LOCUS       NM_001010982            1686 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens arylformamidase (AFMID), transcript variant 2, mRNA.
ACCESSION   NM_001010982 XM_496246
VERSION     NM_001010982.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Lin,K.T., Ma,W.K., Scharner,J., Liu,Y.R. and Krainer,A.R.
  TITLE     A human-specific switch of alternatively spliced AFMID isoforms
            contributes to TP53 mutations and tumor recurrence in
            hepatocellular carcinoma
  JOURNAL   Genome Res 28 (3), 275-284 (2018)
   PUBMED   29449409
  REMARK    GeneRIF: A human-specific switch of alternatively spliced AFMID
            isoforms contributes to TP53 mutations and tumor recurrence in
            hepatocellular carcinoma
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Casabonne,D., Reina,O., Benavente,Y., Becker,N., Maynadie,M.,
            Foretova,L., Cocco,P., Gonzalez-Neira,A., Nieters,A., Boffetta,P.,
            Middeldorp,J.M. and de Sanjose,S.
  TITLE     Single nucleotide polymorphisms of matrix metalloproteinase 9
            (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus
            in chronic lymphocytic leukemia: results from the European
            case-control study EpiLymph
  JOURNAL   Haematologica 96 (2), 323-327 (2011)
   PUBMED   21048031
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Magni,G., Amici,A., Emanuelli,M., Orsomando,G., Raffaelli,N. and
            Ruggieri,S.
  TITLE     Enzymology of NAD+ homeostasis in man
  JOURNAL   Cell Mol Life Sci 61 (1), 19-34 (2004)
   PUBMED   14704851
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087645.19.
            
            On Jan 29, 2021 this sequence version replaced NM_001010982.4.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region compared to variant 1. The resulting
            protein (isoform 2) is shorter but has the same N- and C-termini
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4310167.1, BC132824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409257.10/ ENSP00000386890.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC087645.19        154692-154763       c
            73-163              AC087645.19        151065-151155       c
            164-268             AC087645.19        139522-139626       c
            269-317             AC087645.19        139374-139422       c
            318-403             AC087645.19        137384-137469       c
            404-476             AC087645.19        137225-137297       c
            477-574             AC087645.19        136935-137032       c
            575-653             AC087645.19        136607-136685       c
            654-789             AC087645.19        136387-136522       c
            790-894             AC087645.19        136075-136179       c
            895-1686            AC087645.19        134423-135214       c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1686
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /note="arylformamidase"
                     /db_xref="GeneID:125061"
                     /db_xref="HGNC:HGNC:20910"
     exon            1..72
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..921
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /EC_number="3.5.1.9"
                     /note="isoform 2 is encoded by transcript variant 2;
                     probable arylformamidase; kynurenine formamidase; KFase;
                     N-formylkynurenine formamidase"
                     /codon_start=1
                     /product="kynurenine formamidase isoform 2"
                     /protein_id="NP_001010982.2"
                     /db_xref="CCDS:CCDS32750.2"
                     /db_xref="GeneID:125061"
                     /db_xref="HGNC:HGNC:20910"
                     /translation="MMDVSGVGFPSKVPWKKMSAEELENQYCPSRWVVRLGAEEALRT
                     YSQIGIEATTRARATRKSLLHVPYGDGEGEKVDIYFPDESSEALPFFLFFHGGYWQSG
                     SKDESAFMVHPLTAQGVAVVIVAYGIAPKGTLDHMVDQVTRSVAFVQKRYPSNKGIYL
                     CGHSAGAHLAAMMLLADWTKHGVTPNLRGFFLVSGVFDLEPIVYTSQNVALQLTLEDA
                     QRNSPQLKVAQAQPVDPTCRVLVVVGQFDSPEFHRQSWEFYQTLCQGEWKASFEELHD
                     VDHFEIVENLTQKDNVLTQIILKTIFQ"
     exon            73..163
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            164..268
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            269..317
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            318..403
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            404..476
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            477..574
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            575..653
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            654..789
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            790..894
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1686
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="AFMID"
                     /gene_synonym="FKF; KF; KFA"
                     /note="major polyA site"
ORIGIN      
        1 gtagacgcca tgatggatgt gtctggtgtg ggtttcccaa gcaaggttcc ttggaagaag
       61 atgtctgcag aggagctgga gaatcagtac tgtcccagcc gatgggttgt ccgactggga
      121 gcagaggaag ccttgaggac ctactcacag ataggaattg aagccaccac aagggcccgg
      181 gccaccagga agagcctgct gcatgtcccc tatggagacg gcgaagggga gaaagtggac
      241 atttacttcc ccgacgagtc gtctgaagcc ttgcctttct tcctgttctt tcacggagga
      301 tactggcaga gcggaagtaa ggatgagtct gccttcatgg tccacccgct gacggcacag
      361 ggagtggccg tggtaatagt ggcttacggc atcgccccca aaggcaccct ggaccacatg
      421 gtagaccagg tgacccgcag cgttgcgttt gtccagaagc ggtatccaag caacaaggga
      481 atttacctgt gtggacactc agccggggcc cacctggctg ccatgatgct cctggccgac
      541 tggaccaagc atggggtcac gcccaacctc agaggctttt tcctggtgag tggggtcttt
      601 gacctggagc ccatcgtgta tacttcacag aacgttgctc tccagctgac cctggaggac
      661 gctcagagga atagccccca gctgaaggtg gcccaggcac agccggtgga ccccacctgc
      721 cgtgtgctgg tggtcgtggg ccagttcgac tcccccgaat tccaccgaca gtcctgggag
      781 ttttaccaga ccctgtgtca aggagagtgg aaagcctcat ttgaagagct ccacgatgtg
      841 gaccactttg aaattgttga gaatctgacc cagaaggaca acgtgctcac ccagattatc
      901 ttgaaaacaa tcttccagta gttctgacga tacttggagc ctggtccacg tgcatcccac
      961 cttgggaagc ctctccaaag agctttcgga gctgacactg acagcttcag tttcccccag
     1021 cacccaggag agccttgctg tgtctgtctg cccggcaaga gtccattctc actgctggga
     1081 cactcatgaa aatctccacg tcctccctct tcccagcctg gatggagctc cagggctggg
     1141 gaacgtccgc aagtcaatgc tcagagatgc ccggagctgc ctcttagact cgtctggccc
     1201 atctacctgc tgacagagca tgacaaagat gacgctcaaa agtaatgcca ttacttcttt
     1261 tttttttttt tttttttttt tttttgagat ggagtcttac tctgtcaccc aggctggagt
     1321 gcagtggcgt gatcttggct cactgcaacc tccacctccc gggttcaagc aattctcctg
     1381 cctcagcctc ctgagcagct gggactacag gcgcctgcca tcatgcctgg ctaatttttg
     1441 tatttttagt agagacgggg tttcaacata ttggccaggc tggtctcaaa ctcctaacct
     1501 tgtgattcgc ccgccttggc ctcccaaagt gctgggattc caggcgtgag ccactgcgcc
     1561 cggccagaat ggcattatat ttaaatagtt cataaagaag cacaaaagaa tattatttca
     1621 taacatgtaa aaattatata aaacgtaaat ttccatgttg ataaataaag ttgtattgga
     1681 acacgg
//
