibrogenic phenotype of
            hepatic stellate cells in response to TGFbeta.
REFERENCE   4  (bases 1 to 5430)
  AUTHORS   Doush,Y., Surani,A.A., Navarro-Corcuera,A., McArdle,S.,
            Billett,E.E. and Montiel-Duarte,C.
  TITLE     SP1 and RARalpha regulate AGAP2 expression in cancer
  JOURNAL   Sci Rep 9 (1), 390 (2019)
   PUBMED   30674964
  REMARK    GeneRIF: chromatin immunoprecipitation studies revealed the
            presence of RARalpha, RXRalpha and the lysine acetyl transferase
            PCAF in AGAP2 promoter.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5430)
  AUTHORS   Qi,Q., Kang,S.S., Zhang,S., Pham,C., Fu,H., Brat,D.J. and Ye,K.
  TITLE     Co-amplification of phosphoinositide 3-kinase enhancer A and
            cyclin-dependent kinase 4 triggers glioblastoma progression
  JOURNAL   Oncogene 36 (32), 4562-4572 (2017)
   PUBMED   28368413
  REMARK    GeneRIF: these findings support that PIKE amplification or
            overexpression coordinately acts with CDK4 to drive glioblastoma
            tumorigenesis.
REFERENCE   6  (bases 1 to 5430)
  AUTHORS   Nie,Z., Stanley,K.T., Stauffer,S., Jacques,K.M., Hirsch,D.S.,
            Takei,J. and Randazzo,P.A.
  TITLE     AGAP1, an endosome-associated, phosphoinositide-dependent
            ADP-ribosylation factor GTPase-activating protein that affects
            actin cytoskeleton
  JOURNAL   J Biol Chem 277 (50), 48965-48975 (2002)
   PUBMED   12388557
REFERENCE   7  (bases 1 to 5430)
  AUTHORS   Ye,K., Aghdasi,B., Luo,H.R., Moriarity,J.L., Wu,F.Y., Hong,J.J.,
            Hurt,K.J., Bae,S.S., Suh,P.G. and Snyder,S.H.
  TITLE     Phospholipase C gamma 1 is a physiological guanine nucleotide
            exchange factor for the nuclear GTPase PIKE
  JOURNAL   Nature 415 (6871), 541-544 (2002)
   PUBMED   11823862
REFERENCE   8  (bases 1 to 5430)
  AUTHORS   Ye,K., Hurt,K.J., Wu,F.Y., Fang,M., Luo,H.R., Hong,J.J.,
            Blackshaw,S., Ferris,C.D. and Snyder,S.H.
  TITLE     Pike. A nuclear gtpase that enhances PI3kinase activity and is
            regulated by protein 4.1N
  JOURNAL   Cell 103 (6), 919-930 (2000)
   PUBMED   11136977
REFERENCE   9  (bases 1 to 5430)
  AUTHORS   Elkahloun,A.G., Krizman,D.B., Wang,Z., Hofmann,T.A., Roe,B. and
            Meltzer,P.S.
  TITLE     Transcript mapping in a 46-kb sequenced region at the core of
            12q13.3 amplification in human cancers
  JOURNAL   Genomics 42 (2), 295-301 (1997)
   PUBMED   9192850
REFERENCE   10 (bases 1 to 5430)
  AUTHORS   Yamane,O., Hayashi,T., Sako,S., Kihara,T. and Koyama,M.
  TITLE     Studies on hemorrhagic diathesis of experimental bovine bracken
            poisoning. I. Detection of circulating anticoagulants
  JOURNAL   Nihon Juigaku Zasshi 37 (4), 335-340 (1975)
   PUBMED   1238857
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025165.27.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 17, 2020 this sequence version replaced NM_001122772.2.
            
            Summary: The protein encoded by this gene belongs to the centaurin
            gamma-like family. It mediates anti-apoptotic effects of nerve
            growth factor by activating nuclear phosphoinositide 3-kinase. It
            is overexpressed in cancer cells, and promotes cancer cell
            invasion. Alternatively spliced transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (PIKE-L). This isoform is thought to participate in the prevention
            of neuronal apoptosis by enhancing nuclear phosphoinositide
            3-kinase activity (PMID:14528310).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY128689.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547588.6/ ENSP00000449241.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1664              AC025165.27        130998-132661       c
            1665-1723           AC025165.27        129288-129346       c
            1724-1811           AC025165.27        128511-128598       c
            1812-1897           AC025165.27        128238-128323       c
            1898-2045           AC025165.27        127945-128092       c
            2046-2180           AC025165.27        126764-126898       c
            2181-2290           AC025165.27        126322-126431       c
            2291-2449           AC025165.27        125728-125886       c
            2450-2536           AC025165.27        125475-125561       c
            2537-2641           AC025165.27        125285-125389       c
            2642-2804           AC025165.27        124710-124872       c
            2805-2924           AC025165.27        124414-124533       c
            2925-3053           AC025165.27        123558-123686       c
            3054-3113           AC025165.27        122237-122296       c
            3114-3262           AC025165.27        121856-122004       c
            3263-3353           AC025165.27        121600-121690       c
            3354-3576           AC025165.27        121279-121501       c
            3577-3832           AC025165.27        120893-121148       c
            3833-5430           AC025165.27        119116-120713       c
FEATURES             Location/Qualifiers
     source          1..5430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..5430
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /note="ArfGAP with GTPase domain, ankyrin repeat and PH
                     domain 2"
                     /db_xref="GeneID:116986"
                     /db_xref="HGNC:HGNC:16921"
                     /db_xref="MIM:605476"
     exon            1..1664
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..4075
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /note="isoform PIKE-L is encoded by transcript variant 1;
                     Arf GAP with GTP-binding protein-like, ANK repeat and PH
                     domains 2; centaurin, gamma 1; phosphoinositide 3-kinase
                     enhancer; GTP-binding and GTPase activating protein 2;
                     arf-GAP with GTPase, ANK repeat and PH domain-containing
                     protein 2; phosphatidylinositol 3-kinase enhancer"
                     /codon_start=1
                     /product="arf-GAP with GTPase, ANK repeat and PH
                     domain-containing protein 2 isoform PIKE-L"
                     /protein_id="NP_001116244.1"
                     /db_xref="CCDS:CCDS44932.1"
                     /db_xref="GeneID:116986"
                     /db_xref="HGNC:HGNC:16921"
                     /db_xref="MIM:605476"
                     /translation="MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGA
                     RGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPAR
                     PVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAG
                     GGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGK
                     PRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTL
                     DNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREG
                     GRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAV
                     INSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDG
                     QTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGL
                     ALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKV
                     VTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELR
                     AEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSF
                     LLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRP
                     PRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLK
                     PDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRK
                     MWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ
                     CCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGI
                     HRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREER
                     ESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVED
                     PQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQH
                     GCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV"
     exon            1665..1723
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1811
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1897
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2045
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2180
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2290
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2449
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2536
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2641
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2804
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2924
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3053
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3113
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3262
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3353
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..3576
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..3832
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..5430
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5406..5411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /note="hexamer: ATTAAA"
     polyA_site      5430
                     /gene="AGAP2"
                     /gene_synonym="CENTG1; GGAP2; PIKE"
                     /note="major polyA site"
ORIGIN      
        1 actagcttcc caccctcctc tagaccctct ttccgaccgc atccgcggcc cctgtccctt
       61 gagtcccaat tccccgcccc tgcctccccc gcacaggttc gtttccccta gcctccggtc
      121 cccttttctg ctcccttttc ctctctctcc cccatttgcc cccactactg tcctccccgc
      181 cctcccccac ccatctcagc gcccccaccc aggccggggt ggacggtccg gcgcgcctcc
      241 ctggagcagc accaaggtcc cggggctcca agagggtggg ggcgcagggc ggggagcatg
      301 gggagggggc gccccatgtg atgggagggg ggcgcaagcg gaggcggcgg aggcggcggc
      361 gacagcggag ccgggccggg ggctcagcgg ggtccggggg ctgggggcag cgagcagggc
      421 ggccccatgg ccgggccccc ctgaggcagt ccgggggagt cccctcccct ccccagctcg
      481 ggggtctccg ggccccatga gccggggcgc gggcgcgctt cagcgccgga caacgaccta
      541 cctcatctcg ctgaccctgg ttaagctcga gtcggtgcct ccgccgccgc cttctccgtc
      601 tgcggccgcg gccggcgccg ccggtgccag aggctccgag actggggatc ctggcagccc
      661 ccgaggcgcg gaggagccgg gcaagaagcg gcacgaacgt ctcttccacc ggcaggatgc
      721 gctgtggatc agcacgagca gcgcgggcac cgggggcgcg gagcccccag ccctgtcccc
      781 ggctccggcc agtccggccc gcccagtctc ccccgctccc ggccgccgcc tctccctctg
      841 ggccgtccct ccgggacccc cgctctccgg gggactgagc cccgacccca agcctggggg
      901 cgcccccacc tcctcccggc gccccctgct cagcagcccg agctggggcg gcccggagcc
      961 cgaaggccgg gcgggcggcg gcatccctgg ctcatcctct ccgcaccctg gcaccggcag
     1021 ccggaggctc aaggtggcgc ctcctccgcc ggctcccaag ccttgcaaga ccgtgaccac
     1081 gagtggagcc aaagccggcg ggggcaaggg cgcgggtagc cgcctgtcat ggcccgaaag
     1141 cgagggcaag cccagggtca aggggtcaaa gagcagcgcc gggactggag cttcggtctc
     1201 tgccgccgcc accgccgccg ccgccggggg agggggctct acagcttcga cctctggtgg
     1261 ggtcggggct ggggctggag cccgagggaa gttgtcccct cggaaaggca agagtaagac
     1321 cttggacaac agtgacttgc atccgggacc gcctgccggc tctcctcctc cgctaaccct
     1381 cccaccaact ccgagtccag ccactgctgt caccgctgct tccgcgcagc cccccgggcc
     1441 tgcacctcca atcactctgg agcctccagc tccggggctg aaacggggcc gggagggggg
     1501 ccgagcatcc actcgtgacc gcaagatgct caagtttatc agcggcatct tcaccaagag
     1561 cacaggaggg cctcctggct ccgggcccct tcccggaccc cccagcctgt cttctggcag
     1621 cgggtccagg gagctgctgg gcgccgagct ccgcgcttcc cctaaggctg tgatcaatag
     1681 ccaggaatgg actttgagcc gctccattcc tgaactgcgc ctgggtgtgc tgggcgatgc
     1741 caggagtggg aagtcatcgc tcatccaccg attcctgact ggctcatacc aggtgctgga
     1801 gaagacagag agtgagcagt acaagaaaga aatgttggtg gatggacaga cacatctggt
     1861 gctaatccga gaggaagctg gggcacctga tgccaagttc tcaggctggg cagatgctgt
     1921 gatcttcgtc ttcagcctgg aggatgagaa cagtttccag gctgtgagcc gtctccatgg
     1981 gcagctgagt tcccttcgcg gggagggacg aggaggcctg gccttggcac tggtggggac
     2041 acaagacagg atcagtgctt cctcccctcg ggtggtggga gatgctcgtg ccagagctct
     2101 gtgcgcggac atgaaacgct gcagctacta tgagacttgt gcaacctatg ggctcaatgt
     2161 ggatcgggtc ttccaggagg tggcccagaa ggtggtgacc ttgcgcaagc agcaacagct
     2221 tctggctgcc tgcaagtccc tgcccagctc cccaagccac tcagctgcat ccactccggt
     2281 agctggccag gctagtaacg ggggccacac tagcgactac tcttcttccc tcccgtcctc
     2341 accgaatgtt ggtcaccggg agctccgagc cgaggcagct gcagtggctg gattgagcac
     2401 cccagggtcc ctgcaccggg cagccaagcg caggaccagc ctttttgcga atcgtcgggg
     2461 tagtgactcc gagaaacgaa gcttggatag tcggggagag acaacaggga gtgggcgagc
     2521 catccccatc aaacagagct tcctactaaa acgaagtggc aattccttga acaaagaatg
     2581 gaagaagaaa tatgtaaccc tgtccagtaa tggctttcta ctctaccacc ccagtattaa
     2641 cgattacatc cacagtaccc acggcaagga gatggacttg ctgcgaacaa cagtcaaagt
     2701 cccgggcaag cggcccccga gggccatctc tgcctttggc ccctcagcca gcattaacgg
     2761 gctcgtcaag gacatgagca ctgtccagat gggtgaaggc ctggaagcca ctactcccat
     2821 gccaagccct agccccagcc ccagttccct gcagccacca ccagatcaga catccaaaca
     2881 cctgctgaag ccagaccgga atttggcccg agccctcagc acggactgta ccccatctgg
     2941 agacctgagc cccctgagtc gggaaccccc tccttctccc atggtgaaga agcagaggag
     3001 gaaaaaattg acaacaccat ccaagactga aggctcggct gggcaggctg aagccaagcg
     3061 caaaatgtgg aaactaaaat cctttggtag tttaagaaat atttataaag cagaggaaaa
     3121 ctttgagttc ctgatcgtgt ccagcacggg tcagacgtgg cactttgagg cagccagttt
     3181 tgaggagcgg gatgcctggg tccaggccat cgagagtcag atcctagcca gtctgcaatg
     3241 ctgtgagagc agcaaggtca agctgcgcac agacagccaa agcgaggccg tggccatcca
     3301 ggcgatccgg aacgccaagg ggaattcaat ctgcgtggac tgcggggccc ccaaccccac
     3361 gtgggccagc ttgaacctgg gcgccctcat ctgcatcgag tgttctggca tccaccgcaa
     3421 cctgggcaca cacctgtccc gcgttcgctc gctggacttg gacgactggc cacgggagct
     3481 gaccctggtg ctgacggcta ttggcaacga cacggccaac cgcgtgtggg aaagcgacac
     3541 gcgaggccgt gccaagccct cgcgggactc ttcgcgggag gagcgcgagt cgtggattcg
     3601 cgccaagtac gagcagctac tgttcctggc gccgctgagc acctcggagg agccgctggg
     3661 ccgccagctg tgggccgccg tgcaggccca ggacgtggct accgttctcc tgcttttggc
     3721 ccatgcgcga cacgggccgc tcgacaccag cgtagaggac ccacagctgc gctccccact
     3781 ccacctggcg gccgagctcg cccacgtcgt catcacgcaa ctgctgctgt ggtacggcgc
     3841 ggacgtggcg gcccgtgacg cccagggccg cacggcgctg ttctacgccc gccaggctgg
     3901 aagccagctg tgcgccgaca tccttctcca gcacggctgc ccgggtgagg gcggcagcgc
     3961 ggccaccacg cccagcgcgg ccaccacgcc cagcatcacc gccacgccca gcccccgccg
     4021 ccggagcagc gccgctagcg tgggccgcgc cgacgccccg gttgcgctgg tatagttgcc
     4081 cagcgggaga gacaccccca tccccacgcg ggccgggcac gaccacaccg ggcggaccgc
     4141 tggacagacg cacccactca cctctccgat ccgcaccccg ccccacggga gcacttccta
     4201 cccccacgag ggcacagccc ccacgccttc cagaagacac aaactcacct ccctctcccc
     4261 aacgaggcat ggagacccca gctcaacacg ccccctctcc attgtttcca cactcggatt
     4321 gctctgggtc tacccgctcg gggttcgcgg aaggggaggt ccccagcggt acgggctcct
     4381 aggcgcttgg acatgcccgc ttgtgccccc taggggcgga aagaagaccc ggtcctgccc
     4441 gagctcaaca atcccagggc gggagcccat acccaggctg gctcctgggg cgacgccacg
     4501 ccagagggag ggtttagtac atgggagggc tagccccggg acttggggcc aatacggaaa
     4561 ccctacccct tccatgctca tctcactgcc cagtgaaggg ggcaagggca gcgaggggca
     4621 ggacccctgc tgctcatggg ggtgggggtt cccaaccctt tccgtgaaag ggaccgtgag
     4681 tagtggaaac caggacgtcc cctacaccta cccatgggtg gaagctaaag agtccggggg
     4741 gaaccaagag cctgggtccc tcccactact atcttgggag ggagaaggga tggagcagga
     4801 gcgggctaag agggctgcgg gggccttgta atttattgct ttgttcccca acatggggat
     4861 gggggcgggc aggggcgtgg ggagggcgtt ttggggtagg ggaagcccag ggtgggcagg
     4921 gggtgggttg gggtgggggt gctctcgggt tgtgtctgtg accgtgactg cgtacctgtg
     4981 actgtgcagc gcccgtggtg atctggggta gggggcaccc ctacagtggg acccctcccc
     5041 cattattctt tctgtccagc ccctccctcc cactggagca gctccagagc cattcctcac
     5101 ccccgtgacc tctcccagcc agggctgaga ggattcgagg tggctgggag ggtttccagg
     5161 ccccctgccc cttccccaca aactgggtga tagggcggac ttacctggcc cagccctgcc
     5221 tccctcagcc aacccagccc ttgggctgtc tgtgtcagtg gtttccggtc tttttttttt
     5281 tttttttttc tggctaaaat agtttgcaaa ggaccaggta attggggagg ggagagaggt
     5341 gggggcaagg gggaaatgcc cccccatctc cttggaggca gtggtgtgaa tcttcttcaa
     5401 cagcaattaa agaggaagtg attttgtcta
//
