LOCUS       NM_145207               8116 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens AFG2 AAA ATPase homolog A (AFG2A), transcript variant
            1, mRNA.
ACCESSION   NM_145207
VERSION     NM_145207.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8116)
  AUTHORS   Krishnamoorthy,V., Foglizzo,M., Dilley,R.L., Wu,A., Datta,A.,
            Dutta,P., Campbell,L.J., Degtjarik,O., Musgrove,L.J.,
            Calabrese,A.N., Zeqiraj,E. and Greenberg,R.A.
  TITLE     The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis
            to ensure genome integrity
  JOURNAL   Cell 187 (9), 2250-2268 (2024)
   PUBMED   38554706
REFERENCE   2  (bases 1 to 8116)
  AUTHORS   Ni,C., Schmitz,D.A., Lee,J., Pawlowski,K., Wu,J. and Buszczak,M.
  TITLE     Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5
            control a late step in human ribosome assembly
  JOURNAL   Cell Rep 38 (13), 110597 (2022)
   PUBMED   35354024
  REMARK    GeneRIF: Labeling of heterochronic ribosomes reveals C1ORF109 and
            SPATA5 control a late step in human ribosome assembly.
REFERENCE   3  (bases 1 to 8116)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8116)
  AUTHORS   Kim,S.K., Roche,M.D., Fredericson,M., Dragoo,J.L., Horton,B.H.,
            Avins,A.L., Belanger,H.G., Ioannidis,J.P.A. and Abrams,G.D.
  TITLE     A Genome-wide Association Study for Concussion Risk
  JOURNAL   Med Sci Sports Exerc 53 (4), 704-711 (2021)
   PUBMED   33017352
  REMARK    GeneRIF: A Genome-wide Association Study for Concussion Risk.
REFERENCE   5  (bases 1 to 8116)
  AUTHORS   Tanaka,A.J., Cho,M.T., Millan,F., Juusola,J., Retterer,K.,
            Joshi,C., Niyazov,D., Garnica,A., Gratz,E., Deardorff,M.,
            Wilkins,A., Ortiz-Gonzalez,X., Mathews,K., Panzer,K., Brilstra,E.,
            van Gassen,K.L., Volker-Touw,C.M., van Binsbergen,E., Sobreira,N.,
            Hamosh,A., McKnight,D., Monaghan,K.G. and Chung,W.K.
  TITLE     Mutations in SPATA5 Are Associated with Microcephaly, Intellectual
            Disability, Seizures, and Hearing Loss
  JOURNAL   Am J Hum Genet 97 (3), 457-464 (2015)
   PUBMED   26299366
  REMARK    GeneRIF: Mutations in SPATA5 Are Associated with Microcephaly,
            Intellectual Disability, Seizures, and Hearing Loss.
REFERENCE   6  (bases 1 to 8116)
  AUTHORS   Forstbauer,L.M., Brockschmidt,F.F., Moskvina,V., Herold,C.,
            Redler,S., Herzog,A., Hillmer,A.M., Meesters,C., Heilmann,S.,
            Albert,F., Alblas,M., Hanneken,S., Eigelshoven,S., Giehl,K.A.,
            Jagielska,D., Blume-Peytavi,U., Garcia Bartels,N., Kuhn,J.,
            Hennies,H.C., Goebeler,M., Jung,A., Peitsch,W.K., Kortum,A.K.,
            Moll,I., Kruse,R., Lutz,G., Wolff,H., Blaumeiser,B., Bohm,M.,
            Kirov,G., Becker,T., Nothen,M.M. and Betz,R.C.
  TITLE     Genome-wide pooling approach identifies SPATA5 as a new
            susceptibility locus for alopecia areata
  JOURNAL   Eur J Hum Genet 20 (3), 326-332 (2012)
   PUBMED   22027810
  REMARK    GeneRIF: SPATA5 locus is a new susceptibility locus for Alopecia
            areata (AA).
REFERENCE   7  (bases 1 to 8116)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 8116)
  AUTHORS   Tegha-Dunghu,J., Neumann,B., Reber,S., Krause,R., Erfle,H.,
            Walter,T., Held,M., Rogers,P., Hupfeld,K., Ruppert,T., Ellenberg,J.
            and Gruss,O.J.
  TITLE     EML3 is a nuclear microtubule-binding protein required for the
            correct alignment of chromosomes in metaphase
  JOURNAL   J Cell Sci 121 (Pt 10), 1718-1726 (2008)
   PUBMED   18445686
REFERENCE   9  (bases 1 to 8116)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     FGF signaling inhibitor, SPRY4, is evolutionarily conserved target
            of WNT signaling pathway in progenitor cells
  JOURNAL   Int J Mol Med 17 (3), 529-532 (2006)
   PUBMED   16465403
REFERENCE   10 (bases 1 to 8116)
  AUTHORS   Liu,Y., Black,J., Kisiel,N. and Kulesz-Martin,M.F.
  TITLE     SPAF, a new AAA-protein specific to early spermatogenesis and
            malignant conversion
  JOURNAL   Oncogene 19 (12), 1579-1588 (2000)
   PUBMED   10734318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA619323.1, AK091384.1,
            AL832175.1 and AC026402.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_145207.2.
            
            Summary: This gene encodes a member of the ATPase associated with
            diverse activities family, whose members are defined by a highly
            conserved ATPase domain. Members of this family participate in
            diverse cellular processes that include membrane fusion, DNA
            replication, microtubule severing, and protein degradation. The
            protein encoded by this gene has a putative mitochondrial targeting
            sequence and has been proposed to function in maintenance of
            mitochondrial function and integrity during mouse spermatogenesis.
            Allelic variants in this gene have been associated with epilepsy,
            hearing loss, and cognitive disability syndrome. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361489.1, AL832175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274008.5/ ENSP00000274008.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DA619323.1         9-69
            62-1767             AK091384.1         25-1730
            1768-3299           AL832175.1         1769-3300
            3300-8116           AC026402.3         77843-82659
FEATURES             Location/Qualifiers
     source          1..8116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..8116
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /note="AFG2 AAA ATPase homolog A"
                     /db_xref="GeneID:166378"
                     /db_xref="HGNC:HGNC:18119"
                     /db_xref="MIM:613940"
     exon            1..228
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2747
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /EC_number="3.6.4.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATPase family gene 2 homolog; spermatogenesis associated
                     factor SPAF; spermatogenesis-associated protein 5; ATPase
                     family protein 2 homolog; spermatogenesis-associated
                     factor protein; ribosome biogenesis protein SPATA5;
                     spermatogenesis associated 5; ATPase family gene 2 protein
                     homolog A"
                     /codon_start=1
                     /product="ATPase family gene 2 protein homolog A isoform
                     1"
                     /protein_id="NP_660208.2"
                     /db_xref="CCDS:CCDS3730.1"
                     /db_xref="GeneID:166378"
                     /db_xref="HGNC:HGNC:18119"
                     /db_xref="MIM:613940"
                     /translation="MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSG
                     TLTVTNLLEKVDDKIPKTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWP
                     MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEEL
                     TGCILRKLDGKIVLPGNFLYCTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMA
                     FEQSSMETSSLELSLQLSQLDLEDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPG
                     DGSGLMLEEVTGLKCNFESAREGNEQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNF
                     TEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLL
                     YGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSII
                     FIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAA
                     LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKV
                     LCNEAGLCALRRILKKQPNLPDVKVAGLVKITLKDFLQAMNDIRPSAMREIAIDVPNV
                     SWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALA
                     NESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSIIFFDELDALAVERGSSL
                     GAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPD
                     AATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVCREAALLALEEDIQANL
                     IMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL"
     exon            229..353
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            354..511
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            512..570
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            571..1212
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1342
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1399
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1523
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1779
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1934
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2144
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2198
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2278
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2405
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2570
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..8116
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7951..7956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /note="hexamer: AATAAA"
     polyA_site      7984
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /note="major polyA site"
     regulatory      8093..8098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /note="hexamer: ATTAAA"
     polyA_site      8116
                     /gene="AFG2A"
                     /gene_synonym="AFG2; EHLMRS; NEDHSB; SPAF; SPATA5"
                     /note="major polyA site"
ORIGIN      
        1 ctctcagttg aagcgcgcac attgagtcgg cttttctact gcttcggcta gggtaccttg
       61 tgaccatgtc ttccaagaag aatagaaagc ggttgaacca aagcgcggaa aatggttcgt
      121 ccttgccctc tgctgcttcc tcttgtgcgg aggcacgggc tccttctgct ggatcagact
      181 tcgcggcaac ctccgggact ctgacggtga ccaacttatt agaaaaggta gatgacaaaa
      241 ttcctaaaac attccagaat tcccttattc atcttggact caacactatg aagtctgcaa
      301 atatatgtat aggtcgacca gtgttgctta ctagtttgaa cggaaagcaa gaggtgtata
      361 cagcctggcc tatggcagga tttcctggag gcaaggtcgg cctgagtgaa atggcacaga
      421 aaaatgtggg tgtgaggcct ggtgatgcca tccaggtcca gcctcttgtg ggtgctgtgc
      481 tacaggctga ggaaatggat gtggcactga gtgacaaaga tatggaaatt aatgaagaag
      541 aactgactgg ttgtatcctg agaaaactag atggcaagat tgttttacca ggcaactttc
      601 tgtattgtac attctatgga cgaccgtaca agctgcaagt attgcgagtg aaaggggcag
      661 atggcatgat attgggaggg cctcagagtg actctgacac tgatgcccaa agaatggcct
      721 ttgaacagtc cagcatggaa accagtagcc tggagttatc cttacagcta agccagttag
      781 atctggagga tacccagatc ccaacatcaa gaagtactcc ttataaacca attgatgaca
      841 gaattacaaa taaagccagt gatgttttgc tggatgttac acagagccct ggagatggca
      901 gtggacttat gctagaggaa gtcacaggtc ttaaatgtaa ttttgaatct gccagagaag
      961 gaaatgagca acttactgaa gaagagagac tgctaaagtt cagcatagga gcaaagtgca
     1021 atactgatac tttttatttt atttcttcaa caacaagagt caattttaca gagattgata
     1081 aaaattcaaa agagcaagac aaccaattca aagtaactta tgacatgata ggaggattaa
     1141 gtagccagct gaaagcaatt agagaaataa ttgaattgcc cctcaaacag cctgagcttt
     1201 tcaagagtta tggaattcct gcccctagag gagtgttact ttatggtcct ccaggtactg
     1261 gaaaaacaat gatcgccagg gctgttgcta atgaagttgg agcctatgtt tctgtaatta
     1321 atggtcctga aattataagc aaattctatg gtgagactga agcaaagtta cgtcagatat
     1381 ttgctgaagc cactctacga cacccatcaa ttatttttat tgatgagctg gatgcacttt
     1441 gtccgaaaag agagggggcc cagaatgaag tggaaaaaag agttgtggct tcactcttaa
     1501 cactgatgga tggcattggt tcagaagtaa gtgaaggaca agtgttggtt cttggggcca
     1561 caaatcgccc tcatgccttg gatgctgctc tccgaagacc tgggcgattt gataaagaga
     1621 ttgagattgg agttcccaat gctcaggacc ggctagatat tctccagaaa ctgcttcgaa
     1681 gggtacccca tttgctcact gaggctgagc tgctgcagct ggcaaatagt gctcatggat
     1741 acgttggagc agacttgaaa gtcttgtgta atgaagcagg tctctgtgcc ttgcggagaa
     1801 tcctgaaaaa acagcctaac ctccctgatg tcaaggtggc tggactggtg aagattactc
     1861 tgaaggattt cttgcaggca atgaatgata tcagacccag tgccatgagg gaaatagcaa
     1921 ttgatgtccc aaatgtatcc tggtcagata taggaggact ggaaagtatc aaactgaagt
     1981 tggaacaggc tgtggaatgg cccttaaaac atccagagtc tttcattcga atgggtattc
     2041 agccacctaa aggagttctt ctctatgggc cacctgggtg ctctaaaaca atgatagcaa
     2101 aggctttggc caatgagagt ggactgaatt ttctagctat aaaggggcct gaattaatga
     2161 ataaatatgt tggtgaatct gaaagagcag ttagagagac cttccgaaaa gcaagagcag
     2221 tggcgccttc cattattttc tttgatgaac tggatgcctt agcagttgaa aggggcagtt
     2281 ctttaggtgc tgggaatgta gccgatcgtg ttttggctca gctcttaaca gaaatggatg
     2341 ggattgaaca gctaaaggat gtgaccattt tggcagctac taaccgtcca gataggatag
     2401 acaaggcttt gatgcggcct ggaagaattg atagaatcat ctatgtgcct ttaccggatg
     2461 cagcaacaag aagggaaata tttaagctgc agtttcactc catgcctgtc agtaatgaag
     2521 ttgacctgga tgaactcatc cttcaaaccg acgcatactc aggagcagag attgtagctg
     2581 tctgcagaga ggcagctctt ctggctctgg aagaagacat tcaagccaat ctcatcatga
     2641 aaagacattt cactcaggcc ttgagcactg tgacacctag aattcctgag tcattgagac
     2701 gtttttatga agattatcaa gagaagagtg ggctgcatac actctgagaa aatatatata
     2761 ttcaagatgc tgaaaatcct ttccagagaa aatttgtttc tttttaaaat tttttgagag
     2821 tgttaaaaaa aattttacta ggcaaaatgt ttgaagtatg ttcagtagaa tttaggggct
     2881 ttggttctta cagattttca agtcatgtaa gtacagtgaa aatatctctg agcataagtt
     2941 tcaatcagtt ttacctggaa atttgtggtg tggtttaaaa aacaaatgtt tagctttttc
     3001 atttgcgacc tagtctgttc atcccatgaa gcgatttctt tttccagaat ctgtttgagt
     3061 gtctttctaa aatgccaaac atgttggcat caattttata cagggatata aaaaagtata
     3121 tgtggataaa ttttttgtaa tctttaggga tataaaaaag tgtatgtgga taaatttttt
     3181 gtaatcttta tttttgaagg ccagccagta aaatggccca atgtgccagc caggcttatg
     3241 tggccttgtt ttcaaatata catatatgtg ttatcattaa aattcatata tgcatttttg
     3301 ttttagcctt cttaatctct acctatggcc aaaaaaattt tttttgagag atattttgta
     3361 taatacaatg ccctttgaaa gtgtaagccc actctaagcc tagatcagta ggcttgggtt
     3421 ttttttgttg ttgttttgtc tttttttttt ttttttgaga cagagtctca ctctgtcacc
     3481 taagctggag tgcagtggca cgatcttggc tcactgcaac ctccgcctcc tgagttcaag
     3541 caattctcct gcctcaacct cctgagtagc tgggactaca ggtgtgcacc accacacgca
     3601 gctaattttt atatttttag tagagacaag gtttcaccat gttagccagg ccggtctcga
     3661 actgctggcc tcaggtgacc cacccacctg agcctcccaa agtgctggga ttacaggcgt
     3721 gagccaccat acctggagag gttttgtgtt tttgtttttt tttcataaaa tgcttttaat
     3781 aaatcatatg aagcattcat gtttttactt atacatattt tcagggtacc agtaaacttt
     3841 ttagttcaaa gataggccaa attgtacttt ttttttttta tgagacagag tctcgctgct
     3901 ctgtcgccca ggctagagtg cagtggcgtg atctaggctc actgcaagct ctgcctcctg
     3961 ggtttactta cgccattctc ccgcctcagc ctcctgagta gctgggacta caggtgccca
     4021 ccaccatgcc tggctaattt tttttttttt ttttttttat tagagacagg gtttcaccgt
     4081 gttagccagg atgatctcga tctcctgacc tcgtgatccg cccgcctcgg cctcccaaag
     4141 tgctgggatt acaggcatga gctactgcgc cctgccgcca aattgtaatc ttaaacatat
     4201 tatgttgcat tctaaatatg tatatttatg cttcttgtta tttatcctca ggatttcttc
     4261 acactttatt acttcataaa tactcttgaa aaagctttca gaaagtgatt ctctgacttc
     4321 agatcagaaa ctggcaatgg gaagaatgtg cacttaaact tgatcactgt agatctttga
     4381 aaattcccag aaagacaaat cagacaagaa atacctgatt atcaaaataa tgggctatac
     4441 agttttgtgg tggcatacat tccttgtttg tttgtttaga gataggatct tgttgtgtca
     4501 cccaggctgg aatgcagtgg cacagtcgta gctcactgca ccttcaaact cctggagctc
     4561 aagtgatcct cctgactcag cctcctgagt agctaggaca acaggtgcac actgccatgt
     4621 caggctaatt ttttttttta aacagagaga cagagtcttg ctgtgttgcc caggctggtc
     4681 tccaactcct ggcctcaggt gaccctcctg cctcagcttc ccaaagggct gagattacag
     4741 gtgtgagcca ccatgcccag cctgtggtga catatattct gaagtcacat ctcaaatatt
     4801 taatcctcaa atatatttac atcctcaaaa atatcagatt ttcaagacaa cactggttta
     4861 ccagtacata aacccaccta ggggacaaag aatattacca cttagaactg tgttgtcaaa
     4921 tacaataacc actaattgta tctgaccatt ttaattaaat taattacaat taaataatat
     4981 ttaagaatta gtttatcaga catatcagcc acatttcaaa tgctcaatag ctacatgtgg
     5041 caagggtctg ccacactgga cagagtagaa aacattccca tcattcagaa ggttctcttg
     5101 gacgctgcag atctggaaaa caagacttcc atattgaaat aaatacaacc tcaaaacttt
     5161 tatgctctgt gttcccttta gttgttatct acatagaaaa ttatgaaaca agagaggaac
     5221 ttaccttctt ccctattaaa tatatggcta agggcacaag aaaataagag gaaaacttat
     5281 ccttcagggc ctaaacaagg aaatgaaaga aatctcattc ccaatagaat aaaaaccaga
     5341 agcttgaaat gactctggtg caggaggctg ggtggtgggg aggagggtag cagtctcaat
     5401 caacaagttt agatattaat agccactcaa agccttcagc ccatataaca tgaagtgaca
     5461 actgagctct gcacataatg ctcaagctct ataataacca acactctcag cacaagggta
     5521 gacaagaaaa gaaaaatctc ctgctggcca ggaagaccac aaggaggctt tctgacttgg
     5581 cctgtgcttt tgatttttaa aacatttttt aaaagaggcc tctctgggct gggcgcggtg
     5641 gctcatgcct gtaatcccag cactttggga ggccgaggca ggcggatcac gaggtcagaa
     5701 gatcaagacc atcctggcta acacagtgaa accccgtctc tactaaaaat tcaaaaaatt
     5761 agccgggaat ggtggtgggc gcctgtagtc ccagttactc gggaggctga ggcaggagaa
     5821 tggcgtaaac ccgggagacg gagcttgcag tgagctgaga ttgcgccact gcactccagc
     5881 ctgggtgaca gagtgagact ccgtctcaaa aaaaaaaaaa aaaaaacctc tgagaattct
     5941 gactatgagc ttacctgccc atggctttag aatgatttga attcacacta ccttcaaatt
     6001 catgaaacct caaaacctac aaattaacct aaaaacatgg agccaagcta aaaatgccct
     6061 gggggtaact agcacttgga ctagttacag gaatgtagct tcgtctcaga ggattccaaa
     6121 agctaatgcc ttgcttacca agggcttgta atctcacagg atgtgatggg tggggcctca
     6181 gatctgctga tgggagcata aattggtaca accactttgg aaggcaactg gctatctagc
     6241 aaagttgaag accctacaat ctaacagttc tcctaggtgc atatcccaga gcaagtctca
     6301 cattgatgca gtgagatagt gaataggaaa gttcatagca ccattatttt taagtagtaa
     6361 gaacccggaa acaatctaaa tatccatcag taatagatat atgtgatagt catacaatgg
     6421 aatactgtgg caataaaaaa taattagagc tacatatgaa atagggatga aacatggatg
     6481 aacaaagaat gttttagagg aatatgatat ttaaaatttg aagcatgaaa aatatgtgtt
     6541 tatgggggca tatatagtgg aagaataaat gaatagaaaa gaaaagcacc aaatactggt
     6601 gaggaatttc ctcaggggag aaaagttgag ctgcttcaat tgtgtcagta atgtttcata
     6661 tcttagggtg ggtgatggga atataggtgc tgatttaata tagtctgtac tttttgtgta
     6721 cctaaatatt tcgtgataat ttttaaaaga tgggccttaa accaatacag tcatatcatt
     6781 taactcaatt ccatgaattt acaatgcaat ccacagtgcc cacaacccca tgtttctgga
     6841 aaatcaggag tattgggtac aatggaataa aatgcaagaa ggcaaataag agatcaggct
     6901 tttaggacct aggaaacaaa taaagaggaa tttgttgctg aaagtaatgt gtagctgaca
     6961 ctctcattac ctgacacaat gggagacatt atgtctggga ataagacatc tatttccata
     7021 gcactgtagt cctgcaaagg agttggaagt tatgaatttt taaagatttt agaacattat
     7081 atctttagtc tctcataagc caattattta tatctccaca tagcccatta ttaccattga
     7141 aaaggcatgc aattcttcta tttgaagctt gttccctttt tacaaaagta ctagtaaaaa
     7201 tctgagtcat acaaaagagc aggtcaggtg tcactaataa cagtttacct cagcttcatc
     7261 tccatgaagg ttttacttct aatcccagag tctcatgttt atgtattaca agagtgtatg
     7321 aaagctgggc atggtggcac acaccagtag tcccagctac tcggtcgggg gttgaggtga
     7381 gaggatcgct tgaactcagg agtttgaatc cagcctggtc aatgtagcga gatcctatct
     7441 cttaaaaaaa aaaaaaaaag gggggaacag tgtatgatcc tattatttgg gtttgtgtgt
     7501 gatcgaatac atggtatata gttcatggaa aatttaagct cagcaaggaa agaaaatggc
     7561 cagcttcctg tcttaggaag acaatttact ttttggcatc tgtttggttg aaagtttgcc
     7621 tttgatccag attctttcgg atgtcaggga tattcacatt gacatgtctt tttagtgttc
     7681 caggagattt tagtttgaat agtacaattt tttcttctta caacaaaact tagaacggct
     7741 tctaacttat ttcttcatgg ccaagaaact accctaactt atctcgataa atatttagtt
     7801 ctgtcttatt tctaatgtgt aaaacaggtt ttaaaaataa tatatagatt ttgcatttat
     7861 aaaaaaagat ttaatttata gaaccaaact tgaacatatg tttaatttag cctaatcaga
     7921 aggttacaga aaaagttgct gtaaagatag aataaaggta ttgtactggt ctgtttttac
     7981 tgaagttcca gaatgtgagg ttattagagt cttggcttat tgtgtcatgt tttcctgaat
     8041 gcttcctttg aagatgagca cacaccaaag catcctttga tattatgtat ggattaaatt
     8101 aacactgctt tccaaa
//
