LOCUS       XM_047444288            9036 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ALF transcription elongation factor 3
            (AFF3), transcript variant X20, mRNA.
ACCESSION   XM_047444288
VERSION     XM_047444288.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..9036
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /note="ALF transcription elongation factor 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 41 ESTs, 410 long SRA reads, and 97% coverage
                     of the annotated genomic feature by RNAseq alignments,
                     including 18 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
     CDS             342..2981
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /codon_start=1
                     /product="AF4/FMR2 family member 3 isoform X16"
                     /protein_id="XP_047300244.1"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
                     /translation="MGKNNLWNFRMLLQASLLVFDLLSHNWSQPSSGMLEDDLKLSSD
                     EEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSG
                     SDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGS
                     ESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKS
                     PPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE
                     PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEF
                     IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPV
                     GSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEH
                     LPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEK
                     DSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLT
                     SSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSP
                     GSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIE
                     CGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALL
                     YWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGNSVGSQGSLSNASALSPS
                     TIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHS
                     SMEHLVQYSQQGLHWLRNSAHLS"
ORIGIN      
        1 aatatcaaag aaggctacct aacttcagtt tatgttacta agacgcgttt gaaacttcgt
       61 ggataacctt ttgtttgttt gcctcgtgct gaaatgcaaa aaaattatct gatacttgat
      121 acgaagagga atttacctct gtttaaaaat cacacatttc tcccatgaag catgaagatg
      181 gcttttttaa tttaaaaata ttaactgaca gcttcaagat tgattttttt ttctttaatc
      241 tctaaccaga caaattacta aaagcaagaa ggctcttcct ttaatcttgg acatgtcaca
      301 gatatgacac tgttctgtag gagatggctt tttaactgtg gatggggaag aataaccttt
      361 ggaattttag gatgttgtta caggcaagtt tactagtttt tgacttgcta agccacaact
      421 ggagccagcc ttcatcggga atgctggaag atgaccttaa gctaagcagt gatgaagagg
      481 agaatgaaca gcaggcagct cagagaacgg ctctccgcgc tctctctgac agcgccgtgg
      541 tccagcagcc caactgcaga acctcggtgc cttccagcaa gggcagcagc agcagcagca
      601 gcagcggcag cagcagctcc tccagcgact cagagagcag ctccggatct gactcggaga
      661 ccgagagcag ctccagcgag agtgagggca gcaagccccc ccacttctcc agccccgagg
      721 ctgaaccggc atcctctaac aagtggcagc tggataaatg gctaaacaaa gttaatcccc
      781 acaagcctcc tattctgatc caaaatgaaa gccacgggtc agagagcaat cagtactaca
      841 acccggtgaa agaggacgtc caggactgtg ggaaagtccc cgacgtttgc cagcccagcc
      901 tgagagagaa ggagatcaag agcacttgca aggaggagca aaggccaagg acagccaaca
      961 aggcccctgg gagtaaaggc gtgaagcaga agtccccgcc cgcggccgtg gccgtggcgg
     1021 tgagcgcagc cgccccgcca cccgcagtgc cctgtgcgcc cgcggagaac gcgcccgcgc
     1081 ctgcccggag gtccgcgggc aagaagccca ccaggcgcac cgagaggacc tcagccgggg
     1141 acggcgccaa ctgccaccgg cccgaggagc ccgcggccgc ggacgcgctg gggacgagcg
     1201 tggtggtccc cccggagccc accaaaacca ggccctgtgg caacaacaga gcgagccacc
     1261 gcaaggagct gcgctcctcc gtgacctgcg agaagcgccg cacgcggggg ctaagcagga
     1321 tcgtccccaa atccaaggag ttcattgaga cagagtcgtc atcttcatcc tcctcctcgg
     1381 actccgacct ggagtccgag caggaggagt accctctgtc caaagcacag accgtggctg
     1441 cctctgcctc ctccgggaat gatcagaggc tgaaggaggc cgctgccaac gggggcagtg
     1501 gtcctagggc ccctgtaggc tccatcaacg ccaggaccac cagtgacatc gccaaggagc
     1561 tggaggagca gttctacaca ctggtcccct ttggccggaa cgaacttctc tcccctctaa
     1621 aggacagtga tgagatcagg tctctctggg tcaaaatcga cctgaccctc ctgtccagga
     1681 tcccagaaca cctgccccag gagccagggg tattgagcgc ccctgccacc aaggactctg
     1741 agagcgcacc gcccagccac acctcggaca cacctgcaga aaaggctttg ccaaaatcca
     1801 agaggaaacg caagtgtgac aacgaagacg actacaggga gatcaagaag tcccagggag
     1861 agaaagacag ctcttcaaga ctggccacct ccaccagtaa tactttgtct gcaaaccact
     1921 gcaacatgaa catcaacagt gtggcaatac caataaataa aaatgaaaaa atgcttcggt
     1981 cgcccatctc acccctctct gatgcatcta aacacaaata caccagcgag gacttaactt
     2041 cttccagccg acctaatggc aacagtttgt ttacttcagc ctcttccagc aaaaagccta
     2101 aggccgacag ccagctgcag cctcacggcg gagacctcac gaaagcagct cacaacaatt
     2161 ctgaaaacat tcccctccac aagtcacggc cgcagacgaa gccgtggtct ccaggctcca
     2221 acggccacag ggactgcaag aggcagaaac ttgtcttcga tgatatgcct cgcagtgccg
     2281 attattttat gcaagaagct aaacgaatga agcataaagc agatgcaatg gtggaaaagt
     2341 ttggaaaggc tttgaactat gctgaagcag cattgtcgtt tatcgagtgt ggaaatgcaa
     2401 tggaacaagg ccccatggaa tccaaatctc cttatacgat gtattcagaa acagtagagc
     2461 tcatcaggta tgctatgaga ctaaaaaccc actcaggccc caatgccaca ccagaagaca
     2521 aacaactggc tgcattatgt taccgatgcc tggccctcct gtactggcgg atgtttcgac
     2581 tcaaaaggga ccacgctgta aagtattcaa aagcactaat cgactatttc aagaactcat
     2641 ctaaagccgc ccaagcccca tctccgtggg gggccagtgg aaactccgtg gggtctcagg
     2701 gcagcctctc caacgccagc gccctgtccc cgtcgaccat cgtcagcatc ccacagcgca
     2761 tccaccagat ggcggccaac cacgtcagca tcaccaacag catcctgcac agctacgact
     2821 actgggagat ggccgacaac ctggccaagg aaaaccgaga attcttcaac gacctggatc
     2881 tgctcatggg gccggtcacc ctgcacagca gcatggagca cctggtccag tactcccaac
     2941 agggcctgca ctggctgcgg aacagcgccc acctgtcata gggacctcac cctggggcca
     3001 gagtgggctc tggtctccac agatggctca acgtttttgg acactgtgct actgaaactc
     3061 ccagccacag catttatcag actgcggtga acatttcctc agcattgaac aatgatcttt
     3121 tgcagggcat gtgtgtttgt atgtgtgggt atataagaag ccgcctgtgt atgtgtgtaa
     3181 gatacacagc tcttcagaac acaccttctt tgtctagttt ccataatccc aggctagaca
     3241 aagtgatcag aggtttctga ctagaggaag tacacacaca cacacacaca cacacacaca
     3301 ccgtacactc acacacaatc acagacacac actttctatt ccattccagt gctaaaccgt
     3361 gacttcttag aaaattcaac caaaatctca tgggttagtt aaccaggtgc aatacagcac
     3421 accaaaagct tgactgccag tgaagatgga cctgctctta tactgttgat tactttcagt
     3481 attaatatac tattccccaa ttattttttg attggtatgt attaatgggt aattgaataa
     3541 tgaaaataag ccaggtattt ttgtgccgga agtttactag attgcatgtt accaaatacc
     3601 ctgctcttcc tctaattccc ttcccccatc tgactctatt atcaactaaa tgcattccag
     3661 gcaaacagat ggacactcac agcccttccc agccccacct ccaagtagta tgcaaatggc
     3721 actgagattt agcaaaaacg cggcgtcttt gaaagttaac agacactaag gtagcagtgc
     3781 ctgtgtgttg gagctcagtt aggagttgaa gttttctgca cctgtgataa caagcccacc
     3841 agccacatgc atttcttctt cctgccactg tgactcggtg gctgtagagc cacatggcat
     3901 ttgtcagcca atctgtttca agtcttttct ttccaccaat agctttctta cagattttct
     3961 tggctaaatg aggccattac ctagattgtc ccttcagtag gagcctgaat ccttcgctta
     4021 ccaggctgag agctatttgc catgataatg ctgattctct cactcctcat gcagaatgtg
     4081 cacctgcagc cctttgatgc gttttgattt gggggcgatt tttcaggctt tgattagcag
     4141 gctgcttgca atgcagaaga tcacagttcc tttctggggc agcagcaacc agagcctctt
     4201 cctgtgtcct gtgtgtctgg tatgtttaca ccttgctctg agtttttctc ttgttttctt
     4261 tttttaatta agtttacatt ttagtttctt tgacatcttg tttacagttt ttgtctgatg
     4321 ttttttcttt tgtagtgtct tatgccctag atttagtcat cttgttaaat atatttggat
     4381 atgaaatctt gacgaaaaga aaataactcc tgaaaaagag ggtctatctt gccacacgtt
     4441 aaaaacaaaa ataatgtcct tgtggcctct tacttgataa agttgcacca ggacggtctg
     4501 agaaaggcag gcggtgtaat atgtggtgca atccattttt tcaaggtgat gacggcacaa
     4561 aatacttaga ctagatgctg atccataaac attcactgat attcttacag gttggtttgc
     4621 agtgttaaca tttttgttag cctgatctgt aggtgggaag taagatcatc ataattcctt
     4681 agctctgagc actgattcaa aattgtataa atgactgaac aacttagatg atttgaaatt
     4741 aattgaaaat aagaagggct tgtggaattt gcatttggct ttggccttca agcatttgga
     4801 aatattaaga gaatttccat tttacatgtc tccaactggg gtgcttctta caaccctttc
     4861 actttttttt tgagacgagt ttcgctctgt tgcccaggct ggagtgcagt ggcacgatct
     4921 cggctcactg catcctctgc ctcctgggtt caagtgattg tcccgcctca gcctcccaag
     4981 tagctgggat tacaggtgtg cactaccatg cccagctaat ttttgtgttt ttagtagaga
     5041 ctgggtttca ccatgttggc caggctcgtc tcaaactcct gacctcaggt gatctacccg
     5101 cctccacctc ccaaagtgtt gtgattacag gcgtgagcca ccacacccag ccctttcact
     5161 aatttttggc agagttcaca atcccatcct atgtcagaaa cttgaaccta acttaagaaa
     5221 ttttgagtca tttttttgga ggactgaggc tttgttctac ctactcttga agaatcctga
     5281 tgaaatattc aaacacataa agggatggcc ctggaggtct atcctgcata cctggagagc
     5341 ttctctggtc ctgcccacct tgaaagttgc agactttgtt gtaacatcta tgtgatgagc
     5401 ttccctgtga agccccattt gacaggtggg ccagcagtgt tttatcagca ctctgatggc
     5461 ccacatttcc caggaaaact tcttgaaact taccgttgtg ggcagtggtc agagcgtgta
     5521 gttcttatga ctgtcttgtt tcatctgtgg agcacgtgtg gagcacgttg gtacagcagt
     5581 ttctgtgggg tttggcatgg gtgattttgg ttagtaacca tcctccaatt gttgcttgtg
     5641 aaagtcattc ataacttgtt ccttttactt agttttgttg ttactgctgt tgttgttggt
     5701 ttggttggtt ttgagaccgg gtctggctct gtagcccaag ctggaatgcg gtggcgcgat
     5761 catggctccc tgcagcctca aactcctggg ctcaagcaat cctcctgcct cagcctccca
     5821 agcagctggg aagataggca cgtgccacca cacccggcta attttttctt tatttttttt
     5881 gtagagatgg gggtctcact atgttgccca ggctggtctc aaactcctgg gctcaagcga
     5941 tcctttggcc tcggcctccc aaagtgcatg agccaccatg cctggcctgt ttagttttgt
     6001 ttcaagttga aatacctttc ttgtgttttc taattagaaa agtaatatct actcattgta
     6061 aaaactcaaa cagtgcagaa atgtagaaag tagaaagtgt aagtccctgg ttgtcccttc
     6121 tgcctgagac aaccactgct cacagtttga tgtatatcct tccagagact ctcaaattta
     6181 agcaaataat ttttattacc atgtcttttt atttgaagac gtacatttgc ctccaaagtt
     6241 caacacaagt tcaactgacc atatccttcc atgacctgaa tagatgctat cctttatcac
     6301 gatgttcaat tgcctttgaa agagagtagt ccaggtatat tcctgatcaa aatttggcat
     6361 ttttgatgat actactctac acagatcaga ctcatgtgca gaatcgtgcc tggagagaga
     6421 ggtttggtta agacagagat ttctggaaac attcaaattg caaatggaaa cttgaaaccc
     6481 acaatctaat gaggaatgta ctggaaaaat aatctgaaga gttgacaaat tgtgtactag
     6541 attgaacaca tggaatgcaa tgcaatgaga ctttctgcac taaaacttat cctcatatgt
     6601 acaacaatga tgtgtgtatt atataacagt gatgtgtaca tttctgacac cccatacata
     6661 atatacacag tttgtataaa tgcatacatt taaaaatata tatgtacaat acagctaaca
     6721 taaaactgta gtacgcctga aggatattac tagtgcctaa tattgagtat gagtcactgc
     6781 gtgttcgcat caacttggaa gtgcagtaat tgttataaaa ttaatcagtg cagccaacat
     6841 tatttatgaa tcacatcttt gaaactgtgc agtagcatat acatatatat ttttaaataa
     6901 catttttcac agttttccag agttactgtt gaaatctgca tcaccaaaaa aaaaaaaaag
     6961 caagattttt ttaacaatgt agacactctt cagacccagt aatctgcgtg tgatttccta
     7021 tttgtagatt cccaagagac tttagcagtc accagcctta atgcatgtac aggatattat
     7081 tgtgacttaa tttatctgca gtttttaatc catgtgaaat tggaatttat aaacggactt
     7141 ggattaaaca tgtctgcctt tctaaggttg caaatgttac attaaatgat ttatgttgta
     7201 aatgagagaa gttgagttgt acgtaaaaga catccaccaa tttctgtgaa tatttttaca
     7261 cggaaacttg agaatcaaaa tacgttcaag tcagttgttc tggctcccag tttataatct
     7321 cgaaaagcaa tctttttgtt tcataaatgg cttaaatgta gctcccacag attatcagta
     7381 tgaagtctga catttttcat ggaaaagaag tatgtttttc ttcattataa ctatagttta
     7441 ctatttgtct ttgctatttc ctgatacata cacatacgca cacacgcgcg cacatgcatg
     7501 cacgtatgca catgcacgct cccagtgtcc cagtgaaggc tcaacaggaa gcttgagaag
     7561 gtcatctcaa tggccacagg gttcctgttc aaccagtagc cctgggatgc cgctttgctt
     7621 gtcattcttt agtgtcacaa gttagttccc tgacttgtgt gcagtcaggg aactgcacac
     7681 aactgaaacc aacatggtgg aatcatgttt gcaatatttg gttgagtaaa ataagataat
     7741 tttgaactaa agaagacgga ggcattagac cagtggcttg acatgaagca tcccctatgt
     7801 gggagggtaa gtttgttaac ttcattttta gtcttatctc caaccctttt ccttatcctc
     7861 ctccccaaac taaagaagca gaaacagcaa caaaagcaaa accatccctt cacctgatcc
     7921 agcccatgtc cttagattca aatatccttt gtctttttcc cattatacca tctgacataa
     7981 ctcactcgtg tctagagaga aaaatgcaga aagggtttgt ttgcagatgg gcagttcagt
     8041 tgagtcctca ttaaccaggc agaggggtgc agaagaagcc tgactcaggg tcaccatgga
     8101 gaactcctca tcccagagat gggtgggaca ggaacttggc tttgcttcac caaccactga
     8161 gcttgatact ctttcagagg tggtttgtgc taagaaacac ccagcagtct ttcaagaacg
     8221 ttctcttctg tagctttgcc tgctacacag ctgaagtctg tccctataag aattatattt
     8281 gtaaaaagta atacattttc gaagaaaccc ggatcaagtg gaatcttgaa agttttttta
     8341 atgaaagggg aaaaacaacc tgaccacata aactgcactt ccaaccattt ggaaccagag
     8401 tttatgtcct cattttccca ttctcagaag agcacagttt ttcaatatta caacttcctg
     8461 gcaaatagca caagaaatgt tcagacttga gatttgtgtt ccctttgtcc agattattct
     8521 gtatatgtca ccaaaggggt taacttgttt gcttggcatg aggaaaatta taaactccgt
     8581 tctcaaacta attacatctg cccacggttt tggtttttat tattttaatt ggcactccga
     8641 ggcagcaggg ggtaaatttt gtgttggctg caaggggatt taggttcaca gctcttactc
     8701 acagtaatgg gaatcaaggg attaaatctc tgtgtgttac tttgaaaatc cacctcttac
     8761 agccaatttt atagacattg atctgagggt tgaattcagg gcactaattg ccagtcagta
     8821 caagggtcag catttgtgtt gaagcaccag gggtattgat gtagcctgaa aagctgaatc
     8881 agggacttgg gttttgtttt gttttgtttt ttttacccat ttttaaaata ggaaagctca
     8941 tccagaaata cttggatcta gacatgatat aacatagcac caatgtttag gatttttaga
     9001 gtgctgttgg gtaattaaaa taatatcaat gttcta
//
