LOCUS       NM_001037131           10889 bp    mRNA    linear   PRI 06-FEB-2025
DEFINITION  Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH
            domain 1 (AGAP1), transcript variant 1, mRNA.
ACCESSION   NM_001037131
VERSION     NM_001037131.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10889)
  AUTHORS   Cheng,N., Zhang,H., Zhang,S., Ma,X. and Meng,G.
  TITLE     Crystal structure of the GTP-binding protein-like domain of AGAP1
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 4), 105-112 (2021)
   PUBMED   33830075
  REMARK    GeneRIF: Crystal structure of the GTP-binding protein-like domain
            of AGAP1.
REFERENCE   2  (bases 1 to 10889)
  AUTHORS   Lv,Q., Wang,G., Zhang,Y., Shen,A., Tang,J., Sun,Y., Ma,C. and
            Wang,P.
  TITLE     CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear
            cell renal cell carcinoma
  JOURNAL   J Exp Clin Cancer Res 40 (1), 76 (2021)
   PUBMED   33618745
  REMARK    GeneRIF: CircAGAP1 promotes tumor progression by sponging miR-15-5p
            in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10889)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 10889)
  AUTHORS   Tsutsumi,K., Nakamura,Y., Kitagawa,Y., Suzuki,Y., Shibagaki,Y.,
            Hattori,S. and Ohta,Y.
  TITLE     AGAP1 regulates subcellular localization of FilGAP and control
            cancer cell invasion
  JOURNAL   Biochem Biophys Res Commun 522 (3), 676-683 (2020)
   PUBMED   31785816
  REMARK    GeneRIF: AGAP1 regulates subcellular localization of FilGAP and
            control cancer cell invasion.
REFERENCE   5  (bases 1 to 10889)
  AUTHORS   Nie,Z., Fei,J., Premont,R.T. and Randazzo,P.A.
  TITLE     The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor
            protein complexes AP-1 and AP-3
  JOURNAL   J Cell Sci 118 (Pt 15), 3555-3566 (2005)
   PUBMED   16079295
  REMARK    GeneRIF: The AGAP1 has been found to associate with the adaptor
            protein complex AP-3 and regulate the function of AP-3 endosomes.
REFERENCE   6  (bases 1 to 10889)
  AUTHORS   Wassink,T.H., Piven,J., Vieland,V.J., Jenkins,L., Frantz,R.,
            Bartlett,C.W., Goedken,R., Childress,D., Spence,M.A., Smith,M. and
            Sheffield,V.C.
  TITLE     Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism
            susceptibility gene
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 136B (1), 36-44 (2005)
   PUBMED   15892143
  REMARK    GeneRIF: CENTG2 is an intriguing candidate gene that merits further
            scrutiny for its role in autism.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10889)
  AUTHORS   Meurer,S., Pioch,S., Wagner,K., Muller-Esterl,W. and Gross,S.
  TITLE     AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl
            cyclase
  JOURNAL   J Biol Chem 279 (47), 49346-49354 (2004)
   PUBMED   15381706
  REMARK    GeneRIF: AGAP1 is a novel binding partner of nitric oxide-sensitive
            guanylyl cyclase
REFERENCE   8  (bases 1 to 10889)
  AUTHORS   Nie,Z., Boehm,M., Boja,E.S., Vass,W.C., Bonifacino,J.S., Fales,H.M.
            and Randazzo,P.A.
  TITLE     Specific regulation of the adaptor protein complex AP-3 by the Arf
            GAP AGAP1
  JOURNAL   Dev Cell 5 (3), 513-521 (2003)
   PUBMED   12967569
REFERENCE   9  (bases 1 to 10889)
  AUTHORS   Xia,C., Ma,W., Stafford,L.J., Liu,C., Gong,L., Martin,J.F. and
            Liu,M.
  TITLE     GGAPs, a new family of bifunctional GTP-binding and
            GTPase-activating proteins
  JOURNAL   Mol Cell Biol 23 (7), 2476-2488 (2003)
   PUBMED   12640130
REFERENCE   10 (bases 1 to 10889)
  AUTHORS   Nie,Z., Stanley,K.T., Stauffer,S., Jacques,K.M., Hirsch,D.S.,
            Takei,J. and Randazzo,P.A.
  TITLE     AGAP1, an endosome-associated, phosphoinositide-dependent
            ADP-ribosylation factor GTPase-activating protein that affects
            actin cytoskeleton
  JOURNAL   J Biol Chem 277 (50), 48965-48975 (2002)
   PUBMED   12388557
  REMARK    GeneRIF: overexpression inhibited formation of platelet-derived
            growth factor-induced ruffles and also induced loss of actin stress
            fibers
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012305.7, BC060814.1,
            BC167153.1, BC140856.1, AY033765.1, AK001722.1, AC019047.7 and
            CA446024.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001037131.2.
            
            Summary: This gene encodes a member of an ADP-ribosylation factor
            GTPase-activating protein family involved in membrane trafficking
            and cytoskeleton dynamics. This gene functions as a direct
            regulator of the adaptor-related protein complex 3 on endosomes.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Oct 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC140856.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304032.13/ ENSP00000307634.7
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC012305.7         80317-80365
            50-1086             BC060814.1         4-1040
            1087-1506           BC167153.1         1014-1433
            1507-3575           BC140856.1         1078-3146
            3576-4194           AY033765.1         3334-3952
            4195-4343           AK001722.1         2268-2416
            4344-10225          AC019047.7         155999-161880
            10226-10889         CA446024.1         26-689              c
FEATURES             Location/Qualifiers
     source          1..10889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.2"
     gene            1..10889
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /note="ArfGAP with GTPase domain, ankyrin repeat and PH
                     domain 1"
                     /db_xref="GeneID:116987"
                     /db_xref="HGNC:HGNC:16922"
                     /db_xref="MIM:608651"
     exon            1..807
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             645..3218
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; Arf
                     GAP with GTP-binding protein-like, ANK repeat and PH
                     domains 1; centaurin, gamma 2; GTP-binding and
                     GTPase-activating protein 1; arf-GAP with GTPase, ANK
                     repeat and PH domain-containing protein 1"
                     /codon_start=1
                     /product="arf-GAP with GTPase, ANK repeat and PH
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_001032208.1"
                     /db_xref="CCDS:CCDS33408.1"
                     /db_xref="GeneID:116987"
                     /db_xref="HGNC:HGNC:16922"
                     /db_xref="MIM:608651"
                     /translation="MNYQQQLANSAAIRAEIQRFESVHPNIYSIYELLERVEEPVLQN
                     QIREHVIAIEDAFVNSQEWTLSRSVPELKVGIVGNLASGKSALVHRYLTGTYVQEESP
                     EGGRFKKEIVVDGQSYLLLIRDEGGPPEAQFAMWVDAVIFVFSLEDEISFQTVYHYYS
                     RMANYRNTSEIPLVLVGTQDAISSANPRVIDDARARKLSNDLKRCTYYETCATYGLNV
                     ERVFQDVAQKIVATRKKQQLSIGPCKSLPNSPSHSSVCSAQVSAVHISQTSNGGGSLS
                     DYSSSVPSTPSTSQKELRIDVPPTANTPTPVRKQSKRRSNLFTSRKGSDPDKEKKGLE
                     SRADSIGSGRAIPIKQGMLLKRSGKSLNKEWKKKYVTLCDNGVLTYHPSLHDYMQNVH
                     GKEIDLLRTTVKVPGKRPPRATSACAPISSPKTNGLSKDMSSLHISPNSGNVTSASGS
                     QMASGISLVSFNSRPDGMHQRSYSVSSADQWSEATVIANSAISSDTGLGDSVCSSPSI
                     SSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENFEFIIVSLTGQTW
                     HFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQSIRNMRGNSHC
                     VDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIKVMSSIGN
                     ELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQHLLRAT
                     ADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTAR
                     DAHGNTALAYARQASSQECIDVLLQYGCPDERFVLMATPNLSRRNNNRNNSSGRVPTI
                     I"
     exon            808..866
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..954
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1040
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1182
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1317
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1445
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1601
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1694
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1799
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1968
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2127
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2289
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2444
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2535
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2758
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..3014
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..10889
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10732..10737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      10751
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
     regulatory      10866..10871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /note="hexamer: AATAAA"
     polyA_site      10889
                     /gene="AGAP1"
                     /gene_synonym="AGAP-1; CENTG2; cnt-g2; GGAP1"
                     /note="major polyA site"
ORIGIN      
        1 ggagccctgc gtgccaggga gggggccggc cgggcaggcg gcgggcggcg ctcggagcgg
       61 gctccgcggc ttgcaaggcg cctgcgactc ggtcccaggt cggcgggcgg cgcacggcgg
      121 gctcgcgcgg gggccccggc gcgccgggcg gcgcagtacg cagcgcgcgg acccacgcca
      181 cggccaggag cccagagcag cgcggccaca ctgcccaggg gtcggccctc ggccccggcg
      241 ctcggagcgc ggcggctgcc tgggctttaa tggctgctcc gcggagcagc gcctagggct
      301 ggaaggcggc tgcggctcag gaagtcaccc gagcaagcct ccttcggggc cggccgcacc
      361 cgccgcggcg cgctccatgg gggcgcgctc cccccgggcg gcccgctgac ccgggacgcc
      421 ggggcccgct cgctcgccgg ccgcgcgtcc cggccatgaa ctgagcccgc gggccagccc
      481 cgcgcctgct ccgcccgcgc ctttcttctc gcgcctcctc cgcccgccgc cggcgggccc
      541 ggctccccgg gggctgcggc gccccgggct cggcggcccg cgggccccgg ggcgcggggc
      601 ggcggcggcg gggggcgcgc ggctccgggc gcggcgcctg caccatgaac taccagcagc
      661 agctggccaa ctcggctgcc atccgggccg agatccagcg cttcgagtcg gtccacccca
      721 acatctactc catctacgag ctgctggagc gcgtggagga gccggtgctg cagaaccaga
      781 tccgggagca cgtcatcgcc atcgaagatg ccttcgtgaa cagccaggaa tggacgctga
      841 gtcgatctgt cccggagctc aaagtgggaa ttgtgggtaa cttggccagc ggcaagtctg
      901 ccctggtgca ccggtacctg acgggcacat atgtccagga ggagtctccg gaaggtggca
      961 ggttcaagaa agagattgtc gttgatggac agagctatct gctgctgatc agagatgaag
     1021 ggggcccccc ggaggcgcag tttgccatgt gggtggacgc tgttatattt gtcttcagct
     1081 tggaggatga aataagtttc cagaccgttt accactacta cagtcgaatg gccaactatc
     1141 ggaacacgag cgagattcct ctggttctgg tgggaaccca ggatgccata agttctgcta
     1201 acccgagggt catcgatgac gccagggcga ggaagctctc caacgacctg aaacggtgca
     1261 cgtactacga gacgtgtgct acatacgggc tgaatgtgga gagggtcttc caggacgttg
     1321 cccagaagat tgttgccaca aggaagaagc agcagctgtc cataggaccc tgcaagtcgc
     1381 tacctaattc tcccagccat tcctccgtct gttccgcgca ggtgtctgcc gtgcacatca
     1441 gccagacaag taatggaggt gggagtttaa gcgactattc ctcctccgtt ccatcgactc
     1501 ccagcaccag ccagaaggaa cttcggatcg atgttcctcc cactgccaac acgcccacgc
     1561 ccgttcgcaa gcagtctaag cgccggtcca acctgttcac ctctcggaaa gggagcgacc
     1621 cagacaaaga gaagaaaggc ctggagagtc gtgcggacag cattgggagc ggccgagcca
     1681 tcccaattaa acagggcatg ctgttgaagc gaagtggcaa atcgttgaat aaagagtgga
     1741 aaaagaaata tgtcaccctg tgtgacaatg gcgtgctgac ctatcatccc agtttacatg
     1801 attacatgca gaatgttcat ggtaaggaga ttgaccttct gagaaccact gtgaaagtcc
     1861 cagggaagag gccaccccga gccacgtcag cctgcgcacc catctccagc cctaaaacca
     1921 atggcctatc caaggacatg agcagtttac acatctcacc caattcaggg aatgtcacta
     1981 gtgcatctgg gtctcagatg gcaagcggca tcagcctggt ctccttcaac agccgacccg
     2041 acggcatgca ccagcgctcc tactcagtct ccagtgccga ccagtggagt gaggctacgg
     2101 tcattgcaaa ctcggccatc agcagtgaca cagggctggg tgactccgta tgctccagcc
     2161 ccagtatctc cagcaccacc agccccaagc tcgacccgcc cccctcccct cacgccaaca
     2221 gaaagaagca ccgaaggaag aaaagcacta gcaacttcaa agccgacggc ctgtccggca
     2281 ctgctgaaga acaagaagaa aattttgagt ttatcattgt gtccctcact ggccaaacat
     2341 ggcactttga agccacgacg tatgaggagc gggacgcctg ggtccaagcc atcgagagcc
     2401 agatcctggc cagcctgcag tcgtgcgaga gcagcaagaa caagtcccgg ctgacgagcc
     2461 agagcgaggc catggccctg cagtcgatcc ggaacatgcg cgggaactcc cactgtgtgg
     2521 actgcgagac ccagaatccc aactgggcca gtttgaactt gggagccctc atgtgcatcg
     2581 aatgctcagg gatccaccgg aatcttggca cccacctttc ccgagtccga tctctggacc
     2641 tggatgactg gccagtcgag ctcatcaagg tgatgtcatc catcgggaac gagctagcca
     2701 acagcgtctg ggaagagagc agccaggggc ggacgaaacc atcggtagac tccacaaggg
     2761 aagagaagga acggtggatc cgtgccaagt acgagcagaa gctcttcctg gccccgctgc
     2821 cctgcacgga gctgtccctg ggccagcacc tgctgcgggc caccgccgac gaggacctgc
     2881 ggacggccat cctgctgctg gcacacggct cccgggacga ggtgaacgag acctgcgggg
     2941 agggagacgg ccgcacggcg ctgcatctgg cctgccgcaa ggggaatgtg gtcctggcgc
     3001 agctcctgat ctggtacgga gtggacgtca cggcccgaga tgcccacggg aacacagctc
     3061 tggcctacgc ccggcaggcc tccagccagg agtgcatcga cgtgctgctg cagtacggct
     3121 gccccgacga gcgcttcgtg ctcatggcca cccctaacct gtccaggaga aacaataacc
     3181 ggaacaacag cagtgggagg gtgcccacca tcatctgagg aacagccgtg cccgcctgct
     3241 cgccgcacct gggacgcggc agcctcgccg cattctcgct cagaagtcgc agcacgtgag
     3301 tcccgtcgca tcccctccct cttcctggtg gccacctccc tcccgcccac ccactctcac
     3361 cccaaacaaa atcacaaaac ctggacatcc ctcaaggggc gaagaggcgg ccgggagact
     3421 gcagaagtgg ctccttttca taaactcccc taaaccacac acaggagaga gcgacgggcc
     3481 tcggcccttt gatgatagca catggcgcag gacccttgtc ctggtggcac aagggatggg
     3541 gacgcgaggg ggaggggagg cgaggaacaa ggagaagggg caactttcct taactggcag
     3601 ttgagcacat agtacatttc ccctctacca aacggaacac ttggattcca tctcttctct
     3661 gaggagctcg acggcataaa tcagaagcaa gcacagagtt tgtcaggttt gaagccccta
     3721 tgatggtgtg tgtcaaatca gttgtagcta atctgtccag ggagaatact ggcttcatta
     3781 cacttgtaca gccgagttct tcccgcatta ctgctgttta atagaacgtg attagtcatc
     3841 gccgagaaga aagcatatta gccgaggagg tagtcacgcg gcacgcgccg gtgattgcca
     3901 cgatgtgatt gcaatactct tagaagcacc atattatccc agacatgttc tttcaagccc
     3961 ttggagccct ctctaaattc actgtcatca tttagtatct gtttaatttt tcagtccaaa
     4021 gagaggaaat cagtcgctga gtattatttg actccggtct ccttggtgca aaaacaaaat
     4081 gggaaaaata aataagaata actcagaaac tcaaaaggaa accacaaatt cagctaataa
     4141 tagcatttcg agtatatttc gtaaactaag gaaatacaca aaaggctgtt ttttccgact
     4201 gtaagagata tttgatgtcc ttttgccgag gtggatgtgt tagtctcagg ccctcctgga
     4261 ccacgttgcc caagtcacac aggcttctgt gttatgtatt tagataagat gtgtgaaaat
     4321 atatttgaat aaaagaagtt cataaatatg cattgatttt tgtacagaca aatggcacct
     4381 ctcttaattt ataaattgaa ctggatgtga actaataatg tgcaactagt tgagataaga
     4441 gggttacaga tcattgtaca tggaaaatat tcccagcagt aaacacttcc attaatgtga
     4501 tctacggctt ttgaaaagga gcatctcaga ataagatggt ggtacaattt gcttattaaa
     4561 attgagaaag aaaaaaaaag acacactgga gtatattaga aaggaaaaag aaggaatgtg
     4621 gtctctcatg attgaaagca tgatttagat cggatacggc ttttgctaac caaggaccaa
     4681 gggactctgg caagatgggg tggttttccg aatgccagac cgaggtgcct tacgaaggca
     4741 gctgccaatg gttctgtggc acagactggc tcctgagaac ccagacgacc ttgacctggc
     4801 agcccggccc tccacgctag tacctcgcct gattttccat cgttgcggta tccagccgct
     4861 tcagacgtcc gccgccttca gtggtggtag tcaaatgtag tcaaccaaac cacagcatcc
     4921 cttaggttaa aagcaaacgg ggcagctttg cctagagctc attgacagtg tgatgggggg
     4981 agaagggttg tcacaatgga agatgaggac actagactca tgtagcacag aaacatgaag
     5041 ccacacgcac cggcagcctc cggggtgttc ctcgctctct cgtatgttaa accttatatt
     5101 ttataagagt ttttcctctt atttcacttt ttaaaaaaaa ttaaagtagg tggggaaaaa
     5161 aataaagctt tacacagaat ttatatgtgg gtaagtgttt catggaaatt tctaatctta
     5221 acgaagctaa gtggagctca ctcgtatcca aaagtataac aggtgcagaa gccacaagtc
     5281 tgagaacctt gacgacagtt ccatcgtcct gccatttgat ttttcagtct gcgtttcatc
     5341 actgtgtagc tattgtaaat gtgaatagaa aaaaacaggt cattgcctat ttttgaagaa
     5401 cgcgttggtg ttcgagtcca ctagacacac tcgctccaca cagccttcac cgtagactct
     5461 gtagtggaca cagatatagc ataaatgaaa ttgttaaatt atttcattgt agttaattcc
     5521 cactatagga atgctttatc atagtgaagt ttcttttgag aagaaacgga actccttgag
     5581 gcttctcttt gggatgtata tgagcgtgta catattattc tatgtgttta taatataata
     5641 ttttcccaaa tgacttcttg tttcactttg ccttccacaa cctgaatgcc agattggttt
     5701 tttcccttcc tggcccccag cacaagctgc catgactccc cctcagaaaa cacagcccct
     5761 cctctaccat tctcagtgat gtccatctgc tccactccgc agccactttc tagggcccaa
     5821 gttttggtag cagaaggaaa ggcagttttt gagggtcttt cgaaaaaaag aagacggggc
     5881 agctttgccc agagctcgtt ggcagtctgt ttgtatttca gtgtctaacc agaagtcctt
     5941 tctttgcgga ccgcactctc gttcccactt tcaagctaat taccaccaag gctgggagag
     6001 gcaaggactg ggggcggagc taggaataac tcgtttgaga agggggtgga gttttcgttg
     6061 ttcatttcca tgttcagttc tgtgacgtga cgatgacaga tcaccactgc aggatccccc
     6121 tcacctttcc tgttcagaat taaaactctc ccttgatgag aaacagccag ctgagggagg
     6181 cccacgagcg gcctgtgtaa ccccatgggt gatctggaca catctgcacc cccgcgttca
     6241 gcttcgcgga gactgaactt ggcggggagt ggaggggtgt ggtgcagacc tggctgcagc
     6301 agaaacaccc cgcagggaca gtactctgtg attctgacct caggtgctgg gacgggcaga
     6361 tggtttcccc cgcccagcac cccagtcctg gtccctggtc cctctctctg tttcatccca
     6421 ggaaatgagc agctcgaggg tgagcaagtg acaagttcct gagtcactgg ccccaaaacc
     6481 aggtgcagtg tcctgtctcc caagtgtgtg cacaatgtat atatgcactg gaaaggaggg
     6541 agaaggcagc gggtcactcg ccaatcgcag ggttctcaga cacaggagag agcgggatct
     6601 taatgaattg catttcctgc agagcctcta gtgcacaggc cagttctcgg cagtggcttt
     6661 tcagcacaag ggccttgcat tgaagctccc tcttctgaga tttcacccag cctgatgagg
     6721 cctgcatggt tccggcctcg tcatccagtg tagataccag tcttcctatt tttgtgacat
     6781 ctgcacattt ggggtcattc cctatatctg cataggagct attgctaacc ttgttaggga
     6841 gaaacatggt ctaatgagaa agacagaccc ctaggctcag ctggccctgc catccttcca
     6901 gaggattcct ctgcaactct aggcaagcac ccagcttcct gggctctttt tcctcatctg
     6961 tgaaacttgc agggtgcagt gaggtttcaa accagtgtga taagtgttgg cctcacacct
     7021 ggcccagggg atgctgggag aacaggagca cttgttaata acagaaacac tgatgggacc
     7081 gaagccagtg cacacaccag gaaacctgcc cgtggctgac actgtcctcc agcctgcatt
     7141 ctggggaggc tgtgatgggc acgtttgcca accccccccc cccagtagag cccaggaccc
     7201 tcctctctca gcttgccagt gccctgccct ccacatggcg gggaacagca tcaatgaggt
     7261 ccttgctccc tgagagcctc tctggaacct gcccactttt ctcaacatgt atattctgct
     7321 ttgtagtctg aggttgattt tctagaggcg aggaaggggc tgagttctgc cctcgtgctg
     7381 ttcgctggtg ctgatcaggg ccaagacgac ccttccctct cccccacagc ctgttgaggt
     7441 gccgttgacg tggacagcgc ccctccctta agatgccccc ttgccgttgc catgagccgc
     7501 tgtgactcac gcgtgcactg ggccttgctt ggtgctcccc tcctcctcct gtctgagatc
     7561 ggagcttgct ggagagcacc ccaggtcgcc gtgcttggct gcaggcccgt ccctctctcc
     7621 ccatcctcgg gttcccagcg tgttttgtgc ttgaacttgg tggactcatc ttaccccaca
     7681 agagtggcct gctcaacctg cagcctccaa tgtgccgtag gcgctctagg tccccgtggc
     7741 gcccaggaca ccaactctcc ctccctgcac ttaggatgtt ctggaaatga gaggaaatcc
     7801 acattcctgc cccaggaggt gggaagcctg gcaacgatgt agcttcccct gagatgcggt
     7861 atgatcaggc ctcagcaact actcaggagg caaaggtgtt tggaaagcaa accccaaacc
     7921 tcccggcacg gcatgtgctc tgcttccgtc cctcaccgcc tgcacaaggt cgttgagact
     7981 tttctagaac tccccggggt tgtatttatg gccttcaagc aaacaaattg aaaagcagtc
     8041 aaggaggagt tcagatagaa aagtgctgga gatacacatc tttccttcaa aggaaatgta
     8101 atttatttcc aaccgctgcc tcagacgggg gtttcacatg ttgtgaagtc acatcttgaa
     8161 tgactgtcac cctcatcctt ccccaaaaag ctaaataagg gcctttggca tcaatgcgtg
     8221 cattctccac ctttccgcgg cttgcgcttg gatttctgag tggctttctt cagggagccc
     8281 ttgtggtcat gtgtctttaa tgctgctccc catgccccca ggccaggcca gcacgctcag
     8341 gtgatagcga gtggggccag gagacccccc tgccctgccc agtggacaga tctgccccag
     8401 ccctgctgtg gggacgggcc ctctatcatt taaccacata cattaggttg cttttcagca
     8461 aaatgtcagc tttcctccca ttatgcagga gagagaaggg gcgcaggtgt atctccttag
     8521 agtacacctt ggagctggat cactaagaaa cagtcctcag actggtcctt ccgacacagg
     8581 cagagagtga actggatcgc tggcccctgg gatgctgcgc tgtctgtgat tagagagaag
     8641 tggccagtgt cccgtctgtg attagacaga aacccctgtg gcagactcct cccctctcca
     8701 tgaagaaaga aatatttact tagatattac tgtttcaaaa cacaaacttt attcccctta
     8761 gagaagaaat actgccctta aatagactgt tgaaatatta atggcccccc catttaatca
     8821 gtgtgtctgc ggctttcttc gcgtcacatg tccgcattgg caggtgattc tggaaaggga
     8881 ttctgggaaa ccaacaagtc ttttttaaat ctttgagttg tatgagaaag tatttaagtt
     8941 caccagtgta gtaaacaccc accccagagc agcggtaagc aaacctaaat ctgaaaaccc
     9001 attcttactg tctttcacca tgagatgctg gttttggtgt aaaatgacag cacttggttt
     9061 ggggttttgc acctgttggg tagaactgtt cttgtctgag gtcctcaccc tctacagatg
     9121 ggcctcaggg cctggaggtg ggcagatggg gccagagtgg ccagcagaga cttgcatggg
     9181 ctctgaaagc cccagagctc aggcctaagg ctgctaggtg agaccagcag gcagctgtgg
     9241 catccgacct tgggacgccc aagctgggca gccgctccat gtgccccaaa caggatatcc
     9301 tcatgaatgt gaggagaggc tggctcaggg cttggttttc attttggcct ggcacagggt
     9361 acctgtaggg agcactcccc caacctgagg atggtgaaac catatgatag agactccttg
     9421 tcgaagtcca catcggactg atctagaatg ccccgtgggg ggattgcatg gcctttgcct
     9481 tgagatgcag gtgaaagaaa ggaaccaaac aaggcatgag tgtgttgggg aatcttccca
     9541 gtggagcaaa cccccttaac acaccagctg ttgggaacag ctgcccctaa atccaattaa
     9601 accctcatct ccctggtgct gaacagtcta cactggccca ggaagctaac gtctgagccg
     9661 cttggagagc tttggtaaac agaagacact ggaagcccac tcggtcagca gctgggcatg
     9721 aggatgtcag gggcctttgg acttgaggaa ggacagtcca ggtgcatgga atcctaatgg
     9781 gcctcatgca gacactggaa gcagcccagc cccctgccca ataccacagc cctggggtgt
     9841 cccctgacat tcctggaggt ccctgggcaa atgcatttcc tgcctgggtt ctcagggtag
     9901 gagaacagag aaggctccaa gggtgttggg agtgagccag gggctggtct ggggagtggg
     9961 tctcacgcac tgctcaggtt ggcacgaggg acctccccca tcccaaccca gccccaaggg
    10021 tcccagcagg gctctcagca tggctgtttt gagggtacac aggtggctgg agaggggtgg
    10081 ggcagttgca tggtgggtgg caaagtgtgc atttagaagc tgcttcgtgg cgttaagaac
    10141 ggggggagag ggaccagcac tgtaacgtta gaaataattc cttcttgcag acttgaaaag
    10201 catcagtttc cctcccacgg ctgggttttt gtgtctgaaa tacatctaat tctccagact
    10261 gcagcccctc tcagccccga gcacctgagc gctggggagg cccttattga gctcagcctg
    10321 gagaggggag ggtcgcacgg gtcccggggg caggtctcct gcactggctc ttcccttctg
    10381 ccagcttgga atttggttct catcttgcca caggggtgcg tttcctaaag ggcagccgga
    10441 gcagctcaaa ggtgacaact gagatgcatt tctaggcagg ggcagggaag gccaacccac
    10501 cttgcagcca gttttctgtt tctgtaaata gcagtgtata gagatggaag ggcagcgtgg
    10561 gtgtatccac agatgggttt aggttttttt tttggatgtt ttctattacc tcattcagca
    10621 actttatgtt tcacaatgac tcaatgatgc tttatttata ttgtttgtac tgtaattaaa
    10681 accattgaca gacatttcac tttgcttgtt atttcatatg atcttgtttt gattaaatat
    10741 gccagtttgt attttcctgc cttgggattt ttttgtgtcc gctgtacagt attctaaggg
    10801 aaaaagaaaa agaaagatgt gtaaagtaac agagagaggt ggctatggtg tagagacctc
    10861 tttctaataa agaaatgaaa atatgtcta
//
