LOCUS       NM_001133               1997 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens afamin (AFM), mRNA.
ACCESSION   NM_001133
VERSION     NM_001133.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1997)
  AUTHORS   Dogan,Y., Arslan,O., Oztas,B., Kurtali,A., Daryal,A.S. and
            Eser,M.D.
  TITLE     Comparison of Afamin Values in Umbilical Cord Blood After Delivery
            in Pregnancies With and Without Gestational Diabetes Mellitus
  JOURNAL   Fetal Pediatr Pathol 43 (2), 83-93 (2024)
   PUBMED   38189115
  REMARK    GeneRIF: Comparison of Afamin Values in Umbilical Cord Blood After
            Delivery in Pregnancies With and Without Gestational Diabetes
            Mellitus.
REFERENCE   2  (bases 1 to 1997)
  AUTHORS   Alakbarova,L., Kale,I. and Muhcu,M.
  TITLE     Investigation of serum afamin concentration in pregnant women
            diagnosed with late fetal growth restriction or small for
            gestational age fetus
  JOURNAL   J Matern Fetal Neonatal Med 36 (2), 2240468 (2023)
   PUBMED   37518071
  REMARK    GeneRIF: Investigation of serum afamin concentration in pregnant
            women diagnosed with late fetal growth restriction or small for
            gestational age fetus.
REFERENCE   3  (bases 1 to 1997)
  AUTHORS   Guo,C., Fan,Y., Cheng,J., Deng,Y., Zhang,X., Chen,Y., Jing,H.,
            Li,W., Liu,P., Xie,J., Ning,W., Chen,H. and Zhou,J.
  TITLE     AFM negatively regulates the infiltration of monocytes to mediate
            sepsis-associated acute kidney injury
  JOURNAL   Front Immunol 14, 1049536 (2023)
   PUBMED   36793712
  REMARK    GeneRIF: AFM negatively regulates the infiltration of monocytes to
            mediate sepsis-associated acute kidney injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1997)
  AUTHORS   Juhasz,I., Ujfalusi,S., Seres,I., Lorincz,H., Varga,V.E., Paragh,G.
            Jr., Somodi,S., Harangi,M. and Paragh,G.
  TITLE     Afamin Levels and Their Correlation with Oxidative and Lipid
            Parameters in Non-diabetic, Obese Patients
  JOURNAL   Biomolecules 12 (1), 116 (2022)
   PUBMED   35053264
  REMARK    GeneRIF: Afamin Levels and Their Correlation with Oxidative and
            Lipid Parameters in Non-diabetic, Obese Patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1997)
  AUTHORS   Kurdiova,T., Balaz,M., Kovanicova,Z., Zemkova,E., Kuzma,M.,
            Belan,V., Payer,J., Gasperikova,D., Dieplinger,H., Ukropcova,B. and
            Ukropec,J.
  TITLE     Serum Afamin a Novel Marker of Increased Hepatic Lipid Content
  JOURNAL   Front Endocrinol (Lausanne) 12, 670425 (2021)
   PUBMED   34603196
  REMARK    GeneRIF: Serum Afamin a Novel Marker of Increased Hepatic Lipid
            Content.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1997)
  AUTHORS   Allard,D., Gilbert,S., Lamontagne,A., Hamel,D. and Belanger,L.
  TITLE     Identification of rat alpha-albumin and cDNA cloning of its human
            ortholog
  JOURNAL   Gene 153 (2), 287-288 (1995)
   PUBMED   7875606
REFERENCE   7  (bases 1 to 1997)
  AUTHORS   Lichenstein,H.S., Lyons,D.E., Wurfel,M.M., Johnson,D.A.,
            McGinley,M.D., Leidli,J.C., Trollinger,D.B., Mayer,J.P.,
            Wright,S.D. and Zukowski,M.M.
  TITLE     Afamin is a new member of the albumin, alpha-fetoprotein, and
            vitamin D-binding protein gene family
  JOURNAL   J Biol Chem 269 (27), 18149-18154 (1994)
   PUBMED   7517938
REFERENCE   8  (bases 1 to 1997)
  AUTHORS   Hansson,E., Ronnback,L., Lowenthal,A. and Noppe,M.
  TITLE     Primary cultures from defined brain areas; effects of seeding time
            on cell growth, astroglial content and protein synthesis
  JOURNAL   Brain Res 353 (2), 175-185 (1985)
   PUBMED   4041902
REFERENCE   9  (bases 1 to 1997)
  AUTHORS   Lowenthal,A., Flament-Durand,J., Karcher,D., Noppe,M. and
            Brion,J.P.
  TITLE     Glial cells identified by anti-alpha-albumin (anti-GFA) in human
            pineal gland
  JOURNAL   J Neurochem 38 (3), 863-865 (1982)
   PUBMED   7035619
REFERENCE   10 (bases 1 to 1997)
  AUTHORS   Noppe,M., Lowenthal,A., Karcher,D. and Gheuens,J.
  TITLE     A two-site immunoradiometric assay for the determination of
            alpha-albumin
  JOURNAL   J Immunol Methods 27 (1), 75-81 (1979)
   PUBMED   37276
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U51243.1.
            
            On Jan 15, 2003 this sequence version replaced NM_001133.1.
            
            Summary: This gene is a member of the albumin gene family, which is
            comprised of four genes that localize to chromosome 4 in a tandem
            arrangement. These four genes encode structurally-related serum
            transport proteins that are known to be evolutionarily related. The
            protein encoded by this gene is regulated developmentally,
            expressed in the liver and secreted into the bloodstream. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290556.1, BC109020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226355.5/ ENSP00000226355.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..1997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..1997
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /note="afamin"
                     /db_xref="GeneID:173"
                     /db_xref="HGNC:HGNC:316"
                     /db_xref="MIM:104145"
     exon            1..119
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1831
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /note="alpha-albumin; alpha-Alb; vitamin E binding
                     protein"
                     /codon_start=1
                     /product="afamin precursor"
                     /protein_id="NP_001124.1"
                     /db_xref="CCDS:CCDS3557.1"
                     /db_xref="GeneID:173"
                     /db_xref="HGNC:HGNC:316"
                     /db_xref="MIM:104145"
                     /translation="MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFIEDNIE
                     YITIIAFAQYVQEATFEEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAME
                     GLPQKHNFSHCCSKVDAQRRLCFFYNKKSDVGFLPPFPTLDPEEKCQAYESNRESLLN
                     HFLYEVARRNPFVFAPTLLTVAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSS
                     YQKHVCGALLKFGTKVVHFIYIAILSQKFPKIEFKELISLVEDVSSNYDGCCEGDVVQ
                     CIRDTSKVMNHICSKQDSISSKIKECCEKKIPERGQCIINSNKDDRPKDLSLREGKFT
                     DSENVCQERDADPDTFFAKFTFEYSRRHPDLSIPELLRIVQIYKDLLRNCCNTENPPG
                     CYRYAEDKFNETTEKSLKMVQQECKHFQNLGKDGLKYHYLIRLTKIAPQLSTEELVSL
                     GEKMVTAFTTCCTLSEEFACVDNLADLVFGELCGVNENRTINPAVDHCCKTNFAFRRP
                     CFESLKADKTYVPPPFSQDLFTFHADMCQSQNEELQRKTDRFLVNLVKLKHELTDEEL
                     QSLFTNFANVVDKCCKAESPEVCFNEESPKIGN"
     exon            120..168
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            169..301
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            302..513
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            514..646
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            647..744
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            745..874
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1089
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1222
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1320
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1453
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1677
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1810
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1871
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1997
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /note="hexamer: AATAAA"
     polyA_site      1997
                     /gene="AFM"
                     /gene_synonym="ALB2; ALBA; ALF"
                     /note="major polyA site"
ORIGIN      
        1 actttctttt gtaaatgtgg tttctacaaa gatgaaacta ctaaaactta caggttttat
       61 ttttttcttg ttttttttga ctgaatccct aaccctgccc acacaacctc gggatataga
      121 gaacttcaat agtactcaaa aatttataga agataatatt gaatacatca ccatcattgc
      181 atttgctcag tatgttcagg aagcaacctt tgaagaaatg gaaaagctgg tgaaagacat
      241 ggtagaatac aaagacagat gtatggctga caagacgctc ccagagtgtt caaaattacc
      301 taataatgtt ttacaggaaa aaatatgtgc tatggagggg ctgccacaaa agcataattt
      361 ctcacactgc tgcagtaagg ttgatgctca aagaagactc tgtttcttct ataacaagaa
      421 atctgatgtg ggatttctgc ctcctttccc taccctggat cccgaagaga aatgccaggc
      481 ttatgaaagt aacagagaat cccttttaaa tcacttttta tatgaagttg ccagaaggaa
      541 cccatttgtc ttcgccccta cacttctaac tgttgctgtt cattttgagg aggtggccaa
      601 atcatgttgt gaagaacaaa acaaagtcaa ctgccttcaa acaagggcaa tacctgtcac
      661 acaatattta aaagcatttt cttcttatca aaaacatgtc tgtggggcac ttttgaaatt
      721 tggaaccaaa gttgtacact ttatatatat tgcgatactc agtcaaaaat tccccaagat
      781 tgaatttaag gagcttattt ctcttgtaga agatgtttct tccaactatg atggatgctg
      841 tgaaggggat gttgtgcagt gcatccgtga cacgagcaag gttatgaacc atatttgttc
      901 aaaacaagat tctatctcca gcaaaatcaa agagtgctgt gaaaagaaaa taccagagcg
      961 cggccagtgc ataattaact caaacaaaga tgatagacca aaggatttat ctctaagaga
     1021 aggaaaattt actgacagtg aaaatgtgtg tcaagaacga gatgctgacc cagacacctt
     1081 ctttgcgaag tttacttttg aatactcaag gagacatcca gacctgtcta taccagagct
     1141 tttaagaatt gttcaaatat acaaagatct cctgagaaat tgctgcaaca cagaaaaccc
     1201 tccaggttgt taccgttacg cggaagacaa attcaatgag acaactgaga aaagcctcaa
     1261 gatggtacaa caagaatgta aacatttcca gaatttgggg aaggatggtt tgaaatacca
     1321 ttacctcatc aggctcacga agatagctcc ccaactctcc actgaagaac tggtgtctct
     1381 tggcgagaaa atggtgacag ctttcactac ttgctgtacg ctaagtgaag agtttgcctg
     1441 tgttgataat ttggcagatt tagtttttgg agagttatgt ggagtaaatg aaaatcgaac
     1501 tatcaaccct gctgtggacc actgctgtaa aacaaacttt gccttcagaa ggccctgctt
     1561 tgagagtttg aaagctgata aaacatatgt gcctccacct ttctctcaag atttatttac
     1621 ctttcacgca gacatgtgtc aatctcagaa tgaggagctt cagaggaaga cagacaggtt
     1681 tcttgtcaac ttagtgaagc tgaagcatga actcacagat gaagagctgc agtctttgtt
     1741 tacaaatttc gcaaatgtag tggataagtg ctgcaaagca gagagtcctg aagtctgctt
     1801 taatgaagag agtccaaaaa ttggcaactg aagccagctg ctggagatat gtaaagaaaa
     1861 aagcaccaaa gggaaggctt cctatctgtg tggtgatgaa tcgcatttcc tgagaacaaa
     1921 ataaaaggat ttttctgtaa ctgtcacctg aaataataca ttgcagcaag caataaacac
     1981 aacattttgt aaagtta
//
